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Tag Content
UUCD2 ID IUUC-Cja-019297
UUCD1 version UUC-CaJ-01147
Ensembl Protein ID ENSCJAP00000020726.2
UniProt Accession F7H692; F7H692_CALJA
Genbank Protein ID ENSCJAP00000020726
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID ACFV01143080
Gene Name PAN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000011141.2 ENSCJAT00000021907.2 ENSCJAP00000020726.2
ENSCJAG00000011141.2 ENSCJAT00000021891.2 ENSCJAP00000020711.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.60e-19 71.3 526 912
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 526  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGNNFLRAFRTIPEASAlgliladsdeas 605
           56*********************...55654......57*************99***************99998866777777766666 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++++        +e  +  +      ++  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 606  gkGNLARLIQRWNRFILTQLHQDMQE--------LEVPQ--AYRGAGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 683
           66666666777888888888888833........22222..3344467899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           +l+ p+ ++++k+  +  +++  k+   l+++ + +c++c+k+q + ++  +++lP++L+++    s +e+     +++ +v f+  + 
   Q: 684  TLSYPDGSNSDKTGKNYDFAQVLKRSIcLDQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RMQAEVAFK--MA 768
           *****88777777555555555555442667778*****************************99977666555..588888887..55 PP
   S: 261  lspfcts........peekqke..............................................................kkkYe 279
           ++++  +                                                                              + Y+
   Q: 769  VKKHSGEisknkefaL-----AdwkelgspecvlvcpsieelknvwlpfsirmkmtknkgldvcnwtdgdemqwgparaeeehgVYVYD 852
           5555555223444550.....0555555555555555555555555555555555556666666666666666666666666669**** PP
   S: 280  LiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
           L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 853  LMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 912
           *********9*************999988877777888************9999888654 PP
   
Organism Callithrix jacchus
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Protein Sequence
(Fasta)
MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cja-019297|DUB,USP|Callithrix jacchus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAACTTTG AGGGTCTGGA CCCTGGACTG GCAGAGTATG CCCCAGCCAT GCATTCTGCC 60
CTGGACCCTG TCCTGGATGC CCACCTGAAC CCAAGTCTGC TACAGAATGT GGAGCTGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cja-019297|DUB,USP|Callithrix jacchus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 95.19 0.00e+00 2289.00
IUUC-Apl-003500 Anas platyrhynchos 82.58 0.00e+00 1822.00
IUUC-Aca-004930 Anolis carolinensis 81.83 0.00e+00 1966.00
IUUC-Acl-008214 Aspergillus clavatus 30.94 6.00e-154 538.00
IUUC-Afu-009112 Aspergillus fumigatus 31.05 1.00e-146 514.00
IUUC-Ang-009531 Aspergillus niger 30.43 1.00e-147 517.00
IUUC-Ame-011259 Astyanax mexicanus 74.59 0.00e+00 1793.00
IUUC-Bta-012371 Bos taurus 95.02 0.00e+00 2279.00
IUUC-Bci-013684 Botrytis cinerea 30.53 4.00e-132 466.00
IUUC-Cfa-020489 Canis familiaris 94.52 0.00e+00 2268.00
IUUC-Cpo-022392 Cavia porcellus 93.78 0.00e+00 2279.00
IUUC-Csa-023220 Chlorocebus sabaeus 95.95 0.00e+00 2308.00
IUUC-Csv-025841 Ciona savignyi 45.42 0.00e+00 890.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 31.81 2.00e-160 560.00
IUUC-Cne-026932 Cryptococcus neoformans 42.94 5.00e-73 270.00
IUUC-Dre-028482 Danio rerio 72.57 0.00e+00 1742.00
IUUC-Dno-029398 Dasypus novemcinctus 94.02 0.00e+00 2245.00
IUUC-Dor-030307 Dipodomys ordii 90.41 0.00e+00 1320.00
IUUC-Dme-032111 Drosophila melanogaster 40.65 0.00e+00 858.00
IUUC-Eca-033985 Equus caballus 95.19 0.00e+00 2282.00
IUUC-Eeu-034928 Erinaceus europaeus 77.96 0.00e+00 713.00
IUUC-Fca-035587 Felis catus 95.93 0.00e+00 2303.00
IUUC-Fal-037587 Ficedula albicollis 82.32 0.00e+00 1933.00
IUUC-Fso-038133 Fusarium solani 29.20 3.00e-128 452.00
IUUC-Gmo-039076 Gadus morhua 72.20 0.00e+00 1705.00
IUUC-Ggr-039957 Gaeumannomyces graminis 31.21 3.00e-136 479.00
IUUC-Gga-040948 Gallus gallus 82.86 0.00e+00 2002.00
IUUC-Gac-042396 Gasterosteus aculeatus 72.64 0.00e+00 1753.00
IUUC-Ggo-045412 Gorilla gorilla 96.43 0.00e+00 2311.00
IUUC-Hsa-046076 Homo sapiens 95.41 0.00e+00 2315.00
IUUC-Itr-048143 Ictidomys tridecemlineatus 90.12 0.00e+00 2114.00
IUUC-Kpa-049178 Komagataella pastoris 40.48 7.00e-67 249.00
IUUC-Lch-050279 Latimeria chalumnae 70.36 0.00e+00 1656.00
IUUC-Loc-052872 Lepisosteus oculatus 74.86 0.00e+00 1794.00
IUUC-Lma-052986 Leptosphaeria maculans 32.36 9.00e-155 541.00
IUUC-Laf-054181 Loxodonta africana 92.57 0.00e+00 2237.00
IUUC-Mcc-054812 Macaca mulatta 95.78 0.00e+00 2294.00
IUUC-Meu-056325 Macropus eugenii 88.69 0.00e+00 2154.00
IUUC-Mor-057246 Magnaporthe oryzae 28.82 3.00e-121 430.00
IUUC-Mpo-057464 Magnaporthe poae 31.03 2.00e-138 486.00
IUUC-Mla-058911 Melampsora laricipopulina 32.87 1.00e-102 368.00
IUUC-Mga-059335 Meleagris gallopavo 83.03 0.00e+00 1954.00
IUUC-Mvi-060461 Microbotryum violaceum 34.42 6.00e-144 505.00
IUUC-Mmr-060636 Microcebus murinus 95.37 0.00e+00 2287.00
IUUC-Mmu-063503 Mus musculus 93.31 0.00e+00 2214.00
IUUC-Mpu-066670 Mustela putorius furo 95.19 0.00e+00 2279.00
IUUC-Mlu-068119 Myotis lucifugus 94.52 0.00e+00 2304.00
IUUC-Nfi-068398 Neosartorya fischeri 31.69 6.00e-155 541.00
IUUC-Ncr-068927 Neurospora crassa 29.73 5.00e-127 449.00
IUUC-Nle-069651 Nomascus leucogenys 92.07 0.00e+00 2208.00
IUUC-Opr-070614 Ochotona princeps 93.06 0.00e+00 2245.00
IUUC-Ont-072433 Oreochromis niloticus 73.14 0.00e+00 1808.00
IUUC-Oan-073283 Ornithorhynchus anatinus 73.73 0.00e+00 1424.00
IUUC-Ocu-074401 Oryctolagus cuniculus 93.65 0.00e+00 2252.00
IUUC-Ola-087522 Oryzias latipes 72.62 0.00e+00 1751.00
IUUC-Oga-088226 Otolemur garnettii 94.73 0.00e+00 2278.00
IUUC-Oar-089241 Ovis aries 95.27 0.00e+00 2317.00
IUUC-Pan-092297 Papio anubis 95.42 0.00e+00 2046.00
IUUC-Psi-094043 Pelodiscus sinensis 79.54 0.00e+00 1865.00
IUUC-Pma-094394 Petromyzon marinus 67.58 0.00e+00 1514.00
IUUC-Pno-095053 Phaeosphaeria nodorum 32.39 5.00e-148 518.00
IUUC-Ppa-095188 Physcomitrella patens 32.46 2.00e-157 550.00
IUUC-Pfo-097517 Poecilia formosa 73.85 0.00e+00 1811.00
IUUC-Pca-100471 Procavia capensis 94.31 0.00e+00 2135.00
IUUC-Pva-102805 Pteropus vampyrus 93.71 0.00e+00 1854.00
IUUC-Pte-104021 Pyrenophora teres 31.66 7.00e-157 548.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 31.57 3.00e-156 546.00
IUUC-Rno-105471 Rattus norvegicus 93.36 0.00e+00 2213.00
IUUC-Sce-106235 Saccharomyces cerevisiae 38.84 3.00e-60 227.00
IUUC-Sha-106883 Sarcophilus harrisii 88.48 0.00e+00 1977.00
IUUC-Spo-108169 Schizosaccharomyces pombe 32.18 6.00e-144 505.00
IUUC-Sar-113323 Sorex araneus 95.64 0.00e+00 1718.00
IUUC-Sre-115075 Sporisorium reilianum 29.33 5.00e-68 253.00
IUUC-Ssc-116363 Sus scrofa 93.90 0.00e+00 2281.00
IUUC-Tru-118427 Takifugu rubripes 73.24 0.00e+00 1824.00
IUUC-Tni-120218 Tetraodon nigroviridis 73.50 0.00e+00 1817.00
IUUC-Tre-122177 Trichoderma reesei 31.27 3.00e-148 519.00
IUUC-Tme-127176 Tuber melanosporum 33.07 1.00e-137 484.00
IUUC-Tbe-127641 Tupaia belangeri 96.01 6.00e-176 611.00
IUUC-Ttr-128888 Tursiops truncatus 96.93 0.00e+00 1488.00
IUUC-Uma-129361 Ustilago maydis 38.42 2.00e-63 238.00
IUUC-Xtr-132811 Xenopus tropicalis 76.03 0.00e+00 1845.00
Created Date 25-Jun-2017

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