iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lma-052986

Ensembl Protein ID

CBX91519

UniProt Accession

E4ZJ88; E4ZJ88_LEPMJ

Genbank Protein ID

CBX91519.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

FP929072

Gene Name

PAN2; LEMA_P070270.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
LEMA_P070270.1	CBX91519	CBX91519

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-13	50.5	490	815

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..........gyeqqDa 92
           Gl+ +    Y N +LQ L ++p +r+l l+++ + +  e       +ll++l  l+  l k    + + +++lk+++ +++ +s              +  
   Q: 490  GLETHITNSYANPLLQLLRFTPLIRNLALQHTASPCLFE------SCLLCELGFLIDMLEKAAGLNCQASNFLKTFSGLSNAVSlnlleefapnVALTNMI 584
           677777778*********************777777765......69*********999999999999999999999999988766666555554455556 PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.....slq 188
           q + +flld+++ee+                      ++  + + ++s ++++++ q + +++c +c+n++ r  +++  +l  p k+ +k++     +++
   Q: 585  QNLNRFLLDKVSEEF----------------------RQMLPGQPGPSAMDQVLETQARASMRCAQCANETIRGGKNFVSELVYPAKHVMKNTriprpTFS 663
           777777777777777......................44568999*************************************9999998887788888999 PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fctspeekqke.........kkkYe 279
           ++L++ ++++  +   + +c+kc+++q+++++ +++++P vL+l+    s + +    + +    e+ + +d  + +c +  ++  +            Ye
   Q: 664  QILKASVERQDQT---RGWCTKCNRYQQMVQRKTIQSVPGVLMLNAAIQSHEAKLLWAIPNWLPQEIGIIVDQGQfYCFE-GQDL-KlhlqrgvfdIMVYE 759
           9998777776655...37***************************99996666555555555555565667777845555.3333.23688888889**** PP
   S: 280  Liavv..vHsGslssGHYvayvkn........ekgkWllfdDskVtevkeeevlee 325
           Li+vv  + sG++++ H va ++          ++kW+lf+D  V+++++ee l++
   Q: 760  LIGVVadINSGEHQKPHLVATINTgpssrepdAEDKWYLFNDFLVRPIPKEEALRF 815
           *****555789*************888888777888************99998875 PP

Organism

Leptosphaeria maculans

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEADWDELAI AQLPPPGPHH AAVPISTFAF DTTQELLWTG NNHGRVTSFY GPHLERYTSY 60
RGHTLADGPV KQFLFTEKGI LSISKQSVHY SHRRGLTQWH LTSSDFVDLK CMNFTSKGTR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGCGG ATTGGGACGA GGTACATGAC CACCACAACG CTGCCTGACG CGTTACCAAC 60
TTCACCCTCC CTCAACCTGA AGGCAGTATC AAGCATGAGT GCACCGTGAC TGACCCTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	32.11	5.00e-155	540.00
IUUC-Apl-003500	Anas platyrhynchos	31.04	6.00e-87	314.00
IUUC-Aca-004930	Anolis carolinensis	31.35	8.00e-94	337.00
IUUC-Acl-008214	Aspergillus clavatus	51.93	0.00e+00	1199.00
IUUC-Afu-009112	Aspergillus fumigatus	52.20	0.00e+00	1183.00
IUUC-Ang-009531	Aspergillus niger	51.56	0.00e+00	1152.00
IUUC-Ame-011259	Astyanax mexicanus	30.17	2.00e-86	312.00
IUUC-Bta-012371	Bos taurus	32.37	3.00e-156	544.00
IUUC-Bci-013684	Botrytis cinerea	50.05	0.00e+00	1062.00
IUUC-Cja-019297	Callithrix jacchus	32.06	7.00e-151	526.00
IUUC-Cfa-020489	Canis familiaris	31.53	3.00e-154	538.00
IUUC-Cpo-022392	Cavia porcellus	32.21	4.00e-156	544.00
IUUC-Csa-023220	Chlorocebus sabaeus	32.29	7.00e-154	536.00
IUUC-Csv-025841	Ciona savignyi	27.21	1.00e-63	236.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	53.39	0.00e+00	1193.00
IUUC-Cne-026932	Cryptococcus neoformans	33.89	5.00e-161	560.00
IUUC-Dre-028482	Danio rerio	29.36	6.00e-84	304.00
IUUC-Dno-029398	Dasypus novemcinctus	32.08	6.00e-156	543.00
IUUC-Dor-030307	Dipodomys ordii	32.66	1.00e-92	333.00
IUUC-Dme-032111	Drosophila melanogaster	28.13	5.00e-78	284.00
IUUC-Eca-033985	Equus caballus	32.20	1.00e-155	542.00
IUUC-Eeu-034928	Erinaceus europaeus	30.35	1.00e-39	157.00
IUUC-Fca-035587	Felis catus	32.55	9.00e-159	553.00
IUUC-Fal-037587	Ficedula albicollis	31.24	1.00e-91	330.00
IUUC-Fso-038133	Fusarium solani	52.06	0.00e+00	645.00
IUUC-Gmo-039076	Gadus morhua	29.28	8.00e-83	300.00
IUUC-Ggr-039957	Gaeumannomyces graminis	48.72	0.00e+00	1036.00
IUUC-Gga-040948	Gallus gallus	31.12	4.00e-89	321.00
IUUC-Gac-042396	Gasterosteus aculeatus	30.56	4.00e-88	318.00
IUUC-Ggo-045412	Gorilla gorilla	32.05	1.00e-152	532.00
IUUC-Hsa-046076	Homo sapiens	32.05	2.00e-153	535.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.20	1.00e-125	442.00
IUUC-Kpa-049178	Komagataella pastoris	34.34	4.00e-176	610.00
IUUC-Lch-050279	Latimeria chalumnae	40.88	3.00e-66	245.00
IUUC-Loc-052872	Lepisosteus oculatus	30.96	7.00e-86	310.00
IUUC-Laf-054181	Loxodonta africana	32.26	4.00e-151	527.00
IUUC-Mcc-054812	Macaca mulatta	32.40	5.00e-154	537.00
IUUC-Meu-056325	Macropus eugenii	32.54	2.00e-153	535.00
IUUC-Mor-057246	Magnaporthe oryzae	44.49	0.00e+00	900.00
IUUC-Mpo-057464	Magnaporthe poae	49.04	0.00e+00	1047.00
IUUC-Mla-058911	Melampsora laricipopulina	39.40	3.00e-119	421.00
IUUC-Mga-059335	Meleagris gallopavo	31.12	5.00e-89	321.00
IUUC-Mvi-060461	Microbotryum violaceum	35.60	2.00e-171	595.00
IUUC-Mmr-060636	Microcebus murinus	32.11	3.00e-152	531.00
IUUC-Mmu-063503	Mus musculus	30.91	8.00e-93	333.00
IUUC-Mpu-066670	Mustela putorius furo	32.20	1.00e-155	542.00
IUUC-Mlu-068119	Myotis lucifugus	32.12	3.00e-159	554.00
IUUC-Nfi-068398	Neosartorya fischeri	52.66	0.00e+00	1208.00
IUUC-Ncr-068927	Neurospora crassa	45.16	0.00e+00	951.00
IUUC-Nle-069651	Nomascus leucogenys	31.03	9.00e-145	506.00
IUUC-Opr-070614	Ochotona princeps	32.34	2.00e-152	532.00
IUUC-Ont-072433	Oreochromis niloticus	30.46	2.00e-89	322.00
IUUC-Oan-073283	Ornithorhynchus anatinus	38.82	6.00e-59	221.00
IUUC-Ocu-074401	Oryctolagus cuniculus	30.72	8.00e-90	323.00
IUUC-Ola-087522	Oryzias latipes	31.91	2.00e-153	535.00
IUUC-Oga-088226	Otolemur garnettii	30.63	4.00e-91	328.00
IUUC-Oar-089241	Ovis aries	32.20	1.00e-156	545.00
IUUC-Pan-092297	Papio anubis	32.25	4.00e-142	497.00
IUUC-Psi-094043	Pelodiscus sinensis	30.77	2.00e-87	316.00
IUUC-Pma-094394	Petromyzon marinus	32.19	6.00e-143	500.00
IUUC-Pno-095053	Phaeosphaeria nodorum	89.59	0.00e+00	1918.00
IUUC-Ppa-095188	Physcomitrella patens	29.05	1.00e-121	429.00
IUUC-Pfo-097517	Poecilia formosa	29.70	2.00e-88	319.00
IUUC-Pca-100471	Procavia capensis	32.56	1.00e-152	532.00
IUUC-Pva-102805	Pteropus vampyrus	30.38	2.00e-114	405.00
IUUC-Pte-104021	Pyrenophora teres	88.69	0.00e+00	2081.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	88.52	0.00e+00	2063.00
IUUC-Rno-105471	Rattus norvegicus	32.13	1.00e-158	552.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.35	2.00e-142	498.00
IUUC-Sha-106883	Sarcophilus harrisii	32.36	3.00e-147	514.00
IUUC-Spo-108169	Schizosaccharomyces pombe	38.17	0.00e+00	703.00
IUUC-Sar-113323	Sorex araneus	33.56	4.00e-124	437.00
IUUC-Sre-115075	Sporisorium reilianum	42.65	6.00e-61	228.00
IUUC-Ssc-116363	Sus scrofa	30.77	8.00e-91	327.00
IUUC-Tru-118427	Takifugu rubripes	30.52	1.00e-91	330.00
IUUC-Tni-120218	Tetraodon nigroviridis	31.24	2.00e-92	332.00
IUUC-Tre-122177	Trichoderma reesei	52.19	0.00e+00	1161.00
IUUC-Tme-127176	Tuber melanosporum	44.68	0.00e+00	884.00
IUUC-Tbe-127641	Tupaia belangeri	32.10	3.00e-27	115.00
IUUC-Ttr-128888	Tursiops truncatus	33.85	1.00e-103	370.00
IUUC-Uma-129361	Ustilago maydis	43.82	2.00e-62	233.00
IUUC-Xtr-132811	Xenopus tropicalis	29.73	5.00e-81	294.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence