iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mor-056983

Ensembl Protein ID

MGG_07297T0

UniProt Accession

Q52CS0; A4RIA9; G4MUY4; ATG7_MAGO7

Genbank Protein ID

EHA55718.1

Protein Name

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7

Genbank Nucleotide ID

CM001232

Gene Name

ATG7; MGG_07297

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MGG_07297	MGG_07297T0	MGG_07297T0

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	38.96	6.00e-125	442.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
565	Glycyl thioester intermediate	{ECO:0000250}

Organism

Magnaporthe oryzae

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

Protein Sequence
(Fasta)

MSGNDEAAAA GVAPPQTLQF APFESQIEMP FYSALFSRKL DHDKLDDSVR PVIGLYQPMS 60
ERPPAESTRM QIQGGALSSS HVPMGYTRAD GSIRNFNTIE DFKKADKGAI LRQAGAQIWD 120

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Nucleotide Sequence
(Fasta)

GGTTGACTTT GACCTCAGGT AAGGCGCCTA ATTCAGTAGA AGTGGAGGCC TATTGCAGCC 60
TGGCAAGCCT GGTCAGCACC ACAGATAACC GCATCGATGC TTCCAGGGGA AGTTTCAGAA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0000407--C:pre-autophagosomal structure
GO:0008641--F:small protein activating enzyme activity
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

mgr:MGG_07297

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	31.57	5.00e-90	324.00
IUUC-Aml-002316	Ailuropoda melanoleuca	44.12	7.00e-142	495.00
IUUC-Atr-002579	Amborella trichopoda	40.50	4.00e-140	489.00
IUUC-Apl-003805	Anas platyrhynchos	41.05	1.00e-148	518.00
IUUC-Aca-004618	Anolis carolinensis	42.79	1.00e-131	461.00
IUUC-Aly-005670	Arabidopsis lyrata	39.89	1.00e-122	431.00
IUUC-Ath-007499	Arabidopsis thaliana	40.03	4.00e-124	436.00
IUUC-Ago-007838	Ashbya gossypii	39.22	3.00e-128	450.00
IUUC-Acl-008093	Aspergillus clavatus	56.86	0.00e+00	764.00
IUUC-Afl-008663	Aspergillus flavus	57.14	0.00e+00	699.00
IUUC-Afu-008926	Aspergillus fumigatus	54.24	0.00e+00	722.00
IUUC-Ani-009156	Aspergillus nidulans	58.01	0.00e+00	772.00
IUUC-Ang-009853	Aspergillus niger	62.65	9.00e-81	291.00
IUUC-Aor-010055	Aspergillus oryzae	55.99	0.00e+00	803.00
IUUC-Ate-010281	Aspergillus terreus	50.98	0.00e+00	684.00
IUUC-Ame-010939	Astyanax mexicanus	41.71	1.00e-153	535.00
IUUC-Bgr-012006	Blumeria graminis	56.84	0.00e+00	816.00
IUUC-Bta-012336	Bos taurus	41.95	3.00e-137	480.00
IUUC-Bci-013598	Botrytis cinerea	64.42	0.00e+00	880.00
IUUC-Bdi-014170	Brachypodium distachyon	31.28	2.00e-86	312.00
IUUC-Bol-015357	Brassica oleracea	40.00	3.00e-130	457.00
IUUC-Bra-016835	Brassica rapa	40.54	7.00e-132	462.00
IUUC-Cel-018172	Caenorhabditis elegans	33.87	2.00e-103	368.00
IUUC-Cja-019544	Callithrix jacchus	42.45	7.00e-148	515.00
IUUC-Cfa-021043	Canis familiaris	42.90	5.00e-150	523.00
IUUC-Cpo-022366	Cavia porcellus	41.98	1.00e-147	515.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	43.67	9.00e-74	269.00
IUUC-Csa-023373	Chlorocebus sabaeus	42.35	6.00e-149	519.00
IUUC-Cho-024965	Choloepus hoffmanni	53.80	1.00e-49	189.00
IUUC-Cin-025710	Ciona intestinalis	43.06	4.00e-148	516.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	63.30	0.00e+00	889.00
IUUC-Cne-027083	Cryptococcus neoformans	39.92	3.00e-139	486.00
IUUC-Dre-028740	Danio rerio	39.48	8.00e-133	466.00
IUUC-Dno-029637	Dasypus novemcinctus	42.81	3.00e-141	493.00
IUUC-Dor-030492	Dipodomys ordii	42.22	2.00e-149	521.00
IUUC-Dse-031267	Dothistroma septosporum	48.19	0.00e+00	743.00
IUUC-Dme-032084	Drosophila melanogaster	38.36	9.00e-133	465.00
IUUC-Ete-032616	Echinops telfairi	39.13	3.00e-128	450.00
IUUC-Eca-033991	Equus caballus	41.98	7.00e-148	515.00
IUUC-Eeu-035126	Erinaceus europaeus	52.54	3.00e-64	238.00
IUUC-Fca-035472	Felis catus	42.90	2.00e-149	521.00
IUUC-Fal-037178	Ficedula albicollis	42.05	9.00e-152	528.00
IUUC-Fox-037901	Fusarium oxysporum	65.40	0.00e+00	911.00
IUUC-Fso-038279	Fusarium solani	66.86	0.00e+00	930.00
IUUC-Gmo-039329	Gadus morhua	40.96	1.00e-141	494.00
IUUC-Ggr-040061	Gaeumannomyces graminis	73.41	0.00e+00	1000.00
IUUC-Gga-040244	Gallus gallus	41.52	3.00e-151	526.00
IUUC-Gac-041880	Gasterosteus aculeatus	40.84	4.00e-141	493.00
IUUC-Gma-043235	Glycine max	40.85	2.00e-135	474.00
IUUC-Ggo-045428	Gorilla gorilla	42.22	2.00e-148	517.00
IUUC-Hsa-046183	Homo sapiens	42.35	8.00e-149	519.00
IUUC-Hvu-047509	Hordeum vulgare	31.96	8.00e-88	317.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	43.36	1.00e-142	498.00
IUUC-Kpa-049142	Komagataella pastoris	40.50	6.00e-137	479.00
IUUC-Lch-049601	Latimeria chalumnae	44.18	6.00e-89	320.00
IUUC-Lpe-051496	Leersia perrieri	31.44	1.00e-81	296.00
IUUC-Loc-051751	Lepisosteus oculatus	41.22	7.00e-155	539.00
IUUC-Lma-053203	Leptosphaeria maculans	58.73	0.00e+00	656.00
IUUC-Laf-053424	Loxodonta africana	42.03	5.00e-147	513.00
IUUC-Mcc-054633	Macaca mulatta	42.22	1.00e-148	518.00
IUUC-Meu-056523	Macropus eugenii	38.57	2.00e-121	427.00
IUUC-Mpo-057615	Magnaporthe poae	75.96	0.00e+00	1057.00
IUUC-Mtr-058366	Medicago truncatula	41.07	1.00e-129	455.00
IUUC-Mla-058826	Melampsora laricipopulina	40.16	1.00e-154	538.00
IUUC-Mga-059447	Meleagris gallopavo	41.61	2.00e-150	524.00
IUUC-Mvi-060537	Microbotryum violaceum	41.19	2.00e-148	518.00
IUUC-Mmr-060676	Microcebus murinus	42.31	8.00e-147	512.00
IUUC-Mdo-062967	Monodelphis domestica	41.38	3.00e-140	490.00
IUUC-Mmu-063217	Mus musculus	41.87	1.00e-147	515.00
IUUC-Mac-065527	Musa acuminata	41.07	8.00e-126	442.00
IUUC-Mpu-066417	Mustela putorius furo	42.80	2.00e-148	517.00
IUUC-Mlu-067195	Myotis lucifugus	41.90	2.00e-150	524.00
IUUC-Nfi-068576	Neosartorya fischeri	54.23	0.00e+00	757.00
IUUC-Ncr-068867	Neurospora crassa	68.37	0.00e+00	964.00
IUUC-Nle-069447	Nomascus leucogenys	49.87	6.00e-96	342.00
IUUC-Opr-070737	Ochotona princeps	49.54	1.00e-116	412.00
IUUC-Ont-071260	Oreochromis niloticus	40.19	6.00e-146	509.00
IUUC-Oan-073622	Ornithorhynchus anatinus	40.98	8.00e-99	352.00
IUUC-Ocu-074584	Oryctolagus cuniculus	41.54	5.00e-152	529.00
IUUC-Oba-075483	Oryza barthii	41.90	9.00e-78	283.00
IUUC-Obr-076786	Oryza brachyantha	30.91	6.00e-84	303.00
IUUC-Ogl-077388	Oryza glaberrima	41.90	1.00e-77	283.00
IUUC-Ogu-078618	Oryza glumaepatula	30.29	4.00e-84	304.00
IUUC-Oin-080007	Oryza indica	30.29	5.00e-79	287.00
IUUC-Olo-080994	Oryza longistaminata	44.67	1.00e-77	283.00
IUUC-Ome-081735	Oryza meridionalis	30.14	2.00e-78	285.00
IUUC-Oni-082153	Oryza nivara	30.29	6.00e-79	287.00
IUUC-Opu-083146	Oryza punctata	30.14	2.00e-77	282.00
IUUC-Oru-084919	Oryza rufipogon	30.29	5.00e-79	287.00
IUUC-Osa-086182	Oryza sativa	30.44	5.00e-79	287.00
IUUC-Ola-086441	Oryzias latipes	40.16	6.00e-146	509.00
IUUC-Olu-087664	Ostreococcus lucimarinus	40.40	5.00e-121	426.00
IUUC-Oga-089074	Otolemur garnettii	43.09	1.00e-140	491.00
IUUC-Oar-090159	Ovis aries	41.70	9.00e-136	475.00
IUUC-Ptr-091105	Pan troglodytes	43.70	6.00e-134	469.00
IUUC-Pan-092446	Papio anubis	42.35	1.00e-148	518.00
IUUC-Psi-093372	Pelodiscus sinensis	41.48	3.00e-144	503.00
IUUC-Pma-094661	Petromyzon marinus	40.44	1.00e-126	444.00
IUUC-Pno-094813	Phaeosphaeria nodorum	52.44	0.00e+00	648.00
IUUC-Ppa-095224	Physcomitrella patens	40.53	4.00e-134	470.00
IUUC-Pfo-096565	Poecilia formosa	40.56	9.00e-141	492.00
IUUC-Pop-099702	Populus trichocarpa	38.63	2.00e-138	484.00
IUUC-Pca-100324	Procavia capensis	35.65	1.00e-72	265.00
IUUC-Ppe-101416	Prunus persica	39.48	4.00e-128	450.00
IUUC-Pva-102589	Pteropus vampyrus	39.24	1.00e-131	461.00
IUUC-Pgr-103497	Puccinia graminis	40.19	3.00e-147	513.00
IUUC-Ptt-103718	Puccinia triticina	39.89	2.00e-146	511.00
IUUC-Pte-104206	Pyrenophora teres	56.73	0.00e+00	643.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	53.42	0.00e+00	706.00
IUUC-Rno-105911	Rattus norvegicus	41.90	2.00e-147	514.00
IUUC-Sce-106413	Saccharomyces cerevisiae	39.03	3.00e-133	467.00
IUUC-Sha-106679	Sarcophilus harrisii	41.24	5.00e-145	506.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	38.06	2.00e-138	484.00
IUUC-Spo-108107	Schizosaccharomyces pombe	39.71	4.00e-132	463.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	62.85	0.00e+00	870.00
IUUC-Smo-109677	Selaginella moellendorffii	39.23	2.00e-125	441.00
IUUC-Sit-110319	Setaria italica	41.05	6.00e-78	283.00
IUUC-Sly-111215	Solanum lycopersicum	40.08	1.00e-131	461.00
IUUC-Stu-112442	Solanum tuberosum	40.33	6.00e-131	459.00
IUUC-Sar-113370	Sorex araneus	48.13	2.00e-100	358.00
IUUC-Sbi-114261	Sorghum bicolor	41.91	4.00e-75	274.00
IUUC-Sre-114997	Sporisorium reilianum	40.78	2.00e-149	520.00
IUUC-Ssc-115304	Sus scrofa	42.94	2.00e-145	507.00
IUUC-Tgu-117235	Taeniopygia guttata	41.26	1.00e-150	525.00
IUUC-Tru-118374	Takifugu rubripes	40.43	7.00e-146	509.00
IUUC-Tsy-118966	Tarsius syrichta	36.50	2.00e-110	391.00
IUUC-Tni-120269	Tetraodon nigroviridis	40.23	4.00e-129	453.00
IUUC-Tca-121245	Theobroma cacao	39.72	5.00e-137	479.00
IUUC-Tre-121966	Trichoderma reesei	63.20	0.00e+00	888.00
IUUC-Tvi-122360	Trichoderma virens	62.77	0.00e+00	872.00
IUUC-Tae-125251	Triticum aestivum	31.22	5.00e-90	323.00
IUUC-Tur-126294	Triticum urartu	31.16	8.00e-84	303.00
IUUC-Tme-127117	Tuber melanosporum	51.70	0.00e+00	666.00
IUUC-Tbe-127662	Tupaia belangeri	41.01	1.00e-41	162.00
IUUC-Ttr-129054	Tursiops truncatus	41.00	1.00e-144	505.00
IUUC-Uma-129526	Ustilago maydis	39.69	3.00e-154	537.00
IUUC-Vda-129878	Verticillium dahliae	64.48	0.00e+00	912.00
IUUC-Vpa-130264	Vicugna pacos	37.31	2.00e-74	271.00
IUUC-Vvi-131163	Vitis vinifera	39.00	2.00e-135	474.00
IUUC-Xtr-132328	Xenopus tropicalis	33.24	4.00e-95	340.00
IUUC-Xma-133015	Xiphophorus maculatus	37.95	2.00e-129	454.00
IUUC-Yli-134468	Yarrowia lipolytica	40.47	1.00e-130	458.00
IUUC-Zma-134871	Zea mays	31.55	9.00e-90	323.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence