iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026113

UUCD1 version

UUC-CiS-00445

Ensembl Protein ID

ENSCSAVP00000017559.1

UniProt Accession

H2ZIZ3; H2ZIZ3_CIOSA

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000010345.1	ENSCSAVT00000017750.1	ENSCSAVP00000017559.1
ENSCSAVG00000010345.1	ENSCSAVT00000017751.1	ENSCSAVP00000017560.1
ENSCSAVG00000010345.1	ENSCSAVT00000017752.1	ENSCSAVP00000017561.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.10e-82	276.3	16	524

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAeva.......aeal 81
           YDRQ+rlwG+++q++l++a++++++++++ +E+lKnL+l Gvgs+ +vD+ +++ ++++++F+++++ +g+sK++v         ++ 
   Q: 16   YDRQLRLWGDHGQQALENARICMINVTATSTEILKNLILPGVGSFVIVDGGRISGEDVGNNFFLDPDAIGQSKSKVLfsffvlrHNFS 103
           ***************************************************************************9722222224567 PP
   S: 82   kelnpdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...d 165
            elnpdv+++  ee++++l ++++ Ff  f vV++     +++rk+++l+++ ++pl+++ ++G+ G++r+++ ++ + +s++d    
   Q: 104  LELNPDVKGDYTEEDVNQLLNKNPqFFYSFEVVIVSALDGATQRKLAELLWERKIPLVICYSYGFTGYLRIVVNEHCVVESHPDnahA 191
           8*************************************************************************************** PP
   S: 166  ppqktiPfctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeai 238
           ++++  Pf++l+e+ n         ++++++++  ++ k+l+ +++e++++++++ +ek+++k+kv +++++      edeenfeea 
   Q: 192  DLRLLDPFPELIEYANsidleqmekKEHSHVPYLIILYKYLQAWRKENDGQAPKNWKEKRQFKEKVLEGIRKnehgvqEDEENFEEAA 279
           **************888888888889999*******************************************9*************** PP
   S: 239  eiavkafakttins.ikqllksfecdivtkskspfwv................................................... 274
           + +++a+ ++  ++  +q++++++c  v++++s+fw+                                                   
   Q: 280  KQVNSALVPYKLPDsLRQMFEDPKCTDVSEESSNFWIlanglkqfvenndksllplrgslpdmfsdsesyiklqniykakakqdidlf 367
           **************************************************************************************** PP
   S: 275  ....................sfcsnaealq...................vpekvekdeevvkasap.lylllralerfekkkgrkpge 322
                               +fc na  lq                   + ++v++  +  +as++ +y++lr +++f+++ +r+pg+
   Q: 368  tsylcnfgyvngrlsdqeikRFCRNAHFLQvflvnyfcrgrslsdeykkISQSVLDGLISEEASDAvWYVMLRCVDLFHTNFSRYPGG 455
           ******************************6666666665555555444447777777766666669*******************77 PP
   S: 323  lsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +        +++l ++         g+++ ++dd+++e ++ +++++++++++ gG+aaqEviK+++ +++p+  +++f+++
   Q: 456  C--------LQELTRSW-----GVPGLSEAISDDYVQETCRCGAAELHSVASYMGGVAAQEVIKLITSQYVPVTGVYIFNGL 524
           6........45555533.....56788888***********************************************99986 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

ILKKIKFIMG EKEKKYDRQL RLWGDHGQQA LENARICMIN VTATSTEILK NLILPGVGSF 60
VIVDGGRISG EDVGNNFFLD PDAIGQSKSK VLFSFFVLRH NFSLELNPDV KGDYTEEDVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTGAAAA AAATCAAATT TATAATGGGT GAAAAAGAGA AGAAATATGA TCGTCAGTTA 60
CGTTTATGGG GTGACCACGG ACAACAAGCG TTGGAGAATG CACGGATTTG TATGATCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	39.96	2.00e-106	377.00
IUUC-Aml-002333	Ailuropoda melanoleuca	46.67	3.00e-147	513.00
IUUC-Atr-002644	Amborella trichopoda	39.59	1.00e-97	348.00
IUUC-Apl-003446	Anas platyrhynchos	47.55	2.00e-137	480.00
IUUC-Aca-004450	Anolis carolinensis	47.69	2.00e-146	510.00
IUUC-Aly-006187	Arabidopsis lyrata	39.37	2.00e-108	384.00
IUUC-Ath-007600	Arabidopsis thaliana	39.19	9.00e-108	382.00
IUUC-Ago-007900	Ashbya gossypii	26.20	6.00e-40	156.00
IUUC-Acl-008333	Aspergillus clavatus	34.35	3.00e-79	287.00
IUUC-Afl-008529	Aspergillus flavus	35.04	1.00e-84	305.00
IUUC-Afu-009071	Aspergillus fumigatus	32.80	4.00e-78	283.00
IUUC-Ani-009443	Aspergillus nidulans	33.94	2.00e-75	275.00
IUUC-Ang-009669	Aspergillus niger	34.87	9.00e-82	296.00
IUUC-Aor-009914	Aspergillus oryzae	34.56	2.00e-82	298.00
IUUC-Ate-010450	Aspergillus terreus	34.23	6.00e-82	296.00
IUUC-Ame-011183	Astyanax mexicanus	45.56	5.00e-144	502.00
IUUC-Bgr-012111	Blumeria graminis	34.26	3.00e-69	254.00
IUUC-Bta-012583	Bos taurus	46.48	2.00e-147	513.00
IUUC-Bci-013892	Botrytis cinerea	34.51	3.00e-70	257.00
IUUC-Bdi-014592	Brachypodium distachyon	39.78	3.00e-103	367.00
IUUC-Bol-016399	Brassica oleracea	38.66	3.00e-106	377.00
IUUC-Bra-017506	Brassica rapa	38.49	5.00e-104	369.00
IUUC-Cel-018456	Caenorhabditis elegans	32.71	2.00e-87	315.00
IUUC-Cja-020007	Callithrix jacchus	46.96	2.00e-146	511.00
IUUC-Cfa-020324	Canis familiaris	46.48	3.00e-147	513.00
IUUC-Cpo-022248	Cavia porcellus	44.32	6.00e-86	309.00
IUUC-Csa-023149	Chlorocebus sabaeus	44.00	2.00e-111	394.00
IUUC-Cho-024537	Choloepus hoffmanni	35.16	5.00e-86	310.00
IUUC-Cin-025763	Ciona intestinalis	75.23	0.00e+00	820.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.31	2.00e-68	251.00
IUUC-Cne-026884	Cryptococcus neoformans	32.05	8.00e-73	266.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.39	1.00e-24	106.00
IUUC-Dre-028140	Danio rerio	45.93	3.00e-145	506.00
IUUC-Dno-030033	Dasypus novemcinctus	47.88	3.00e-127	446.00
IUUC-Dor-030513	Dipodomys ordii	56.88	6.00e-32	130.00
IUUC-Dse-031536	Dothistroma septosporum	31.83	2.00e-73	268.00
IUUC-Dme-031683	Drosophila melanogaster	40.85	6.00e-110	389.00
IUUC-Ete-032420	Echinops telfairi	40.15	1.00e-117	415.00
IUUC-Eca-033992	Equus caballus	43.56	3.00e-111	393.00
IUUC-Eeu-034713	Erinaceus europaeus	33.33	2.00e-36	145.00
IUUC-Fca-036548	Felis catus	46.34	4.00e-144	503.00
IUUC-Fal-037600	Ficedula albicollis	47.94	2.00e-136	477.00
IUUC-Fox-038037	Fusarium oxysporum	33.96	5.00e-78	283.00
IUUC-Fso-038387	Fusarium solani	34.70	1.00e-80	291.00
IUUC-Gmo-038562	Gadus morhua	45.10	2.00e-145	507.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.15	1.00e-75	275.00
IUUC-Gga-041129	Gallus gallus	48.23	3.00e-141	493.00
IUUC-Gac-042558	Gasterosteus aculeatus	44.67	3.00e-141	493.00
IUUC-Gma-043610	Glycine max	40.15	1.00e-104	371.00
IUUC-Ggo-045611	Gorilla gorilla	46.41	5.00e-146	509.00
IUUC-Hsa-046563	Homo sapiens	46.67	4.00e-147	513.00
IUUC-Hvu-047790	Hordeum vulgare	38.64	8.00e-68	249.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	46.48	7.00e-146	508.00
IUUC-Kpa-049309	Komagataella pastoris	35.40	2.00e-78	284.00
IUUC-Lch-050038	Latimeria chalumnae	43.81	3.00e-137	480.00
IUUC-Lpe-051535	Leersia perrieri	37.66	2.00e-82	298.00
IUUC-Loc-051917	Lepisosteus oculatus	42.50	3.00e-127	447.00
IUUC-Lma-053112	Leptosphaeria maculans	32.38	7.00e-78	283.00
IUUC-Laf-053690	Loxodonta africana	46.30	2.00e-146	510.00
IUUC-Mcc-055117	Macaca mulatta	45.70	1.00e-142	498.00
IUUC-Meu-056761	Macropus eugenii	37.94	1.00e-103	368.00
IUUC-Mor-057230	Magnaporthe oryzae	34.24	1.00e-79	289.00
IUUC-Mpo-057514	Magnaporthe poae	34.39	2.00e-74	271.00
IUUC-Mtr-058551	Medicago truncatula	37.91	3.00e-98	350.00
IUUC-Mla-059183	Melampsora laricipopulina	35.64	3.00e-100	357.00
IUUC-Mga-060144	Meleagris gallopavo	47.48	4.00e-138	483.00
IUUC-Mvi-060221	Microbotryum violaceum	35.21	2.00e-86	311.00
IUUC-Mmr-061325	Microcebus murinus	45.86	3.00e-142	496.00
IUUC-Mdo-062532	Monodelphis domestica	46.85	3.00e-147	513.00
IUUC-Mmu-063956	Mus musculus	46.11	1.00e-146	511.00
IUUC-Mac-064521	Musa acuminata	41.50	3.00e-110	390.00
IUUC-Mpu-066716	Mustela putorius furo	45.06	3.00e-136	477.00
IUUC-Mlu-067459	Myotis lucifugus	46.21	1.00e-145	508.00
IUUC-Nfi-068245	Neosartorya fischeri	33.27	3.00e-79	287.00
IUUC-Ncr-068910	Neurospora crassa	34.25	1.00e-82	298.00
IUUC-Nle-070034	Nomascus leucogenys	45.03	5.00e-138	483.00
IUUC-Opr-070552	Ochotona princeps	42.44	1.00e-113	401.00
IUUC-Ont-071426	Oreochromis niloticus	45.02	2.00e-144	504.00
IUUC-Oan-073389	Ornithorhynchus anatinus	42.51	8.00e-102	362.00
IUUC-Ocu-074911	Oryctolagus cuniculus	46.11	2.00e-146	510.00
IUUC-Oba-075437	Oryza barthii	39.18	7.00e-93	332.00
IUUC-Obr-076684	Oryza brachyantha	39.37	4.00e-87	313.00
IUUC-Ogl-077170	Oryza glaberrima	39.18	7.00e-93	332.00
IUUC-Ogu-078844	Oryza glumaepatula	38.95	1.00e-84	305.00
IUUC-Oin-079105	Oryza indica	39.18	2.00e-92	330.00
IUUC-Olo-080943	Oryza longistaminata	36.58	5.00e-78	283.00
IUUC-Oni-082891	Oryza nivara	36.75	4.00e-85	306.00
IUUC-Opu-083457	Oryza punctata	39.55	3.00e-93	333.00
IUUC-Oru-084960	Oryza rufipogon	36.50	4.00e-78	283.00
IUUC-Osa-085358	Oryza sativa	38.99	3.00e-91	327.00
IUUC-Ola-086420	Oryzias latipes	42.63	8.00e-90	322.00
IUUC-Olu-087625	Ostreococcus lucimarinus	27.65	1.00e-47	182.00
IUUC-Oga-088810	Otolemur garnettii	46.11	5.00e-148	516.00
IUUC-Oar-089196	Ovis aries	46.04	1.00e-145	508.00
IUUC-Ptr-090617	Pan troglodytes	46.67	3.00e-147	513.00
IUUC-Pan-092761	Papio anubis	46.48	2.00e-146	510.00
IUUC-Psi-093191	Pelodiscus sinensis	45.57	7.00e-140	488.00
IUUC-Pma-094380	Petromyzon marinus	47.39	5.00e-140	489.00
IUUC-Pno-095084	Phaeosphaeria nodorum	30.74	5.00e-68	251.00
IUUC-Ppa-095798	Physcomitrella patens	38.80	4.00e-106	377.00
IUUC-Pfo-096467	Poecilia formosa	45.40	3.00e-144	503.00
IUUC-Pab-098255	Pongo abelii	47.66	4.00e-128	449.00
IUUC-Pop-099722	Populus trichocarpa	39.96	8.00e-108	382.00
IUUC-Pca-100807	Procavia capensis	47.01	2.00e-65	241.00
IUUC-Ppe-101280	Prunus persica	38.35	1.00e-106	378.00
IUUC-Pva-102333	Pteropus vampyrus	44.75	8.00e-135	472.00
IUUC-Pgr-103401	Puccinia graminis	28.78	2.00e-67	248.00
IUUC-Ptt-103889	Puccinia triticina	26.22	1.00e-56	212.00
IUUC-Pte-104355	Pyrenophora teres	32.57	2.00e-79	288.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.21	7.00e-77	279.00
IUUC-Rno-105810	Rattus norvegicus	46.30	5.00e-146	509.00
IUUC-Sce-106397	Saccharomyces cerevisiae	28.01	3.00e-40	157.00
IUUC-Sha-106770	Sarcophilus harrisii	56.00	2.00e-92	330.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.21	6.00e-66	243.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.96	1.00e-76	278.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	35.94	1.00e-73	268.00
IUUC-Smo-109296	Selaginella moellendorffii	35.78	3.00e-93	334.00
IUUC-Sit-110157	Setaria italica	39.34	6.00e-108	382.00
IUUC-Sly-111105	Solanum lycopersicum	37.14	1.00e-103	368.00
IUUC-Stu-112469	Solanum tuberosum	36.96	2.00e-103	367.00
IUUC-Sar-113083	Sorex araneus	33.52	3.00e-92	330.00
IUUC-Sbi-113813	Sorghum bicolor	38.69	6.00e-106	376.00
IUUC-Sre-115058	Sporisorium reilianum	33.77	1.00e-70	259.00
IUUC-Tgu-116772	Taeniopygia guttata	48.43	2.00e-138	484.00
IUUC-Tru-118686	Takifugu rubripes	44.65	2.00e-143	500.00
IUUC-Tsy-119111	Tarsius syrichta	50.36	8.00e-80	289.00
IUUC-Tni-120231	Tetraodon nigroviridis	41.10	2.00e-123	434.00
IUUC-Tca-121491	Theobroma cacao	40.37	1.00e-102	365.00
IUUC-Tre-122103	Trichoderma reesei	35.96	8.00e-81	292.00
IUUC-Tvi-122672	Trichoderma virens	35.46	2.00e-79	288.00
IUUC-Tae-125679	Triticum aestivum	40.15	2.00e-106	378.00
IUUC-Tur-126487	Triticum urartu	38.96	3.00e-101	360.00
IUUC-Tme-127097	Tuber melanosporum	34.30	1.00e-84	305.00
IUUC-Ttr-128465	Tursiops truncatus	43.83	4.00e-132	463.00
IUUC-Uma-129645	Ustilago maydis	34.13	4.00e-73	267.00
IUUC-Vda-129989	Verticillium dahliae	31.33	2.00e-58	218.00
IUUC-Vpa-130529	Vicugna pacos	44.01	2.00e-134	471.00
IUUC-Vvi-131059	Vitis vinifera	39.78	6.00e-104	369.00
IUUC-Xtr-132002	Xenopus tropicalis	48.52	4.00e-151	526.00
IUUC-Xma-133930	Xiphophorus maculatus	45.47	3.00e-142	496.00
IUUC-Yli-134505	Yarrowia lipolytica	33.65	1.00e-78	285.00
IUUC-Zma-135895	Zea mays	38.72	6.00e-104	369.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence