iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087522

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

BAAF04011099

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000015195.1	ENSORLT00000019040.1	ENSORLP00000019039.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.80e-21	75.3	532	930

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+ +  + +++l+a++++ e    g    D+ E +
   Q: 532  NAYCNCMIQVLYFLEPIRCLVQN---HLCQK------EFCLACELGFLFHMLDLSRGNPCQASNFLRAFRTIPEASAlGLILSDSDEQT 611
           56*********************...55654......57*******************************9999855666666666655 PP
   S: 97   a.flldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
               l +l ++ ++    + +++++e+e+ +  +    ++++  ++ +s+i +lF+ +++++  c +c+++++r +  l ++++ p+++
   Q: 612  GkAKLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGASSSSLGSSVESVIGKLFGCEVENSSLC-RCAKETVRSSLTLLFTMHYPEQN 697
           3134566666665544323333333333333..45555788999*********************.8******************9777 PP
   S: 181  etkke....slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           +++k     ++ ++L++    e+     + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k++ ++ f++ ++ +   
   Q: 698  SQEKVikehDFAEILKKSICLEQS---TQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSAKEA--EFWKVQAEYAFNKAMQKEAKD 781
           665444444777777766665555...569*****************************9976665..445899999999888888655 PP
   S: 266  ts..................................................................peekqke.....kkkYeLiav 283
           ts                                                                        +        Y+L+  
   Q: 782  TSkldeapppmpsewcldgeelcsmegltidtraedlrhvwipltlkmsisksqgleisscsegdelsA-----TeeeegASLYDLVVT 865
           555677777777777777777777777777777777777777777777777777777666666666662.....0444449******** PP
   S: 284  vvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlf 334
           v H   +  +G  va++k            ++++W+lf+D  +++++++ev ++    + + +l+
   Q: 866  VPHIQdGRTGGNLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKTEVAQFDVswKVPAILY 930
           *******************999988877777888*****************99765554555555 PP

Organism

Oryzias latipes

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

LFPSMNFEGL DAGMGEFPPN LHGTLDAGLE PSMDPHLNPS LLQGVELEAE GLTMTVPEPV 60
HMMEGIFSEL HSVVSEVGIP VTATHFDNQE EMLWMGNHRG HVTSFFGPTM GRYSSFQVHA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGCATGGA CACCTATGCG CCAAAACATT CCAACAAAAG GTTAGAAAAT ACTTTAAACA 60
CGAATTTTTA ATGAGTCCAT TTTTAAAGAT ATGACAAAAT CTGCTTAGCG TTGTGTGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	75.12	0.00e+00	1791.00
IUUC-Apl-003500	Anas platyrhynchos	76.90	0.00e+00	1673.00
IUUC-Aca-004930	Anolis carolinensis	75.25	0.00e+00	1805.00
IUUC-Acl-008214	Aspergillus clavatus	31.50	7.00e-156	545.00
IUUC-Afu-009112	Aspergillus fumigatus	30.71	1.00e-144	507.00
IUUC-Ang-009531	Aspergillus niger	30.76	1.00e-144	507.00
IUUC-Ame-011259	Astyanax mexicanus	86.53	0.00e+00	2054.00
IUUC-Bta-012371	Bos taurus	75.04	0.00e+00	1778.00
IUUC-Bci-013684	Botrytis cinerea	30.21	9.00e-134	471.00
IUUC-Cja-019297	Callithrix jacchus	72.87	0.00e+00	1734.00
IUUC-Cfa-020489	Canis familiaris	74.96	0.00e+00	1776.00
IUUC-Cpo-022392	Cavia porcellus	74.96	0.00e+00	1805.00
IUUC-Csa-023220	Chlorocebus sabaeus	74.38	0.00e+00	1777.00
IUUC-Csv-025841	Ciona savignyi	46.65	1.00e-128	454.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	28.16	2.00e-84	307.00
IUUC-Cne-026932	Cryptococcus neoformans	44.09	5.00e-73	269.00
IUUC-Dre-028482	Danio rerio	84.89	0.00e+00	2043.00
IUUC-Dno-029398	Dasypus novemcinctus	74.92	0.00e+00	1781.00
IUUC-Dor-030307	Dipodomys ordii	70.10	0.00e+00	1011.00
IUUC-Dme-032111	Drosophila melanogaster	40.42	0.00e+00	875.00
IUUC-Eca-033985	Equus caballus	75.12	0.00e+00	1781.00
IUUC-Eeu-034928	Erinaceus europaeus	77.56	2.00e-171	597.00
IUUC-Fca-035587	Felis catus	75.04	0.00e+00	1800.00
IUUC-Fal-037587	Ficedula albicollis	76.57	0.00e+00	1791.00
IUUC-Fso-038133	Fusarium solani	32.16	3.00e-95	343.00
IUUC-Gmo-039076	Gadus morhua	85.41	0.00e+00	2040.00
IUUC-Ggr-039957	Gaeumannomyces graminis	31.48	6.00e-138	485.00
IUUC-Gga-040948	Gallus gallus	76.79	0.00e+00	1823.00
IUUC-Gac-042396	Gasterosteus aculeatus	89.79	0.00e+00	2131.00
IUUC-Ggo-045412	Gorilla gorilla	74.55	0.00e+00	1779.00
IUUC-Hsa-046076	Homo sapiens	74.55	0.00e+00	1779.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	69.68	0.00e+00	1589.00
IUUC-Kpa-049178	Komagataella pastoris	41.07	4.00e-66	246.00
IUUC-Lch-050279	Latimeria chalumnae	74.91	0.00e+00	845.00
IUUC-Loc-052872	Lepisosteus oculatus	84.31	0.00e+00	1991.00
IUUC-Lma-052986	Leptosphaeria maculans	32.31	3.00e-158	552.00
IUUC-Laf-054181	Loxodonta africana	72.55	0.00e+00	1741.00
IUUC-Mcc-054812	Macaca mulatta	74.47	0.00e+00	1769.00
IUUC-Meu-056325	Macropus eugenii	76.01	0.00e+00	1811.00
IUUC-Mor-057246	Magnaporthe oryzae	28.95	1.00e-114	407.00
IUUC-Mpo-057464	Magnaporthe poae	30.86	1.00e-136	481.00
IUUC-Mla-058911	Melampsora laricipopulina	32.37	5.00e-105	375.00
IUUC-Mga-059335	Meleagris gallopavo	77.23	0.00e+00	1776.00
IUUC-Mvi-060461	Microbotryum violaceum	33.18	1.00e-136	481.00
IUUC-Mmr-060636	Microcebus murinus	74.63	0.00e+00	1773.00
IUUC-Mmu-063503	Mus musculus	73.96	0.00e+00	1767.00
IUUC-Mpu-066670	Mustela putorius furo	75.21	0.00e+00	1785.00
IUUC-Mlu-068119	Myotis lucifugus	74.79	0.00e+00	1838.00
IUUC-Nfi-068398	Neosartorya fischeri	31.30	5.00e-154	538.00
IUUC-Ncr-068927	Neurospora crassa	27.41	2.00e-120	427.00
IUUC-Nle-069651	Nomascus leucogenys	71.70	0.00e+00	1694.00
IUUC-Opr-070614	Ochotona princeps	74.45	0.00e+00	1755.00
IUUC-Ont-072433	Oreochromis niloticus	89.64	0.00e+00	2169.00
IUUC-Oan-073283	Ornithorhynchus anatinus	67.50	0.00e+00	1261.00
IUUC-Ocu-074401	Oryctolagus cuniculus	74.06	0.00e+00	1769.00
IUUC-Olu-087831	Ostreococcus lucimarinus	37.21	1.30e+00	29.60
IUUC-Oga-088226	Otolemur garnettii	73.62	0.00e+00	1781.00
IUUC-Oar-089241	Ovis aries	74.88	0.00e+00	1804.00
IUUC-Pan-092297	Papio anubis	76.35	0.00e+00	1613.00
IUUC-Psi-094043	Pelodiscus sinensis	73.38	0.00e+00	1688.00
IUUC-Pma-094394	Petromyzon marinus	66.94	0.00e+00	1500.00
IUUC-Pno-095053	Phaeosphaeria nodorum	32.55	6.00e-143	501.00
IUUC-Ppa-095188	Physcomitrella patens	31.49	9.00e-160	557.00
IUUC-Pfo-097517	Poecilia formosa	91.82	0.00e+00	2233.00
IUUC-Pca-100471	Procavia capensis	76.28	0.00e+00	1708.00
IUUC-Pva-102805	Pteropus vampyrus	72.92	0.00e+00	1402.00
IUUC-Pte-104021	Pyrenophora teres	31.93	7.00e-160	558.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.60	8.00e-158	551.00
IUUC-Rno-105471	Rattus norvegicus	74.59	0.00e+00	1781.00
IUUC-Sce-106235	Saccharomyces cerevisiae	36.59	9.00e-61	228.00
IUUC-Sha-106883	Sarcophilus harrisii	76.24	0.00e+00	1691.00
IUUC-Spo-108169	Schizosaccharomyces pombe	35.39	5.00e-111	395.00
IUUC-Sar-113323	Sorex araneus	75.53	0.00e+00	1325.00
IUUC-Sre-115075	Sporisorium reilianum	47.75	2.00e-58	221.00
IUUC-Ssc-116363	Sus scrofa	74.06	0.00e+00	1786.00
IUUC-Tru-118427	Takifugu rubripes	89.98	0.00e+00	2201.00
IUUC-Tni-120218	Tetraodon nigroviridis	90.50	0.00e+00	2189.00
IUUC-Tre-122177	Trichoderma reesei	30.88	7.00e-153	535.00
IUUC-Tme-127176	Tuber melanosporum	31.59	5.00e-132	465.00
IUUC-Tbe-127641	Tupaia belangeri	66.73	8.00e-170	591.00
IUUC-Ttr-128888	Tursiops truncatus	74.31	0.00e+00	1125.00
IUUC-Uma-129361	Ustilago maydis	50.45	2.00e-61	231.00
IUUC-Xtr-132811	Xenopus tropicalis	72.73	0.00e+00	1711.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence