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Tag Content
UUCD2 ID IUUC-Itr-048143
UUCD1 version UUC-SpT-00751
Ensembl Protein ID ENSSTOP00000014297.2
UniProt Accession I3MQP5; I3MQP5_ICTTR
Genbank Protein ID ENSSTOP00000014297
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID AGTP01085337
Gene Name PAN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSTOG00000015974.2 ENSSTOT00000015978.2 ENSSTOP00000014297.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.30e-21 76.3 510 896
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 510  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 589
           56*********************...55654......57*************9*****************9999866766666666665 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++           +e +  ++ + a ++  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 590  gkGNLARLIQRWNRFILTQLHQDM-----------QELEVPQAYRGAGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 666
           555556666667777777777777...........2333334566678899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+     +++ +v f+  + +
   Q: 667  TLSYPEDKTGKNYDFAQVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RMQAEVAFK--MAV 748
           **********999**99999888766665...69****************************99977666555..588888887..556 PP
   S: 262  spfcts........peekqke.................................................................... 274
           +++  +                                                                                   
   Q: 749  KKHGGEisknkefsL-----Adrkelgspegvllcpsieelknvwlpfsirmkmtknkgldvcnwtevqvlsslgtsqwgparaeeehg 832
           655555333444440.....045555555555555555555556666666666666666666666666666666666666666666666 PP
   S: 275  kkkYeLiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleet 326
            + Y+L+a vvH   s  +G  va++k            ++++W+lf+D  ++++++ e +++ 
   Q: 833  VYVYDLMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKYEAVQFD 896
           9*************9*************999988877777888************998877765 PP
   
Organism Ictidomys tridecemlineatus
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Protein Sequence
(Fasta)
MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPTLERYSS FQVNGSDDIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Itr-048143|DUB,USP|Ictidomys tridecemlineatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCATGATAT CCATTCTAGG CCCACTGGTG CTCTTCTGCT GAAGGTTGGC TCAGGCATTT 60
ACAGGGACTG TGGCAAGGAA GGGTGTGACG CAGGTCTATC AGCTGTCATC ATCATGAACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Itr-048143|DUB,USP|Ictidomys tridecemlineatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0472--Membrane
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 90.42 0.00e+00 2106.00
IUUC-Apl-003500 Anas platyrhynchos 80.67 0.00e+00 1707.00
IUUC-Aca-004930 Anolis carolinensis 78.55 0.00e+00 1833.00
IUUC-Acl-008214 Aspergillus clavatus 29.91 2.00e-137 483.00
IUUC-Afu-009112 Aspergillus fumigatus 30.16 5.00e-130 458.00
IUUC-Ang-009531 Aspergillus niger 29.50 4.00e-133 469.00
IUUC-Ame-011259 Astyanax mexicanus 70.19 0.00e+00 1648.00
IUUC-Bta-012371 Bos taurus 90.56 0.00e+00 2115.00
IUUC-Bci-013684 Botrytis cinerea 39.94 4.00e-60 226.00
IUUC-Cja-019297 Callithrix jacchus 90.12 0.00e+00 2115.00
IUUC-Cfa-020489 Canis familiaris 90.05 0.00e+00 2096.00
IUUC-Cpo-022392 Cavia porcellus 89.42 0.00e+00 2117.00
IUUC-Csa-023220 Chlorocebus sabaeus 90.17 0.00e+00 2113.00
IUUC-Csv-025841 Ciona savignyi 43.45 0.00e+00 806.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 30.87 8.00e-142 498.00
IUUC-Cne-026932 Cryptococcus neoformans 31.84 1.00e-65 245.00
IUUC-Dre-028482 Danio rerio 69.35 0.00e+00 1611.00
IUUC-Dno-029398 Dasypus novemcinctus 89.88 0.00e+00 2090.00
IUUC-Dor-030307 Dipodomys ordii 87.78 0.00e+00 1251.00
IUUC-Dme-032111 Drosophila melanogaster 39.72 0.00e+00 791.00
IUUC-Eca-033985 Equus caballus 91.14 0.00e+00 2118.00
IUUC-Eeu-034928 Erinaceus europaeus 85.35 0.00e+00 676.00
IUUC-Fca-035587 Felis catus 90.75 0.00e+00 2112.00
IUUC-Fal-037587 Ficedula albicollis 79.48 0.00e+00 1811.00
IUUC-Fso-038133 Fusarium solani 39.89 1.00e-65 244.00
IUUC-Gmo-039076 Gadus morhua 68.37 0.00e+00 1580.00
IUUC-Ggr-039957 Gaeumannomyces graminis 30.78 4.00e-123 436.00
IUUC-Gga-040948 Gallus gallus 79.73 0.00e+00 1865.00
IUUC-Gac-042396 Gasterosteus aculeatus 69.63 0.00e+00 1632.00
IUUC-Ggo-045412 Gorilla gorilla 90.58 0.00e+00 2112.00
IUUC-Hsa-046076 Homo sapiens 90.34 0.00e+00 2116.00
IUUC-Kpa-049178 Komagataella pastoris 38.55 6.00e-57 216.00
IUUC-Lch-050279 Latimeria chalumnae 67.48 0.00e+00 1526.00
IUUC-Loc-052872 Lepisosteus oculatus 71.69 0.00e+00 1653.00
IUUC-Lma-052986 Leptosphaeria maculans 30.51 2.00e-129 457.00
IUUC-Laf-054181 Loxodonta africana 89.46 0.00e+00 2106.00
IUUC-Mcc-054812 Macaca mulatta 90.64 0.00e+00 2115.00
IUUC-Meu-056325 Macropus eugenii 85.51 0.00e+00 1991.00
IUUC-Mor-057246 Magnaporthe oryzae 28.26 2.00e-107 384.00
IUUC-Mpo-057464 Magnaporthe poae 30.48 4.00e-124 439.00
IUUC-Mla-058911 Melampsora laricipopulina 31.69 4.00e-95 343.00
IUUC-Mga-059335 Meleagris gallopavo 79.85 0.00e+00 1829.00
IUUC-Mvi-060461 Microbotryum violaceum 33.73 9.00e-131 461.00
IUUC-Mmr-060636 Microcebus murinus 90.81 0.00e+00 2116.00
IUUC-Mmu-063503 Mus musculus 90.47 0.00e+00 2102.00
IUUC-Mpu-066670 Mustela putorius furo 90.89 0.00e+00 2113.00
IUUC-Mlu-068119 Myotis lucifugus 89.72 0.00e+00 2131.00
IUUC-Nfi-068398 Neosartorya fischeri 30.74 2.00e-139 489.00
IUUC-Ncr-068927 Neurospora crassa 28.72 1.00e-110 394.00
IUUC-Nle-069651 Nomascus leucogenys 86.36 0.00e+00 2014.00
IUUC-Opr-070614 Ochotona princeps 89.44 0.00e+00 2087.00
IUUC-Ont-072433 Oreochromis niloticus 69.53 0.00e+00 1664.00
IUUC-Oan-073283 Ornithorhynchus anatinus 71.82 0.00e+00 1357.00
IUUC-Ocu-074401 Oryctolagus cuniculus 90.23 0.00e+00 2117.00
IUUC-Ola-087522 Oryzias latipes 69.43 0.00e+00 1603.00
IUUC-Oga-088226 Otolemur garnettii 90.33 0.00e+00 2121.00
IUUC-Oar-089241 Ovis aries 90.26 0.00e+00 2134.00
IUUC-Pan-092297 Papio anubis 89.70 0.00e+00 1869.00
IUUC-Psi-094043 Pelodiscus sinensis 76.46 0.00e+00 1725.00
IUUC-Pma-094394 Petromyzon marinus 63.50 0.00e+00 1393.00
IUUC-Pno-095053 Phaeosphaeria nodorum 31.23 2.00e-121 430.00
IUUC-Ppa-095188 Physcomitrella patens 30.34 1.00e-136 481.00
IUUC-Pfo-097517 Poecilia formosa 70.51 0.00e+00 1674.00
IUUC-Pca-100471 Procavia capensis 88.79 0.00e+00 1959.00
IUUC-Pva-102805 Pteropus vampyrus 90.03 0.00e+00 1738.00
IUUC-Pte-104021 Pyrenophora teres 30.97 5.00e-88 319.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 30.82 3.00e-87 317.00
IUUC-Rno-105471 Rattus norvegicus 89.62 0.00e+00 2083.00
IUUC-Sce-106235 Saccharomyces cerevisiae 35.77 3.00e-53 203.00
IUUC-Sha-106883 Sarcophilus harrisii 84.58 0.00e+00 1837.00
IUUC-Spo-108169 Schizosaccharomyces pombe 30.55 7.00e-121 428.00
IUUC-Sar-113323 Sorex araneus 91.79 0.00e+00 1608.00
IUUC-Sre-115075 Sporisorium reilianum 30.60 2.00e-59 224.00
IUUC-Ssc-116363 Sus scrofa 90.48 0.00e+00 2134.00
IUUC-Tru-118427 Takifugu rubripes 70.12 0.00e+00 1682.00
IUUC-Tni-120218 Tetraodon nigroviridis 69.93 0.00e+00 1685.00
IUUC-Tre-122177 Trichoderma reesei 30.01 9.00e-131 461.00
IUUC-Tme-127176 Tuber melanosporum 31.90 8.00e-123 434.00
IUUC-Tbe-127641 Tupaia belangeri 91.21 5.00e-165 575.00
IUUC-Ttr-128888 Tursiops truncatus 91.42 0.00e+00 1361.00
IUUC-Uma-129361 Ustilago maydis 47.87 1.00e-55 211.00
IUUC-Xtr-132811 Xenopus tropicalis 73.21 0.00e+00 1728.00
Created Date 25-Jun-2017

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