iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000005674.5	ENSGALT00000009099.5	ENSGALP00000009085.5
ENSGALG00000005674.5	ENSGALT00000052200.1	ENSGALP00000056499.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.10e-70	236.0	402	781

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avspr 71
           Gl N gN CY+N++LQ+L+++p++ +l+++  +   ++++++ +++++++s+ +l++e++      k k+              a++p+
   Q: 402  GLINKGNWCYINATLQALVACPPMYHLMKS-IPMY-SKSQRPCTSTPMIDSFVRLMNEFTnmpvppKAKQAlgdkivrdirpgaAFEPT 488
           9*****************************.3333.34455899***************8777664333337888889999999***** PP
   S: 72   ellkalkkeaeefs.gyeqqDaqEflaflldqleeelkk..................eknkpkeeeeeedkselsdeaeekkkkknk.. 139
            +++ l  +++++s + +q+Da+E+l f+l++l+ee+                    e ++ +eeee++++ e s++++e+   +nk  
   Q: 489  YIYRLLTVIKSSLSeKGRQEDAEEYLGFILNGLHEEMLTlkkllsphneklsvsngpEVQTVREEEEQDEQGEGSEDEWEQVGPRNKss 577
           *9999999999966599********************4455688888888988888755555555555555555555555555555555 PP
   S: 140  .........slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaek 219
                    ++i+d+F+g+++ +++ ++  ++s + +pf++l+l++++++ +   ++qd+Les +++e+++g    y++k k+++e ++
   Q: 578  vtrqadfvqTPITDIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSDKIR---TVQDALESLVARESVQG----YTTKTKQEVEISR 658
           555556777***********9.688999999*******************99...****************8....99999******** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG.slssGHYvayvknekg 304
           +++l++lP+vL+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k    +++Y+L+avv+H+G s+ +GHY+++v +   
   Q: 659  RVTLEELPPVLVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISKELLSPGVKSKIfkgQRTYRLFAVVYHHGnSATGGHYTTDVFQIGL 746
           ********************9998886.****************99998877766888****************************877 PP
   S: 305  k.WllfdDskVtevkeeevleetg.staYvlfYkr 337
           + Wl++dD+ V+++++ +v++ ++ +taY+l+Y+r
   Q: 747  NgWLRIDDQAVKVINQYQVVKPSAeRTAYLLYYRR 781
           77*****************998778********98 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAVNGAQYIF GEFSPDEFNQ FFVTPRCSVE LPPYNETVSC GIKSTGEEYQ RIEFGVNEVI 60
ETESSVLNNT DYSISSTLNP QAPEFILSCA PAQKTPDETN YNSIDCQFSD PTLTLDSGSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGTGCGTGC GAGAGAAGAT GGCGGCGGCG GGGGCAGCAG CGTGAGGCGC ACGGGAGACG 60
CCGAGCTCCC CACGGAAGCG GGCCGTCATG GCCGTGAACG GCGCCCAGGT ACCGCCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF07145--PAM2
PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	31.96	1.00e-47	184.00
IUUC-Aml-001584	Ailuropoda melanoleuca	77.58	0.00e+00	1166.00
IUUC-Atr-002927	Amborella trichopoda	34.62	9.00e-60	224.00
IUUC-Apl-003988	Anas platyrhynchos	95.94	0.00e+00	1427.00
IUUC-Aca-004461	Anolis carolinensis	97.01	5.00e-174	603.00
IUUC-Aly-006038	Arabidopsis lyrata	34.27	1.00e-55	210.00
IUUC-Ath-007328	Arabidopsis thaliana	34.02	4.00e-54	205.00
IUUC-Ago-007717	Ashbya gossypii	27.74	2.00e-44	174.00
IUUC-Acl-008188	Aspergillus clavatus	35.68	2.00e-63	237.00
IUUC-Afl-008456	Aspergillus flavus	36.60	4.00e-49	188.00
IUUC-Afu-009067	Aspergillus fumigatus	36.67	2.00e-65	243.00
IUUC-Ani-009483	Aspergillus nidulans	35.05	3.00e-62	233.00
IUUC-Ang-009639	Aspergillus niger	35.38	1.00e-62	234.00
IUUC-Aor-010040	Aspergillus oryzae	34.69	9.00e-62	231.00
IUUC-Ate-010310	Aspergillus terreus	34.52	7.00e-62	231.00
IUUC-Ame-011012	Astyanax mexicanus	76.41	1.00e-172	600.00
IUUC-Bgr-012311	Blumeria graminis	35.34	3.00e-47	183.00
IUUC-Bta-013299	Bos taurus	76.40	0.00e+00	1122.00
IUUC-Bci-013783	Botrytis cinerea	36.41	2.00e-61	230.00
IUUC-Bdi-015039	Brachypodium distachyon	32.75	1.00e-51	197.00
IUUC-Bol-015806	Brassica oleracea	36.57	2.00e-64	240.00
IUUC-Bra-017076	Brassica rapa	35.94	5.00e-65	241.00
IUUC-Cja-018715	Callithrix jacchus	76.60	0.00e+00	1164.00
IUUC-Cfa-020194	Canis familiaris	79.22	0.00e+00	1184.00
IUUC-Cpo-022272	Cavia porcellus	66.46	0.00e+00	943.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	35.00	3.00e-34	139.00
IUUC-Csa-023310	Chlorocebus sabaeus	78.72	0.00e+00	1179.00
IUUC-Cho-024966	Choloepus hoffmanni	74.68	0.00e+00	799.00
IUUC-Cin-025616	Ciona intestinalis	48.92	1.00e-109	390.00
IUUC-Csv-026043	Ciona savignyi	46.63	3.00e-100	358.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	34.12	7.00e-47	182.00
IUUC-Cne-026962	Cryptococcus neoformans	35.29	1.00e-49	192.00
IUUC-Cme-027113	Cyanidioschyzon merolae	30.91	3.00e-37	149.00
IUUC-Dre-028072	Danio rerio	80.04	0.00e+00	746.00
IUUC-Dno-029489	Dasypus novemcinctus	78.49	0.00e+00	1218.00
IUUC-Dor-031068	Dipodomys ordii	69.35	6.00e-134	471.00
IUUC-Dse-031553	Dothistroma septosporum	36.90	9.00e-60	225.00
IUUC-Dme-031759	Drosophila melanogaster	42.13	6.00e-86	312.00
IUUC-Ete-032549	Echinops telfairi	67.92	0.00e+00	788.00
IUUC-Eca-033380	Equus caballus	77.71	0.00e+00	1188.00
IUUC-Eeu-034818	Erinaceus europaeus	76.00	0.00e+00	1134.00
IUUC-Fca-035535	Felis catus	76.95	0.00e+00	1043.00
IUUC-Fal-036627	Ficedula albicollis	89.04	0.00e+00	1332.00
IUUC-Fox-037904	Fusarium oxysporum	36.90	1.00e-55	211.00
IUUC-Fso-038170	Fusarium solani	33.87	2.00e-54	207.00
IUUC-Gmo-039499	Gadus morhua	70.62	0.00e+00	690.00
IUUC-Ggr-040042	Gaeumannomyces graminis	35.09	1.00e-61	231.00
IUUC-Gac-041345	Gasterosteus aculeatus	78.88	0.00e+00	696.00
IUUC-Gma-044407	Glycine max	35.55	4.00e-60	225.00
IUUC-Ggo-044652	Gorilla gorilla	77.12	0.00e+00	1194.00
IUUC-Hsa-045864	Homo sapiens	77.00	0.00e+00	1192.00
IUUC-Hvu-047071	Hordeum vulgare	33.00	1.00e-54	207.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	82.74	0.00e+00	935.00
IUUC-Kpa-049132	Komagataella pastoris	31.17	1.00e-46	180.00
IUUC-Lch-050040	Latimeria chalumnae	76.33	0.00e+00	1043.00
IUUC-Lpe-050772	Leersia perrieri	29.22	2.00e-17	83.60
IUUC-Loc-052449	Lepisosteus oculatus	77.43	0.00e+00	758.00
IUUC-Lma-053248	Leptosphaeria maculans	35.12	4.00e-59	223.00
IUUC-Laf-054121	Loxodonta africana	77.58	0.00e+00	1184.00
IUUC-Mcc-055514	Macaca mulatta	78.36	0.00e+00	1174.00
IUUC-Meu-056873	Macropus eugenii	75.67	0.00e+00	867.00
IUUC-Mor-057243	Magnaporthe oryzae	33.33	4.00e-59	223.00
IUUC-Mpo-057439	Magnaporthe poae	35.20	7.00e-62	232.00
IUUC-Mtr-058457	Medicago truncatula	33.76	1.00e-57	217.00
IUUC-Mla-058929	Melampsora laricipopulina	30.74	8.00e-57	214.00
IUUC-Mga-060157	Meleagris gallopavo	96.27	0.00e+00	1457.00
IUUC-Mvi-060442	Microbotryum violaceum	32.38	1.00e-54	208.00
IUUC-Mmr-061062	Microcebus murinus	76.54	0.00e+00	1182.00
IUUC-Mdo-062798	Monodelphis domestica	83.23	0.00e+00	1253.00
IUUC-Mmu-064050	Mus musculus	73.00	0.00e+00	1117.00
IUUC-Mac-065202	Musa acuminata	33.89	2.00e-54	206.00
IUUC-Mpu-066554	Mustela putorius furo	76.60	0.00e+00	1135.00
IUUC-Mlu-068003	Myotis lucifugus	77.53	0.00e+00	1178.00
IUUC-Nfi-068612	Neosartorya fischeri	35.62	6.00e-64	239.00
IUUC-Ncr-068878	Neurospora crassa	34.18	5.00e-51	196.00
IUUC-Nle-069661	Nomascus leucogenys	76.88	0.00e+00	1180.00
IUUC-Opr-070944	Ochotona princeps	74.15	1.00e-163	569.00
IUUC-Ont-071266	Oreochromis niloticus	61.38	0.00e+00	860.00
IUUC-Oan-073442	Ornithorhynchus anatinus	85.31	0.00e+00	1219.00
IUUC-Ocu-073788	Oryctolagus cuniculus	73.66	0.00e+00	1026.00
IUUC-Oba-075085	Oryza barthii	34.05	1.00e-37	149.00
IUUC-Obr-076663	Oryza brachyantha	32.06	3.00e-47	182.00
IUUC-Ogl-076937	Oryza glaberrima	30.23	2.00e-50	193.00
IUUC-Ogu-078909	Oryza glumaepatula	30.43	2.00e-48	186.00
IUUC-Oin-079617	Oryza indica	31.45	4.00e-50	192.00
IUUC-Olo-081043	Oryza longistaminata	26.52	9.00e-25	108.00
IUUC-Ome-081646	Oryza meridionalis	25.19	1.00e-23	104.00
IUUC-Oni-082914	Oryza nivara	30.43	1.00e-48	187.00
IUUC-Oru-084878	Oryza rufipogon	30.43	1.00e-48	187.00
IUUC-Osa-085822	Oryza sativa	30.89	1.00e-52	200.00
IUUC-Ola-086931	Oryzias latipes	59.34	0.00e+00	818.00
IUUC-Oga-088443	Otolemur garnettii	76.45	0.00e+00	1178.00
IUUC-Oar-089325	Ovis aries	74.94	0.00e+00	1050.00
IUUC-Ptr-091584	Pan troglodytes	74.50	0.00e+00	1111.00
IUUC-Pan-092551	Papio anubis	76.38	0.00e+00	1142.00
IUUC-Psi-093366	Pelodiscus sinensis	90.38	0.00e+00	871.00
IUUC-Pno-095136	Phaeosphaeria nodorum	34.85	2.00e-50	194.00
IUUC-Ppa-095574	Physcomitrella patens	36.96	4.00e-62	232.00
IUUC-Pfo-097462	Poecilia formosa	79.83	0.00e+00	726.00
IUUC-Pab-098547	Pongo abelii	76.88	0.00e+00	1178.00
IUUC-Pop-099529	Populus trichocarpa	37.85	7.00e-65	241.00
IUUC-Pca-101066	Procavia capensis	69.99	0.00e+00	1045.00
IUUC-Ppe-102110	Prunus persica	35.96	7.00e-62	231.00
IUUC-Pva-103015	Pteropus vampyrus	73.91	0.00e+00	1111.00
IUUC-Ptt-103998	Puccinia triticina	32.26	2.00e-54	206.00
IUUC-Pte-104417	Pyrenophora teres	33.41	1.00e-56	214.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	34.71	3.00e-55	210.00
IUUC-Rno-105533	Rattus norvegicus	74.50	0.00e+00	1133.00
IUUC-Sce-106160	Saccharomyces cerevisiae	27.11	9.00e-41	162.00
IUUC-Sha-106590	Sarcophilus harrisii	82.98	0.00e+00	1233.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	35.28	9.00e-58	217.00
IUUC-Spo-108353	Schizosaccharomyces pombe	35.91	5.00e-63	234.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	36.22	9.00e-61	228.00
IUUC-Smo-108842	Selaginella moellendorffii	36.07	3.00e-38	151.00
IUUC-Sit-110781	Setaria italica	33.26	2.00e-56	213.00
IUUC-Sly-111797	Solanum lycopersicum	34.69	6.00e-57	214.00
IUUC-Stu-112188	Solanum tuberosum	34.61	5.00e-58	218.00
IUUC-Sbi-114862	Sorghum bicolor	33.14	4.00e-45	175.00
IUUC-Sre-115162	Sporisorium reilianum	34.24	2.00e-65	244.00
IUUC-Ssc-115505	Sus scrofa	89.35	2.00e-158	551.00
IUUC-Tgu-116535	Taeniopygia guttata	89.71	0.00e+00	1343.00
IUUC-Tru-117542	Takifugu rubripes	59.86	0.00e+00	871.00
IUUC-Tni-120200	Tetraodon nigroviridis	59.61	0.00e+00	862.00
IUUC-Tca-121548	Theobroma cacao	33.63	8.00e-47	181.00
IUUC-Tre-122124	Trichoderma reesei	32.27	2.00e-61	230.00
IUUC-Tvi-122457	Trichoderma virens	34.76	4.00e-54	206.00
IUUC-Tae-125646	Triticum aestivum	34.68	6.00e-58	218.00
IUUC-Tme-127180	Tuber melanosporum	38.92	1.00e-70	260.00
IUUC-Tbe-127530	Tupaia belangeri	66.24	0.00e+00	922.00
IUUC-Ttr-128549	Tursiops truncatus	71.21	0.00e+00	1048.00
IUUC-Uma-129381	Ustilago maydis	33.19	1.00e-61	231.00
IUUC-Vda-129889	Verticillium dahliae	33.24	5.00e-54	206.00
IUUC-Vpa-130100	Vicugna pacos	72.20	0.00e+00	1047.00
IUUC-Vvi-131366	Vitis vinifera	34.47	3.00e-64	239.00
IUUC-Xtr-132048	Xenopus tropicalis	68.87	0.00e+00	1014.00
IUUC-Xma-133593	Xiphophorus maculatus	78.97	0.00e+00	719.00
IUUC-Yli-134338	Yarrowia lipolytica	30.00	2.00e-34	140.00
IUUC-Zma-135586	Zea mays	29.40	1.00e-50	194.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence