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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063416
UUCD1 version UUC-MuM-01139
Ensembl Protein ID ENSMUSP00000028278.7
UniProt Accession O35593; Q3UB50; Q9CZY6; PSDE_MOUSE
Genbank Protein ID CAA73514.1; BAB27974.1; BAE30114.1; BAE30648.1; AAH03742.1
Protein Name 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit RPN11; MAD1
Genbank Nucleotide ID Y13071; AK012013; AK151104; AK151733; BC003742
Gene Name Psmd14; Pad1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026914.15 ENSMUST00000028278.13 ENSMUSP00000028278.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/JAMM 1.00e-07 32.9 113 126
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPgf+cwlS+VD
   Q: 113  HSHPGFGCWLSGVD 126
           *************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Protein Sequence
(Fasta)
MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP MEVMGLMLGE 60
FVDDYTVRVI DVFAMPQSGT GVSVEAVDPV FQAKMLDMLK QTGRPEMVVG WYHSHPGFGC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063416|DUB,JAMM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACTCCAATT GGCGGTAGAA GAAAGGAAGC CGAAGGAAGC CGGGAACCCG GAAGTACTTC 60
TCTGCAGAGG CCTGGGCGAC TCTTTTGAAT GGAATCGGGC TGATTCATCG CCTGTTCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063416|DUB,JAMM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C
Pfam

PF01398--JAB
PF13012--MitMem_reg
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0031597--C:cytosolic proteasome complex
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0022624--C:proteasome accessory complex
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0061133--F:endopeptidase activator activity
GO:0004175--F:endopeptidase activity
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0070628--F:proteasome binding
GO:0000724--P:double-strand break repair via homologous recombination
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0070536--P:protein K63-linked deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0045471--P:response to ethanol
KEGG mmu:59029
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000544 Aegilops tauschii 81.72 9.00e-134 469.00
IUUC-Aml-001416 Ailuropoda melanoleuca 100.00 2.00e-174 604.00
IUUC-Atr-002629 Amborella trichopoda 83.99 1.00e-131 462.00
IUUC-Apl-004046 Anas platyrhynchos 99.33 6.00e-179 619.00
IUUC-Aca-005228 Anolis carolinensis 99.31 5.00e-173 600.00
IUUC-Aly-005457 Arabidopsis lyrata 82.35 4.00e-134 470.00
IUUC-Ath-007290 Arabidopsis thaliana 82.35 4.00e-134 470.00
IUUC-Ago-007866 Ashbya gossypii 65.98 3.00e-110 391.00
IUUC-Acl-008338 Aspergillus clavatus 70.59 5.00e-108 383.00
IUUC-Afl-008431 Aspergillus flavus 70.98 2.00e-121 428.00
IUUC-Afu-008909 Aspergillus fumigatus 70.98 5.00e-116 410.00
IUUC-Ani-009174 Aspergillus nidulans 70.98 4.00e-121 427.00
IUUC-Ang-009854 Aspergillus niger 71.17 2.00e-120 425.00
IUUC-Aor-009942 Aspergillus oryzae 70.98 6.00e-121 427.00
IUUC-Ate-010377 Aspergillus terreus 70.63 5.00e-121 427.00
IUUC-Ame-011628 Astyanax mexicanus 97.86 2.00e-153 535.00
IUUC-Bgr-012263 Blumeria graminis 69.04 3.00e-108 385.00
IUUC-Bta-012375 Bos taurus 100.00 2.00e-174 604.00
IUUC-Bci-013850 Botrytis cinerea 71.68 7.00e-112 396.00
IUUC-Bdi-014135 Brachypodium distachyon 83.27 2.00e-130 458.00
IUUC-Bol-016172 Brassica oleracea 82.35 4.00e-134 470.00
IUUC-Bra-017926 Brassica rapa 82.35 4.00e-134 470.00
IUUC-Cel-018247 Caenorhabditis elegans 76.90 8.00e-133 466.00
IUUC-Cja-019210 Callithrix jacchus 98.35 2.00e-178 617.00
IUUC-Cfa-020926 Canis familiaris 98.38 8.00e-170 589.00
IUUC-Cpo-021572 Cavia porcellus 100.00 2.00e-174 604.00
IUUC-Cre-022925 Chlamydomonas reinhardtii 76.90 1.00e-129 455.00
IUUC-Csa-023496 Chlorocebus sabaeus 100.00 2.00e-174 604.00
IUUC-Cho-024525 Choloepus hoffmanni 92.78 6.00e-160 556.00
IUUC-Cin-025492 Ciona intestinalis 90.00 2.00e-158 551.00
IUUC-Cgl-026493 Colletotrichum gloeosporioides 68.68 3.00e-101 361.00
IUUC-Cne-026785 Cryptococcus neoformans 69.93 3.00e-117 414.00
IUUC-Cme-027105 Cyanidioschyzon merolae 61.17 3.00e-101 361.00
IUUC-Dre-028788 Danio rerio 98.64 3.00e-175 607.00
IUUC-Dno-029058 Dasypus novemcinctus 100.00 1.00e-174 605.00
IUUC-Dor-031015 Dipodomys ordii 91.07 4.00e-153 533.00
IUUC-Dse-031242 Dothistroma septosporum 71.93 3.00e-123 434.00
IUUC-Dme-031668 Drosophila melanogaster 89.69 7.00e-159 552.00
IUUC-Ete-033146 Echinops telfairi 90.73 1.00e-137 482.00
IUUC-Eca-033734 Equus caballus 100.00 2.00e-174 604.00
IUUC-Eeu-035168 Erinaceus europaeus 71.85 1.00e-92 332.00
IUUC-Fca-036426 Felis catus 100.00 2.00e-174 604.00
IUUC-Fal-036954 Ficedula albicollis 99.31 5.00e-173 600.00
IUUC-Fox-037838 Fusarium oxysporum 71.28 3.00e-119 421.00
IUUC-Fso-038374 Fusarium solani 70.92 5.00e-119 420.00
IUUC-Gmo-038918 Gadus morhua 98.28 1.00e-171 595.00
IUUC-Ggr-039954 Gaeumannomyces graminis 70.82 9.00e-120 422.00
IUUC-Gga-040377 Gallus gallus 99.31 5.00e-173 600.00
IUUC-Gac-042386 Gasterosteus aculeatus 98.39 0.00e+00 635.00
IUUC-Gma-042811 Glycine max 82.70 2.00e-134 471.00
IUUC-Ggo-044916 Gorilla gorilla 100.00 6.00e-175 606.00
IUUC-Hsa-045865 Homo sapiens 100.00 2.00e-174 604.00
IUUC-Hvu-047188 Hordeum vulgare 81.72 4.00e-134 470.00
IUUC-Itr-048154 Ictidomys tridecemlineatus 98.90 1.00e-105 375.00
IUUC-Kpa-049128 Komagataella pastoris 73.31 1.00e-115 409.00
IUUC-Lch-050167 Latimeria chalumnae 93.17 4.00e-160 556.00
IUUC-Lpe-051086 Leersia perrieri 82.07 1.00e-133 469.00
IUUC-Loc-052888 Lepisosteus oculatus 98.63 2.00e-172 597.00
IUUC-Lma-052962 Leptosphaeria maculans 69.47 7.00e-120 423.00
IUUC-Laf-053949 Loxodonta africana 100.00 2.00e-174 604.00
IUUC-Mcc-055279 Macaca mulatta 98.03 2.00e-168 585.00
IUUC-Meu-055956 Macropus eugenii 91.07 1.00e-154 538.00
IUUC-Mor-057166 Magnaporthe oryzae 71.17 2.00e-111 395.00
IUUC-Mpo-057344 Magnaporthe poae 70.82 5.00e-120 423.00
IUUC-Mtr-057857 Medicago truncatula 83.04 3.00e-135 474.00
IUUC-Mla-058938 Melampsora laricipopulina 75.70 1.00e-131 462.00
IUUC-Mga-060093 Meleagris gallopavo 99.31 5.00e-173 600.00
IUUC-Mvi-060565 Microbotryum violaceum 72.98 9.00e-126 442.00
IUUC-Mmr-060899 Microcebus murinus 97.92 1.00e-167 582.00
IUUC-Mdo-062175 Monodelphis domestica 99.66 2.00e-173 601.00
IUUC-Mac-065642 Musa acuminata 81.72 3.00e-133 467.00
IUUC-Mpu-065946 Mustela putorius furo 100.00 2.00e-174 604.00
IUUC-Mlu-067835 Myotis lucifugus 98.68 6.00e-178 616.00
IUUC-Nfi-068279 Neosartorya fischeri 70.98 6.00e-116 410.00
IUUC-Ncr-068821 Neurospora crassa 70.46 2.00e-109 388.00
IUUC-Nle-069212 Nomascus leucogenys 100.00 2.00e-174 604.00
IUUC-Opr-070928 Ochotona princeps 64.29 1.00e-79 289.00
IUUC-Ont-072135 Oreochromis niloticus 98.63 2.00e-172 597.00
IUUC-Oan-072755 Ornithorhynchus anatinus 99.66 2.00e-173 601.00
IUUC-Ocu-074433 Oryctolagus cuniculus 100.00 1.00e-158 551.00
IUUC-Oba-075678 Oryza barthii 82.07 6.00e-134 469.00
IUUC-Obr-076756 Oryza brachyantha 82.07 1.00e-133 469.00
IUUC-Ogl-077831 Oryza glaberrima 83.27 2.00e-130 458.00
IUUC-Ogu-078941 Oryza glumaepatula 82.07 6.00e-134 469.00
IUUC-Oin-080184 Oryza indica 82.07 6.00e-134 469.00
IUUC-Olo-080580 Oryza longistaminata 83.27 2.00e-130 457.00
IUUC-Ome-081739 Oryza meridionalis 80.69 3.00e-128 451.00
IUUC-Oni-082063 Oryza nivara 82.07 6.00e-134 469.00
IUUC-Opu-083207 Oryza punctata 82.07 1.00e-133 469.00
IUUC-Oru-085034 Oryza rufipogon 82.07 6.00e-134 469.00
IUUC-Osa-085486 Oryza sativa 82.07 6.00e-134 469.00
IUUC-Ola-087317 Oryzias latipes 98.63 2.00e-172 597.00
IUUC-Olu-087889 Ostreococcus lucimarinus 76.12 8.00e-132 462.00
IUUC-Oga-088032 Otolemur garnettii 100.00 4.00e-175 607.00
IUUC-Oar-090237 Ovis aries 100.00 3.00e-177 613.00
IUUC-Ptr-090881 Pan troglodytes 100.00 2.00e-174 604.00
IUUC-Pan-092658 Papio anubis 100.00 7.00e-175 605.00
IUUC-Psi-093672 Pelodiscus sinensis 99.66 2.00e-173 601.00
IUUC-Pma-094213 Petromyzon marinus 95.19 1.00e-166 578.00
IUUC-Pno-095038 Phaeosphaeria nodorum 69.47 1.00e-119 422.00
IUUC-Ppa-095467 Physcomitrella patens 85.12 1.00e-138 486.00
IUUC-Pfo-096322 Poecilia formosa 98.63 2.00e-172 597.00
IUUC-Pab-098484 Pongo abelii 100.00 2.00e-174 604.00
IUUC-Pop-099564 Populus trichocarpa 82.70 2.00e-134 471.00
IUUC-Pca-100785 Procavia capensis 93.05 4.00e-141 493.00
IUUC-Ppe-101727 Prunus persica 82.35 2.00e-133 468.00
IUUC-Pva-102569 Pteropus vampyrus 100.00 1.00e-176 612.00
IUUC-Pgr-103351 Puccinia graminis 75.35 6.00e-131 459.00
IUUC-Ptt-103763 Puccinia triticina 69.72 2.00e-117 415.00
IUUC-Pte-104088 Pyrenophora teres 69.82 9.00e-120 422.00
IUUC-Pyt-104597 Pyrenophora triticirepentis 70.19 4.00e-112 397.00
IUUC-Rno-105115 Rattus norvegicus 100.00 2.00e-174 604.00
IUUC-Sce-106353 Saccharomyces cerevisiae 67.59 3.00e-112 398.00
IUUC-Sha-107476 Sarcophilus harrisii 99.66 2.00e-173 601.00
IUUC-Sja-107807 Schizosaccharomyces japonicus 71.28 6.00e-124 436.00
IUUC-Spo-108255 Schizosaccharomyces pombe 70.59 3.00e-114 404.00
IUUC-Ssl-108392 Sclerotinia sclerotiorum 71.89 2.00e-111 395.00
IUUC-Smo-108824 Selaginella moellendorffii 83.04 3.00e-146 511.00
IUUC-Sit-110287 Setaria italica 82.07 1.00e-133 469.00
IUUC-Sly-111656 Solanum lycopersicum 82.01 3.00e-134 471.00
IUUC-Stu-112827 Solanum tuberosum 82.01 7.00e-134 469.00
IUUC-Sar-112979 Sorex araneus 83.51 3.00e-139 487.00
IUUC-Sbi-113841 Sorghum bicolor 82.07 1.00e-133 469.00
IUUC-Sre-114930 Sporisorium reilianum 77.06 1.00e-130 459.00
IUUC-Ssc-116058 Sus scrofa 100.00 4.00e-175 607.00
IUUC-Tgu-116499 Taeniopygia guttata 99.31 5.00e-173 600.00
IUUC-Tru-117576 Takifugu rubripes 98.63 2.00e-172 597.00
IUUC-Tsy-119371 Tarsius syrichta 91.41 6.00e-155 539.00
IUUC-Tni-120868 Tetraodon nigroviridis 98.39 6.00e-171 592.00
IUUC-Tca-121292 Theobroma cacao 82.70 2.00e-134 471.00
IUUC-Tre-122183 Trichoderma reesei 70.82 3.00e-115 407.00
IUUC-Tvi-122566 Trichoderma virens 70.82 2.00e-115 408.00
IUUC-Tae-125156 Triticum aestivum 81.72 9.00e-134 469.00
IUUC-Tur-126034 Triticum urartu 82.92 2.00e-130 458.00
IUUC-Tme-126903 Tuber melanosporum 71.93 2.00e-123 435.00
IUUC-Tbe-127525 Tupaia belangeri 91.11 5.00e-145 506.00
IUUC-Ttr-129072 Tursiops truncatus 100.00 2.00e-176 611.00
IUUC-Uma-129471 Ustilago maydis 77.42 2.00e-131 461.00
IUUC-Vda-129956 Verticillium dahliae 70.18 3.00e-110 391.00
IUUC-Vpa-130490 Vicugna pacos 100.00 2.00e-176 611.00
IUUC-Vvi-131302 Vitis vinifera 82.70 2.00e-134 471.00
IUUC-Xtr-132059 Xenopus tropicalis 98.97 1.00e-172 598.00
IUUC-Xma-133101 Xiphophorus maculatus 98.63 2.00e-172 597.00
IUUC-Yli-134638 Yarrowia lipolytica 71.02 4.00e-120 424.00
IUUC-Zma-135910 Zea mays 82.07 1.00e-133 469.00
Created Date 25-Jun-2017

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