iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012472

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 J2; E2 ubiquitin-conjugating enzyme J2

Genbank Nucleotide ID

BC111185

Gene Name

UBE2J2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015882.4	ENSBTAT00000021109.4	ENSBTAP00000021109.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.20e-28	98.9	16	125

Active Site

Position(s)	Description	Evidence
94	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk..ifhPnvyenGkvClsilk 87
           Rlk+++ +++kdp+++i a+p  + ++ ew++++ Gpe tpYegg+++ ++ fp+++PfkPP++ ++t+  +f++    n+++Clsi +
   Q: 16   RLKQDYLRIKKDPVPYICAEPLPS-NILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPngRFKC----NTRLCLSITD 99
           99**********************.9*******************************************555555....59*******8 PP
   S: 88   .eeekWspalsvesvllsiqsllaep 112
            ++++W+pa+sv+++l+++ s++ e 
   Q: 100  fHPDTWNPAWSVSTILTGLLSFMVEK 125
           89********************9764 PP

Organism

Bos taurus

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Protein Sequence
(Fasta)

MSSNSVKRAP TTATQRLKQD YLRIKKDPVP YICAEPLPSN ILEWHYVVRG PEMTPYEGGY 60
YHGKLIFPRE FPFKPPSIYM ITPNGRFKCN TRLCLSITDF HPDTWNPAWS VSTILTGLLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTTCTTCA AGGACACAGG TGAGTCTGCA GGGTCTCTCT TAACCTTTGT ATCTGAGGAA 60
AGTCACATTG GCGAAGGACC TGCTGGGACA GGCAGTAAAG ACTCTGCAAG GCTCATGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0000209--P:protein polyubiquitination
GO:0006986--P:response to unfolded protein
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

bta:506103

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002152	Ailuropoda melanoleuca	98.07	1.00e-135	475.00
IUUC-Atr-003156	Amborella trichopoda	54.22	1.00e-53	202.00
IUUC-Apl-004224	Anas platyrhynchos	91.89	4.00e-114	403.00
IUUC-Aca-005049	Anolis carolinensis	89.69	8.00e-129	452.00
IUUC-Aly-006195	Arabidopsis lyrata	53.80	1.00e-49	189.00
IUUC-Ath-006640	Arabidopsis thaliana	53.80	3.00e-50	191.00
IUUC-Ago-007987	Ashbya gossypii	52.60	3.00e-53	201.00
IUUC-Acl-008060	Aspergillus clavatus	56.34	2.00e-43	168.00
IUUC-Afl-008561	Aspergillus flavus	56.34	4.00e-43	168.00
IUUC-Afu-008860	Aspergillus fumigatus	56.34	4.00e-43	167.00
IUUC-Ani-009333	Aspergillus nidulans	54.93	2.00e-42	165.00
IUUC-Ang-009810	Aspergillus niger	57.04	1.00e-43	169.00
IUUC-Aor-010127	Aspergillus oryzae	56.34	4.00e-43	168.00
IUUC-Ate-010362	Aspergillus terreus	38.87	6.00e-44	171.00
IUUC-Ame-010627	Astyanax mexicanus	88.51	4.00e-130	456.00
IUUC-Bgr-012069	Blumeria graminis	50.70	1.00e-39	156.00
IUUC-Bci-013843	Botrytis cinerea	53.52	2.00e-40	159.00
IUUC-Bdi-014467	Brachypodium distachyon	52.69	4.00e-50	191.00
IUUC-Bol-015471	Brassica oleracea	50.29	2.00e-52	198.00
IUUC-Bra-017799	Brassica rapa	53.50	8.00e-50	189.00
IUUC-Cel-018278	Caenorhabditis elegans	60.23	6.00e-52	196.00
IUUC-Cja-018817	Callithrix jacchus	92.79	3.00e-114	404.00
IUUC-Cfa-020885	Canis familiaris	98.07	2.00e-135	474.00
IUUC-Cpo-022326	Cavia porcellus	96.14	3.00e-142	497.00
IUUC-Cre-022635	Chlamydomonas reinhardtii	58.23	1.00e-54	205.00
IUUC-Csa-023646	Chlorocebus sabaeus	95.37	6.00e-140	489.00
IUUC-Cho-025075	Choloepus hoffmanni	78.57	7.00e-65	239.00
IUUC-Cin-025389	Ciona intestinalis	73.14	4.00e-80	290.00
IUUC-Csv-026315	Ciona savignyi	57.20	5.00e-83	300.00
IUUC-Cgl-026602	Colletotrichum gloeosporioides	53.52	4.00e-42	164.00
IUUC-Cne-026808	Cryptococcus neoformans	51.41	4.00e-42	163.00
IUUC-Dre-028455	Danio rerio	88.80	4.00e-131	460.00
IUUC-Dno-029667	Dasypus novemcinctus	94.59	1.00e-138	485.00
IUUC-Dor-030747	Dipodomys ordii	80.73	1.00e-117	415.00
IUUC-Dse-031231	Dothistroma septosporum	50.70	2.00e-39	155.00
IUUC-Dme-031841	Drosophila melanogaster	51.79	3.00e-77	281.00
IUUC-Ete-032258	Echinops telfairi	85.45	2.00e-123	434.00
IUUC-Eca-033602	Equus caballus	75.29	3.00e-102	364.00
IUUC-Eeu-034443	Erinaceus europaeus	96.52	2.00e-107	380.00
IUUC-Fca-036167	Felis catus	93.10	6.00e-122	429.00
IUUC-Fal-037114	Ficedula albicollis	88.00	1.00e-96	345.00
IUUC-Fox-037957	Fusarium oxysporum	58.87	5.00e-40	157.00
IUUC-Fso-038277	Fusarium solani	55.63	3.00e-43	168.00
IUUC-Gmo-039501	Gadus morhua	83.52	1.00e-109	389.00
IUUC-Ggr-040010	Gaeumannomyces graminis	56.34	4.00e-43	167.00
IUUC-Gga-041257	Gallus gallus	91.51	6.00e-112	396.00
IUUC-Gac-041433	Gasterosteus aculeatus	84.29	2.00e-110	391.00
IUUC-Gma-043529	Glycine max	50.00	5.00e-53	200.00
IUUC-Ggo-044437	Gorilla gorilla	90.43	2.00e-115	407.00
IUUC-Hsa-046693	Homo sapiens	95.37	5.00e-140	489.00
IUUC-Itr-048477	Ictidomys tridecemlineatus	96.91	7.00e-134	469.00
IUUC-Kpa-049391	Komagataella pastoris	54.72	7.00e-42	163.00
IUUC-Lch-049617	Latimeria chalumnae	91.51	9.00e-121	426.00
IUUC-Lpe-050949	Leersia perrieri	50.90	3.00e-48	184.00
IUUC-Loc-052157	Lepisosteus oculatus	90.08	4.00e-122	430.00
IUUC-Lma-053128	Leptosphaeria maculans	55.07	2.00e-41	162.00
IUUC-Laf-054455	Loxodonta africana	95.37	1.00e-125	442.00
IUUC-Mcc-054756	Macaca mulatta	95.37	6.00e-140	489.00
IUUC-Meu-056106	Macropus eugenii	78.10	2.00e-102	364.00
IUUC-Mor-057202	Magnaporthe oryzae	55.63	9.00e-43	166.00
IUUC-Mpo-057349	Magnaporthe poae	55.63	1.00e-42	166.00
IUUC-Mtr-058271	Medicago truncatula	41.49	3.00e-49	187.00
IUUC-Mla-058894	Melampsora laricipopulina	51.75	8.00e-43	165.00
IUUC-Mga-059493	Meleagris gallopavo	91.51	6.00e-112	396.00
IUUC-Mvi-060232	Microbotryum violaceum	47.40	2.00e-41	162.00
IUUC-Mmr-060957	Microcebus murinus	96.91	1.00e-143	501.00
IUUC-Mdo-062141	Monodelphis domestica	94.98	4.00e-130	456.00
IUUC-Mmu-063882	Mus musculus	95.37	1.00e-130	458.00
IUUC-Mac-064530	Musa acuminata	47.32	3.00e-51	194.00
IUUC-Mpu-065902	Mustela putorius furo	97.68	5.00e-135	473.00
IUUC-Mlu-068008	Myotis lucifugus	98.07	1.00e-134	471.00
IUUC-Nfi-068515	Neosartorya fischeri	56.34	2.00e-43	168.00
IUUC-Ncr-068755	Neurospora crassa	54.23	2.00e-41	162.00
IUUC-Opr-071201	Ochotona princeps	92.04	4.00e-89	320.00
IUUC-Ont-071311	Oreochromis niloticus	83.91	3.00e-107	380.00
IUUC-Oan-073310	Ornithorhynchus anatinus	90.35	5.00e-129	453.00
IUUC-Ocu-074514	Oryctolagus cuniculus	95.37	2.00e-140	490.00
IUUC-Oba-075200	Oryza barthii	51.16	1.00e-48	186.00
IUUC-Obr-076396	Oryza brachyantha	49.73	1.00e-49	189.00
IUUC-Ogl-077398	Oryza glaberrima	51.16	2.00e-48	185.00
IUUC-Ogu-078362	Oryza glumaepatula	51.16	1.00e-48	186.00
IUUC-Oin-079625	Oryza indica	51.16	1.00e-48	186.00
IUUC-Olo-080620	Oryza longistaminata	45.39	4.00e-29	121.00
IUUC-Ome-081187	Oryza meridionalis	51.16	2.00e-48	185.00
IUUC-Oni-082271	Oryza nivara	51.16	2.00e-48	185.00
IUUC-Opu-083487	Oryza punctata	50.58	1.00e-47	182.00
IUUC-Oru-085263	Oryza rufipogon	51.16	1.00e-48	186.00
IUUC-Osa-085694	Oryza sativa	51.16	1.00e-48	186.00
IUUC-Ola-086450	Oryzias latipes	86.10	9.00e-119	419.00
IUUC-Olu-087733	Ostreococcus lucimarinus	41.27	2.00e-25	108.00
IUUC-Oga-088054	Otolemur garnettii	90.55	1.00e-127	448.00
IUUC-Oar-089486	Ovis aries	99.61	2.00e-137	481.00
IUUC-Pan-092633	Papio anubis	95.37	6.00e-140	489.00
IUUC-Psi-093165	Pelodiscus sinensis	86.96	9.00e-39	152.00
IUUC-Pno-095025	Phaeosphaeria nodorum	55.80	1.00e-42	166.00
IUUC-Ppa-095641	Physcomitrella patens	56.96	3.00e-54	204.00
IUUC-Pfo-096423	Poecilia formosa	85.44	3.00e-104	370.00
IUUC-Pab-097771	Pongo abelii	95.75	3.00e-140	490.00
IUUC-Pop-099714	Populus trichocarpa	52.91	4.00e-54	204.00
IUUC-Pca-100493	Procavia capensis	84.65	5.00e-83	300.00
IUUC-Ppe-102054	Prunus persica	50.58	3.00e-52	198.00
IUUC-Pva-102224	Pteropus vampyrus	94.98	3.00e-130	457.00
IUUC-Pgr-103530	Puccinia graminis	51.28	1.00e-46	179.00
IUUC-Ptt-103776	Puccinia triticina	50.65	2.00e-45	175.00
IUUC-Pte-104166	Pyrenophora teres	53.62	2.00e-41	162.00
IUUC-Pyt-104570	Pyrenophora triticirepentis	53.62	3.00e-41	161.00
IUUC-Rno-105593	Rattus norvegicus	95.37	2.00e-130	458.00
IUUC-Sce-106212	Saccharomyces cerevisiae	58.49	5.00e-52	197.00
IUUC-Sha-106767	Sarcophilus harrisii	93.44	2.00e-128	451.00
IUUC-Sja-107907	Schizosaccharomyces japonicus	48.81	3.00e-48	184.00
IUUC-Spo-108094	Schizosaccharomyces pombe	53.80	2.00e-48	185.00
IUUC-Ssl-108556	Sclerotinia sclerotiorum	53.52	8.00e-41	160.00
IUUC-Smo-108965	Selaginella moellendorffii	52.91	2.00e-54	205.00
IUUC-Sit-110407	Setaria italica	55.49	3.00e-51	194.00
IUUC-Sly-111642	Solanum lycopersicum	52.60	1.00e-48	186.00
IUUC-Stu-112336	Solanum tuberosum	48.68	1.00e-47	182.00
IUUC-Sbi-114327	Sorghum bicolor	55.49	5.00e-51	194.00
IUUC-Sre-115170	Sporisorium reilianum	54.78	2.00e-42	166.00
IUUC-Ssc-116385	Sus scrofa	98.46	6.00e-136	476.00
IUUC-Tgu-117041	Taeniopygia guttata	89.19	2.00e-103	368.00
IUUC-Tru-117697	Takifugu rubripes	85.88	2.00e-113	401.00
IUUC-Tsy-119024	Tarsius syrichta	87.26	5.00e-129	453.00
IUUC-Tni-120466	Tetraodon nigroviridis	84.53	1.00e-111	395.00
IUUC-Tca-121569	Theobroma cacao	47.34	8.00e-51	193.00
IUUC-Tre-121882	Trichoderma reesei	55.63	1.00e-42	166.00
IUUC-Tvi-122466	Trichoderma virens	54.93	3.00e-42	165.00
IUUC-Tae-124797	Triticum aestivum	53.49	1.00e-50	192.00
IUUC-Tur-126536	Triticum urartu	53.85	2.00e-50	191.00
IUUC-Tme-127051	Tuber melanosporum	57.75	4.00e-45	174.00
IUUC-Tbe-128095	Tupaia belangeri	95.98	3.00e-96	343.00
IUUC-Ttr-128466	Tursiops truncatus	98.84	6.00e-137	479.00
IUUC-Uma-129383	Ustilago maydis	54.14	6.00e-42	164.00
IUUC-Vda-130013	Verticillium dahliae	55.97	4.00e-41	161.00
IUUC-Vvi-131251	Vitis vinifera	52.15	3.00e-47	181.00
IUUC-Xtr-132408	Xenopus tropicalis	90.35	9.00e-140	488.00
IUUC-Xma-133893	Xiphophorus maculatus	86.21	7.00e-105	373.00
IUUC-Yli-134618	Yarrowia lipolytica	58.55	7.00e-51	193.00
IUUC-Zma-135216	Zea mays	54.88	8.00e-51	193.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence