iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028041

Ensembl Protein ID

ENSDARP00000137095.1

UniProt Accession

A0A0R4IPD0; A0A0R4IPD0_DANRE

Genbank Protein ID

ENSDARP00000137095

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

BX649644

Gene Name

siah1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000030871.8	ENSDART00000165079.1	ENSDARP00000137095.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.57	7.00e-126	447.00	IUUC-Dme-031700
E3 activity/RING/RING	88.34	3.00e-170	595.00	IUUC-Hsa-046357
E3 activity/RING/RING	97.87	2.00e-167	585.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSATVRLQPV YSWKGVLKLF SCIAARTASK PKEVHTFQGK KKDVLGNLMD EEMSRQTATA 60
LPTGTSKCPP SQRVPTLSGT TASNSDLASL FECPVCFDYV LPPILQCQSG HLVCSNCRPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCGCGAC ACCGAGACTG CCGGGCGACA GCAGCGTCTC TTTTTAGCGA ATGTGGAAAC 60
ACAAACAACC AAACGATTAA CGGACATATA ACCTAACGCT GCCCGACGTG TGGTGAATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.32	1.00e-45	176.00
IUUC-Aml-001186	Ailuropoda melanoleuca	85.93	8.00e-170	589.00
IUUC-Atr-002857	Amborella trichopoda	36.57	7.00e-45	174.00
IUUC-Apl-003813	Anas platyrhynchos	97.16	1.00e-167	581.00
IUUC-Aca-005014	Anolis carolinensis	94.24	6.00e-169	586.00
IUUC-Aly-006522	Arabidopsis lyrata	37.96	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	4.00e-42	165.00
IUUC-Ame-011196	Astyanax mexicanus	97.60	0.00e+00	681.00
IUUC-Bta-012887	Bos taurus	85.93	5.00e-170	590.00
IUUC-Bdi-014200	Brachypodium distachyon	37.55	3.00e-46	179.00
IUUC-Bol-015523	Brassica oleracea	35.95	2.00e-41	162.00
IUUC-Bra-017336	Brassica rapa	34.38	2.00e-41	162.00
IUUC-Cel-018320	Caenorhabditis elegans	63.17	7.00e-117	414.00
IUUC-Cja-019796	Callithrix jacchus	88.31	3.00e-171	594.00
IUUC-Cfa-020642	Canis familiaris	93.24	1.00e-169	588.00
IUUC-Cpo-022348	Cavia porcellus	97.52	2.00e-168	584.00
IUUC-Csa-023974	Chlorocebus sabaeus	88.34	1.00e-171	595.00
IUUC-Cin-025674	Ciona intestinalis	78.37	4.00e-135	473.00
IUUC-Csv-026233	Ciona savignyi	84.65	2.00e-132	464.00
IUUC-Dno-029764	Dasypus novemcinctus	97.17	5.00e-168	583.00
IUUC-Dme-031700	Drosophila melanogaster	83.47	5.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	96.63	3.00e-157	548.00
IUUC-Eca-033536	Equus caballus	97.16	1.00e-167	581.00
IUUC-Eeu-035314	Erinaceus europaeus	96.63	2.00e-157	548.00
IUUC-Fca-035362	Felis catus	87.38	7.00e-170	589.00
IUUC-Fal-037487	Ficedula albicollis	87.65	1.00e-168	585.00
IUUC-Gga-040269	Gallus gallus	97.16	1.00e-167	581.00
IUUC-Gac-042282	Gasterosteus aculeatus	99.29	3.00e-170	590.00
IUUC-Gma-042926	Glycine max	35.55	9.00e-41	160.00
IUUC-Ggo-045444	Gorilla gorilla	88.34	1.00e-171	595.00
IUUC-Hsa-046357	Homo sapiens	88.34	1.00e-171	595.00
IUUC-Hvu-047574	Hordeum vulgare	36.96	1.00e-45	176.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	97.52	2.00e-168	584.00
IUUC-Lch-049504	Latimeria chalumnae	96.45	1.00e-166	578.00
IUUC-Lpe-050879	Leersia perrieri	40.25	6.00e-43	167.00
IUUC-Loc-052191	Lepisosteus oculatus	95.36	4.00e-175	607.00
IUUC-Laf-053668	Loxodonta africana	97.16	1.00e-167	581.00
IUUC-Mcc-054640	Macaca mulatta	88.34	1.00e-171	595.00
IUUC-Mtr-058747	Medicago truncatula	33.92	3.00e-42	166.00
IUUC-Mga-059503	Meleagris gallopavo	97.17	4.00e-168	583.00
IUUC-Mmr-060794	Microcebus murinus	97.52	2.00e-168	584.00
IUUC-Mmu-064129	Mus musculus	97.87	8.00e-169	585.00
IUUC-Mac-065014	Musa acuminata	35.40	2.00e-43	169.00
IUUC-Mpu-066488	Mustela putorius furo	85.93	6.00e-170	589.00
IUUC-Mlu-067207	Myotis lucifugus	97.17	1.00e-168	585.00
IUUC-Nle-069706	Nomascus leucogenys	88.31	3.00e-171	593.00
IUUC-Ont-071849	Oreochromis niloticus	99.29	9.00e-171	592.00
IUUC-Ocu-074876	Oryctolagus cuniculus	86.23	1.00e-170	591.00
IUUC-Oba-075454	Oryza barthii	40.66	3.00e-43	168.00
IUUC-Obr-076037	Oryza brachyantha	35.43	2.00e-40	160.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	3.00e-43	168.00
IUUC-Ogu-078910	Oryza glumaepatula	40.83	5.00e-43	168.00
IUUC-Oin-079749	Oryza indica	40.66	3.00e-43	168.00
IUUC-Olo-080244	Oryza longistaminata	34.83	2.00e-40	160.00
IUUC-Ome-081318	Oryza meridionalis	40.66	3.00e-43	168.00
IUUC-Oni-083109	Oryza nivara	40.66	3.00e-43	168.00
IUUC-Opu-084065	Oryza punctata	41.08	1.00e-43	169.00
IUUC-Oru-084785	Oryza rufipogon	40.66	3.00e-43	168.00
IUUC-Osa-085610	Oryza sativa	40.66	3.00e-43	168.00
IUUC-Ola-086814	Oryzias latipes	99.29	3.00e-170	590.00
IUUC-Oga-088399	Otolemur garnettii	97.52	2.00e-168	584.00
IUUC-Oar-089323	Ovis aries	87.62	1.00e-168	585.00
IUUC-Ptr-090692	Pan troglodytes	97.53	4.00e-169	587.00
IUUC-Pan-092012	Papio anubis	88.34	1.00e-171	595.00
IUUC-Psi-093687	Pelodiscus sinensis	85.93	3.00e-171	593.00
IUUC-Pma-094387	Petromyzon marinus	92.61	7.00e-159	552.00
IUUC-Ppa-095212	Physcomitrella patens	35.82	1.00e-40	160.00
IUUC-Pfo-097134	Poecilia formosa	99.29	3.00e-170	590.00
IUUC-Pab-097555	Pongo abelii	88.34	1.00e-171	595.00
IUUC-Pop-099970	Populus trichocarpa	35.29	9.00e-45	173.00
IUUC-Ppe-101760	Prunus persica	36.10	2.00e-43	169.00
IUUC-Rno-104866	Rattus norvegicus	97.87	8.00e-169	585.00
IUUC-Sha-106547	Sarcophilus harrisii	85.93	8.00e-170	589.00
IUUC-Smo-109412	Selaginella moellendorffii	33.91	9.00e-40	157.00
IUUC-Sit-110595	Setaria italica	37.11	2.00e-42	166.00
IUUC-Sly-111259	Solanum lycopersicum	38.04	1.00e-41	163.00
IUUC-Stu-112571	Solanum tuberosum	36.76	1.00e-41	164.00
IUUC-Sbi-114090	Sorghum bicolor	37.50	3.00e-43	169.00
IUUC-Tgu-116579	Taeniopygia guttata	97.16	1.00e-167	581.00
IUUC-Tru-118250	Takifugu rubripes	93.97	5.00e-160	556.00
IUUC-Tni-120488	Tetraodon nigroviridis	98.23	8.00e-166	575.00
IUUC-Tca-121228	Theobroma cacao	34.01	1.00e-41	163.00
IUUC-Tae-123647	Triticum aestivum	37.32	1.00e-45	176.00
IUUC-Tur-126259	Triticum urartu	35.11	1.00e-39	156.00
IUUC-Ttr-129166	Tursiops truncatus	96.68	4.00e-141	494.00
IUUC-Vvi-131451	Vitis vinifera	37.86	5.00e-42	164.00
IUUC-Xtr-132553	Xenopus tropicalis	97.52	2.00e-168	584.00
IUUC-Xma-133670	Xiphophorus maculatus	99.29	3.00e-170	590.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence