iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pyt-104682

Ensembl Protein ID

EDU41087

UniProt Accession

B2VWT7; B2VWT7_PYRTR

Genbank Protein ID

EDU41087.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

DS231615

Gene Name

PAN2; PTRG_01649

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PTRG_01649	EDU41087	EDU41087

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-11	42.7	491	816

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..........gyeqqDa 92
           Gl+ +    Y N +LQ   ++p +r+l l+++ + +  e       +ll++l  l+  l k    + + +++lk+++ +++ +s                 
   Q: 491  GLETHITNSYANPLLQLFRFTPLIRNLALQHTASPCLFE------SCLLCELGFLIDMLEKAAGLNCQASNFLKTFSGLSNAVSlnlleefapnVALTSMI 585
           677777778*********************777777665......69999999999999999999999999999999999887755554444433333344 PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.....slq 188
           q + +flld+++ee+                      ++  +   ++s ++++++ q + +++c +c+n++ r  +++  +l  p k+ +k++     +++
   Q: 586  QNLNRFLLDKVSEEF----------------------RQMLPGHTGPSAMDQVLETQARASMRCAQCNNETIRGGKNFVNELVYPAKHVMKNTriprpTFS 664
           566666666666666......................445688999*******************************999999999998877788888999 PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq..ksrekinkkvefpleLdlsp.fcts.......peekqkekkkYe 279
           ++L++ ++++  +   + +c+kc+++q+++++ +++++P vL+l+    s + +   ++++ + ++v   + +d  + fc +        ++++++   Ye
   Q: 665  QILKASVERQDQT---RGWCTKCNRYQQMVQRKTIQSVPGVLMLNAAIQSHEAKLlwSMPNWLPQEVG--IIVDQGQfFCFEgqdlklhLQRGVHQIMVYE 760
           9998777776655...37**************************987774444331133333334443..334444533333222222223344449**** PP
   S: 280  Liavv..vHsGslssGHYvayvkn........ekgkWllfdDskVtevkeeevlee 325
           L+++v  + sG++++ H va ++          +++W lf+D  V+++++ee l++
   Q: 761  LVGIVadINSGEHQKPHLVATINTgpssreedAEDRWHLFNDFLVRPIPKEEALRF 816
           *****555789*************888877655666*************9999876 PP

Organism

Pyrenophora triticirepentis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEADWDELAI VHLPPPGPHL PAVPISTFAF DTTQELLWTG NNHGRVTSLY GPHLERYTAF 60
RGHAPPDGPV KQFLFTEKGI ISISKQSVHY SHRRGLTQWH LTNPDFKDLK CMNFTSKGTR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCCG ACTGGGATGA GGTATAGCTA GCTTTTCTCT ATACTTAGCC TGCAATCATT 60
ATCGCAGCCC TCAACACTAC AAGCGCATAG CGACTGACTG TTGCATAGCT AGCCATCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.76	5.00e-158	550.00
IUUC-Apl-003500	Anas platyrhynchos	31.22	8.00e-90	323.00
IUUC-Aca-004930	Anolis carolinensis	30.73	3.00e-96	345.00
IUUC-Acl-008214	Aspergillus clavatus	52.88	0.00e+00	1209.00
IUUC-Afu-009112	Aspergillus fumigatus	52.79	0.00e+00	1179.00
IUUC-Ang-009531	Aspergillus niger	52.01	0.00e+00	1166.00
IUUC-Ame-011259	Astyanax mexicanus	29.46	6.00e-88	317.00
IUUC-Bta-012371	Bos taurus	32.11	4.00e-159	553.00
IUUC-Bci-013684	Botrytis cinerea	48.17	0.00e+00	1058.00
IUUC-Cja-019297	Callithrix jacchus	31.54	1.00e-153	535.00
IUUC-Cfa-020489	Canis familiaris	31.76	6.00e-157	546.00
IUUC-Cpo-022392	Cavia porcellus	31.74	2.00e-157	548.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.94	1.00e-156	545.00
IUUC-Csv-025841	Ciona savignyi	27.59	3.00e-63	235.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	53.41	0.00e+00	1199.00
IUUC-Cne-026932	Cryptococcus neoformans	34.14	2.00e-163	568.00
IUUC-Dre-028482	Danio rerio	28.45	1.00e-83	303.00
IUUC-Dno-029398	Dasypus novemcinctus	30.77	3.00e-91	328.00
IUUC-Dor-030307	Dipodomys ordii	31.94	2.00e-93	335.00
IUUC-Dme-032111	Drosophila melanogaster	27.98	8.00e-79	287.00
IUUC-Eca-033985	Equus caballus	31.85	4.00e-158	550.00
IUUC-Eeu-034928	Erinaceus europaeus	30.60	4.00e-41	162.00
IUUC-Fca-035587	Felis catus	32.20	2.00e-161	561.00
IUUC-Fal-037587	Ficedula albicollis	32.44	2.00e-157	548.00
IUUC-Fso-038133	Fusarium solani	47.33	0.00e+00	1008.00
IUUC-Gmo-039076	Gadus morhua	28.63	1.00e-84	306.00
IUUC-Ggr-039957	Gaeumannomyces graminis	47.24	0.00e+00	1026.00
IUUC-Gga-040948	Gallus gallus	32.09	4.00e-157	547.00
IUUC-Gac-042396	Gasterosteus aculeatus	30.10	4.00e-89	321.00
IUUC-Ggo-045412	Gorilla gorilla	31.68	7.00e-156	543.00
IUUC-Hsa-046076	Homo sapiens	31.68	1.00e-155	542.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.90	6.00e-86	310.00
IUUC-Kpa-049178	Komagataella pastoris	33.93	2.00e-177	614.00
IUUC-Lch-050279	Latimeria chalumnae	40.22	2.00e-67	249.00
IUUC-Loc-052872	Lepisosteus oculatus	30.66	1.00e-89	323.00
IUUC-Lma-052986	Leptosphaeria maculans	88.52	0.00e+00	2078.00
IUUC-Laf-054181	Loxodonta africana	30.53	1.00e-86	313.00
IUUC-Mcc-054812	Macaca mulatta	31.79	6.00e-157	546.00
IUUC-Meu-056325	Macropus eugenii	30.53	1.00e-89	323.00
IUUC-Mor-057246	Magnaporthe oryzae	43.73	0.00e+00	886.00
IUUC-Mpo-057464	Magnaporthe poae	48.42	0.00e+00	1053.00
IUUC-Mla-058911	Melampsora laricipopulina	39.73	6.00e-121	427.00
IUUC-Mga-059335	Meleagris gallopavo	32.30	4.00e-155	540.00
IUUC-Mvi-060461	Microbotryum violaceum	34.78	2.00e-170	592.00
IUUC-Mmr-060636	Microcebus murinus	31.94	8.00e-155	539.00
IUUC-Mmu-063503	Mus musculus	30.73	6.00e-94	337.00
IUUC-Mpu-066670	Mustela putorius furo	31.94	1.00e-158	552.00
IUUC-Mlu-068119	Myotis lucifugus	31.88	5.00e-161	560.00
IUUC-Nfi-068398	Neosartorya fischeri	53.34	0.00e+00	1207.00
IUUC-Ncr-068927	Neurospora crassa	46.10	0.00e+00	958.00
IUUC-Nle-069651	Nomascus leucogenys	30.99	5.00e-147	513.00
IUUC-Opr-070614	Ochotona princeps	31.85	1.00e-154	539.00
IUUC-Ont-072433	Oreochromis niloticus	31.95	1.00e-156	546.00
IUUC-Oan-073283	Ornithorhynchus anatinus	38.53	2.00e-59	222.00
IUUC-Ocu-074401	Oryctolagus cuniculus	30.66	9.00e-92	330.00
IUUC-Ola-087522	Oryzias latipes	31.24	2.00e-155	541.00
IUUC-Oga-088226	Otolemur garnettii	30.58	8.00e-93	333.00
IUUC-Oar-089241	Ovis aries	32.11	3.00e-159	554.00
IUUC-Pan-092297	Papio anubis	32.04	3.00e-145	507.00
IUUC-Psi-094043	Pelodiscus sinensis	30.34	1.00e-88	319.00
IUUC-Pma-094394	Petromyzon marinus	31.95	3.00e-144	504.00
IUUC-Pno-095053	Phaeosphaeria nodorum	89.14	0.00e+00	1909.00
IUUC-Ppa-095188	Physcomitrella patens	27.85	8.00e-116	410.00
IUUC-Pfo-097517	Poecilia formosa	31.89	4.00e-157	547.00
IUUC-Pca-100471	Procavia capensis	31.97	2.00e-154	538.00
IUUC-Pva-102805	Pteropus vampyrus	32.43	5.00e-92	330.00
IUUC-Pte-104021	Pyrenophora teres	99.03	0.00e+00	2291.00
IUUC-Rno-105471	Rattus norvegicus	31.79	1.00e-161	562.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.15	2.00e-144	504.00
IUUC-Sha-106883	Sarcophilus harrisii	30.24	9.00e-83	300.00
IUUC-Spo-108169	Schizosaccharomyces pombe	38.35	0.00e+00	697.00
IUUC-Sar-113323	Sorex araneus	33.08	3.00e-124	438.00
IUUC-Sre-115075	Sporisorium reilianum	42.03	4.00e-61	228.00
IUUC-Ssc-116363	Sus scrofa	30.58	2.00e-92	332.00
IUUC-Tru-118427	Takifugu rubripes	30.49	2.00e-93	336.00
IUUC-Tni-120218	Tetraodon nigroviridis	30.63	6.00e-94	337.00
IUUC-Tre-122177	Trichoderma reesei	52.73	0.00e+00	1167.00
IUUC-Tme-127176	Tuber melanosporum	46.69	0.00e+00	915.00
IUUC-Tbe-127641	Tupaia belangeri	33.47	4.00e-29	122.00
IUUC-Ttr-128888	Tursiops truncatus	33.29	5.00e-104	370.00
IUUC-Uma-129361	Ustilago maydis	43.19	3.00e-63	235.00
IUUC-Xtr-132811	Xenopus tropicalis	29.71	1.00e-82	300.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence