iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007241

UUCD1 version

UUC-ArT-00291

Ensembl Protein ID

AT4G34040.1

UniProt Accession

O49500; MBR2_ARATH

Genbank Protein ID

CAA17568.1; CAB80121.1; AEE86313.1; AAU05489.1; AAV85696.1; BAF01129.1

Protein Name

E3 ubiquitin-protein ligase MBR2; HAL3-interacting protein 1 homolog; MED25-binding RING-H2 protein 2; RING-H2 finger MBR2; RING-type E3 ubiquitin transferase MBR2

Genbank Nucleotide ID

AL021961; AL161584; CP002687; BT015366; BT020341; AK229265

Gene Name

MBR2; HIP1; At4g34040

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G34040	AT4G34040.1	AT4G34040.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-06	29.5	619	660

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e++   +d + +l+CgH fh+ C+++w       + + +CP+C+
   Q: 619  CCVCQEEYaegDD-LGTLGCGHEFHTACVKQW------LMLKNLCPICK 660
           ********66544.9999**************......**********6 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that functions as regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way. Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering. May function downstream of HAL3 and be required for HAL3-regulated plant growth. Activation of MBR2 by HAL3 may lead to the degradation of cell cycle suppressors, resulting in enhancement of cell division and plant growth.

Protein Sequence
(Fasta)

MQGPRSTGDS STGINYADGE PICSTNSETT SNNILNPVDV QFPNNTTGSG RPTYASSSSH 60
VVQNHNWWSF GESSSRLGPS DHLNSNGSKT DRQLLSDGYG FEEGQSGMLL PGESFLRGSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATAAAAACT CTTTACAATA AATTATGTCT GCCTGTTTCA ATTTACCAAA CTTCTTTTGA 60
TTAAAATCTT TGGAACCAAA TTAAATTTTA ATTACACGAA AATGTGTTTG TAAGAAAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0287--Flowering
KW-0341--Growth regulation
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0009908--P:flower development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0040008--P:regulation of growth
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT4G34040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000325	Aegilops tauschii	49.74	4.00e-46	179.00
IUUC-Aly-006551	Arabidopsis lyrata	95.50	0.00e+00	1137.00
IUUC-Cel-018318	Caenorhabditis elegans	50.98	6.00e-13	68.20
IUUC-Gac-041830	Gasterosteus aculeatus	29.63	9.00e-14	72.00
IUUC-Gma-044405	Glycine max	38.19	9.00e-92	330.00
IUUC-Hvu-047680	Hordeum vulgare	56.32	6.00e-54	204.00
IUUC-Lpe-051474	Leersia perrieri	53.26	9.00e-50	191.00
IUUC-Loc-052174	Lepisosteus oculatus	33.60	5.00e-15	76.30
IUUC-Mtr-057919	Medicago truncatula	42.89	3.00e-82	298.00
IUUC-Mac-065663	Musa acuminata	44.93	8.00e-54	203.00
IUUC-Oba-075898	Oryza barthii	53.89	2.00e-49	189.00
IUUC-Obr-076185	Oryza brachyantha	53.26	2.00e-48	186.00
IUUC-Ogl-077587	Oryza glaberrima	53.89	2.00e-49	189.00
IUUC-Oin-079127	Oryza indica	53.89	2.00e-49	189.00
IUUC-Olo-080490	Oryza longistaminata	53.89	2.00e-49	189.00
IUUC-Ome-081637	Oryza meridionalis	55.75	7.00e-52	197.00
IUUC-Oni-082106	Oryza nivara	53.89	2.00e-49	189.00
IUUC-Opu-084108	Oryza punctata	54.75	1.00e-49	191.00
IUUC-Oru-085229	Oryza rufipogon	53.89	2.00e-49	189.00
IUUC-Osa-085404	Oryza sativa	53.89	2.00e-49	189.00
IUUC-Pop-098817	Populus trichocarpa	42.56	6.00e-103	367.00
IUUC-Sit-110290	Setaria italica	54.34	1.00e-51	197.00
IUUC-Sbi-113819	Sorghum bicolor	53.98	1.00e-50	194.00
IUUC-Tni-120063	Tetraodon nigroviridis	33.06	2.00e-14	73.90
IUUC-Tca-121420	Theobroma cacao	53.54	5.00e-115	407.00
IUUC-Tae-123230	Triticum aestivum	54.02	3.00e-49	189.00
IUUC-Tur-126323	Triticum urartu	54.02	3.00e-49	189.00
IUUC-Vvi-131609	Vitis vinifera	43.28	4.00e-109	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence