iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mor-057246

Ensembl Protein ID

MGG_17449T0

UniProt Accession

A4RF51; G4NC15; PAN2_MAGO7

Genbank Protein ID

EHA49018.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

CM001235

Gene Name

PAN2; MGG_17449

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MGG_17449	MGG_17449T0	MGG_17449T0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.20e-14	50.7	504	860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..........gyeq 89
           Gl+N+    Y NS+LQ L ++p lr+l l++   ++       ++ +ll++l  l  ++ k +  + + +++lk+l++     +          +++ 
   Q: 504  GLENHITNSYANSLLQLLRFTPILRNLALQHAATSCL------DQHCLLCELGYLCDSMEKARGASCQATNMLKMLSQHPAAANlhlldgdriaSSSA 595
           9*****************************6666665......457*******************************999888888999999988889 PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp..gkeetkke 185
              q +l+flld ++++   +++  ++++e+++ +++++  + ++ k+++s  ++++   l  + +  + ++     ++ l  +  v   +    k++
   Q: 596  MKIQGLLRFLLDFMSRDY-GKTSPGINDLENATATSSQSLIRCDQCKSETSRPQTNYVQDLAYSPVTSNGNKGVDVADSYLAAQQGVArgRMAPAKLP 692
           999***************.4467777777777777788888888888888888888888888888888888888888888888888873322234455 PP
   S: 186  slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqk..srekinkkvefpleLdlsp.fcts.......peekqk 273
           s++++L++  ++e+++     +c++c+++q  + +  +k++P+vL  +    s++e++    +  + ++v f   +d ++ fc +        ++++ 
   Q: 693  SFSQILKKSIEREQVTR---GWCTTCRGYQPLSMRKIIKSIPQVLAANTCISSVEEKKLwaTPGWLPEEVGF--IIDKEHiFCYEgaeldwlIKNGKY 785
           ***************96...9*************************99888877776641134456666666..477777677777777777334444 PP
   S: 274  ekkkYeLiavvvHsG..slssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfYk 336
           + + Y+L++ vv      + + H va+++          k +W lf+D +V++++  e l+++   +t+ v++++
   Q: 786  KLYVYSLMGLVVNIEpgPTFKPHPVAIINAahsepqkpAKSQWHLFNDFHVKPISAREALTFNTswKTPLVVMFQ 860
           59*******8876644266689*******9777777766788****************99988777777777665 PP

Organism

Magnaporthe oryzae

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MDADWGEIAQ YHTQLGYRPD PTNPSAHHSA PTAVAFDTRS ELLWVGKDQG RVAAYVYFLN 60
NGIMEFQRHI AFLSHPRQQG PVHQFLFNET GVISLGSHNV HMAQRGGMCL ANIGHVNMTN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCAACAT TGATCCATCA ACAAGGCTCG AAACCACCAC CGCTACTATC ATTCCTCAGG 60
CGGGACTCTT TGCTCCAAGG CGGCACAAGG CCGCTGACCG CTCCCAGCAA GAAAAAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

mgr:MGG_17449

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	29.05	8.00e-126	443.00
IUUC-Apl-003500	Anas platyrhynchos	27.89	6.00e-108	384.00
IUUC-Aca-004930	Anolis carolinensis	28.78	8.00e-122	430.00
IUUC-Acl-008214	Aspergillus clavatus	43.01	0.00e+00	902.00
IUUC-Afu-009112	Aspergillus fumigatus	42.63	0.00e+00	881.00
IUUC-Ang-009531	Aspergillus niger	42.77	0.00e+00	863.00
IUUC-Ame-011259	Astyanax mexicanus	27.83	2.00e-115	409.00
IUUC-Bta-012371	Bos taurus	29.05	4.00e-125	441.00
IUUC-Bci-013684	Botrytis cinerea	44.97	0.00e+00	975.00
IUUC-Cja-019297	Callithrix jacchus	28.44	1.00e-121	429.00
IUUC-Cfa-020489	Canis familiaris	29.05	5.00e-124	437.00
IUUC-Cpo-022392	Cavia porcellus	29.16	2.00e-121	429.00
IUUC-Csa-023220	Chlorocebus sabaeus	28.89	4.00e-125	441.00
IUUC-Cho-024952	Choloepus hoffmanni	27.42	2.30e-02	33.10
IUUC-Csv-025841	Ciona savignyi	27.26	3.00e-89	322.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	50.49	0.00e+00	1139.00
IUUC-Cne-026932	Cryptococcus neoformans	30.85	7.00e-132	463.00
IUUC-Dre-028482	Danio rerio	38.30	2.00e-58	219.00
IUUC-Dno-029398	Dasypus novemcinctus	29.05	4.00e-122	431.00
IUUC-Dor-030307	Dipodomys ordii	30.52	1.00e-81	296.00
IUUC-Dme-032111	Drosophila melanogaster	26.56	1.00e-58	220.00
IUUC-Eca-033985	Equus caballus	28.95	1.00e-124	439.00
IUUC-Eeu-034928	Erinaceus europaeus	26.51	1.00e-24	107.00
IUUC-Fca-035587	Felis catus	28.99	3.00e-127	448.00
IUUC-Fal-037587	Ficedula albicollis	29.40	9.00e-125	439.00
IUUC-Fso-038133	Fusarium solani	49.19	4.00e-178	617.00
IUUC-Gmo-039076	Gadus morhua	25.54	1.00e-55	210.00
IUUC-Ggr-039957	Gaeumannomyces graminis	58.60	0.00e+00	1344.00
IUUC-Gga-040948	Gallus gallus	28.94	2.00e-121	428.00
IUUC-Gac-042396	Gasterosteus aculeatus	26.83	7.00e-60	224.00
IUUC-Ggo-045412	Gorilla gorilla	28.80	2.00e-124	438.00
IUUC-Hsa-046076	Homo sapiens	28.89	3.00e-125	441.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	27.88	2.00e-107	382.00
IUUC-Kpa-049178	Komagataella pastoris	31.66	3.00e-154	537.00
IUUC-Lch-050279	Latimeria chalumnae	38.51	2.00e-56	213.00
IUUC-Loc-052872	Lepisosteus oculatus	26.15	1.00e-61	230.00
IUUC-Lma-052986	Leptosphaeria maculans	44.49	0.00e+00	929.00
IUUC-Laf-054181	Loxodonta africana	38.29	1.00e-62	233.00
IUUC-Mcc-054812	Macaca mulatta	28.55	4.00e-122	431.00
IUUC-Meu-056325	Macropus eugenii	29.16	5.00e-121	427.00
IUUC-Mpo-057464	Magnaporthe poae	59.23	0.00e+00	1358.00
IUUC-Mla-058911	Melampsora laricipopulina	34.53	1.00e-99	356.00
IUUC-Mga-059335	Meleagris gallopavo	28.93	3.00e-122	431.00
IUUC-Mvi-060461	Microbotryum violaceum	32.71	2.00e-150	525.00
IUUC-Mmr-060636	Microcebus murinus	28.63	2.00e-122	432.00
IUUC-Mmu-063503	Mus musculus	29.23	4.00e-124	437.00
IUUC-Mpu-066670	Mustela putorius furo	28.97	1.00e-123	436.00
IUUC-Mlu-068119	Myotis lucifugus	29.14	2.00e-129	455.00
IUUC-Nfi-068398	Neosartorya fischeri	43.16	0.00e+00	905.00
IUUC-Ncr-068927	Neurospora crassa	44.95	0.00e+00	930.00
IUUC-Nle-069651	Nomascus leucogenys	28.40	5.00e-117	414.00
IUUC-Opr-070614	Ochotona princeps	28.63	3.00e-123	434.00
IUUC-Ont-072433	Oreochromis niloticus	28.90	4.00e-120	424.00
IUUC-Oan-073283	Ornithorhynchus anatinus	35.21	1.00e-53	203.00
IUUC-Ocu-074401	Oryctolagus cuniculus	26.94	2.00e-63	236.00
IUUC-Ola-087522	Oryzias latipes	28.55	1.00e-115	409.00
IUUC-Oga-088226	Otolemur garnettii	26.79	2.00e-65	243.00
IUUC-Oar-089241	Ovis aries	29.22	1.00e-128	452.00
IUUC-Pan-092297	Papio anubis	29.24	6.00e-120	423.00
IUUC-Psi-094043	Pelodiscus sinensis	28.24	3.00e-110	391.00
IUUC-Pma-094394	Petromyzon marinus	29.54	5.00e-119	421.00
IUUC-Pno-095053	Phaeosphaeria nodorum	43.73	0.00e+00	851.00
IUUC-Ppa-095188	Physcomitrella patens	37.60	3.00e-58	219.00
IUUC-Pfo-097517	Poecilia formosa	29.17	1.00e-122	432.00
IUUC-Pca-100471	Procavia capensis	29.54	6.00e-126	443.00
IUUC-Pva-102805	Pteropus vampyrus	27.87	2.00e-97	348.00
IUUC-Pte-104021	Pyrenophora teres	43.77	0.00e+00	920.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	43.64	0.00e+00	912.00
IUUC-Rno-105471	Rattus norvegicus	28.90	3.00e-124	437.00
IUUC-Sce-106235	Saccharomyces cerevisiae	27.52	5.00e-110	390.00
IUUC-Sha-106883	Sarcophilus harrisii	29.17	7.00e-117	413.00
IUUC-Spo-108169	Schizosaccharomyces pombe	34.61	4.00e-177	613.00
IUUC-Sar-113323	Sorex araneus	37.18	2.00e-59	223.00
IUUC-Sre-115075	Sporisorium reilianum	39.47	3.00e-54	206.00
IUUC-Ssc-116363	Sus scrofa	26.93	1.00e-63	236.00
IUUC-Tru-118427	Takifugu rubripes	29.10	1.00e-119	422.00
IUUC-Tni-120218	Tetraodon nigroviridis	29.27	3.00e-120	424.00
IUUC-Tre-122177	Trichoderma reesei	50.18	0.00e+00	1117.00
IUUC-Tme-127176	Tuber melanosporum	39.29	0.00e+00	733.00
IUUC-Tbe-127641	Tupaia belangeri	27.64	3.00e-19	89.40
IUUC-Ttr-128888	Tursiops truncatus	31.43	3.00e-92	332.00
IUUC-Uma-129361	Ustilago maydis	47.75	2.00e-53	203.00
IUUC-Xtr-132811	Xenopus tropicalis	25.44	1.00e-60	226.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence