iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093879

Ensembl Protein ID

ENSPSIP00000016203.1

UniProt Accession

K7G7E2; K7G7E2_PELSI

Genbank Protein ID

ENSPSIP00000016203

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AGCU01058026

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000014442.1	ENSPSIT00000016279.1	ENSPSIP00000016203.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	38.38	3.00e-15	74.30	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pelodiscus sinensis

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPMSLVVE FGGGAELLFD GIKKHQVTLP CQPEPWDIRN LLKWIKQNLL KERPELFIQG 60
DTVRPGILVL INDADWELMG ELDYKLQNQD NVVFISTLHG G 101

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Nucleotide Sequence
(Fasta)

CCTCCTTCAA GATGGCGGCG CCCATGTCCC TGGTGGTGGA GTTTGGGTGA GTGCGGGGCG 60
GGGACCGGGC TACAGCGAGG TGCCTGGAGC AGGGGGGCGT GGGATGCCTG TGCCCTGTGG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

KEGG

pss:102459301

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	86.14	3.00e-48	182.00
IUUC-Atr-003089	Amborella trichopoda	59.60	3.00e-31	125.00
IUUC-Apl-003382	Anas platyrhynchos	90.11	1.00e-45	172.00
IUUC-Aca-004981	Anolis carolinensis	86.14	2.00e-49	186.00
IUUC-Aly-005517	Arabidopsis lyrata	54.35	3.00e-27	112.00
IUUC-Ath-006718	Arabidopsis thaliana	53.57	6.00e-24	101.00
IUUC-Ago-007917	Ashbya gossypii	43.16	5.00e-19	85.10
IUUC-Acl-008054	Aspergillus clavatus	70.00	4.00e-16	75.50
IUUC-Afl-008704	Aspergillus flavus	56.18	1.00e-21	93.60
IUUC-Aor-009890	Aspergillus oryzae	56.44	8.00e-26	108.00
IUUC-Bta-012448	Bos taurus	84.16	1.00e-47	180.00
IUUC-Bci-013865	Botrytis cinerea	46.53	1.00e-22	97.10
IUUC-Bdi-014980	Brachypodium distachyon	58.14	1.00e-23	100.00
IUUC-Bol-016055	Brassica oleracea	56.25	6.00e-24	101.00
IUUC-Bra-016845	Brassica rapa	56.25	6.00e-24	101.00
IUUC-Cel-018485	Caenorhabditis elegans	33.01	4.00e-12	62.40
IUUC-Cja-019587	Callithrix jacchus	86.14	3.00e-48	182.00
IUUC-Cfa-020653	Canis familiaris	83.17	2.00e-47	179.00
IUUC-Cpo-021622	Cavia porcellus	86.14	3.00e-48	182.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	54.26	7.00e-25	104.00
IUUC-Csa-023756	Chlorocebus sabaeus	88.61	1.00e-36	145.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	47.52	6.00e-23	98.60
IUUC-Cne-026953	Cryptococcus neoformans	58.25	1.00e-29	121.00
IUUC-Cme-027314	Cyanidioschyzon merolae	42.71	1.00e-19	87.40
IUUC-Dre-027884	Danio rerio	79.21	9.00e-45	170.00
IUUC-Dno-029262	Dasypus novemcinctus	86.25	8.00e-36	142.00
IUUC-Dor-030601	Dipodomys ordii	56.44	7.00e-24	101.00
IUUC-Dme-031893	Drosophila melanogaster	63.73	4.00e-33	132.00
IUUC-Ete-032773	Echinops telfairi	81.19	5.00e-44	168.00
IUUC-Eca-034187	Equus caballus	85.15	4.00e-48	182.00
IUUC-Eeu-034808	Erinaceus europaeus	83.17	4.00e-47	178.00
IUUC-Fca-036107	Felis catus	86.14	1.00e-48	183.00
IUUC-Fal-036607	Ficedula albicollis	91.21	1.00e-46	176.00
IUUC-Fox-037698	Fusarium oxysporum	47.12	6.00e-23	98.60
IUUC-Gmo-039492	Gadus morhua	78.22	2.00e-44	169.00
IUUC-Ggr-039965	Gaeumannomyces graminis	48.08	4.00e-21	93.60
IUUC-Gga-041268	Gallus gallus	91.09	2.00e-51	192.00
IUUC-Gac-042111	Gasterosteus aculeatus	78.22	2.00e-45	172.00
IUUC-Gma-043240	Glycine max	64.06	1.00e-22	97.10
IUUC-Ggo-045176	Gorilla gorilla	87.34	4.00e-29	119.00
IUUC-Hsa-046077	Homo sapiens	86.14	5.00e-41	158.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	86.52	2.00e-35	139.00
IUUC-Kpa-049157	Komagataella pastoris	43.43	7.00e-19	84.70
IUUC-Lch-049889	Latimeria chalumnae	84.16	3.00e-46	175.00
IUUC-Lpe-050783	Leersia perrieri	58.33	2.00e-22	96.70
IUUC-Loc-052400	Lepisosteus oculatus	83.17	9.00e-47	177.00
IUUC-Lma-053259	Leptosphaeria maculans	47.47	1.00e-21	94.00
IUUC-Laf-053596	Loxodonta africana	83.50	3.00e-46	176.00
IUUC-Mcc-054845	Macaca mulatta	82.65	9.00e-43	164.00
IUUC-Meu-055968	Macropus eugenii	85.15	3.00e-48	182.00
IUUC-Mor-057126	Magnaporthe oryzae	47.12	1.00e-20	91.70
IUUC-Mpo-057311	Magnaporthe poae	49.50	1.00e-22	98.20
IUUC-Mtr-058266	Medicago truncatula	64.06	3.00e-22	95.90
IUUC-Mla-058847	Melampsora laricipopulina	39.81	1.00e-11	61.20
IUUC-Mga-059468	Meleagris gallopavo	91.21	4.00e-46	175.00
IUUC-Mvi-060235	Microbotryum violaceum	34.44	4.00e-18	83.60
IUUC-Mdo-061948	Monodelphis domestica	83.17	1.00e-47	180.00
IUUC-Mmu-063946	Mus musculus	83.17	7.00e-47	177.00
IUUC-Mac-064812	Musa acuminata	57.83	3.00e-24	102.00
IUUC-Mpu-066763	Mustela putorius furo	83.17	1.00e-46	177.00
IUUC-Mlu-066970	Myotis lucifugus	87.34	9.00e-37	143.00
IUUC-Ncr-068824	Neurospora crassa	45.54	5.00e-20	89.00
IUUC-Nle-069849	Nomascus leucogenys	87.34	3.00e-36	143.00
IUUC-Opr-070227	Ochotona princeps	86.14	3.00e-48	182.00
IUUC-Ont-072530	Oreochromis niloticus	79.21	4.00e-45	172.00
IUUC-Oan-073191	Ornithorhynchus anatinus	82.02	2.00e-40	156.00
IUUC-Ocu-074460	Oryctolagus cuniculus	84.69	1.00e-46	176.00
IUUC-Oba-075499	Oryza barthii	60.24	1.00e-22	98.60
IUUC-Obr-076896	Oryza brachyantha	64.06	2.00e-21	95.50
IUUC-Ogl-077834	Oryza glaberrima	60.24	3.00e-23	99.40
IUUC-Ogu-078622	Oryza glumaepatula	60.24	3.00e-23	99.40
IUUC-Oin-079358	Oryza indica	60.24	1.00e-22	99.40
IUUC-Olo-081035	Oryza longistaminata	57.45	5.00e-24	103.00
IUUC-Oni-082425	Oryza nivara	60.24	3.00e-23	99.40
IUUC-Opu-083461	Oryza punctata	58.54	5.00e-22	96.70
IUUC-Oru-084875	Oryza rufipogon	60.56	1.00e-20	90.50
IUUC-Oga-089128	Otolemur garnettii	85.15	5.00e-48	181.00
IUUC-Oar-089896	Ovis aries	84.16	1.00e-47	180.00
IUUC-Ptr-091618	Pan troglodytes	87.34	4.00e-29	119.00
IUUC-Pan-092238	Papio anubis	88.61	1.00e-36	145.00
IUUC-Pma-094484	Petromyzon marinus	78.22	7.00e-34	134.00
IUUC-Ppa-095801	Physcomitrella patens	56.79	2.00e-22	96.30
IUUC-Pfo-097192	Poecilia formosa	79.21	1.00e-45	173.00
IUUC-Pab-098203	Pongo abelii	86.14	6.00e-41	158.00
IUUC-Pop-099614	Populus trichocarpa	53.57	2.00e-22	96.30
IUUC-Pca-100507	Procavia capensis	86.08	1.00e-36	143.00
IUUC-Ppe-101174	Prunus persica	58.59	3.00e-30	122.00
IUUC-Pva-102735	Pteropus vampyrus	84.16	2.00e-44	169.00
IUUC-Pgr-103510	Puccinia graminis	40.78	2.00e-12	64.30
IUUC-Ptt-103918	Puccinia triticina	38.46	1.00e-10	58.20
IUUC-Pte-104173	Pyrenophora teres	47.57	1.00e-23	100.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	47.57	2.00e-23	100.00
IUUC-Rno-105820	Rattus norvegicus	84.16	3.00e-47	179.00
IUUC-Sce-106366	Saccharomyces cerevisiae	38.38	8.00e-16	74.30
IUUC-Sja-107727	Schizosaccharomyces japonicus	42.71	2.00e-17	80.10
IUUC-Spo-108074	Schizosaccharomyces pombe	42.86	4.00e-11	58.90
IUUC-Smo-108944	Selaginella moellendorffii	57.30	5.00e-25	104.00
IUUC-Sit-110277	Setaria italica	55.95	2.00e-23	99.80
IUUC-Sly-111505	Solanum lycopersicum	53.57	3.00e-24	102.00
IUUC-Stu-112076	Solanum tuberosum	54.76	9.00e-25	104.00
IUUC-Sbi-114274	Sorghum bicolor	58.44	4.00e-23	99.00
IUUC-Sre-114953	Sporisorium reilianum	60.20	5.00e-28	115.00
IUUC-Ssc-115418	Sus scrofa	84.16	7.00e-48	181.00
IUUC-Tgu-117311	Taeniopygia guttata	91.21	1.00e-46	176.00
IUUC-Tru-118598	Takifugu rubripes	80.90	7.00e-40	154.00
IUUC-Tni-120109	Tetraodon nigroviridis	75.49	1.00e-41	160.00
IUUC-Tca-120942	Theobroma cacao	54.22	6.00e-23	98.20
IUUC-Tre-122099	Trichoderma reesei	47.87	2.00e-16	76.30
IUUC-Tvi-122285	Trichoderma virens	52.88	4.00e-21	92.80
IUUC-Tae-125193	Triticum aestivum	67.19	2.00e-22	97.10
IUUC-Tur-126677	Triticum urartu	56.58	6.00e-20	88.60
IUUC-Tme-127120	Tuber melanosporum	47.12	2.00e-23	100.00
IUUC-Tbe-128050	Tupaia belangeri	61.39	1.00e-29	120.00
IUUC-Ttr-129019	Tursiops truncatus	82.18	8.00e-45	171.00
IUUC-Uma-129483	Ustilago maydis	55.88	1.00e-24	104.00
IUUC-Vda-129690	Verticillium dahliae	40.18	1.00e-16	77.40
IUUC-Vvi-131174	Vitis vinifera	54.22	2.00e-23	99.80
IUUC-Xma-133862	Xiphophorus maculatus	79.21	1.00e-45	173.00
IUUC-Yli-134398	Yarrowia lipolytica	47.06	3.00e-19	85.90
IUUC-Zma-134964	Zea mays	56.79	3.00e-22	95.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence