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Tag Content
UUCD2 ID IUUC-Nle-069828
UUCD1 version UUC-NoL-01051
Ensembl Protein ID ENSNLEP00000016725.1
UniProt Accession G1RU01; G1RU01_NOMLE
Genbank Protein ID ENSNLEP00000016725
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID ADFV01180929
Gene Name USP45
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000013744.1 ENSNLET00000017576.1 ENSNLEP00000016725.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.50e-85 287.3 191 814
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellka 76
           G++NlgNtC++N+v+Q L+++  l++l++++ ke+  + +                ++ g+l+++l  +++++ +++k+  sp+ l+++
   Q: 191  GITNLGNTCFFNAVMQNLAQTYMLTDLMNDEIKESSTKLKIfpssdsqldplvveLSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQ 279
           9*****************************555555444446667777777888888888***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclec 159
           l+++a++f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+ec
   Q: 280  LCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCEEC 368
           *******************************99888888888888877777773443335555555555******************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................... 185
           +n+s+ ++pf+d+slp+ +++ +k++                                                               
   Q: 369  ANISTVKDPFIDISLPIIEERVSKPLlsgrmnkyrslqetdhdqysgnviienihqpraakkhssskdksqlihdrkcirklssgetvv 457
           *********************99888*************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 458  tyqknenlemngdslmfaslmnsesplnesptddsekeashsesnvdadsepsesesaskqtglfrsssgsgvhpdgplyrlsagelly 546
           ***************************************************************************************** PP
   S: 186  ..........................................................................slqdcLesftkeeel 200
                                                                                     s+q+cL +ft+ e l
   Q: 547  tketdsgdkemaeaiselrlsstvtgdqdfdrenqplsishnlcflegkhlrshspqnafqtlsqsyittskecSIQSCLYQFTSVELL 635
           ***************************************************************************************** PP
   S: 201  egenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
            g+nk+ ce+c+k+++                   a+k+l ++++P vLilhLkRf  ++++ s +k+n++v+fpl Ldl+pfc+ +++
   Q: 636  MGNNKLLCENCTKNKQkyqeeasfaekkvegvytnARKQLLISTVPAVLILHLKRF--HQAGLSVRKVNRHVDFPLVLDLAPFCSATCK 722
           ************88888999999999999999999*********************..9999************************998 PP
   S: 271  kqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgstaY 331
           +++   k+ Y L+++v HsGs+++GHY+ayvk                           + g+W++++D++V++v+e++ l+   ++aY
   Q: 723  NVSMgdKVLYGLYGIVEHSGSMREGHYTAYVKVrtpsrklsehttkkknvpglkeadseSAGQWVHVSDTYVQVVPESRALS---AQAY 808
           87667799*************************999999999999999999999888877888*******************...**** PP
   S: 332  vlfYkr 337
           +lfY+r
   Q: 809  LLFYER 814
           ****98 PP
   
Organism Nomascus leucogenys
Protein Sequence
(Fasta)
MRVKDPIKAL PEKAKRSKRP TVPHDEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 60
VCSECLKERR FYDGQLVLPS DIWLCLKCGF QGCGKNSESQ HSLKHFESSR TEPHCIIINL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Nle-069828|DUB,USP|Nomascus leucogenys
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACACCTTGG TCGCAGCGGC GGTATGGTCG CCGCAGTTTC TCGGTCTTCG CTTCGGCGAC 60
CTTAACCCCC TTGTGGGTGG GCGAGGCTGG AAGAGAGGCT CCCCACCCCA CTTGGCTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Nle-069828|DUB,USP|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG nle:100605394
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002331 Ailuropoda melanoleuca 73.30 0.00e+00 1082.00
IUUC-Apl-003512 Anas platyrhynchos 67.60 0.00e+00 1052.00
IUUC-Aca-004284 Anolis carolinensis 61.61 0.00e+00 947.00
IUUC-Ame-010735 Astyanax mexicanus 64.68 4.00e-88 318.00
IUUC-Bta-012880 Bos taurus 81.56 0.00e+00 1256.00
IUUC-Cja-019144 Callithrix jacchus 92.28 0.00e+00 1500.00
IUUC-Cfa-020971 Canis familiaris 82.67 0.00e+00 721.00
IUUC-Cpo-022497 Cavia porcellus 69.55 0.00e+00 1071.00
IUUC-Csa-023910 Chlorocebus sabaeus 93.40 0.00e+00 1427.00
IUUC-Cho-024358 Choloepus hoffmanni 61.42 2.00e-107 382.00
IUUC-Dre-028106 Danio rerio 60.67 1.00e-149 523.00
IUUC-Dno-029456 Dasypus novemcinctus 76.53 0.00e+00 704.00
IUUC-Dor-030438 Dipodomys ordii 64.31 0.00e+00 945.00
IUUC-Dme-031870 Drosophila melanogaster 47.31 1.00e-36 148.00
IUUC-Ete-032736 Echinops telfairi 64.73 0.00e+00 927.00
IUUC-Eca-034211 Equus caballus 82.68 0.00e+00 1323.00
IUUC-Eeu-034797 Erinaceus europaeus 82.58 4.00e-86 311.00
IUUC-Fca-035947 Felis catus 77.66 0.00e+00 1138.00
IUUC-Fal-037199 Ficedula albicollis 67.21 0.00e+00 922.00
IUUC-Gmo-039228 Gadus morhua 61.11 4.00e-139 488.00
IUUC-Gga-040823 Gallus gallus 64.05 3.00e-166 578.00
IUUC-Gac-042406 Gasterosteus aculeatus 60.39 2.00e-135 476.00
IUUC-Ggo-045402 Gorilla gorilla 96.70 0.00e+00 1573.00
IUUC-Hsa-046430 Homo sapiens 96.32 0.00e+00 1573.00
IUUC-Itr-048855 Ictidomys tridecemlineatus 82.05 0.00e+00 756.00
IUUC-Lch-049547 Latimeria chalumnae 58.60 0.00e+00 905.00
IUUC-Loc-052842 Lepisosteus oculatus 58.72 0.00e+00 888.00
IUUC-Laf-053988 Loxodonta africana 83.19 0.00e+00 1338.00
IUUC-Mcc-055491 Macaca mulatta 89.23 0.00e+00 1434.00
IUUC-Meu-056256 Macropus eugenii 64.88 7.00e-176 610.00
IUUC-Mtr-057945 Medicago truncatula 30.96 3.00e-32 134.00
IUUC-Mla-059026 Melampsora laricipopulina 31.22 1.00e-16 81.30
IUUC-Mga-059833 Meleagris gallopavo 60.51 1.00e-168 586.00
IUUC-Mmr-060952 Microcebus murinus 84.72 0.00e+00 1330.00
IUUC-Mdo-062642 Monodelphis domestica 70.65 0.00e+00 1078.00
IUUC-Mmu-063945 Mus musculus 77.05 0.00e+00 1207.00
IUUC-Mpu-065944 Mustela putorius furo 75.46 0.00e+00 1158.00
IUUC-Mlu-067049 Myotis lucifugus 81.49 0.00e+00 1249.00
IUUC-Opr-070672 Ochotona princeps 70.27 9.00e-141 494.00
IUUC-Ont-072121 Oreochromis niloticus 59.37 1.00e-133 470.00
IUUC-Oan-073656 Ornithorhynchus anatinus 64.46 0.00e+00 1013.00
IUUC-Ocu-074323 Oryctolagus cuniculus 80.95 0.00e+00 1248.00
IUUC-Ola-087238 Oryzias latipes 59.95 3.00e-145 508.00
IUUC-Oga-088379 Otolemur garnettii 77.15 0.00e+00 1216.00
IUUC-Oar-089718 Ovis aries 81.56 0.00e+00 1258.00
IUUC-Ptr-091358 Pan troglodytes 96.57 0.00e+00 1574.00
IUUC-Pan-092023 Papio anubis 94.49 0.00e+00 1529.00
IUUC-Psi-093256 Pelodiscus sinensis 66.34 0.00e+00 981.00
IUUC-Pfo-097285 Poecilia formosa 51.72 2.00e-119 422.00
IUUC-Pab-098539 Pongo abelii 97.06 0.00e+00 1585.00
IUUC-Pca-100610 Procavia capensis 67.81 0.00e+00 913.00
IUUC-Pva-102985 Pteropus vampyrus 89.49 0.00e+00 685.00
IUUC-Rno-105538 Rattus norvegicus 76.56 0.00e+00 1209.00
IUUC-Sha-107022 Sarcophilus harrisii 73.44 8.00e-180 624.00
IUUC-Sja-107712 Schizosaccharomyces japonicus 28.09 6.00e-21 96.30
IUUC-Spo-108149 Schizosaccharomyces pombe 30.66 2.00e-20 94.40
IUUC-Sar-113637 Sorex araneus 69.96 0.00e+00 1050.00
IUUC-Ssc-115870 Sus scrofa 81.56 0.00e+00 1306.00
IUUC-Tgu-116907 Taeniopygia guttata 67.64 0.00e+00 1059.00
IUUC-Tru-117835 Takifugu rubripes 52.50 4.00e-109 389.00
IUUC-Tsy-118869 Tarsius syrichta 84.30 0.00e+00 1191.00
IUUC-Tni-119716 Tetraodon nigroviridis 64.37 5.00e-92 332.00
IUUC-Tbe-128041 Tupaia belangeri 65.93 0.00e+00 946.00
IUUC-Ttr-128901 Tursiops truncatus 80.44 0.00e+00 1262.00
IUUC-Vpa-130331 Vicugna pacos 82.43 0.00e+00 1182.00
IUUC-Xtr-131794 Xenopus tropicalis 52.96 0.00e+00 781.00
Created Date 25-Jun-2017

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