iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092761

Ensembl Protein ID

ENSPANP00000013040.1

UniProt Accession

A0A096NJ91; A0A096NJ91_PAPAN

Genbank Protein ID

ENSPANP00000013040

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AHZZ01074298

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000017004.1	ENSPANT00000004972.1	ENSPANP00000013040.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.10e-133	445.6	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F+++++++gk++Ae+a+e+l+eln+dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f+vVv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTVVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****99999999998***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk++++fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCVNITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  +
   Q: 369  gqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDNPdneivLYLMLRAVDRFNKQHGRYPGVSNYQVEEDIgkL 457
           *************99********7777777888888**************9***********************************999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           ********....********************************************************9776 PP

Organism

Papio anubis

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGCTCA GTGCGCCGGC GCGCTTGTGG AGCTGGTGGC GGCGCTCCGC TGGGGCTCAG 60
CTGTTCTCCG CGCTGCGGGC GCAGCCATGG CGCAGCCGGG GAAGCTGCTC AAGGAGCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.72	8.00e-127	447.00
IUUC-Aml-002333	Ailuropoda melanoleuca	97.39	0.00e+00	1089.00
IUUC-Atr-002644	Amborella trichopoda	41.32	3.00e-115	408.00
IUUC-Apl-003446	Anas platyrhynchos	84.20	0.00e+00	920.00
IUUC-Aca-004450	Anolis carolinensis	80.49	0.00e+00	920.00
IUUC-Aly-006187	Arabidopsis lyrata	40.19	8.00e-126	443.00
IUUC-Ath-007600	Arabidopsis thaliana	40.75	3.00e-127	448.00
IUUC-Ago-007900	Ashbya gossypii	26.97	5.00e-40	158.00
IUUC-Acl-008333	Aspergillus clavatus	34.70	6.00e-82	298.00
IUUC-Afl-008529	Aspergillus flavus	36.56	2.00e-87	317.00
IUUC-Afu-009071	Aspergillus fumigatus	34.05	6.00e-83	301.00
IUUC-Ani-009443	Aspergillus nidulans	33.69	2.00e-79	289.00
IUUC-Ang-009669	Aspergillus niger	33.69	1.00e-83	303.00
IUUC-Aor-009914	Aspergillus oryzae	35.88	3.00e-84	306.00
IUUC-Ate-010450	Aspergillus terreus	34.89	4.00e-85	308.00
IUUC-Ame-011183	Astyanax mexicanus	72.21	0.00e+00	831.00
IUUC-Bgr-012111	Blumeria graminis	33.21	1.00e-66	247.00
IUUC-Bta-012583	Bos taurus	97.94	0.00e+00	1096.00
IUUC-Bci-013892	Botrytis cinerea	33.58	5.00e-66	245.00
IUUC-Bdi-014592	Brachypodium distachyon	43.51	4.00e-129	454.00
IUUC-Bol-016399	Brassica oleracea	39.92	4.00e-124	438.00
IUUC-Bra-017506	Brassica rapa	38.81	3.00e-120	425.00
IUUC-Cel-018456	Caenorhabditis elegans	36.16	4.00e-94	338.00
IUUC-Cja-020007	Callithrix jacchus	98.14	0.00e+00	1097.00
IUUC-Cfa-020324	Canis familiaris	97.94	0.00e+00	1094.00
IUUC-Cpo-022248	Cavia porcellus	66.60	0.00e+00	649.00
IUUC-Csa-023149	Chlorocebus sabaeus	99.34	0.00e+00	937.00
IUUC-Cho-024537	Choloepus hoffmanni	85.47	0.00e+00	810.00
IUUC-Cin-025763	Ciona intestinalis	49.91	1.00e-155	543.00
IUUC-Csv-026113	Ciona savignyi	46.48	7.00e-146	510.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.82	2.00e-66	246.00
IUUC-Cne-026884	Cryptococcus neoformans	30.07	7.00e-72	265.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.11	5.00e-19	89.40
IUUC-Dre-028140	Danio rerio	73.22	0.00e+00	852.00
IUUC-Dno-030033	Dasypus novemcinctus	97.67	0.00e+00	964.00
IUUC-Dor-030513	Dipodomys ordii	68.69	2.00e-115	409.00
IUUC-Dse-031536	Dothistroma septosporum	35.29	1.00e-86	313.00
IUUC-Dme-031683	Drosophila melanogaster	44.65	3.00e-127	448.00
IUUC-Ete-032420	Echinops telfairi	83.14	0.00e+00	888.00
IUUC-Eca-033992	Equus caballus	97.98	0.00e+00	918.00
IUUC-Eeu-034713	Erinaceus europaeus	80.31	5.00e-118	417.00
IUUC-Fca-036548	Felis catus	96.82	0.00e+00	1083.00
IUUC-Fal-037600	Ficedula albicollis	81.03	0.00e+00	889.00
IUUC-Fox-038037	Fusarium oxysporum	33.76	2.00e-77	283.00
IUUC-Fso-038387	Fusarium solani	34.77	3.00e-79	289.00
IUUC-Gmo-038562	Gadus morhua	71.40	0.00e+00	824.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.17	2.00e-73	270.00
IUUC-Gga-041129	Gallus gallus	84.67	0.00e+00	944.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.69	0.00e+00	834.00
IUUC-Gma-043610	Glycine max	41.15	4.00e-121	428.00
IUUC-Ggo-045611	Gorilla gorilla	98.51	0.00e+00	1096.00
IUUC-Hsa-046563	Homo sapiens	99.06	0.00e+00	1100.00
IUUC-Hvu-047790	Hordeum vulgare	38.11	3.00e-77	282.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	98.13	0.00e+00	1096.00
IUUC-Kpa-049309	Komagataella pastoris	35.67	2.00e-83	303.00
IUUC-Lch-050038	Latimeria chalumnae	76.79	0.00e+00	859.00
IUUC-Lpe-051535	Leersia perrieri	41.65	3.00e-112	398.00
IUUC-Loc-051917	Lepisosteus oculatus	69.56	0.00e+00	793.00
IUUC-Lma-053112	Leptosphaeria maculans	35.75	2.00e-88	320.00
IUUC-Laf-053690	Loxodonta africana	97.00	0.00e+00	1088.00
IUUC-Mcc-055117	Macaca mulatta	97.21	0.00e+00	1084.00
IUUC-Meu-056761	Macropus eugenii	77.37	0.00e+00	833.00
IUUC-Mor-057230	Magnaporthe oryzae	33.63	4.00e-78	285.00
IUUC-Mpo-057514	Magnaporthe poae	33.63	1.00e-71	263.00
IUUC-Mtr-058551	Medicago truncatula	40.47	5.00e-118	417.00
IUUC-Mla-059183	Melampsora laricipopulina	36.98	1.00e-96	347.00
IUUC-Mga-060144	Meleagris gallopavo	82.95	0.00e+00	916.00
IUUC-Mvi-060221	Microbotryum violaceum	35.99	1.00e-82	300.00
IUUC-Mmr-061325	Microcebus murinus	95.16	0.00e+00	1064.00
IUUC-Mdo-062532	Monodelphis domestica	91.74	0.00e+00	1031.00
IUUC-Mmu-063956	Mus musculus	97.19	0.00e+00	1089.00
IUUC-Mac-064521	Musa acuminata	40.93	1.00e-123	436.00
IUUC-Mpu-066716	Mustela putorius furo	97.01	0.00e+00	1026.00
IUUC-Mlu-067459	Myotis lucifugus	95.71	0.00e+00	1068.00
IUUC-Nfi-068245	Neosartorya fischeri	34.41	6.00e-83	301.00
IUUC-Ncr-068910	Neurospora crassa	34.00	2.00e-77	283.00
IUUC-Nle-070034	Nomascus leucogenys	96.38	0.00e+00	1052.00
IUUC-Opr-070552	Ochotona princeps	87.43	0.00e+00	890.00
IUUC-Ont-071426	Oreochromis niloticus	73.35	0.00e+00	852.00
IUUC-Oan-073389	Ornithorhynchus anatinus	84.04	0.00e+00	781.00
IUUC-Ocu-074911	Oryctolagus cuniculus	96.44	0.00e+00	1088.00
IUUC-Oba-075437	Oryza barthii	43.13	2.00e-119	422.00
IUUC-Obr-076684	Oryza brachyantha	43.16	7.00e-115	407.00
IUUC-Ogl-077170	Oryza glaberrima	43.13	2.00e-119	422.00
IUUC-Ogu-078844	Oryza glumaepatula	43.91	2.00e-112	399.00
IUUC-Oin-079105	Oryza indica	43.13	8.00e-119	420.00
IUUC-Olo-080943	Oryza longistaminata	40.64	3.00e-107	382.00
IUUC-Oni-082891	Oryza nivara	40.27	1.00e-112	400.00
IUUC-Opu-083457	Oryza punctata	43.13	6.00e-119	421.00
IUUC-Oru-084960	Oryza rufipogon	40.64	3.00e-107	382.00
IUUC-Osa-085358	Oryza sativa	43.32	2.00e-119	422.00
IUUC-Ola-086420	Oryzias latipes	71.31	4.00e-168	583.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.06	7.00e-62	231.00
IUUC-Oga-088810	Otolemur garnettii	96.25	0.00e+00	1082.00
IUUC-Oar-089196	Ovis aries	97.39	0.00e+00	1092.00
IUUC-Ptr-090617	Pan troglodytes	99.06	0.00e+00	1101.00
IUUC-Psi-093191	Pelodiscus sinensis	86.85	0.00e+00	965.00
IUUC-Pma-094380	Petromyzon marinus	62.27	0.00e+00	665.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.67	2.00e-75	278.00
IUUC-Ppa-095875	Physcomitrella patens	40.19	1.00e-120	426.00
IUUC-Pfo-096467	Poecilia formosa	72.40	0.00e+00	832.00
IUUC-Pab-098255	Pongo abelii	98.87	0.00e+00	920.00
IUUC-Pop-099722	Populus trichocarpa	40.75	2.00e-125	442.00
IUUC-Pca-100807	Procavia capensis	79.25	5.00e-119	421.00
IUUC-Ppe-101280	Prunus persica	40.60	3.00e-124	438.00
IUUC-Pva-102333	Pteropus vampyrus	93.11	0.00e+00	1030.00
IUUC-Pgr-103401	Puccinia graminis	32.14	2.00e-81	296.00
IUUC-Ptt-103889	Puccinia triticina	27.67	2.00e-58	220.00
IUUC-Pte-104355	Pyrenophora teres	36.54	1.00e-91	330.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.54	7.00e-93	334.00
IUUC-Rno-105810	Rattus norvegicus	96.44	0.00e+00	1081.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.21	2.00e-37	149.00
IUUC-Sha-106770	Sarcophilus harrisii	90.81	5.00e-156	543.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.33	5.00e-79	288.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.46	3.00e-84	305.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.55	1.00e-68	253.00
IUUC-Smo-109296	Selaginella moellendorffii	42.61	4.00e-124	438.00
IUUC-Sit-110157	Setaria italica	44.59	5.00e-136	477.00
IUUC-Sly-111105	Solanum lycopersicum	39.93	1.00e-122	433.00
IUUC-Stu-112469	Solanum tuberosum	40.44	2.00e-124	439.00
IUUC-Sar-113083	Sorex araneus	73.45	0.00e+00	755.00
IUUC-Sbi-113813	Sorghum bicolor	44.59	5.00e-135	474.00
IUUC-Sre-115058	Sporisorium reilianum	39.11	1.00e-85	310.00
IUUC-Tgu-116772	Taeniopygia guttata	80.65	0.00e+00	888.00
IUUC-Tru-118686	Takifugu rubripes	71.64	0.00e+00	836.00
IUUC-Tsy-119111	Tarsius syrichta	89.75	5.00e-151	527.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.42	0.00e+00	753.00
IUUC-Tca-121491	Theobroma cacao	40.60	1.00e-117	416.00
IUUC-Tre-122103	Trichoderma reesei	36.95	5.00e-83	301.00
IUUC-Tvi-122672	Trichoderma virens	36.65	1.00e-75	277.00
IUUC-Tae-125679	Triticum aestivum	43.32	8.00e-129	454.00
IUUC-Tur-126487	Triticum urartu	41.60	4.00e-122	431.00
IUUC-Tme-127097	Tuber melanosporum	39.27	3.00e-95	342.00
IUUC-Ttr-128465	Tursiops truncatus	90.32	0.00e+00	1001.00
IUUC-Uma-129645	Ustilago maydis	33.83	3.00e-90	326.00
IUUC-Vda-129989	Verticillium dahliae	30.91	7.00e-57	214.00
IUUC-Vpa-130529	Vicugna pacos	92.92	0.00e+00	1035.00
IUUC-Vvi-131059	Vitis vinifera	41.34	8.00e-123	434.00
IUUC-Xtr-132002	Xenopus tropicalis	78.94	0.00e+00	909.00
IUUC-Xma-133930	Xiphophorus maculatus	73.00	0.00e+00	839.00
IUUC-Yli-134505	Yarrowia lipolytica	35.05	2.00e-86	312.00
IUUC-Zma-135895	Zea mays	44.85	4.00e-134	471.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence