iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068698

Ensembl Protein ID

EAA26907

UniProt Accession

Q7RWR0; Q7RWR0_NEUCR

Genbank Protein ID

EAA26907.2

Protein Name

Ubiquitin-activating enzyme E1 1

Genbank Nucleotide ID

CM002239

Gene Name

NCU04370

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU04370	EAA26907	EAA26907

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.80e-195	648.3	426	911

Active Site

Position(s)	Description	Evidence
609	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn..veahe 94
           YD+Qi+++G e qek+++ k +lvGag++GcE+lKn +++G+     g+itv+Dmd +e+snlnrqFLfr++dvg+ K+++aa+a++ +npd +  +++ +
   Q: 426  YDGQIAVFGKEFQEKISNVKQFLVGAGAIGCEMLKNWAMIGLgtgpeGKITVTDMDSIEKSNLNRQFLFRPKDVGQMKSDCAAKAAQAMNPDLEghIVSLK 526
           *********************************************************************************************72256678 PP
   S: 95   esiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.. 190
           +++++++eei+   F + +d+V +aldn+ear++v+r+c+  ++pl+esgtlG++G+++v+++ lte+ys+s+dpp++++P+ctl+++pn++ehti wa  
   Q: 527  DRVSPETEEIFneeFWQGLDGVTNALDNVEARTYVDRRCVFFHKPLLESGTLGTKGNTQVVLPRLTESYSSSQDPPEQSFPMCTLRSFPNKIEHTIAWAre 627
           99*******99999**************************************************************************************9 PP
   S: 191  ..........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv....... 274
                     + +n +l + +  +++l++  s + +++++   + lk e++ +fe+++++a+  f+k+++n i+qll +f++d v++ ++pfw+       
   Q: 628  lfessfvkpaETVNLYLTQPNYLDTTLKQ--SGNEKATLEMLADFLKHERPLTFEDCVQWARMLFEKQYNNAIQQLLYNFPKDSVSSTGTPFWSgpkrapd 726
           99999999997777777666666666663..34444444445555888***************************************************** PP
   S: 275  .....................................................sfcsnaealqvpekvekdeevvkasaplylllralerfekkkgrkpge 322
                                                                s ++ ++  ++p+ ++++++  +++++l  l+  l + ++  g k ++
   Q: 727  plkfdpenpthfsfleaatnlhafnysinakgkskadylralegmivpdfspdSNVKIQADEKEPDPNADNTAF-DDESELGNLKSQLPEPKSLAGFKLNV 826
           **************************999999999999999999999998888777777788888888888774.555569******************** PP
   S: 323  lsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           ++fekddd   ++d++taa+nlrae+++iep +d++++k iag+iipaiatt+a v Gl+++E++K+++g  + e++kn f+++a+
   Q: 827  VEFEKDDDTnyHIDFITAASNLRAENYKIEP-ADRHKTKFIAGKIIPAIATTTALVTGLVVLELYKIIDGktDIEQYKNGFINLAL 911
           *******************************.**************************************777888******9875 PP

Organism

Neurospora crassa

Protein Sequence
(Fasta)

MTDTQKNEVD LVTRMQVDES VAGTTAEIDE SLYSRQLYVL GHEAMKRMSA SNVLIVGLKG 60
LGVEIAKNVA LAGVKSLTLH DPEPAAWADL SAQFFLRPED VGKPRDQVTA PRVAELNAYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACATCCCC GCCGCCCGAC CTTCCAGATT ACAGACAGCT TCCACTTCCA CTTGCACTTG 60
CACTTGCACT TGCACCTTGA CATAGTACGA CATAGTAGCA CTTGCGCTTG ATCCGTCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity

KEGG

ncr:NCU04370

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	45.71	0.00e+00	812.00
IUUC-Aml-001311	Ailuropoda melanoleuca	54.57	0.00e+00	1111.00
IUUC-Atr-002684	Amborella trichopoda	44.25	0.00e+00	846.00
IUUC-Apl-004158	Anas platyrhynchos	42.36	0.00e+00	691.00
IUUC-Aca-004620	Anolis carolinensis	55.59	0.00e+00	1107.00
IUUC-Aly-005515	Arabidopsis lyrata	46.18	0.00e+00	879.00
IUUC-Ath-006891	Arabidopsis thaliana	45.88	0.00e+00	882.00
IUUC-Ago-007873	Ashbya gossypii	62.07	0.00e+00	1208.00
IUUC-Acl-008181	Aspergillus clavatus	69.68	0.00e+00	1446.00
IUUC-Afl-008455	Aspergillus flavus	70.29	0.00e+00	1408.00
IUUC-Afu-009065	Aspergillus fumigatus	70.55	0.00e+00	1476.00
IUUC-Ani-009371	Aspergillus nidulans	70.34	0.00e+00	1441.00
IUUC-Ang-009737	Aspergillus niger	70.26	0.00e+00	1454.00
IUUC-Aor-010007	Aspergillus oryzae	70.29	0.00e+00	1408.00
IUUC-Ate-010466	Aspergillus terreus	69.31	0.00e+00	1475.00
IUUC-Ame-010933	Astyanax mexicanus	55.05	0.00e+00	1037.00
IUUC-Bgr-012281	Blumeria graminis	73.28	0.00e+00	1555.00
IUUC-Bta-012767	Bos taurus	55.63	0.00e+00	1117.00
IUUC-Bci-013721	Botrytis cinerea	77.12	0.00e+00	1571.00
IUUC-Bdi-014009	Brachypodium distachyon	44.97	0.00e+00	859.00
IUUC-Bol-015665	Brassica oleracea	46.18	0.00e+00	862.00
IUUC-Bra-017685	Brassica rapa	45.91	0.00e+00	877.00
IUUC-Cel-018260	Caenorhabditis elegans	45.14	0.00e+00	828.00
IUUC-Cja-019152	Callithrix jacchus	55.25	0.00e+00	1110.00
IUUC-Cfa-020622	Canis familiaris	53.70	0.00e+00	1056.00
IUUC-Cpo-022526	Cavia porcellus	55.16	0.00e+00	1092.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	44.91	0.00e+00	791.00
IUUC-Csa-023780	Chlorocebus sabaeus	55.54	0.00e+00	1107.00
IUUC-Cho-024682	Choloepus hoffmanni	41.51	8.00e-101	360.00
IUUC-Cin-025790	Ciona intestinalis	53.85	0.00e+00	1097.00
IUUC-Csv-026084	Ciona savignyi	53.16	0.00e+00	1096.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	77.57	0.00e+00	1701.00
IUUC-Cne-026960	Cryptococcus neoformans	60.68	0.00e+00	1211.00
IUUC-Cme-027290	Cyanidioschyzon merolae	43.94	0.00e+00	806.00
IUUC-Dre-028149	Danio rerio	55.24	0.00e+00	1072.00
IUUC-Dno-028884	Dasypus novemcinctus	55.06	0.00e+00	1112.00
IUUC-Dor-030229	Dipodomys ordii	52.82	0.00e+00	1044.00
IUUC-Dse-031524	Dothistroma septosporum	69.44	0.00e+00	1445.00
IUUC-Dme-032045	Drosophila melanogaster	51.62	0.00e+00	1013.00
IUUC-Ete-033124	Echinops telfairi	43.95	9.00e-156	542.00
IUUC-Eca-033330	Equus caballus	55.25	0.00e+00	1112.00
IUUC-Eeu-035323	Erinaceus europaeus	41.15	1.00e-153	535.00
IUUC-Fca-036255	Felis catus	55.16	0.00e+00	1110.00
IUUC-Fal-036848	Ficedula albicollis	42.77	0.00e+00	705.00
IUUC-Fox-038007	Fusarium oxysporum	75.73	0.00e+00	853.00
IUUC-Fso-038339	Fusarium solani	77.58	0.00e+00	1605.00
IUUC-Gmo-039338	Gadus morhua	52.28	0.00e+00	1021.00
IUUC-Ggr-039823	Gaeumannomyces graminis	79.36	0.00e+00	1754.00
IUUC-Gga-040747	Gallus gallus	42.37	0.00e+00	690.00
IUUC-Gac-041773	Gasterosteus aculeatus	52.28	0.00e+00	1023.00
IUUC-Gma-043198	Glycine max	46.05	0.00e+00	862.00
IUUC-Ggo-045336	Gorilla gorilla	55.16	0.00e+00	1093.00
IUUC-Hsa-045982	Homo sapiens	55.06	0.00e+00	1091.00
IUUC-Hvu-047418	Hordeum vulgare	45.45	0.00e+00	845.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	55.06	0.00e+00	1106.00
IUUC-Kpa-049112	Komagataella pastoris	60.64	0.00e+00	1184.00
IUUC-Lch-050371	Latimeria chalumnae	55.39	0.00e+00	1105.00
IUUC-Lpe-051299	Leersia perrieri	44.33	0.00e+00	875.00
IUUC-Loc-052936	Lepisosteus oculatus	55.47	0.00e+00	1093.00
IUUC-Lma-053315	Leptosphaeria maculans	71.77	0.00e+00	1539.00
IUUC-Laf-053948	Loxodonta africana	54.67	0.00e+00	1082.00
IUUC-Mcc-055843	Macaca mulatta	55.74	0.00e+00	1113.00
IUUC-Meu-056258	Macropus eugenii	54.96	0.00e+00	1091.00
IUUC-Mor-057269	Magnaporthe oryzae	81.50	0.00e+00	1748.00
IUUC-Mpo-057435	Magnaporthe poae	79.36	0.00e+00	1707.00
IUUC-Mtr-058572	Medicago truncatula	46.16	0.00e+00	853.00
IUUC-Mla-059176	Melampsora laricipopulina	59.07	0.00e+00	1162.00
IUUC-Mga-059721	Meleagris gallopavo	42.10	0.00e+00	669.00
IUUC-Mvi-060437	Microbotryum violaceum	57.70	0.00e+00	1165.00
IUUC-Mmr-061405	Microcebus murinus	53.79	0.00e+00	1066.00
IUUC-Mdo-062032	Monodelphis domestica	52.94	0.00e+00	1051.00
IUUC-Mmu-063280	Mus musculus	54.86	0.00e+00	1102.00
IUUC-Mac-065505	Musa acuminata	46.39	0.00e+00	880.00
IUUC-Mpu-066409	Mustela putorius furo	55.25	0.00e+00	1113.00
IUUC-Mlu-067217	Myotis lucifugus	54.86	0.00e+00	1096.00
IUUC-Nfi-068407	Neosartorya fischeri	69.81	0.00e+00	1454.00
IUUC-Nle-070072	Nomascus leucogenys	52.52	0.00e+00	1004.00
IUUC-Opr-070715	Ochotona princeps	39.64	9.00e-158	549.00
IUUC-Ont-071671	Oreochromis niloticus	55.44	0.00e+00	1075.00
IUUC-Oan-073268	Ornithorhynchus anatinus	42.57	0.00e+00	672.00
IUUC-Ocu-074544	Oryctolagus cuniculus	55.35	0.00e+00	1114.00
IUUC-Oba-075913	Oryza barthii	46.00	0.00e+00	863.00
IUUC-Obr-076557	Oryza brachyantha	46.08	0.00e+00	841.00
IUUC-Ogl-077371	Oryza glaberrima	46.00	0.00e+00	863.00
IUUC-Ogu-078793	Oryza glumaepatula	46.00	0.00e+00	863.00
IUUC-Oin-079710	Oryza indica	45.91	0.00e+00	861.00
IUUC-Olo-080255	Oryza longistaminata	45.81	0.00e+00	861.00
IUUC-Ome-081171	Oryza meridionalis	46.00	0.00e+00	864.00
IUUC-Oni-082365	Oryza nivara	45.61	0.00e+00	850.00
IUUC-Opu-083977	Oryza punctata	45.61	0.00e+00	855.00
IUUC-Oru-085015	Oryza rufipogon	46.00	0.00e+00	863.00
IUUC-Osa-085455	Oryza sativa	46.00	0.00e+00	865.00
IUUC-Ola-087002	Oryzias latipes	54.81	0.00e+00	1074.00
IUUC-Olu-087687	Ostreococcus lucimarinus	44.13	0.00e+00	796.00
IUUC-Oga-088594	Otolemur garnettii	55.06	0.00e+00	1089.00
IUUC-Oar-090068	Ovis aries	55.48	0.00e+00	1120.00
IUUC-Ptr-090609	Pan troglodytes	43.34	0.00e+00	707.00
IUUC-Pan-092114	Papio anubis	55.74	0.00e+00	1113.00
IUUC-Psi-093489	Pelodiscus sinensis	42.37	0.00e+00	704.00
IUUC-Pma-094214	Petromyzon marinus	47.34	4.00e-38	148.00
IUUC-Pno-095154	Phaeosphaeria nodorum	70.38	0.00e+00	1516.00
IUUC-Ppa-095227	Physcomitrella patens	47.76	0.00e+00	879.00
IUUC-Pfo-097184	Poecilia formosa	53.98	0.00e+00	1060.00
IUUC-Pab-097861	Pongo abelii	55.35	0.00e+00	1080.00
IUUC-Pop-098934	Populus trichocarpa	45.63	0.00e+00	868.00
IUUC-Pca-100347	Procavia capensis	52.82	0.00e+00	912.00
IUUC-Ppe-102012	Prunus persica	45.43	0.00e+00	873.00
IUUC-Pva-102584	Pteropus vampyrus	55.64	0.00e+00	1145.00
IUUC-Pgr-103336	Puccinia graminis	57.86	0.00e+00	1122.00
IUUC-Ptt-103939	Puccinia triticina	58.05	0.00e+00	1119.00
IUUC-Pte-104200	Pyrenophora teres	70.99	0.00e+00	1540.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	70.39	0.00e+00	1528.00
IUUC-Rno-105462	Rattus norvegicus	55.06	0.00e+00	1097.00
IUUC-Sce-106245	Saccharomyces cerevisiae	60.93	0.00e+00	1246.00
IUUC-Sha-107142	Sarcophilus harrisii	53.89	0.00e+00	1084.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	60.02	0.00e+00	1253.00
IUUC-Spo-108034	Schizosaccharomyces pombe	59.38	0.00e+00	1209.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	75.43	0.00e+00	1565.00
IUUC-Smo-108912	Selaginella moellendorffii	46.50	0.00e+00	845.00
IUUC-Sit-110281	Setaria italica	45.59	0.00e+00	868.00
IUUC-Sly-110914	Solanum lycopersicum	45.76	0.00e+00	887.00
IUUC-Stu-112109	Solanum tuberosum	45.37	0.00e+00	887.00
IUUC-Sar-113737	Sorex araneus	55.06	0.00e+00	1109.00
IUUC-Sbi-114520	Sorghum bicolor	45.76	0.00e+00	874.00
IUUC-Sre-115148	Sporisorium reilianum	57.57	0.00e+00	1140.00
IUUC-Ssc-115777	Sus scrofa	55.31	0.00e+00	1116.00
IUUC-Tgu-116565	Taeniopygia guttata	42.37	0.00e+00	700.00
IUUC-Tru-118742	Takifugu rubripes	54.91	0.00e+00	1037.00
IUUC-Tsy-119436	Tarsius syrichta	39.43	2.00e-143	501.00
IUUC-Tni-120401	Tetraodon nigroviridis	55.83	0.00e+00	1050.00
IUUC-Tca-121672	Theobroma cacao	46.09	0.00e+00	873.00
IUUC-Tre-122009	Trichoderma reesei	77.39	0.00e+00	1586.00
IUUC-Tvi-122259	Trichoderma virens	78.41	0.00e+00	1605.00
IUUC-Tae-125676	Triticum aestivum	45.76	0.00e+00	877.00
IUUC-Tur-126330	Triticum urartu	45.93	0.00e+00	857.00
IUUC-Tme-127055	Tuber melanosporum	63.49	0.00e+00	1285.00
IUUC-Tbe-127487	Tupaia belangeri	57.29	1.00e-162	565.00
IUUC-Ttr-128331	Tursiops truncatus	55.30	0.00e+00	1099.00
IUUC-Uma-129387	Ustilago maydis	57.55	0.00e+00	1145.00
IUUC-Vda-129977	Verticillium dahliae	77.51	0.00e+00	1578.00
IUUC-Vpa-130716	Vicugna pacos	41.80	0.00e+00	674.00
IUUC-Vvi-130857	Vitis vinifera	45.65	0.00e+00	875.00
IUUC-Xtr-132947	Xenopus tropicalis	38.10	0.00e+00	638.00
IUUC-Xma-133805	Xiphophorus maculatus	53.98	0.00e+00	1043.00
IUUC-Yli-134547	Yarrowia lipolytica	61.33	0.00e+00	1265.00
IUUC-Zma-135052	Zea mays	45.63	0.00e+00	875.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence