iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090492

UUCD1 version

UUC-PaT-00562

Ensembl Protein ID

ENSPTRP00000028353.3

UniProt Accession

H2QQA2; H2QQA2_PANTR

Genbank Protein ID

JAA08403.1; JAA16021.1; JAA29570.1; JAA35599.1

Protein Name

F-box and WD repeat domain containing 7

Genbank Nucleotide ID

AACZ03032586; GABF01006124; GABD01003530; GABE01009140

Gene Name

FBXW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000016514.6	ENSPTRT00000030701.3	ENSPTRP00000028353.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.00e-61	199.2	623	656
UBD/Beta-Prp	1.10e-102	343.3	374	656

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 623  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 656
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 374  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 458
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 459  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 541
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 542  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 627  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 656
           *************************98776 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV 60
GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATCAGG AACTGCTCTC TGTGGGCAGC AAAAGACGAC GAACTGGAGG CTCTCTGAGA 60
GGTAACCCTT CCTCAAGCCA GGTAGATGAA GAACAGATGA ATCGTGTGGT AGAAGAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	97.88	0.00e+00	1228.00
IUUC-Apl-003489	Anas platyrhynchos	91.09	0.00e+00	1203.00
IUUC-Aca-005318	Anolis carolinensis	98.00	0.00e+00	1099.00
IUUC-Ago-007794	Ashbya gossypii	31.07	7.00e-62	231.00
IUUC-Acl-008123	Aspergillus clavatus	32.40	6.00e-75	275.00
IUUC-Afl-008730	Aspergillus flavus	31.33	7.00e-74	271.00
IUUC-Afu-009014	Aspergillus fumigatus	32.53	2.00e-75	276.00
IUUC-Ani-009332	Aspergillus nidulans	33.47	2.00e-80	293.00
IUUC-Ang-009790	Aspergillus niger	31.71	3.00e-76	279.00
IUUC-Aor-010215	Aspergillus oryzae	30.71	1.00e-74	274.00
IUUC-Ate-010535	Aspergillus terreus	32.09	3.00e-76	279.00
IUUC-Ame-010898	Astyanax mexicanus	94.16	0.00e+00	1047.00
IUUC-Bgr-012075	Blumeria graminis	33.40	2.00e-79	290.00
IUUC-Bta-012391	Bos taurus	98.73	0.00e+00	1109.00
IUUC-Bci-013725	Botrytis cinerea	33.20	2.00e-78	286.00
IUUC-Cel-018495	Caenorhabditis elegans	48.73	2.00e-131	462.00
IUUC-Cja-018902	Callithrix jacchus	99.15	0.00e+00	1229.00
IUUC-Cfa-020237	Canis familiaris	97.47	0.00e+00	1227.00
IUUC-Cpo-022234	Cavia porcellus	98.73	0.00e+00	1111.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.54	6.00e-49	187.00
IUUC-Csa-023532	Chlorocebus sabaeus	99.86	0.00e+00	1207.00
IUUC-Cho-025026	Choloepus hoffmanni	83.83	0.00e+00	773.00
IUUC-Cin-025516	Ciona intestinalis	70.34	4.00e-141	494.00
IUUC-Csv-026312	Ciona savignyi	75.47	0.00e+00	755.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.82	4.00e-85	308.00
IUUC-Cne-027018	Cryptococcus neoformans	33.08	3.00e-73	270.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	3.00e-31	130.00
IUUC-Dre-028303	Danio rerio	94.09	0.00e+00	1049.00
IUUC-Dno-029576	Dasypus novemcinctus	97.31	0.00e+00	1214.00
IUUC-Dor-030196	Dipodomys ordii	93.36	0.00e+00	1212.00
IUUC-Dse-031558	Dothistroma septosporum	38.98	2.00e-70	260.00
IUUC-Dme-031702	Drosophila melanogaster	76.61	0.00e+00	802.00
IUUC-Ete-032791	Echinops telfairi	90.93	0.00e+00	1004.00
IUUC-Eca-033424	Equus caballus	98.73	0.00e+00	1110.00
IUUC-Eeu-034996	Erinaceus europaeus	93.80	0.00e+00	1186.00
IUUC-Fca-036422	Felis catus	97.05	0.00e+00	1241.00
IUUC-Fal-037267	Ficedula albicollis	98.36	0.00e+00	1097.00
IUUC-Fox-037800	Fusarium oxysporum	34.07	2.00e-84	306.00
IUUC-Fso-038258	Fusarium solani	34.21	2.00e-83	303.00
IUUC-Gmo-039119	Gadus morhua	83.73	0.00e+00	902.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.66	3.00e-85	309.00
IUUC-Gga-040667	Gallus gallus	92.93	0.00e+00	1194.00
IUUC-Gac-042423	Gasterosteus aculeatus	74.63	0.00e+00	803.00
IUUC-Ggo-044422	Gorilla gorilla	99.86	0.00e+00	1211.00
IUUC-Hsa-045898	Homo sapiens	100.00	0.00e+00	1211.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.79	0.00e+00	976.00
IUUC-Kpa-049097	Komagataella pastoris	32.06	2.00e-76	280.00
IUUC-Lch-050414	Latimeria chalumnae	94.53	0.00e+00	1089.00
IUUC-Loc-052348	Lepisosteus oculatus	96.01	0.00e+00	1074.00
IUUC-Lma-053185	Leptosphaeria maculans	32.40	4.00e-72	266.00
IUUC-Laf-054054	Loxodonta africana	97.04	0.00e+00	1241.00
IUUC-Mcc-055056	Macaca mulatta	99.86	0.00e+00	1207.00
IUUC-Meu-056778	Macropus eugenii	93.45	0.00e+00	741.00
IUUC-Mor-057133	Magnaporthe oryzae	39.13	4.00e-74	273.00
IUUC-Mpo-057542	Magnaporthe poae	39.13	4.00e-74	273.00
IUUC-Mla-059081	Melampsora laricipopulina	32.57	1.00e-76	280.00
IUUC-Mga-059255	Meleagris gallopavo	93.35	0.00e+00	1187.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	2.00e-67	251.00
IUUC-Mmr-061292	Microcebus murinus	99.01	0.00e+00	1231.00
IUUC-Mdo-062304	Monodelphis domestica	93.44	0.00e+00	1206.00
IUUC-Mmu-063610	Mus musculus	93.94	0.00e+00	1271.00
IUUC-Mpu-065931	Mustela putorius furo	98.31	0.00e+00	1230.00
IUUC-Mlu-066976	Myotis lucifugus	97.46	0.00e+00	1265.00
IUUC-Nfi-068428	Neosartorya fischeri	31.93	3.00e-75	276.00
IUUC-Ncr-068688	Neurospora crassa	35.97	2.00e-87	316.00
IUUC-Nle-070174	Nomascus leucogenys	99.86	0.00e+00	1209.00
IUUC-Opr-070851	Ochotona princeps	86.58	0.00e+00	654.00
IUUC-Ont-071997	Oreochromis niloticus	93.28	0.00e+00	1072.00
IUUC-Oan-072936	Ornithorhynchus anatinus	93.50	0.00e+00	1246.00
IUUC-Ocu-074742	Oryctolagus cuniculus	99.64	0.00e+00	1139.00
IUUC-Obr-076806	Oryza brachyantha	31.52	1.00e-29	125.00
IUUC-Oin-079809	Oryza indica	31.52	6.00e-30	126.00
IUUC-Ola-087098	Oryzias latipes	94.09	0.00e+00	1060.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	4.00e-38	150.00
IUUC-Oga-088884	Otolemur garnettii	100.00	0.00e+00	786.00
IUUC-Oar-090220	Ovis aries	96.06	0.00e+00	1212.00
IUUC-Pan-091770	Papio anubis	99.58	0.00e+00	1203.00
IUUC-Psi-093207	Pelodiscus sinensis	98.73	0.00e+00	1111.00
IUUC-Pma-094749	Petromyzon marinus	83.67	0.00e+00	945.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	6.00e-71	262.00
IUUC-Pfo-096493	Poecilia formosa	94.37	0.00e+00	1060.00
IUUC-Pab-098141	Pongo abelii	98.73	0.00e+00	1110.00
IUUC-Pca-100571	Procavia capensis	97.38	0.00e+00	847.00
IUUC-Pva-102988	Pteropus vampyrus	97.74	0.00e+00	1234.00
IUUC-Pgr-103612	Puccinia graminis	35.66	5.00e-62	232.00
IUUC-Ptt-103698	Puccinia triticina	35.55	1.00e-41	164.00
IUUC-Pte-104275	Pyrenophora teres	32.36	1.00e-73	271.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	39.09	8.00e-70	258.00
IUUC-Rno-105706	Rattus norvegicus	92.99	0.00e+00	1237.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.39	6.00e-61	228.00
IUUC-Sha-107653	Sarcophilus harrisii	96.05	0.00e+00	1246.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	3.00e-79	290.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.14	9.00e-63	234.00
IUUC-Sar-113600	Sorex araneus	93.35	0.00e+00	1120.00
IUUC-Sre-114901	Sporisorium reilianum	44.21	1.00e-67	251.00
IUUC-Ssc-115787	Sus scrofa	96.46	0.00e+00	1198.00
IUUC-Tgu-117510	Taeniopygia guttata	93.35	0.00e+00	1189.00
IUUC-Tru-117819	Takifugu rubripes	93.97	0.00e+00	1082.00
IUUC-Tsy-118828	Tarsius syrichta	98.45	0.00e+00	1245.00
IUUC-Tni-120468	Tetraodon nigroviridis	93.65	0.00e+00	1071.00
IUUC-Tre-122193	Trichoderma reesei	36.25	2.00e-85	309.00
IUUC-Tvi-122615	Trichoderma virens	35.03	7.00e-84	304.00
IUUC-Tme-127021	Tuber melanosporum	34.55	1.00e-83	304.00
IUUC-Tbe-127925	Tupaia belangeri	100.00	0.00e+00	1104.00
IUUC-Ttr-128899	Tursiops truncatus	98.87	0.00e+00	1226.00
IUUC-Uma-129449	Ustilago maydis	43.16	9.00e-67	249.00
IUUC-Vda-129802	Verticillium dahliae	36.20	1.00e-87	317.00
IUUC-Vpa-130082	Vicugna pacos	98.87	0.00e+00	1049.00
IUUC-Xtr-132213	Xenopus tropicalis	87.78	0.00e+00	1163.00
IUUC-Xma-133646	Xiphophorus maculatus	94.71	0.00e+00	1053.00
IUUC-Yli-134429	Yarrowia lipolytica	34.27	9.00e-87	314.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence