iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118350

UUCD1 version

UUC-TaR-01163

Ensembl Protein ID

ENSTRUP00000026413.1

UniProt Accession

H2TP07; H2TP07_TAKRU

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000010477.1	ENSTRUT00000026520.1	ENSTRUP00000026413.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-58	200.2	326	854
UBD/Alpha-Helix/UBA	4.00e-19	69.3	723	761

Active Site

Position(s)	Description	Evidence
335	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
817	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.......wkskkk................ 66
           tG+kNlgN+CY+NSv+Q+L+ +p++ + + + +  k+ +e+pk+p++++ ++++kl   l                             
   Q: 326  TGMKNLGNSCYLNSVMQVLFTVPDFENKYVS-NIDKIIDEAPKDPSQDFKTQVAKLGYGLlsgkyskP----Aldpgeengtseargdq 409
           7******************************.8888889999******************55555440....15555555555555666 PP
   S: 67   .avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqi 154
             ++pr++++ +++ ++efs+++qqDaqE+l ++++ +e+++                             ++ +  s+ F++ ++++i
   Q: 410  iGIAPRMFKALIGWGHPEFSTNRQQDAQEYLLHFINMVERNC-----------------------------RSGTNPSEAFRFLVEEKI 469
           6*****************************************.............................66778899********** PP
   S: 155  kclecdnvssreepfldlslpvpgkeetkke........................slqdcLesftkeeelegenkyycekckkkqeaek 219
           +c++ ++ + ++   + ++lpvp+++ t+                           ++ c+++ +++e l++   ++++  ++k++a+k
   Q: 470  VCQQSQKAKYTQRVDYIIQLPVPMDQATNAAeelqeaerrrdegdasaptvraqiPFTACMAAHSEPEILTD---FWSSAVQAKTTATK 555
           **************************9887799**************************************7...************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................................... 267
           ++++ ++P+ L++++k+f+f  + ++++k++ ++++p++Ldls   ++                                         
   Q: 556  TTRFASFPDHLVIQIKKFTFGLD-WVPKKLDVSIDVPDTLDLSALRATgqqpgeellpevappplmtpdvevkgilgsqgneeddslys 643
           ********************997.*******************9888866777777777777777777777777777766666666666 PP
   S: 268  ...........................................................................peekqke....... 274
                                                                                      p     +       
   Q: 644  plnvlfllpapaldestvshlcemgfplesckravyfsgntgidaatnwimshmddadftaplvlpgcssgagttP-----Tesiseeh 727
           6666666666666666666666666666666666666666666655555555555555555555555555555550.....05555555 PP
   S: 275  .....................................................................kkkYeLiavvvHsG.slssG 293
                                                                                + kYeL+a ++H+G s+ +G
   Q: 728  letivsmgfsrdqatkalratsndlqraldwifsntndlesmdiseggrsaaesesasepppgprvrdgPGKYELFAFISHMGtSTMCG 816
           556666666666666666666666667777777777777777788888888888888899999999999******************** PP
   S: 294  HYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HYv+++k+ +++W+ f+D+kV ++  e+  +   + +Y++fY+r
   Q: 817  HYVCHIKK-DQQWVIFNDQKVCAS--EKPPK---DMGYLYFYRR 854
           ********.999*********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           ++e+ le +v+MGF+r++a +aLra++n+l++A++++++
   Q: 723  ISEEHLETIVSMGFSRDQATKALRATSNDLQRALDWIFS 761
           68999********************************97 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MADVGDVLMS VLSTIRVPKP GDRVHKDECA LSFASPESEG GLYVCMNSFL GFGSQYVERH 60
YARTGQRAYL HIKRTRKTKE EDNNSGSGHP PKKKPTRLAI GIEGGFDVEQ DQYEEDIKVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGGGCCAG CACTCAGAGC ACCAAGCGTC TCACGTAAAC TCCTGAATAG CTAACTCACC 60
ATGGCGGACG TCGGGGACGT ATTAATGTCC GTTTTGTCCA CAATTCGCGT TCCGAAACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	65.38	0.00e+00	1140.00
IUUC-Atr-002580	Amborella trichopoda	42.43	0.00e+00	663.00
IUUC-Apl-003774	Anas platyrhynchos	65.62	0.00e+00	1111.00
IUUC-Aca-005368	Anolis carolinensis	63.58	0.00e+00	1136.00
IUUC-Aly-005727	Arabidopsis lyrata	44.90	0.00e+00	672.00
IUUC-Ath-006974	Arabidopsis thaliana	44.90	0.00e+00	673.00
IUUC-Ago-007890	Ashbya gossypii	26.50	6.00e-69	255.00
IUUC-Acl-008057	Aspergillus clavatus	33.69	7.00e-120	424.00
IUUC-Afu-008805	Aspergillus fumigatus	32.39	1.00e-104	374.00
IUUC-Ang-009720	Aspergillus niger	32.09	2.00e-107	383.00
IUUC-Aor-010111	Aspergillus oryzae	31.86	6.00e-113	401.00
IUUC-Ate-010531	Aspergillus terreus	30.89	5.00e-98	352.00
IUUC-Ame-011893	Astyanax mexicanus	80.54	0.00e+00	1223.00
IUUC-Bgr-012183	Blumeria graminis	31.44	2.00e-110	393.00
IUUC-Bta-013179	Bos taurus	65.89	0.00e+00	1148.00
IUUC-Bci-013858	Botrytis cinerea	32.91	6.00e-116	411.00
IUUC-Bdi-014904	Brachypodium distachyon	43.25	0.00e+00	634.00
IUUC-Bol-015296	Brassica oleracea	45.06	0.00e+00	679.00
IUUC-Bra-017939	Brassica rapa	44.96	0.00e+00	687.00
IUUC-Cel-018625	Caenorhabditis elegans	32.63	5.00e-117	415.00
IUUC-Cja-019063	Callithrix jacchus	64.84	0.00e+00	1124.00
IUUC-Cfa-020976	Canis familiaris	64.68	0.00e+00	1127.00
IUUC-Cpo-022265	Cavia porcellus	64.60	0.00e+00	1123.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	38.73	2.00e-105	376.00
IUUC-Csa-024177	Chlorocebus sabaeus	62.86	0.00e+00	1006.00
IUUC-Cho-024702	Choloepus hoffmanni	59.41	0.00e+00	649.00
IUUC-Cin-025411	Ciona intestinalis	47.46	0.00e+00	762.00
IUUC-Csv-026347	Ciona savignyi	44.53	0.00e+00	753.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	33.02	2.00e-102	367.00
IUUC-Cne-026831	Cryptococcus neoformans	33.91	7.00e-112	398.00
IUUC-Dre-027982	Danio rerio	82.71	0.00e+00	1345.00
IUUC-Dno-029034	Dasypus novemcinctus	65.89	0.00e+00	1148.00
IUUC-Dor-030479	Dipodomys ordii	65.90	2.00e-142	500.00
IUUC-Dse-031467	Dothistroma septosporum	32.79	3.00e-114	406.00
IUUC-Dme-032075	Drosophila melanogaster	46.65	0.00e+00	733.00
IUUC-Ete-032865	Echinops telfairi	59.95	0.00e+00	1008.00
IUUC-Eca-034059	Equus caballus	65.51	0.00e+00	1147.00
IUUC-Eeu-035304	Erinaceus europaeus	62.03	0.00e+00	1035.00
IUUC-Fca-035515	Felis catus	65.77	0.00e+00	1151.00
IUUC-Fal-037271	Ficedula albicollis	64.15	0.00e+00	1063.00
IUUC-Fox-037745	Fusarium oxysporum	33.92	3.00e-119	422.00
IUUC-Fso-038158	Fusarium solani	33.76	3.00e-115	409.00
IUUC-Gmo-039071	Gadus morhua	82.52	0.00e+00	1340.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.49	8.00e-109	387.00
IUUC-Gga-040635	Gallus gallus	65.70	0.00e+00	1170.00
IUUC-Gac-042528	Gasterosteus aculeatus	83.59	0.00e+00	1381.00
IUUC-Gma-043614	Glycine max	43.47	0.00e+00	655.00
IUUC-Ggo-044602	Gorilla gorilla	65.65	0.00e+00	1144.00
IUUC-Hsa-045959	Homo sapiens	65.65	0.00e+00	1144.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	65.81	0.00e+00	1143.00
IUUC-Kpa-049156	Komagataella pastoris	30.47	7.00e-94	338.00
IUUC-Lch-049648	Latimeria chalumnae	64.11	0.00e+00	1111.00
IUUC-Lpe-051523	Leersia perrieri	42.81	0.00e+00	647.00
IUUC-Loc-052520	Lepisosteus oculatus	70.14	0.00e+00	1114.00
IUUC-Lma-053216	Leptosphaeria maculans	33.33	2.00e-102	368.00
IUUC-Laf-054327	Loxodonta africana	65.77	0.00e+00	1141.00
IUUC-Mcc-055443	Macaca mulatta	65.65	0.00e+00	1146.00
IUUC-Meu-056298	Macropus eugenii	66.78	0.00e+00	801.00
IUUC-Mor-057106	Magnaporthe oryzae	33.60	6.00e-116	411.00
IUUC-Mpo-057589	Magnaporthe poae	33.33	5.00e-113	402.00
IUUC-Mtr-058680	Medicago truncatula	44.65	0.00e+00	680.00
IUUC-Mla-058903	Melampsora laricipopulina	32.27	9.00e-108	384.00
IUUC-Mga-059669	Meleagris gallopavo	65.12	0.00e+00	1105.00
IUUC-Mvi-060476	Microbotryum violaceum	32.95	7.00e-106	378.00
IUUC-Mmr-060575	Microcebus murinus	65.65	0.00e+00	1145.00
IUUC-Mdo-062183	Monodelphis domestica	64.01	0.00e+00	1103.00
IUUC-Mmu-063592	Mus musculus	65.89	0.00e+00	1154.00
IUUC-Mpu-066082	Mustela putorius furo	64.21	0.00e+00	1120.00
IUUC-Mlu-067345	Myotis lucifugus	65.42	0.00e+00	1133.00
IUUC-Nfi-068558	Neosartorya fischeri	33.74	4.00e-115	409.00
IUUC-Ncr-068960	Neurospora crassa	32.48	2.00e-103	369.00
IUUC-Nle-070173	Nomascus leucogenys	64.44	0.00e+00	1121.00
IUUC-Opr-070556	Ochotona princeps	66.67	0.00e+00	1164.00
IUUC-Ont-071502	Oreochromis niloticus	86.48	0.00e+00	1406.00
IUUC-Ocu-074861	Oryctolagus cuniculus	64.44	0.00e+00	1125.00
IUUC-Oba-075109	Oryza barthii	42.99	0.00e+00	650.00
IUUC-Obr-076292	Oryza brachyantha	44.51	0.00e+00	634.00
IUUC-Ogl-077065	Oryza glaberrima	43.93	0.00e+00	674.00
IUUC-Ogu-078776	Oryza glumaepatula	42.87	0.00e+00	661.00
IUUC-Oin-080048	Oryza indica	44.05	0.00e+00	672.00
IUUC-Olo-080711	Oryza longistaminata	41.31	5.00e-169	587.00
IUUC-Ome-081506	Oryza meridionalis	42.16	5.00e-171	594.00
IUUC-Oni-082320	Oryza nivara	42.21	0.00e+00	645.00
IUUC-Opu-083801	Oryza punctata	42.87	0.00e+00	637.00
IUUC-Oru-085139	Oryza rufipogon	42.26	0.00e+00	645.00
IUUC-Osa-085713	Oryza sativa	44.05	0.00e+00	677.00
IUUC-Ola-086951	Oryzias latipes	87.30	0.00e+00	1377.00
IUUC-Olu-087822	Ostreococcus lucimarinus	39.79	2.00e-164	572.00
IUUC-Oga-088625	Otolemur garnettii	65.58	0.00e+00	1132.00
IUUC-Oar-089995	Ovis aries	65.54	0.00e+00	1131.00
IUUC-Ptr-090640	Pan troglodytes	64.83	0.00e+00	1140.00
IUUC-Pan-091974	Papio anubis	65.66	0.00e+00	1137.00
IUUC-Psi-093957	Pelodiscus sinensis	65.47	0.00e+00	1176.00
IUUC-Pma-094242	Petromyzon marinus	68.57	6.00e-150	523.00
IUUC-Pno-094835	Phaeosphaeria nodorum	33.94	3.00e-97	349.00
IUUC-Ppa-095901	Physcomitrella patens	45.98	0.00e+00	718.00
IUUC-Pfo-097148	Poecilia formosa	85.78	0.00e+00	1382.00
IUUC-Pab-098068	Pongo abelii	60.91	0.00e+00	1004.00
IUUC-Pop-098943	Populus trichocarpa	45.13	0.00e+00	680.00
IUUC-Pca-100738	Procavia capensis	65.47	0.00e+00	779.00
IUUC-Ppe-101315	Prunus persica	43.97	0.00e+00	650.00
IUUC-Pva-102154	Pteropus vampyrus	65.46	0.00e+00	1139.00
IUUC-Pgr-103343	Puccinia graminis	32.45	1.00e-96	347.00
IUUC-Ptt-103928	Puccinia triticina	28.90	1.00e-94	341.00
IUUC-Pte-104306	Pyrenophora teres	33.41	2.00e-99	357.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.99	4.00e-100	358.00
IUUC-Rno-105801	Rattus norvegicus	66.12	0.00e+00	1154.00
IUUC-Sce-106304	Saccharomyces cerevisiae	26.00	1.00e-60	228.00
IUUC-Sha-107635	Sarcophilus harrisii	63.58	0.00e+00	1108.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	29.16	7.00e-87	315.00
IUUC-Smo-108848	Selaginella moellendorffii	44.15	0.00e+00	665.00
IUUC-Sit-110728	Setaria italica	43.80	0.00e+00	698.00
IUUC-Sly-111523	Solanum lycopersicum	43.47	0.00e+00	689.00
IUUC-Sbi-114419	Sorghum bicolor	43.06	0.00e+00	679.00
IUUC-Sre-115225	Sporisorium reilianum	32.64	9.00e-107	381.00
IUUC-Ssc-115686	Sus scrofa	65.69	0.00e+00	1141.00
IUUC-Tgu-117346	Taeniopygia guttata	65.74	0.00e+00	1154.00
IUUC-Tni-120658	Tetraodon nigroviridis	92.31	0.00e+00	1469.00
IUUC-Tca-121585	Theobroma cacao	45.09	0.00e+00	668.00
IUUC-Tre-122043	Trichoderma reesei	32.45	2.00e-105	377.00
IUUC-Tvi-122303	Trichoderma virens	33.29	9.00e-107	381.00
IUUC-Tae-123798	Triticum aestivum	42.89	0.00e+00	648.00
IUUC-Tur-126732	Triticum urartu	40.65	4.00e-174	604.00
IUUC-Tme-126909	Tuber melanosporum	32.49	2.00e-104	373.00
IUUC-Tbe-127261	Tupaia belangeri	59.51	0.00e+00	689.00
IUUC-Uma-129599	Ustilago maydis	33.52	3.00e-113	402.00
IUUC-Vda-129688	Verticillium dahliae	32.40	2.00e-106	379.00
IUUC-Vvi-131116	Vitis vinifera	43.33	0.00e+00	650.00
IUUC-Xtr-131953	Xenopus tropicalis	65.20	0.00e+00	1077.00
IUUC-Xma-133837	Xiphophorus maculatus	85.66	0.00e+00	1381.00
IUUC-Yli-134510	Yarrowia lipolytica	33.65	9.00e-115	407.00
IUUC-Zma-135786	Zea mays	42.53	0.00e+00	649.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence