iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042406

UUCD1 version

UUC-GaA-01241

Ensembl Protein ID

ENSGACP00000006620.1

UniProt Accession

G3NMQ7; G3NMQ7_GASAC

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000005006.1	ENSGACT00000006637.1	ENSGACP00000006620.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-88	297.7	196	791

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellka 76
           +G++NlgNtC++N+v+Q Ls+++ l +l+ e k +  + + +              ++ ++l+ ++  +++++ +  k+ ++p+ l+++
   Q: 196  KGINNLGNTCFFNAVMQNLSQTHMLIDLIQEVKDKGYKLRISptvdatvspltvtLSSPEPLTAAMFLFLHNMKEPGKGPINPKILFNQ 284
           59*****************************44444433333446667777777777788***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclec 159
           l+++a++f+gy+qqD+qE+l++lld+++ e +k+ +  + +++++ ++++ de      + + k+  + ++++++F g+l+++i+c+ec
   Q: 285  LCQKAPRFKGYQQQDSQELLHYLLDSIRVEETKRVKAGILKAFNNPTEKTADEetkrqvKAYGKEGVKMNFVDRIFVGELTNTIMCEEC 373
           ****************************99988666666666655555555553333336677777777******************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................... 185
           +++s+ +e f+d+slp+ +++ +k+                                                                
   Q: 374  EHISTVKEAFIDISLPIIEERISKPWhpgrvgkggreqdpppglqggasfsgtrrpqktqeaewtanlintlskkqqsrrslssveekv 462
           *********************88766*************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 463  agcsaerqeedgvaagsacgvsvckmaaagslsdgserdsapqdssndadseasesewaprpfssshgharqggavkqlvtavskvnia 551
           ***************************************************************************************** PP
   S: 186  .................................................slqdcLesftkeeelegenkyycekckkkqe......... 216
                                                            s+q+cL++ft+ e l g+nk+ ce+c+++++         
   Q: 552  ftagevaplthrspeepgetqsrdnlhhqhhqgafqalshsytpsskecSIQSCLHQFTSVELLMGNNKLLCESCTERRQkqlrksssa 640
           ****************************************************************************999999999999* PP
   S: 217  ..........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsGslssG 293
                     a+k++ +++lP+v++lhLkRf  ++++++ +k+n++v+fpl Ldl+pfc+ ++++ +   ++ Y+L+++v HsGs+++G
   Q: 641  dkkvekiytsARKQMLISSLPPVITLHLKRF--HQAGMNLRKVNRHVDFPLILDLAPFCSASCKNLAAgeRVLYSLYGIVEHSGSMRGG 727
           *******************************..9999************************99888766699***************** PP
   S: 294  HYvayvkn.......................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HY+ayvk                         +g+W++++D++V++v+e++vl+   s+aY+lfY++
   Q: 728  HYTAYVKVrapqrkteqlqknlsgtrdagssFQGQWVYISDTTVQTVPESRVLN---SQAYLLFYEE 791
           ********999999999999998888888777999*******************...********96 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MRLKDPFSLK AADMTKRTNK PRKPRDEESS DEVSEMSGLT CQHVSKAVDL SSVKKSVLSN 60
VWLVCAECLK ERTLIDGEPA ASHDILVCLK CGFQGCNQSG IQHAVRHHQA FHPESHCITI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGCTAA AGGACCCTTT CTCTCTGAAA GCCGCCGATA TGACTAAGCG GACTAATAAA 60
CCGAGAAAAC CTCGAGATGA GGAGTCCTCA GATGAAGTCA GTGGTAAGTC ACTGAAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	58.85	6.00e-128	451.00
IUUC-Apl-003512	Anas platyrhynchos	57.23	8.00e-165	573.00
IUUC-Aca-004284	Anolis carolinensis	57.65	0.00e+00	854.00
IUUC-Aly-006422	Arabidopsis lyrata	29.29	1.00e-28	122.00
IUUC-Ath-006732	Arabidopsis thaliana	29.01	1.00e-31	132.00
IUUC-Ame-010735	Astyanax mexicanus	61.28	1.00e-147	516.00
IUUC-Bta-012880	Bos taurus	52.71	0.00e+00	789.00
IUUC-Bol-015941	Brassica oleracea	31.18	3.00e-29	124.00
IUUC-Bra-016751	Brassica rapa	30.91	2.00e-28	122.00
IUUC-Cja-019144	Callithrix jacchus	59.46	3.00e-148	519.00
IUUC-Cfa-020971	Canis familiaris	58.12	2.00e-146	513.00
IUUC-Cpo-022497	Cavia porcellus	59.10	1.00e-144	507.00
IUUC-Csa-023910	Chlorocebus sabaeus	59.95	4.00e-148	518.00
IUUC-Cho-024358	Choloepus hoffmanni	42.32	2.00e-71	263.00
IUUC-Dre-028106	Danio rerio	70.17	0.00e+00	1124.00
IUUC-Dno-029456	Dasypus novemcinctus	48.63	2.00e-116	412.00
IUUC-Dor-030438	Dipodomys ordii	48.65	7.00e-103	368.00
IUUC-Dme-031870	Drosophila melanogaster	50.67	9.00e-36	145.00
IUUC-Ete-032736	Echinops telfairi	50.94	5.00e-121	428.00
IUUC-Eca-034211	Equus caballus	53.37	1.00e-151	530.00
IUUC-Eeu-034797	Erinaceus europaeus	67.26	1.00e-67	250.00
IUUC-Fca-035947	Felis catus	53.34	0.00e+00	763.00
IUUC-Fal-037199	Ficedula albicollis	55.85	0.00e+00	750.00
IUUC-Gmo-039228	Gadus morhua	84.52	0.00e+00	687.00
IUUC-Gga-040823	Gallus gallus	73.36	1.00e-92	333.00
IUUC-Ggo-045402	Gorilla gorilla	59.95	2.00e-148	520.00
IUUC-Hsa-046430	Homo sapiens	51.07	0.00e+00	802.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	48.17	2.00e-121	429.00
IUUC-Lch-049547	Latimeria chalumnae	52.77	0.00e+00	823.00
IUUC-Loc-052842	Lepisosteus oculatus	64.29	0.00e+00	1038.00
IUUC-Laf-053988	Loxodonta africana	53.37	1.00e-151	530.00
IUUC-Mcc-055491	Macaca mulatta	60.25	2.00e-144	506.00
IUUC-Meu-056256	Macropus eugenii	69.16	2.00e-87	317.00
IUUC-Mla-059026	Melampsora laricipopulina	33.50	1.00e-19	91.30
IUUC-Mga-059833	Meleagris gallopavo	73.36	8.00e-93	334.00
IUUC-Mmr-060952	Microcebus murinus	54.62	1.00e-147	516.00
IUUC-Mdo-062642	Monodelphis domestica	65.60	4.00e-152	531.00
IUUC-Mmu-063945	Mus musculus	52.49	0.00e+00	819.00
IUUC-Mpu-065944	Mustela putorius furo	51.48	3.00e-145	509.00
IUUC-Mlu-067049	Myotis lucifugus	52.23	0.00e+00	784.00
IUUC-Nle-069828	Nomascus leucogenys	60.39	5.00e-148	518.00
IUUC-Opr-070672	Ochotona princeps	46.68	1.00e-89	324.00
IUUC-Ont-072121	Oreochromis niloticus	79.34	0.00e+00	1233.00
IUUC-Oan-073656	Ornithorhynchus anatinus	55.19	0.00e+00	851.00
IUUC-Ocu-074323	Oryctolagus cuniculus	52.54	0.00e+00	801.00
IUUC-Ola-087238	Oryzias latipes	77.83	0.00e+00	1235.00
IUUC-Oga-088379	Otolemur garnettii	51.80	0.00e+00	769.00
IUUC-Oar-089718	Ovis aries	52.58	0.00e+00	784.00
IUUC-Ptr-091358	Pan troglodytes	59.95	8.00e-149	521.00
IUUC-Pan-092023	Papio anubis	59.95	2.00e-148	520.00
IUUC-Psi-093256	Pelodiscus sinensis	63.31	2.00e-156	546.00
IUUC-Pfo-097285	Poecilia formosa	75.40	0.00e+00	1109.00
IUUC-Pab-098539	Pongo abelii	51.07	0.00e+00	814.00
IUUC-Pca-100610	Procavia capensis	55.91	5.00e-102	365.00
IUUC-Pva-102985	Pteropus vampyrus	59.89	3.00e-136	479.00
IUUC-Rno-105538	Rattus norvegicus	53.86	2.00e-152	532.00
IUUC-Sha-107022	Sarcophilus harrisii	61.18	1.00e-144	506.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	31.46	5.00e-20	93.20
IUUC-Sar-113637	Sorex araneus	53.66	9.00e-146	510.00
IUUC-Ssc-115870	Sus scrofa	53.70	0.00e+00	831.00
IUUC-Tgu-116907	Taeniopygia guttata	57.30	0.00e+00	876.00
IUUC-Tru-117835	Takifugu rubripes	68.55	0.00e+00	1003.00
IUUC-Tsy-118869	Tarsius syrichta	51.95	4.00e-116	412.00
IUUC-Tni-119716	Tetraodon nigroviridis	74.17	0.00e+00	902.00
IUUC-Tbe-128041	Tupaia belangeri	67.24	7.00e-93	335.00
IUUC-Ttr-128901	Tursiops truncatus	50.36	0.00e+00	768.00
IUUC-Vpa-130331	Vicugna pacos	52.14	0.00e+00	744.00
IUUC-Xtr-131794	Xenopus tropicalis	48.60	0.00e+00	719.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence