iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088897

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03164762

Gene Name

UBE2K

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000008264.2	ENSOGAT00000008268.2	ENSOGAP00000007399.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.40e-45	154.4	15	146
UBD/Alpha-Helix/UBA	4.50e-11	42.5	161	199

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 5    elkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekW 92
           e+ +++++++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+ilk  ++W
   Q: 15   EILKINETSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDILK--DQW 100
           7789999*************.9***************************************************99********9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
            +a+++++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 101  AAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 146
           *******************************************986 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 161  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 199
           6789*********************************97 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

FNSIFLLKDK IESCEILKIN ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTAATTCTA TATTCTTATT AAAAGATAAG ATTGAGTCAT GTGAAATTTT AAAAATGTGA 60
GTTTTAAGTT ACATTTTGTC TCTATACTAA ACATTCTGTG CTAAAAATAT TTAATATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	66.67	2.00e-25	108.00
IUUC-Aml-001286	Ailuropoda melanoleuca	93.94	3.00e-100	357.00
IUUC-Atr-003063	Amborella trichopoda	48.91	5.00e-38	150.00
IUUC-Apl-004122	Anas platyrhynchos	99.43	6.00e-95	339.00
IUUC-Aca-004565	Anolis carolinensis	99.44	1.00e-97	348.00
IUUC-Aly-006390	Arabidopsis lyrata	49.20	4.00e-42	164.00
IUUC-Ath-006637	Arabidopsis thaliana	47.06	2.00e-39	154.00
IUUC-Ago-007714	Ashbya gossypii	45.20	3.00e-36	144.00
IUUC-Acl-008189	Aspergillus clavatus	52.08	6.00e-27	114.00
IUUC-Afl-008489	Aspergillus flavus	42.65	1.00e-27	116.00
IUUC-Afu-008850	Aspergillus fumigatus	41.87	7.00e-28	117.00
IUUC-Ani-009361	Aspergillus nidulans	52.55	3.00e-25	108.00
IUUC-Ang-009548	Aspergillus niger	51.39	8.00e-26	110.00
IUUC-Aor-010105	Aspergillus oryzae	42.65	1.00e-27	116.00
IUUC-Ate-010389	Aspergillus terreus	41.67	4.00e-27	114.00
IUUC-Ame-011454	Astyanax mexicanus	90.91	9.00e-98	348.00
IUUC-Bgr-012255	Blumeria graminis	50.00	2.00e-32	132.00
IUUC-Bta-012992	Bos taurus	93.94	3.00e-100	357.00
IUUC-Bci-013806	Botrytis cinerea	44.15	3.00e-35	141.00
IUUC-Bdi-015024	Brachypodium distachyon	53.61	3.00e-38	150.00
IUUC-Bol-015985	Brassica oleracea	47.42	1.00e-42	166.00
IUUC-Bra-016805	Brassica rapa	47.21	6.00e-43	166.00
IUUC-Cel-018353	Caenorhabditis elegans	51.06	5.00e-51	193.00
IUUC-Cja-019051	Callithrix jacchus	93.43	2.00e-99	354.00
IUUC-Cfa-020016	Canis familiaris	93.94	3.00e-100	357.00
IUUC-Cpo-022026	Cavia porcellus	93.94	3.00e-100	357.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	50.55	3.00e-40	157.00
IUUC-Csa-023059	Chlorocebus sabaeus	93.94	3.00e-100	357.00
IUUC-Cho-024276	Choloepus hoffmanni	96.60	2.00e-73	267.00
IUUC-Cin-025598	Ciona intestinalis	61.41	6.00e-51	193.00
IUUC-Csv-025831	Ciona savignyi	63.28	3.00e-50	191.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	51.52	8.00e-33	133.00
IUUC-Cne-027068	Cryptococcus neoformans	42.86	2.00e-38	152.00
IUUC-Dre-028139	Danio rerio	90.91	1.00e-97	348.00
IUUC-Dno-029169	Dasypus novemcinctus	93.43	7.00e-100	355.00
IUUC-Dor-030382	Dipodomys ordii	79.80	5.00e-79	286.00
IUUC-Dse-031335	Dothistroma septosporum	60.17	1.00e-35	143.00
IUUC-Dme-032003	Drosophila melanogaster	64.74	1.00e-62	232.00
IUUC-Ete-032868	Echinops telfairi	84.85	2.00e-78	285.00
IUUC-Eca-033428	Equus caballus	93.94	3.00e-100	357.00
IUUC-Eeu-035103	Erinaceus europaeus	73.44	5.00e-49	186.00
IUUC-Fca-035366	Felis catus	93.94	3.00e-100	357.00
IUUC-Fal-037016	Ficedula albicollis	93.94	3.00e-100	357.00
IUUC-Fox-037969	Fusarium oxysporum	46.84	1.00e-32	132.00
IUUC-Fso-038296	Fusarium solani	43.58	1.00e-34	139.00
IUUC-Gmo-039135	Gadus morhua	89.90	3.00e-96	343.00
IUUC-Ggr-039768	Gaeumannomyces graminis	51.06	6.00e-24	103.00
IUUC-Gga-041018	Gallus gallus	93.43	5.00e-100	356.00
IUUC-Gac-041503	Gasterosteus aculeatus	90.40	3.00e-97	347.00
IUUC-Gma-042779	Glycine max	52.91	4.00e-41	160.00
IUUC-Ggo-045032	Gorilla gorilla	93.94	3.00e-100	357.00
IUUC-Hsa-046490	Homo sapiens	93.94	3.00e-100	357.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	93.94	3.00e-100	357.00
IUUC-Lch-050588	Latimeria chalumnae	68.25	1.00e-75	275.00
IUUC-Lpe-051070	Leersia perrieri	49.21	9.00e-30	122.00
IUUC-Loc-052549	Lepisosteus oculatus	91.41	4.00e-98	350.00
IUUC-Lma-052949	Leptosphaeria maculans	53.47	1.00e-36	145.00
IUUC-Laf-053688	Loxodonta africana	100.00	1.00e-97	348.00
IUUC-Mcc-055606	Macaca mulatta	93.94	3.00e-100	357.00
IUUC-Mor-056946	Magnaporthe oryzae	39.47	4.00e-22	97.80
IUUC-Mpo-057441	Magnaporthe poae	53.28	6.00e-24	103.00
IUUC-Mtr-058002	Medicago truncatula	52.33	3.00e-41	160.00
IUUC-Mla-059007	Melampsora laricipopulina	43.48	1.00e-36	146.00
IUUC-Mga-059254	Meleagris gallopavo	98.89	3.00e-97	347.00
IUUC-Mvi-060346	Microbotryum violaceum	43.09	1.00e-31	129.00
IUUC-Mmr-061211	Microcebus murinus	93.94	3.00e-100	357.00
IUUC-Mdo-062458	Monodelphis domestica	92.93	1.00e-97	348.00
IUUC-Mmu-063648	Mus musculus	93.94	3.00e-100	357.00
IUUC-Mac-065447	Musa acuminata	50.55	4.00e-39	154.00
IUUC-Mpu-066407	Mustela putorius furo	93.94	8.00e-100	356.00
IUUC-Mlu-067682	Myotis lucifugus	99.44	6.00e-98	349.00
IUUC-Nfi-068517	Neosartorya fischeri	41.87	6.00e-28	117.00
IUUC-Ncr-068749	Neurospora crassa	53.97	7.00e-36	143.00
IUUC-Nle-069712	Nomascus leucogenys	91.46	2.00e-98	350.00
IUUC-Opr-070651	Ochotona princeps	93.94	3.00e-100	357.00
IUUC-Ont-071433	Oreochromis niloticus	90.40	3.00e-97	347.00
IUUC-Oan-073058	Ornithorhynchus anatinus	100.00	1.00e-78	284.00
IUUC-Ocu-074939	Oryctolagus cuniculus	93.94	3.00e-100	357.00
IUUC-Oba-075530	Oryza barthii	53.94	1.00e-29	122.00
IUUC-Obr-076838	Oryza brachyantha	53.99	4.00e-29	120.00
IUUC-Ogl-077606	Oryza glaberrima	53.94	1.00e-29	122.00
IUUC-Ogu-078238	Oryza glumaepatula	53.94	1.00e-29	122.00
IUUC-Oin-079643	Oryza indica	53.94	3.00e-29	121.00
IUUC-Ome-081274	Oryza meridionalis	53.94	1.00e-29	122.00
IUUC-Oni-082651	Oryza nivara	53.94	1.00e-29	122.00
IUUC-Opu-083933	Oryza punctata	53.94	2.00e-29	121.00
IUUC-Oru-085054	Oryza rufipogon	53.94	3.00e-29	121.00
IUUC-Osa-085716	Oryza sativa	53.94	3.00e-29	121.00
IUUC-Ola-087043	Oryzias latipes	90.40	3.00e-97	347.00
IUUC-Olu-087846	Ostreococcus lucimarinus	47.31	2.00e-41	161.00
IUUC-Oar-089673	Ovis aries	97.84	3.00e-98	350.00
IUUC-Ptr-091295	Pan troglodytes	93.94	3.00e-100	357.00
IUUC-Pan-092034	Papio anubis	99.44	2.00e-97	347.00
IUUC-Psi-093498	Pelodiscus sinensis	93.94	3.00e-100	357.00
IUUC-Pma-094115	Petromyzon marinus	79.90	5.00e-85	306.00
IUUC-Pno-095102	Phaeosphaeria nodorum	43.72	5.00e-37	147.00
IUUC-Ppa-095326	Physcomitrella patens	47.06	1.00e-37	149.00
IUUC-Pfo-096940	Poecilia formosa	90.40	3.00e-97	347.00
IUUC-Pab-098279	Pongo abelii	93.94	3.00e-100	357.00
IUUC-Pop-099543	Populus trichocarpa	52.30	3.00e-42	164.00
IUUC-Pca-100782	Procavia capensis	93.43	3.00e-98	350.00
IUUC-Ppe-101789	Prunus persica	52.00	4.00e-36	144.00
IUUC-Pva-102147	Pteropus vampyrus	100.00	3.00e-52	197.00
IUUC-Pgr-103643	Puccinia graminis	44.03	7.00e-37	147.00
IUUC-Ptt-103772	Puccinia triticina	46.85	2.00e-35	142.00
IUUC-Pte-104370	Pyrenophora teres	52.08	1.00e-35	142.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	42.16	2.00e-35	142.00
IUUC-Rno-104984	Rattus norvegicus	93.94	3.00e-100	357.00
IUUC-Sce-106394	Saccharomyces cerevisiae	43.48	1.00e-33	136.00
IUUC-Sha-106848	Sarcophilus harrisii	98.38	5.00e-98	349.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	46.28	2.00e-38	152.00
IUUC-Smo-109656	Selaginella moellendorffii	48.92	1.00e-38	152.00
IUUC-Sit-110639	Setaria italica	52.41	3.00e-37	147.00
IUUC-Sly-110978	Solanum lycopersicum	52.30	2.00e-42	165.00
IUUC-Stu-112088	Solanum tuberosum	52.30	7.00e-43	166.00
IUUC-Sar-113285	Sorex araneus	84.36	4.00e-76	276.00
IUUC-Sbi-113986	Sorghum bicolor	52.41	4.00e-37	147.00
IUUC-Ssc-116314	Sus scrofa	93.94	3.00e-100	357.00
IUUC-Tgu-117427	Taeniopygia guttata	99.44	2.00e-97	347.00
IUUC-Tru-118618	Takifugu rubripes	85.35	5.00e-92	330.00
IUUC-Tsy-119208	Tarsius syrichta	96.86	4.00e-100	356.00
IUUC-Tni-119667	Tetraodon nigroviridis	90.91	1.00e-97	348.00
IUUC-Tca-121446	Theobroma cacao	51.38	5.00e-43	166.00
IUUC-Tre-122053	Trichoderma reesei	39.88	6.00e-30	124.00
IUUC-Tae-125119	Triticum aestivum	54.22	7.00e-31	126.00
IUUC-Tme-127024	Tuber melanosporum	52.82	8.00e-38	150.00
IUUC-Tbe-127752	Tupaia belangeri	95.81	1.00e-98	351.00
IUUC-Ttr-128287	Tursiops truncatus	100.00	2.00e-97	347.00
IUUC-Uma-129512	Ustilago maydis	41.08	1.00e-34	139.00
IUUC-Vda-129947	Verticillium dahliae	42.20	9.00e-31	126.00
IUUC-Vpa-130481	Vicugna pacos	94.42	3.00e-100	357.00
IUUC-Vvi-131429	Vitis vinifera	48.37	2.00e-39	155.00
IUUC-Xtr-132710	Xenopus tropicalis	79.79	1.00e-85	308.00
IUUC-Xma-134308	Xiphophorus maculatus	89.90	9.00e-97	345.00
IUUC-Yli-134523	Yarrowia lipolytica	44.58	7.00e-33	133.00
IUUC-Zma-135733	Zea mays	51.12	2.00e-35	141.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence