iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006666

UUCD1 version

UUC-ArT-01695

Ensembl Protein ID

AT1G10570.1

UniProt Accession

Q8RWN0; Q3EDF1; Q9XIJ4; ULP1C_ARATH

Genbank Protein ID

AAD39580.1; AEE28595.1; AEE28596.1; AAM12980.1; AAM91198.1

Protein Name

Ubiquitin-like-specific protease 1C; Protein OVERLY TOLERANT TO SALT 2

Genbank Nucleotide ID

AC007067; CP002684; CP002684; AY092981; AY128798

Gene Name

ULP1C; OTS2; At1g10570; T10O24.20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G10570	AT1G10570.2	AT1G10570.2
AT1G10570	AT1G10570.1	AT1G10570.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/ULP	6.00e-34	118.7	332	523

Active Site

Position(s)	Description	Evidence
426	N/A	{ECO:0000250}
449		{ECO:0000250}
512		{ECO:0000250}

Domain Profile

DUB/ULP

   S: 2    svtnedlkcLeegeflnDviidfylkylvlekl.kkekverihifssffykklkq.kerr.........rvktwtrkvdlfekdlifvpineaaHWsl 88
           +v+ +dlkcL++ge+l+  +i+fy+ y+  + +  ++++ ++h+f++ffykkl++   ++         + ++w +  dlf k++if+pi+e+ HWsl
   Q: 332  QVSLKDLKCLSPGEYLTSPVINFYIRYVQHHVFsADKTAANCHFFNTFFYKKLTEaVSYKgndrdayfvKFRRWWKGFDLFCKSYIFIPIHEDLHWSL 429
           68889*********************87777776778899**************955677999*********************************** PP
   S: 89   avvcf......kkksilllDSlrgasksnvvkklreylev...evkkks..krefskeklk.......gsnpkvpqQkNssDCGvyvlqyvesl 164
           +++c+      +  +i++lDSl  + ++ + ++++++l++   + ++       +s ++++       ++ ++vpqQkN++DCG+++l +++ +
   Q: 430  VIICIpdkedeSGLTIIHLDSLGLHPRNLIFNNVKRFLREewnYLNQDAplDLPISAKVWRdlpnminEAEVQVPQQKNDFDCGLFLLFFIRRF 523
           *****5554444458*******767777788999999998554222222112345555554111110045566****************99875 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Protease activity mainly directed at deconjugating SUM1 and SUM2 from their target proteins. Regulates salt stress responses and flowering time. Redundant with ULP1D.

Protein Sequence
(Fasta)

MKRQRAIELD RVKKTMLNID WDDALGDEEV PELEIIATDK IPPREPTLSG YEPAVSVRSL 60
RDNELDDHLK RQRSLLTRLG DKLADKGEKI RNRIGELEYE KQRRMFQQRT KMQDADNGCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAAACC AGAAAGATTT CAGACCGAAA CCTAAATAAT ATTGAGTAAG TTTATTCGAA 60
GAAGAGATGA AGAGACAAAG AGCAATCGAG TTAGATCGAG TGAAGAAGAC AATGTTGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0016926--P:protein desumoylation
GO:0009651--P:response to salt stress
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT1G10570

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005089	Anolis carolinensis	34.68	2.00e-16	80.90
IUUC-Aly-006537	Arabidopsis lyrata	91.42	0.00e+00	1020.00
IUUC-Afl-008482	Aspergillus flavus	32.41	8.00e-15	75.90
IUUC-Ani-009366	Aspergillus nidulans	32.74	3.00e-16	80.10
IUUC-Aor-010192	Aspergillus oryzae	30.69	6.00e-11	63.20
IUUC-Bci-013906	Botrytis cinerea	33.05	1.00e-13	72.40
IUUC-Bol-015537	Brassica oleracea	68.52	0.00e+00	693.00
IUUC-Bra-017938	Brassica rapa	66.67	0.00e+00	663.00
IUUC-Eeu-034776	Erinaceus europaeus	31.25	3.00e-13	70.10
IUUC-Fal-036736	Ficedula albicollis	35.66	5.00e-14	73.20
IUUC-Lpe-051158	Leersia perrieri	46.89	5.00e-70	258.00
IUUC-Lma-053172	Leptosphaeria maculans	36.70	4.00e-14	73.90
IUUC-Oba-075399	Oryza barthii	50.43	7.00e-70	257.00
IUUC-Ogu-078425	Oryza glumaepatula	50.00	4.00e-68	251.00
IUUC-Olo-080689	Oryza longistaminata	50.00	9.00e-69	254.00
IUUC-Ome-081527	Oryza meridionalis	50.85	5.00e-70	258.00
IUUC-Oni-082476	Oryza nivara	50.00	5.00e-69	254.00
IUUC-Opu-084112	Oryza punctata	50.85	3.00e-70	258.00
IUUC-Oru-085206	Oryza rufipogon	50.00	9.00e-69	254.00
IUUC-Ola-086425	Oryzias latipes	33.59	7.00e-15	75.10
IUUC-Pno-094801	Phaeosphaeria nodorum	37.27	8.00e-15	75.50
IUUC-Pfo-096792	Poecilia formosa	33.33	2.00e-18	87.40
IUUC-Ssl-108654	Sclerotinia sclerotiorum	34.57	2.00e-09	57.00
IUUC-Smo-108860	Selaginella moellendorffii	39.68	6.00e-39	154.00
IUUC-Sbi-113778	Sorghum bicolor	42.91	9.00e-56	209.00
IUUC-Sre-115211	Sporisorium reilianum	30.83	9.00e-12	65.90
IUUC-Tre-121879	Trichoderma reesei	31.41	6.00e-14	72.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence