iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003624

Ensembl Protein ID

ENSAPLP00000006857.1

UniProt Accession

U3IHY5; U3IHY5_ANAPL

Genbank Protein ID

ENSAPLP00000006857

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01132878

Gene Name

DDB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000007174.1	ENSAPLT00000007508.1	ENSAPLP00000006857.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DDB1	0	1735.7	13	1135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DDB1

   S: 18   klvvgnftshkelNLliaksnrieiflvtpeglrpvvevklegsiavlrlfrpknekkdllfilteryntlilelrdidessevvtr 104
            ++ g+fts+++lNLliak++r+ei++vt+eglrpv+     g+ av++lfrpk+e+kdllfilt++yn++ile+++ ++s++++tr
   Q: 13   VSLSGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVK----XGKTAVMELFRPKGESKDLLFILTAKYNACILEYKQNGDSIDIITR 95
           57789*******************************9....599******************************************* PP
   S: 105  adgevlDdigrssdsGlinviepkirlialelyqglfklIvldndikelkafnirleelnvsdvkflilltqptgrvlviyqdddgk 191
           a+g+v+D+igr+s++G+i++i+p++r+i+l+ly+glfk+I+ld+++kelkafnirleel+v+dvkfl+++++pt  ++++yqd++g+
   Q: 96   AHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRENKELKAFNIRLEELQVIDVKFLYGCQAPT--ICFVYQDPQGR 180
           **************************************************************************..*********** PP
   S: 192  hlktyelslkdKeFvkis.kqesiekeaellipvpsqlvgvlvlgeesivyksadnykdvdPylirqstairyervdnngirylLgd 277
           h+ktye+sl++KeF+k++ kqe++e+ea+++i+vp++++g++++g+esi+y+++d+y +++P++i+qst+++++rvd ng+rylLgd
   Q: 181  HVKTYEVSLREKEFNKGPwKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGD 267
           *************************************************************************************** PP
   S: 278  fdGelkllllsaeeemsG.vevkslkielLgeisiaesisyldngllfvgsrfgdsQlvklisestgkgsyvvilerfknlkpIvdl 363
           ++G+l++lll++ee+m+G v++k+l++elLge+siae+++yldng++fvgsr+gdsQlvkl+++s+++gsyvv++e+f+nl+pIvd+
   Q: 268  MEGRLFMLLLEKEEQMDGtVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDM 354
           *************************************************************************************** PP
   S: 364  vvvdldrrgqgqvvtvsgaskdGslRvirlgigieelasvdlkgvigllslkstidestdnslvlafvsetkvlnlntgeeledtel 450
           +vvdl+r+gqgq+vt+sga+k+GslR+ir+gigi+e+as+dl+g++gl++l+s+  ++tdn+lvl+fv++t+vl+ln gee+e+tel
   Q: 355  CVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDCHRETDNTLVLSFVGQTRVLMLN-GEEVEETEL 440
           *****************************************************************************.********* PP
   S: 451  sgvlsdlqtlltqdvidykqllqvTsqsvrLvssqikrllkeWkaknleiigvassNteqvliaatsndlvyleigdgeldltsttt 537
           +g+++d+qt+++ +v +++ql+q+Ts+svrLvs++ k+l++eWk++n+++i+vas+N++qv++a+ +++l+ylei ++el+++s t+
   Q: 441  TGFVDDQQTFFCGNV-AHQQLIQITSASVRLVSQEPKALVSEWKEPNGKNISVASCNSNQVVVAV-GRALYYLEIRPQELRQISCTE 525
           ***************.************************************************9.********************* PP
   S: 538  lenevavldlinieddpnlsdleavglltdiskrililpdletiykeklggeiipRsilltefEnvtYlLialgdGalvsyildidt 624
           +e+eva+ld+++++d++ +s l+a+gl+tdis+ril+lp++e+++ke+lggeiipRsil+t+fE+ +YlL+algdGal+++ l  +t
   Q: 526  MEHEVACLDITPLGDTNGMSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLSLET 612
           *************************************************************************************** PP
   S: 625  gdesdakksnlgtspgtlktfkslsttqvfassDrPtvIyssskkLvfSnVnlkeVqylCsldseaypdslalanngslvigtvddi 711
           g +sd+kk++lgt+p++l+tf+slstt+vfa+sDrPtvIyss++kLvfSnVnlkeV+y+C+l+s++ypdslalann++l+igt+d+i
   Q: 613  GLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEI 699
           *************************************************************************************** PP
   S: 712  qklkiRsiplgeslrriayqesvitfgvisdrreldf.klklkalrnnasilalvpdiennklfsdglrilelseleenevnfllvl 797
           qkl+iR++pl+es+r+i+yqe++++fgv+s+r+e+++ +++++alr++as++al+++++ +klfs++++ +e+s++ee+ev++ll++
   Q: 700  QKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDaSGGTTALRPSASTQALSSSVSTSKLFSSSTAPHETSFGEEVEVHNLLII 786
           *************************************9************************************************* PP
   S: 798  DkntfelllaqdlrewEtavsllSqklkdDseeyyvvktalvlpeenelkkgrilvfsvedslklkLltvaekkvkgavidlvklNg 884
           D++tfe+l+a+++ ++E+a+sl+S+kl++D+++y++v+ta+v+pee+e+k+gri+vf+++d+   kL+  aek+vkgav+++v++Ng
   Q: 787  DQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFHYSDG---KLQSLAEKEVKGAVYSMVEFNG 870
           **************************************************************...********************** PP
   S: 885  kllaainseirlyewkvmgtdekelrkeCernntilaLtlktrkdfivVgDlmrsvtLllykdlegsfeEsardynlewmsaveiln 971
           klla+ins++rlyew    t ekelr+eC+++n+i+aL+lkt++dfi+VgDlmrsv Ll+yk +eg+feE+ard+n++wmsaveil+
   Q: 871  KLLASINSTVRLYEW----TAEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILD 953
           ***************....******************************************************************** PP
   S: 972  ddiflgaencgNlfvvkkdikagltdeerslleevgefrlgefvevfrfgtlvlqdvgerevnrssevifgtengeigvilrlrrel 1058
           dd+flgaen++Nlfv++kd +a++tdeer++l+evg  +lgefv+vf++g+lv+q++ge++++++++v+fgt+ng+ig++++l++++
   Q: 954  DDNFLGAENAFNLFVCQKD-SAATTDEERQHLQEVGLSHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESW 1039
           *******************.******************************************************************* PP
   S: 1059 lkflrnlestlkkvikrvakieHs...syRsFetekrterasgfvdgdLiesilDlsrdkavdilkvl.yekrwnskkevsveeivK 1141
           +++l +++++l+kvik+v+kieHs    +RsF+te++te+a+gf+dgdLies+lD+sr+k+++++++l  ++++++k+e++v++++K
   Q: 1040 YNLLLDMQNRLNKVIKSVGKIEHSlcgTWRSFHTERKTEPATGFIDGDLIESFL

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

TPLRWGLTAS LSVSLSGHFT SAEDLNLLIA KNTRLEIYVV TAEGLRPVKX GKTAVMELFR 60
PKGESKDLLF ILTAKYNACI LEYKQNGDSI DIITRAHGNV QDRIGRPSET GIIGIIDPEC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCCGCTGC GGTGGGGGCT GACGGCCTCT CTCTCTGTTT CTCTTTCAGG GCACTTCACC 60
TCGGCGGAGG ACCTGAACCT GCTGATCGCC AAGAACACGC GGCTGGAGAT CTACGTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004871--Cleavage/polyA-sp_fac_asu_C
IPR031297--DDB1
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF03178--CPSF_A

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0035518--P:histone H2A monoubiquitination
GO:0051702--P:interaction with symbiont
GO:0043066--P:negative regulation of apoptotic process
GO:0046726--P:positive regulation by virus of viral protein levels in host cell
GO:0045070--P:positive regulation of viral genome replication
GO:1902188--P:positive regulation of viral release from host cell
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1901990--P:regulation of mitotic cell cycle phase transition
GO:0070914--P:UV-damage excision repair
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000120	Aegilops tauschii	49.58	0.00e+00	1094.00
IUUC-Aml-002096	Ailuropoda melanoleuca	96.53	0.00e+00	2196.00
IUUC-Atr-002742	Amborella trichopoda	51.76	0.00e+00	1145.00
IUUC-Aca-005085	Anolis carolinensis	96.44	0.00e+00	2196.00
IUUC-Aly-005857	Arabidopsis lyrata	52.24	0.00e+00	1147.00
IUUC-Ath-006658	Arabidopsis thaliana	52.07	0.00e+00	1143.00
IUUC-Acl-008149	Aspergillus clavatus	26.75	3.00e-99	356.00
IUUC-Afl-008549	Aspergillus flavus	27.96	3.00e-105	376.00
IUUC-Afu-009076	Aspergillus fumigatus	27.02	3.00e-109	389.00
IUUC-Ani-009302	Aspergillus nidulans	27.17	3.00e-85	310.00
IUUC-Ang-009636	Aspergillus niger	28.16	3.00e-81	296.00
IUUC-Aor-010073	Aspergillus oryzae	27.92	5.00e-108	385.00
IUUC-Ate-010422	Aspergillus terreus	27.19	1.00e-100	361.00
IUUC-Ame-011643	Astyanax mexicanus	80.09	0.00e+00	1795.00
IUUC-Bgr-012164	Blumeria graminis	26.10	8.00e-91	328.00
IUUC-Bta-012494	Bos taurus	96.53	0.00e+00	2196.00
IUUC-Bci-013957	Botrytis cinerea	26.52	2.00e-86	313.00
IUUC-Bdi-014186	Brachypodium distachyon	51.98	0.00e+00	1138.00
IUUC-Bol-015922	Brassica oleracea	52.51	0.00e+00	1157.00
IUUC-Bra-017300	Brassica rapa	52.51	0.00e+00	1150.00
IUUC-Cel-018239	Caenorhabditis elegans	36.89	0.00e+00	758.00
IUUC-Cja-019165	Callithrix jacchus	96.44	0.00e+00	2195.00
IUUC-Cfa-020406	Canis familiaris	96.53	0.00e+00	2196.00
IUUC-Cpo-022154	Cavia porcellus	95.91	0.00e+00	2182.00
IUUC-Cre-022557	Chlamydomonas reinhardtii	39.74	0.00e+00	740.00
IUUC-Csa-024061	Chlorocebus sabaeus	96.44	0.00e+00	2195.00
IUUC-Cho-024554	Choloepus hoffmanni	90.40	0.00e+00	922.00
IUUC-Cin-025466	Ciona intestinalis	61.42	0.00e+00	1431.00
IUUC-Csv-026370	Ciona savignyi	60.33	0.00e+00	1311.00
IUUC-Cgl-026595	Colletotrichum gloeosporioides	26.03	2.00e-92	333.00
IUUC-Cme-027342	Cyanidioschyzon merolae	27.58	7.00e-115	408.00
IUUC-Dre-027448	Danio rerio	91.23	0.00e+00	1026.00
IUUC-Dno-029794	Dasypus novemcinctus	96.06	0.00e+00	2061.00
IUUC-Dor-030789	Dipodomys ordii	83.42	0.00e+00	967.00
IUUC-Dse-031491	Dothistroma septosporum	27.62	7.00e-110	391.00
IUUC-Dme-031940	Drosophila melanogaster	60.62	0.00e+00	1333.00
IUUC-Ete-032913	Echinops telfairi	78.85	0.00e+00	847.00
IUUC-Eca-033777	Equus caballus	96.00	0.00e+00	2175.00
IUUC-Eeu-034900	Erinaceus europaeus	94.95	0.00e+00	1100.00
IUUC-Fca-035869	Felis catus	96.53	0.00e+00	2196.00
IUUC-Fal-036777	Ficedula albicollis	99.11	0.00e+00	2243.00
IUUC-Fox-037954	Fusarium oxysporum	26.90	4.00e-100	359.00
IUUC-Fso-038292	Fusarium solani	26.09	1.00e-104	374.00
IUUC-Gmo-038815	Gadus morhua	82.00	0.00e+00	969.00
IUUC-Ggr-039907	Gaeumannomyces graminis	25.96	8.00e-93	335.00
IUUC-Gga-040995	Gallus gallus	98.58	0.00e+00	2235.00
IUUC-Gac-042390	Gasterosteus aculeatus	88.62	0.00e+00	1935.00
IUUC-Gma-042904	Glycine max	51.63	0.00e+00	1100.00
IUUC-Ggo-044891	Gorilla gorilla	96.53	0.00e+00	2199.00
IUUC-Hsa-046709	Homo sapiens	96.44	0.00e+00	2195.00
IUUC-Hvu-047504	Hordeum vulgare	51.72	0.00e+00	1120.00
IUUC-Itr-048678	Ictidomys tridecemlineatus	96.44	0.00e+00	2196.00
IUUC-Lch-050565	Latimeria chalumnae	93.02	0.00e+00	2143.00
IUUC-Lpe-051260	Leersia perrieri	52.07	0.00e+00	1137.00
IUUC-Loc-052091	Lepisosteus oculatus	82.49	0.00e+00	1489.00
IUUC-Lma-053246	Leptosphaeria maculans	25.02	3.00e-100	359.00
IUUC-Laf-053502	Loxodonta africana	96.27	0.00e+00	2192.00
IUUC-Mcc-054802	Macaca mulatta	96.51	0.00e+00	2177.00
IUUC-Meu-056808	Macropus eugenii	94.54	0.00e+00	1421.00
IUUC-Mor-057253	Magnaporthe oryzae	25.76	2.00e-78	287.00
IUUC-Mpo-057562	Magnaporthe poae	25.79	6.00e-90	325.00
IUUC-Mtr-057743	Medicago truncatula	51.10	0.00e+00	1116.00
IUUC-Mla-059154	Melampsora laricipopulina	25.05	2.00e-69	257.00
IUUC-Mga-059824	Meleagris gallopavo	99.07	0.00e+00	2156.00
IUUC-Mvi-060279	Microbotryum violaceum	27.60	2.00e-105	376.00
IUUC-Mmr-061215	Microcebus murinus	96.00	0.00e+00	2179.00
IUUC-Mdo-062028	Monodelphis domestica	95.98	0.00e+00	1866.00
IUUC-Mmu-064327	Mus musculus	96.44	0.00e+00	2193.00
IUUC-Mac-065445	Musa acuminata	52.33	0.00e+00	1118.00
IUUC-Mpu-065814	Mustela putorius furo	93.33	0.00e+00	2099.00
IUUC-Mlu-067136	Myotis lucifugus	96.44	0.00e+00	2189.00
IUUC-Nfi-068355	Neosartorya fischeri	27.02	5.00e-103	369.00
IUUC-Ncr-068620	Neurospora crassa	25.28	1.00e-84	308.00
IUUC-Nle-069566	Nomascus leucogenys	96.33	0.00e+00	2162.00
IUUC-Opr-070915	Ochotona princeps	89.07	0.00e+00	1832.00
IUUC-Ont-071753	Oreochromis niloticus	89.91	0.00e+00	2059.00
IUUC-Oan-073187	Ornithorhynchus anatinus	97.20	0.00e+00	2038.00
IUUC-Ocu-074619	Oryctolagus cuniculus	96.62	0.00e+00	2197.00
IUUC-Oba-075091	Oryza barthii	44.58	0.00e+00	876.00
IUUC-Obr-076425	Oryza brachyantha	52.44	0.00e+00	1139.00
IUUC-Ogu-078794	Oryza glumaepatula	52.24	0.00e+00	1142.00
IUUC-Oin-079725	Oryza indica	52.15	0.00e+00	1129.00
IUUC-Olo-080842	Oryza longistaminata	50.85	0.00e+00	1074.00
IUUC-Ome-081818	Oryza meridionalis	52.33	0.00e+00	1145.00
IUUC-Oni-082879	Oryza nivara	51.54	0.00e+00	1120.00
IUUC-Opu-083361	Oryza punctata	51.65	0.00e+00	1135.00
IUUC-Oru-084781	Oryza rufipogon	52.24	0.00e+00	1144.00
IUUC-Osa-086293	Oryza sativa	52.24	0.00e+00	1144.00
IUUC-Ola-086881	Oryzias latipes	89.48	0.00e+00	2051.00
IUUC-Olu-087674	Ostreococcus lucimarinus	44.67	0.00e+00	918.00
IUUC-Oga-089056	Otolemur garnettii	96.44	0.00e+00	2192.00
IUUC-Oar-089457	Ovis aries	96.66	0.00e+00	2161.00
IUUC-Ptr-091179	Pan troglodytes	96.62	0.00e+00	2194.00
IUUC-Pan-092019	Papio anubis	96.36	0.00e+00	2194.00
IUUC-Psi-093407	Pelodiscus sinensis	96.98	0.00e+00	2206.00
IUUC-Pma-094272	Petromyzon marinus	86.15	0.00e+00	1830.00
IUUC-Pno-094864	Phaeosphaeria nodorum	26.13	3.00e-106	379.00
IUUC-Ppa-095885	Physcomitrella patens	52.55	0.00e+00	1124.00
IUUC-Pfo-096083	Poecilia formosa	89.65	0.00e+00	2048.00
IUUC-Pab-098652	Pongo abelii	91.86	0.00e+00	2063.00
IUUC-Pop-099593	Populus trichocarpa	52.34	0.00e+00	1094.00
IUUC-Pca-100189	Procavia capensis	96.43	0.00e+00	1293.00
IUUC-Ppe-101987	Prunus persica	51.59	0.00e+00	1077.00
IUUC-Pva-102605	Pteropus vampyrus	96.36	0.00e+00	2189.00
IUUC-Pgr-103659	Puccinia graminis	24.71	8.00e-61	229.00
IUUC-Ptt-103884	Puccinia triticina	23.47	3.00e-52	200.00
IUUC-Pte-104233	Pyrenophora teres	26.40	1.00e-107	384.00
IUUC-Pyt-104454	Pyrenophora triticirepentis	26.56	4.00e-105	375.00
IUUC-Rno-106004	Rattus norvegicus	96.44	0.00e+00	2192.00
IUUC-Sha-106726	Sarcophilus harrisii	95.34	0.00e+00	2055.00
IUUC-Sja-107864	Schizosaccharomyces japonicus	24.09	1.00e-71	264.00
IUUC-Spo-108029	Schizosaccharomyces pombe	26.27	1.00e-93	337.00
IUUC-Ssl-108441	Sclerotinia sclerotiorum	25.66	2.00e-77	284.00
IUUC-Smo-108808	Selaginella moellendorffii	51.94	0.00e+00	1170.00
IUUC-Sit-109735	Setaria italica	52.53	0.00e+00	1136.00
IUUC-Sly-111520	Solanum lycopersicum	51.84	0.00e+00	1118.00
IUUC-Sar-113606	Sorex araneus	94.19	2.00e-132	466.00
IUUC-Sbi-114539	Sorghum bicolor	51.57	0.00e+00	1123.00
IUUC-Sre-114936	Sporisorium reilianum	25.77	2.00e-63	237.00
IUUC-Ssc-116038	Sus scrofa	96.53	0.00e+00	2196.00
IUUC-Tgu-117512	Taeniopygia guttata	98.31	0.00e+00	2226.00
IUUC-Tru-117593	Takifugu rubripes	88.51	0.00e+00	2027.00
IUUC-Tsy-119513	Tarsius syrichta	94.00	0.00e+00	1179.00
IUUC-Tni-120551	Tetraodon nigroviridis	84.88	0.00e+00	1698.00
IUUC-Tca-121505	Theobroma cacao	52.52	0.00e+00	1116.00
IUUC-Tre-122136	Trichoderma reesei	26.26	3.00e-98	353.00
IUUC-Tvi-122512	Trichoderma virens	25.25	6.00e-95	342.00
IUUC-Tae-122891	Triticum aestivum	51.54	0.00e+00	1120.00
IUUC-Tur-126451	Triticum urartu	52.53	0.00e+00	1047.00
IUUC-Tme-127057	Tuber melanosporum	28.64	7.00e-107	381.00
IUUC-Ttr-128891	Tursiops truncatus	91.94	0.00e+00	1442.00
IUUC-Uma-129583	Ustilago maydis	25.54	1.00e-53	205.00
IUUC-Vda-129870	Verticillium dahliae	25.50	6.00e-90	325.00
IUUC-Vpa-130117	Vicugna pacos	92.52	0.00e+00	1694.00
IUUC-Vvi-131033	Vitis vinifera	51.37	0.00e+00	1118.00
IUUC-Xtr-131987	Xenopus tropicalis	91.36	0.00e+00	2073.00
IUUC-Xma-134117	Xiphophorus maculatus	88.66	0.00e+00	1999.00
IUUC-Zma-134758	Zea mays	52.51	0.00e+00	1142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence