iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013278

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WD repeat-containing protein 1

Genbank Nucleotide ID

DAAA02018593

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000013607.5	ENSBTAT00000018092.5	ENSBTAP00000018092.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-39	131.2	233	263
UBD/Beta-Prp	1.20e-62	211.9	55	279

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d t+l+s+s+D+t k+WD+
   Q: 233  HDGGIYAISWsPDsTRLLSASGDKTSKIWDV 263
           99*********999****************7 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlk 91
           ++h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++
   Q: 55   TEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEIT 143
           4566667778*************************998777742334567***********99999999887777777789******** PP
   S: 92   ghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tg 177
           gh++ + s+++ +s+ ++lv+Gs+d+ +  ++ +  +    t s h ++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l  ++
   Q: 144  GHNKVINSVDIKQSRpYRLVTGSDDNCAAFFEGPPFKFKF-TISDHGRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALggSK 231
           *************999******************999999.**********************************************88 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnv 225
           +h++ +y +s+++++++l+s+s d+t k+wd+  +++v+t++  ++  
   Q: 232  AHDGGIYAISWSPDSTRLLSASGDKTSKIWDVNVNSVVNTFTMGSNVL 279
           8***************************************98766544 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MPYEIKKVFA SLPQVERGVS KIVGGDPKGN SFLYTNGKCV ILRNIDNPAI ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATTCGCGG CGCGCGCGGC CCCTGCAGGC TCTCTGGCGA GCGCGGCGCG GTAACAAGTG 60
GGCAAGGATG CCGTACGAGA TCAGTAAGTG CCGCGGCCCG GTGCGCCCCC CGCCCCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	35.60	1.00e-82	300.00
IUUC-Aml-002368	Ailuropoda melanoleuca	95.51	0.00e+00	1175.00
IUUC-Atr-003160	Amborella trichopoda	37.36	1.00e-114	407.00
IUUC-Apl-004012	Anas platyrhynchos	89.11	0.00e+00	1091.00
IUUC-Aca-004707	Anolis carolinensis	83.50	0.00e+00	1057.00
IUUC-Aly-006465	Arabidopsis lyrata	36.97	1.00e-110	393.00
IUUC-Ath-006740	Arabidopsis thaliana	36.97	4.00e-110	391.00
IUUC-Ago-007920	Ashbya gossypii	28.39	2.00e-74	273.00
IUUC-Acl-008262	Aspergillus clavatus	36.42	2.00e-108	386.00
IUUC-Afl-008471	Aspergillus flavus	33.39	1.00e-79	290.00
IUUC-Afu-008989	Aspergillus fumigatus	38.71	5.00e-98	351.00
IUUC-Ani-009167	Aspergillus nidulans	38.46	8.00e-118	417.00
IUUC-Ang-009595	Aspergillus niger	38.01	4.00e-105	375.00
IUUC-Aor-009908	Aspergillus oryzae	37.16	2.00e-104	372.00
IUUC-Ate-010580	Aspergillus terreus	37.85	1.00e-110	395.00
IUUC-Ame-011269	Astyanax mexicanus	61.00	5.00e-135	474.00
IUUC-Bgr-011996	Blumeria graminis	34.31	9.00e-107	380.00
IUUC-Bci-013925	Botrytis cinerea	35.93	2.00e-107	382.00
IUUC-Bdi-014659	Brachypodium distachyon	35.41	1.00e-103	370.00
IUUC-Bol-016043	Brassica oleracea	35.46	1.00e-107	384.00
IUUC-Bra-017139	Brassica rapa	36.87	1.00e-108	387.00
IUUC-Cel-018417	Caenorhabditis elegans	41.23	2.00e-125	442.00
IUUC-Cja-019952	Callithrix jacchus	95.21	0.00e+00	1157.00
IUUC-Cfa-020225	Canis familiaris	95.87	0.00e+00	1189.00
IUUC-Cpo-021900	Cavia porcellus	94.01	0.00e+00	1165.00
IUUC-Csa-023028	Chlorocebus sabaeus	96.37	0.00e+00	1167.00
IUUC-Cho-025030	Choloepus hoffmanni	67.67	0.00e+00	747.00
IUUC-Cin-025152	Ciona intestinalis	54.86	6.00e-80	290.00
IUUC-Csv-025986	Ciona savignyi	37.20	3.00e-93	335.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	38.44	1.00e-112	400.00
IUUC-Cne-026814	Cryptococcus neoformans	34.89	1.00e-99	357.00
IUUC-Dre-027498	Danio rerio	81.03	5.00e-96	343.00
IUUC-Dno-029383	Dasypus novemcinctus	94.39	0.00e+00	1146.00
IUUC-Dor-030633	Dipodomys ordii	93.58	0.00e+00	1082.00
IUUC-Dse-031526	Dothistroma septosporum	38.39	1.00e-117	417.00
IUUC-Dme-031597	Drosophila melanogaster	47.93	4.00e-168	584.00
IUUC-Ete-032780	Echinops telfairi	84.10	0.00e+00	1040.00
IUUC-Eca-034306	Equus caballus	94.68	0.00e+00	1150.00
IUUC-Eeu-034531	Erinaceus europaeus	73.52	3.00e-134	471.00
IUUC-Fca-036301	Felis catus	96.01	0.00e+00	1202.00
IUUC-Fal-037361	Ficedula albicollis	88.93	0.00e+00	1139.00
IUUC-Fox-037924	Fusarium oxysporum	35.34	1.00e-101	363.00
IUUC-Fso-038199	Fusarium solani	34.96	3.00e-98	352.00
IUUC-Gmo-039238	Gadus morhua	72.65	0.00e+00	898.00
IUUC-Ggr-039830	Gaeumannomyces graminis	35.47	2.00e-96	346.00
IUUC-Gga-040235	Gallus gallus	89.77	0.00e+00	1117.00
IUUC-Gac-042363	Gasterosteus aculeatus	72.16	0.00e+00	927.00
IUUC-Gma-044189	Glycine max	36.66	3.00e-111	395.00
IUUC-Ggo-044632	Gorilla gorilla	93.74	0.00e+00	1129.00
IUUC-Hsa-045792	Homo sapiens	95.54	0.00e+00	1185.00
IUUC-Hvu-047517	Hordeum vulgare	35.46	7.00e-109	387.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	95.01	0.00e+00	1165.00
IUUC-Kpa-049183	Komagataella pastoris	32.89	6.00e-86	311.00
IUUC-Lch-050428	Latimeria chalumnae	76.94	0.00e+00	1007.00
IUUC-Lpe-051306	Leersia perrieri	36.11	2.00e-109	389.00
IUUC-Loc-052096	Lepisosteus oculatus	71.92	0.00e+00	902.00
IUUC-Lma-053313	Leptosphaeria maculans	39.44	4.00e-117	417.00
IUUC-Laf-054060	Loxodonta africana	92.74	0.00e+00	1139.00
IUUC-Mcc-055619	Macaca mulatta	94.11	0.00e+00	1136.00
IUUC-Meu-056689	Macropus eugenii	77.89	0.00e+00	627.00
IUUC-Mor-056940	Magnaporthe oryzae	35.82	4.00e-98	352.00
IUUC-Mpo-057557	Magnaporthe poae	28.41	4.00e-59	222.00
IUUC-Mtr-057922	Medicago truncatula	35.90	3.00e-110	392.00
IUUC-Mla-059103	Melampsora laricipopulina	33.80	2.00e-78	286.00
IUUC-Mga-060150	Meleagris gallopavo	89.40	0.00e+00	1105.00
IUUC-Mvi-060448	Microbotryum violaceum	31.78	1.00e-76	280.00
IUUC-Mmr-061226	Microcebus murinus	93.89	0.00e+00	1150.00
IUUC-Mdo-062674	Monodelphis domestica	91.91	0.00e+00	1150.00
IUUC-Mmu-064170	Mus musculus	95.21	0.00e+00	1180.00
IUUC-Mac-065124	Musa acuminata	37.28	2.00e-113	403.00
IUUC-Mpu-066001	Mustela putorius furo	91.73	0.00e+00	1162.00
IUUC-Mlu-067253	Myotis lucifugus	94.84	0.00e+00	1175.00
IUUC-Nfi-068550	Neosartorya fischeri	38.71	5.00e-113	401.00
IUUC-Ncr-068948	Neurospora crassa	36.82	3.00e-114	405.00
IUUC-Nle-070115	Nomascus leucogenys	92.62	0.00e+00	1065.00
IUUC-Opr-070254	Ochotona princeps	92.17	0.00e+00	1099.00
IUUC-Ont-071666	Oreochromis niloticus	75.74	0.00e+00	962.00
IUUC-Oan-073594	Ornithorhynchus anatinus	93.09	2.00e-169	588.00
IUUC-Ocu-074824	Oryctolagus cuniculus	92.90	0.00e+00	1124.00
IUUC-Oba-075010	Oryza barthii	36.33	2.00e-110	392.00
IUUC-Obr-076364	Oryza brachyantha	37.03	6.00e-112	397.00
IUUC-Ogl-077019	Oryza glaberrima	36.33	2.00e-110	392.00
IUUC-Ogu-078496	Oryza glumaepatula	36.33	2.00e-110	392.00
IUUC-Oin-080116	Oryza indica	36.50	9.00e-111	394.00
IUUC-Olo-080290	Oryza longistaminata	36.33	5.00e-110	391.00
IUUC-Ome-081969	Oryza meridionalis	36.33	3.00e-110	392.00
IUUC-Oni-082075	Oryza nivara	36.33	2.00e-110	392.00
IUUC-Opu-083959	Oryza punctata	36.54	3.00e-110	392.00
IUUC-Oru-084711	Oryza rufipogon	36.33	2.00e-110	392.00
IUUC-Osa-085958	Oryza sativa	36.50	9.00e-111	394.00
IUUC-Ola-086968	Oryzias latipes	75.91	0.00e+00	974.00
IUUC-Oga-089108	Otolemur garnettii	94.60	0.00e+00	1202.00
IUUC-Oar-089986	Ovis aries	92.79	0.00e+00	1144.00
IUUC-Ptr-091281	Pan troglodytes	95.83	0.00e+00	1175.00
IUUC-Pan-092585	Papio anubis	96.37	0.00e+00	1168.00
IUUC-Psi-093811	Pelodiscus sinensis	87.87	0.00e+00	1126.00
IUUC-Pma-094396	Petromyzon marinus	70.73	0.00e+00	911.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.30	3.00e-109	389.00
IUUC-Ppa-095876	Physcomitrella patens	36.39	5.00e-112	398.00
IUUC-Pfo-096973	Poecilia formosa	75.41	0.00e+00	996.00
IUUC-Pab-098391	Pongo abelii	95.71	0.00e+00	1165.00
IUUC-Pop-098850	Populus trichocarpa	37.42	2.00e-112	399.00
IUUC-Pca-100257	Procavia capensis	60.60	2.00e-91	329.00
IUUC-Ppe-101578	Prunus persica	37.97	4.00e-114	405.00
IUUC-Pva-102872	Pteropus vampyrus	90.28	0.00e+00	1131.00
IUUC-Pgr-103593	Puccinia graminis	33.56	5.00e-82	298.00
IUUC-Pte-104365	Pyrenophora teres	39.00	5.00e-111	395.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.67	3.00e-113	402.00
IUUC-Rno-105737	Rattus norvegicus	95.87	0.00e+00	1215.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.53	2.00e-70	260.00
IUUC-Sha-107084	Sarcophilus harrisii	90.20	0.00e+00	1015.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	35.36	2.00e-111	396.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.06	1.00e-95	343.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	35.93	9.00e-108	384.00
IUUC-Smo-109255	Selaginella moellendorffii	34.87	1.00e-100	360.00
IUUC-Sit-109962	Setaria italica	37.42	1.00e-112	400.00
IUUC-Sly-110897	Solanum lycopersicum	38.46	7.00e-115	407.00
IUUC-Stu-111971	Solanum tuberosum	38.46	2.00e-114	405.00
IUUC-Sar-113415	Sorex araneus	72.69	1.00e-109	390.00
IUUC-Sbi-114857	Sorghum bicolor	36.93	2.00e-110	392.00
IUUC-Sre-114900	Sporisorium reilianum	33.82	1.00e-92	333.00
IUUC-Tgu-117256	Taeniopygia guttata	88.87	0.00e+00	1133.00
IUUC-Tru-117871	Takifugu rubripes	70.58	0.00e+00	900.00
IUUC-Tsy-119172	Tarsius syrichta	95.00	9.00e-136	476.00
IUUC-Tni-120339	Tetraodon nigroviridis	70.63	0.00e+00	933.00
IUUC-Tca-121609	Theobroma cacao	37.22	3.00e-112	399.00
IUUC-Tre-122076	Trichoderma reesei	36.16	2.00e-95	342.00
IUUC-Tvi-122528	Trichoderma virens	34.81	1.00e-97	350.00
IUUC-Tae-124549	Triticum aestivum	35.78	9.00e-110	390.00
IUUC-Tur-126845	Triticum urartu	35.58	9.00e-82	297.00
IUUC-Tme-127217	Tuber melanosporum	35.63	3.00e-105	375.00
IUUC-Tbe-127526	Tupaia belangeri	92.90	0.00e+00	1152.00
IUUC-Ttr-128898	Tursiops truncatus	89.13	0.00e+00	1107.00
IUUC-Uma-129631	Ustilago maydis	32.79	1.00e-95	343.00
IUUC-Vda-129732	Verticillium dahliae	35.44	7.00e-94	338.00
IUUC-Vvi-131217	Vitis vinifera	38.11	9.00e-113	400.00
IUUC-Xtr-132860	Xenopus tropicalis	74.55	0.00e+00	948.00
IUUC-Xma-133830	Xiphophorus maculatus	75.41	0.00e+00	997.00
IUUC-Yli-134335	Yarrowia lipolytica	32.85	4.00e-76	278.00
IUUC-Zma-135907	Zea mays	36.93	2.00e-111	396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence