iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132811

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AAMC01034914

Gene Name

pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000009434.3	ENSXETT00000062606.1	ENSXETP00000059847.1
ENSXETG00000009434.3	ENSXETT00000020788.2	ENSXETP00000020788.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-20	73.0	520	928

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+++ ++ +r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 520  NAYCNCMIQVMYLLEAVRCLVQN---HLCQK------EFCLSCELGFLFHMLDLSRGDPCQASNFLRAFRTIPEAAAlGLILADSDEAT 599
           56*********************...55654......57*********************************99965577888888877 PP
   S: 97   afl.ldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
             + l +l ++  +    + +++++e+ e  +  +s  ++++  +++ s+i +lF+ ++++  +c +c+++++r ++ l ++l+ p+ +
   Q: 600  GKInLGRLIQSWCRflltQLHQETQEL-EGPQAYRSVGSSSSFASSGGSVIGQLFGCEVENCSMC-RCGKETVRVSTTLLFTLSYPETN 686
           554355555555455663344444444.555577888899999******************9999.8*******************999 PP
   S: 181  etkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldls..pfct 266
           +++  +  +  e   +   le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+   r + +  ++  l+  dl+  + +t
   Q: 687  SNA--QDFEFVEVLRRSICLEQSTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSTKEADFWRAQAEHAFKKALRkADLNfpSANT 773
           653..33455666677777888889******************************9988888887777776666555555555213333 PP
   S: 267  s............peekqke...............................................................kkkYeL 280
           +            +                                                                     ++ Y+L
   Q: 774  NeknigdwddlnnT-----GvppptfipsveelrnvwvpcslkmklsktkglevlncmeneeyvtvspassnwhvcyddkdesTNVYDL 857
           34555555555550.....05555555555555555555555555555555555666666666666666666666666666669***** PP
   S: 281  iavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfYkr 337
           +a vvH      +G  va++k            ++++W+lf+D  +++v++ e +++    + + +lfY++
   Q: 858  MATVVHILdPRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPVDKCEAVQFDMtwKVPAILFYTK 928
           ********788899********999988877777888************9988887766788899999987 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFDGLDPAL AEYAPSLHPP LDPVLDAHLN PSLLQTVELD HEALEGLPVA DPVSMMEGMY 60
SELQTAVSEV GVPVSAVHFD LHEEMLWVGN HGGHATSFFG HDLERYSSFQ VHGSNDIRQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGAGTTGT GCTGTGTGCT TTAGGCGGGC AGAAAGGAAG GTGTGTATGC TATGCGATTA 60
TTATTTGTAT ATGTATGGCT CTTTGCACTG TGATGTTACA CACAGGCACT ACAATACCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	78.84	0.00e+00	1876.00
IUUC-Apl-003500	Anas platyrhynchos	80.84	0.00e+00	1785.00
IUUC-Aca-004930	Anolis carolinensis	82.20	0.00e+00	1954.00
IUUC-Acl-008214	Aspergillus clavatus	30.21	1.00e-81	298.00
IUUC-Afu-009112	Aspergillus fumigatus	28.85	5.00e-72	266.00
IUUC-Ang-009531	Aspergillus niger	30.47	2.00e-141	496.00
IUUC-Ame-011259	Astyanax mexicanus	75.19	0.00e+00	1818.00
IUUC-Bta-012371	Bos taurus	79.62	0.00e+00	1883.00
IUUC-Bci-013684	Botrytis cinerea	46.82	1.00e-69	258.00
IUUC-Cja-019297	Callithrix jacchus	76.88	0.00e+00	1834.00
IUUC-Cfa-020489	Canis familiaris	78.79	0.00e+00	1863.00
IUUC-Cpo-022392	Cavia porcellus	78.26	0.00e+00	1878.00
IUUC-Csa-023220	Chlorocebus sabaeus	79.00	0.00e+00	1880.00
IUUC-Csv-025841	Ciona savignyi	44.95	0.00e+00	889.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	28.36	9.00e-85	308.00
IUUC-Cne-026932	Cryptococcus neoformans	43.82	1.00e-72	268.00
IUUC-Dre-028482	Danio rerio	73.40	0.00e+00	1766.00
IUUC-Dno-029398	Dasypus novemcinctus	79.28	0.00e+00	1879.00
IUUC-Dor-030307	Dipodomys ordii	73.17	0.00e+00	1039.00
IUUC-Dme-032111	Drosophila melanogaster	41.16	0.00e+00	879.00
IUUC-Eca-033985	Equus caballus	79.53	0.00e+00	1882.00
IUUC-Eeu-034928	Erinaceus europaeus	79.45	0.00e+00	631.00
IUUC-Fca-035587	Felis catus	79.09	0.00e+00	1896.00
IUUC-Fal-037587	Ficedula albicollis	81.05	0.00e+00	1921.00
IUUC-Fso-038133	Fusarium solani	41.37	7.00e-76	278.00
IUUC-Gmo-039076	Gadus morhua	72.90	0.00e+00	1731.00
IUUC-Ggr-039957	Gaeumannomyces graminis	31.12	2.00e-135	476.00
IUUC-Gga-040948	Gallus gallus	82.36	0.00e+00	1939.00
IUUC-Gac-042396	Gasterosteus aculeatus	73.50	0.00e+00	1798.00
IUUC-Ggo-045412	Gorilla gorilla	78.92	0.00e+00	1878.00
IUUC-Hsa-046076	Homo sapiens	79.00	0.00e+00	1881.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	73.65	0.00e+00	1710.00
IUUC-Kpa-049178	Komagataella pastoris	39.29	2.00e-65	244.00
IUUC-Lch-050279	Latimeria chalumnae	72.74	0.00e+00	874.00
IUUC-Loc-052872	Lepisosteus oculatus	75.64	0.00e+00	1798.00
IUUC-Lma-052986	Leptosphaeria maculans	30.00	4.00e-87	316.00
IUUC-Laf-054181	Loxodonta africana	77.20	0.00e+00	1857.00
IUUC-Mcc-054812	Macaca mulatta	79.20	0.00e+00	1877.00
IUUC-Meu-056325	Macropus eugenii	80.23	0.00e+00	1903.00
IUUC-Mor-057246	Magnaporthe oryzae	28.07	1.00e-109	391.00
IUUC-Mpo-057464	Magnaporthe poae	31.35	9.00e-141	494.00
IUUC-Mla-058911	Melampsora laricipopulina	41.07	2.00e-69	258.00
IUUC-Mga-059335	Meleagris gallopavo	81.66	0.00e+00	1896.00
IUUC-Mvi-060461	Microbotryum violaceum	31.41	4.00e-141	496.00
IUUC-Mmr-060636	Microcebus murinus	79.20	0.00e+00	1876.00
IUUC-Mmu-063503	Mus musculus	78.12	0.00e+00	1882.00
IUUC-Mpu-066670	Mustela putorius furo	79.20	0.00e+00	1879.00
IUUC-Mlu-068119	Myotis lucifugus	79.20	0.00e+00	1937.00
IUUC-Nfi-068398	Neosartorya fischeri	30.03	4.00e-82	299.00
IUUC-Ncr-068927	Neurospora crassa	40.95	5.00e-72	266.00
IUUC-Nle-069651	Nomascus leucogenys	75.37	0.00e+00	1796.00
IUUC-Opr-070614	Ochotona princeps	78.21	0.00e+00	1848.00
IUUC-Ont-072433	Oreochromis niloticus	74.34	0.00e+00	1825.00
IUUC-Oan-073283	Ornithorhynchus anatinus	70.19	0.00e+00	1336.00
IUUC-Ocu-074401	Oryctolagus cuniculus	78.92	0.00e+00	1889.00
IUUC-Ola-087522	Oryzias latipes	72.82	0.00e+00	1751.00
IUUC-Oga-088226	Otolemur garnettii	78.65	0.00e+00	1895.00
IUUC-Oar-089241	Ovis aries	79.09	0.00e+00	1905.00
IUUC-Pan-092297	Papio anubis	79.30	0.00e+00	1684.00
IUUC-Psi-094043	Pelodiscus sinensis	79.03	0.00e+00	1847.00
IUUC-Pma-094394	Petromyzon marinus	67.51	0.00e+00	1543.00
IUUC-Pno-095053	Phaeosphaeria nodorum	29.26	1.00e-73	271.00
IUUC-Ppa-095188	Physcomitrella patens	31.39	2.00e-163	569.00
IUUC-Pfo-097517	Poecilia formosa	73.86	0.00e+00	1810.00
IUUC-Pca-100471	Procavia capensis	78.32	0.00e+00	1772.00
IUUC-Pva-102805	Pteropus vampyrus	74.35	0.00e+00	1456.00
IUUC-Pte-104021	Pyrenophora teres	30.17	3.00e-88	320.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	29.88	3.00e-87	316.00
IUUC-Rno-105471	Rattus norvegicus	78.05	0.00e+00	1863.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.99	3.00e-61	230.00
IUUC-Sha-106883	Sarcophilus harrisii	80.14	0.00e+00	1767.00
IUUC-Spo-108169	Schizosaccharomyces pombe	30.96	3.00e-140	493.00
IUUC-Sar-113323	Sorex araneus	78.10	0.00e+00	1375.00
IUUC-Sre-115075	Sporisorium reilianum	39.65	1.00e-63	238.00
IUUC-Ssc-116363	Sus scrofa	78.79	0.00e+00	1901.00
IUUC-Tru-118427	Takifugu rubripes	74.17	0.00e+00	1847.00
IUUC-Tni-120218	Tetraodon nigroviridis	73.71	0.00e+00	1852.00
IUUC-Tre-122177	Trichoderma reesei	27.88	4.00e-76	280.00
IUUC-Tme-127176	Tuber melanosporum	31.22	4.00e-139	488.00
IUUC-Tbe-127641	Tupaia belangeri	69.98	0.00e+00	643.00
IUUC-Ttr-128888	Tursiops truncatus	78.19	0.00e+00	1158.00
IUUC-Uma-129361	Ustilago maydis	39.30	2.00e-64	241.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence