iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068927

Ensembl Protein ID

EDO65208

UniProt Accession

P0C581; A7UWG8; Q7S6P3; PAN2_NEUCR

Genbank Protein ID

EDO65208.2

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit pan2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

CM002241

Gene Name

pan2; NCU04792; NCU10733

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU10733	EDO65208	EDO65208

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-17	61.2	495	836

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee.fs.........gyeqqDa 92
           Gl+N     Y NS+LQ+++ +p lr++ l++   ++ +      + +ll++l  +f  l+k++  +   +++l+al+++++  +s         ++    +
   Q: 495  GLENNITNSYANSLLQVMHYTPLLRNMALQHAATACLA------DPCLLCELGYVFDMLQKGEGPSCHATNMLRALNHTSNAsVSgvlediakdKNPSTLV 589
           999999999*********************66666654......46*************999999999999999999887774555555544434444446 PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......s 186
           + +++fl+d+++++ k   + p+++e            + +++    +l+++l++   + qikc +c++vs r+ + +  +l  p  +  + +       +
   Q: 590  KNLTMFLFDKISQDYKG--TPPISTE------LERTLFKLNQPPNPLDLVKRLLETDARYQIKCMHCQHVSPRTATTFVNKLCYPAAKP-NIRgmkaqriT 681
           78888899999998833..3333333......333457778889999************************888887777777664442.2223455555* PP
   S: 187  lqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls....p.fcts.....peekqke... 274
           ++++L++  ++e ++   k yc+kc+++q+  ++  + ++P vL l     + ++    r+  ++   +p+e+ +     + +c +           +   
   Q: 682  FSQVLKAGLENEAVN---KGYCTKCQRYQNLDQRKIIFNIPAVLALCTEITTAEH----RKLWSTPGWLPEEIGIIvdqgHvYCYEgddlkL-----Hlnr 770
           **************8...69**************************999884443....445566777776655544444335655433330.....1455 PP
   S: 275  ....kkkYeLia.vvvHsG.slssGHYvayvkn........ekgkWllfdDskVtevkeeevleet 326
                + Y+L++ vv+ +  s+++ H va v+         ++++W lf+D +V+ +++ e l+++
   Q: 771  gihnITVYSLVGtVVNVETkSPQKSHLVATVNVgraepeskDQDRWHLFNDFSVRGISKVEALTFN 836
           55559******955667889*************888877554555************998888765 PP

Organism

Neurospora crassa

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pabp-1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MDSRDWTQLG CVAYPSPIHP DYHAGPASTI AFDNQDELLW IGTQKGFAGS FIGRELKRFT 60
AFRIHPETDG PLRQFLFVDK GVIFLGSRSV YMAARSGVPI WSIRHESMQD LRAMSFTSKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGGAGTCG GACAAAGCAA TGGCTTCGCT CTTCTCCCAT TCACCAACTT TACGTATTCA 60
ACAATATTTC CAACCCAGTC TGCAGTTCTT AAACTGTGGG AACGGTATTT GCTTCCAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

ncr:NCU10733

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	29.74	3.00e-137	481.00
IUUC-Apl-003500	Anas platyrhynchos	28.32	1.00e-110	392.00
IUUC-Aca-004930	Anolis carolinensis	29.38	4.00e-133	467.00
IUUC-Acl-008214	Aspergillus clavatus	43.14	0.00e+00	932.00
IUUC-Afu-009112	Aspergillus fumigatus	43.33	0.00e+00	902.00
IUUC-Ang-009531	Aspergillus niger	42.81	0.00e+00	898.00
IUUC-Ame-011259	Astyanax mexicanus	28.89	5.00e-131	460.00
IUUC-Bta-012371	Bos taurus	29.87	7.00e-137	479.00
IUUC-Bci-013684	Botrytis cinerea	44.41	0.00e+00	985.00
IUUC-Cja-019297	Callithrix jacchus	29.50	5.00e-133	467.00
IUUC-Cfa-020489	Canis familiaris	30.04	3.00e-135	474.00
IUUC-Cpo-022392	Cavia porcellus	29.75	1.00e-136	479.00
IUUC-Csa-023220	Chlorocebus sabaeus	29.78	4.00e-136	477.00
IUUC-Csv-025841	Ciona savignyi	27.44	8.00e-98	350.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	53.71	0.00e+00	1193.00
IUUC-Cne-026932	Cryptococcus neoformans	31.96	1.00e-142	499.00
IUUC-Dre-028482	Danio rerio	28.35	3.00e-126	444.00
IUUC-Dno-029398	Dasypus novemcinctus	29.75	1.00e-134	472.00
IUUC-Dor-030307	Dipodomys ordii	30.35	8.00e-87	313.00
IUUC-Dme-032111	Drosophila melanogaster	28.13	4.00e-121	427.00
IUUC-Eca-033985	Equus caballus	29.78	1.00e-136	479.00
IUUC-Eeu-034928	Erinaceus europaeus	26.49	8.00e-27	114.00
IUUC-Fca-035587	Felis catus	29.70	1.00e-138	486.00
IUUC-Fal-037587	Ficedula albicollis	29.84	2.00e-133	468.00
IUUC-Fso-038133	Fusarium solani	52.84	0.00e+00	673.00
IUUC-Gmo-039076	Gadus morhua	27.50	7.00e-125	440.00
IUUC-Ggr-039957	Gaeumannomyces graminis	50.40	0.00e+00	1095.00
IUUC-Gga-040948	Gallus gallus	29.56	5.00e-133	467.00
IUUC-Gac-042396	Gasterosteus aculeatus	27.76	2.00e-122	432.00
IUUC-Ggo-045412	Gorilla gorilla	29.78	5.00e-136	477.00
IUUC-Hsa-046076	Homo sapiens	29.70	1.00e-135	475.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	28.72	7.00e-115	406.00
IUUC-Kpa-049178	Komagataella pastoris	30.72	1.00e-147	515.00
IUUC-Lch-050279	Latimeria chalumnae	27.35	9.00e-106	376.00
IUUC-Loc-052872	Lepisosteus oculatus	40.52	1.00e-67	249.00
IUUC-Lma-052986	Leptosphaeria maculans	45.12	0.00e+00	990.00
IUUC-Laf-054181	Loxodonta africana	29.90	1.00e-132	465.00
IUUC-Mcc-054812	Macaca mulatta	29.87	7.00e-136	476.00
IUUC-Meu-056325	Macropus eugenii	29.94	2.00e-136	478.00
IUUC-Mor-057246	Magnaporthe oryzae	44.88	0.00e+00	946.00
IUUC-Mpo-057464	Magnaporthe poae	50.90	0.00e+00	1105.00
IUUC-Mla-058911	Melampsora laricipopulina	36.51	4.00e-108	384.00
IUUC-Mga-059335	Meleagris gallopavo	29.59	4.00e-127	447.00
IUUC-Mvi-060461	Microbotryum violaceum	31.98	7.00e-144	503.00
IUUC-Mmr-060636	Microcebus murinus	29.87	1.00e-134	472.00
IUUC-Mmu-063503	Mus musculus	29.97	2.00e-137	481.00
IUUC-Mpu-066670	Mustela putorius furo	29.78	5.00e-137	480.00
IUUC-Mlu-068119	Myotis lucifugus	29.54	3.00e-141	494.00
IUUC-Nfi-068398	Neosartorya fischeri	43.22	0.00e+00	925.00
IUUC-Nle-069651	Nomascus leucogenys	28.57	8.00e-128	449.00
IUUC-Opr-070614	Ochotona princeps	29.83	3.00e-134	471.00
IUUC-Ont-072433	Oreochromis niloticus	28.07	5.00e-126	444.00
IUUC-Oan-073283	Ornithorhynchus anatinus	40.00	3.00e-65	241.00
IUUC-Ocu-074401	Oryctolagus cuniculus	29.12	1.00e-126	446.00
IUUC-Ola-087522	Oryzias latipes	27.47	6.00e-125	440.00
IUUC-Oga-088226	Otolemur garnettii	29.86	3.00e-137	481.00
IUUC-Oar-089241	Ovis aries	29.70	9.00e-139	486.00
IUUC-Pan-092297	Papio anubis	29.76	1.00e-123	436.00
IUUC-Psi-094043	Pelodiscus sinensis	40.36	5.00e-62	231.00
IUUC-Pma-094394	Petromyzon marinus	28.71	1.00e-117	416.00
IUUC-Pno-095053	Phaeosphaeria nodorum	46.92	0.00e+00	912.00
IUUC-Ppa-095188	Physcomitrella patens	39.20	5.00e-59	221.00
IUUC-Pfo-097517	Poecilia formosa	28.27	8.00e-131	459.00
IUUC-Pca-100471	Procavia capensis	29.42	8.00e-134	469.00
IUUC-Pva-102805	Pteropus vampyrus	31.19	5.00e-88	317.00
IUUC-Pte-104021	Pyrenophora teres	46.53	0.00e+00	993.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	46.53	0.00e+00	987.00
IUUC-Rno-105471	Rattus norvegicus	30.17	1.00e-139	489.00
IUUC-Sce-106235	Saccharomyces cerevisiae	29.36	5.00e-111	394.00
IUUC-Sha-106883	Sarcophilus harrisii	29.72	6.00e-129	453.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.76	1.00e-168	585.00
IUUC-Sar-113323	Sorex araneus	30.19	6.00e-106	377.00
IUUC-Sre-115075	Sporisorium reilianum	42.35	6.00e-63	234.00
IUUC-Ssc-116363	Sus scrofa	29.32	1.00e-129	456.00
IUUC-Tru-118427	Takifugu rubripes	39.88	5.00e-70	258.00
IUUC-Tni-120218	Tetraodon nigroviridis	40.11	3.00e-71	262.00
IUUC-Tre-122177	Trichoderma reesei	50.93	0.00e+00	1117.00
IUUC-Tme-127176	Tuber melanosporum	39.46	0.00e+00	739.00
IUUC-Tbe-127641	Tupaia belangeri	24.08	3.00e-24	105.00
IUUC-Ttr-128888	Tursiops truncatus	32.36	3.00e-98	351.00
IUUC-Uma-129361	Ustilago maydis	42.35	2.00e-63	236.00
IUUC-Xtr-132811	Xenopus tropicalis	40.95	4.00e-70	258.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence