iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093734

Ensembl Protein ID

ENSPSIP00000020522.1

UniProt Accession

K7GJR1; K7GJR1_PELSI

Genbank Protein ID

ENSPSIP00000020522

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AGCU01115720

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000018148.1	ENSPSIT00000020619.1	ENSPSIP00000020522.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	89.31	0.00e+00	1587.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
803	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Pelodiscus sinensis

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

LGNGGGRGGV SKKRGHVLLL NEAALTNQDF AVDVNTALPL QVAPASVPMD LRLDHQFSMP 60
VTEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGGAAACG GTGGTGGGAG GGGAGGTGTT TCCAAAAAGA GGGGGCACGT TTTGCTTTTA 60
AATGAAGCTG CATTGACAAA CCAAGATTGA GGCCTTTTAC AATATGAAAT CTGAGACATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000749	Aegilops tauschii	48.56	8.00e-61	228.00
IUUC-Aml-002279	Ailuropoda melanoleuca	89.76	0.00e+00	1644.00
IUUC-Atr-002745	Amborella trichopoda	36.69	1.00e-71	263.00
IUUC-Apl-003250	Anas platyrhynchos	92.33	0.00e+00	1689.00
IUUC-Aca-004668	Anolis carolinensis	84.57	0.00e+00	1638.00
IUUC-Aly-006432	Arabidopsis lyrata	40.66	1.00e-68	253.00
IUUC-Ath-007355	Arabidopsis thaliana	41.97	2.00e-74	273.00
IUUC-Ago-007972	Ashbya gossypii	37.84	3.00e-69	256.00
IUUC-Acl-008187	Aspergillus clavatus	39.69	1.00e-71	264.00
IUUC-Afl-008399	Aspergillus flavus	43.88	1.00e-40	160.00
IUUC-Afu-008954	Aspergillus fumigatus	35.81	6.00e-59	221.00
IUUC-Ani-009142	Aspergillus nidulans	38.50	2.00e-67	250.00
IUUC-Ang-009522	Aspergillus niger	29.34	4.00e-34	139.00
IUUC-Aor-010069	Aspergillus oryzae	38.22	2.00e-65	243.00
IUUC-Ate-010291	Aspergillus terreus	40.36	2.00e-73	270.00
IUUC-Ame-010780	Astyanax mexicanus	39.12	5.00e-73	269.00
IUUC-Bta-013215	Bos taurus	88.78	0.00e+00	1627.00
IUUC-Bci-013789	Botrytis cinerea	36.23	4.00e-66	245.00
IUUC-Bdi-014007	Brachypodium distachyon	41.24	9.00e-72	264.00
IUUC-Bol-015468	Brassica oleracea	41.33	8.00e-75	274.00
IUUC-Bra-016680	Brassica rapa	41.58	2.00e-74	273.00
IUUC-Cel-018220	Caenorhabditis elegans	38.22	2.00e-66	247.00
IUUC-Cja-019816	Callithrix jacchus	89.00	0.00e+00	1660.00
IUUC-Cfa-020861	Canis familiaris	88.82	0.00e+00	1617.00
IUUC-Cpo-021562	Cavia porcellus	87.55	0.00e+00	1637.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	51.13	2.00e-53	201.00
IUUC-Csa-023612	Chlorocebus sabaeus	88.95	0.00e+00	1628.00
IUUC-Csv-026359	Ciona savignyi	53.72	1.00e-89	322.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	35.49	2.00e-65	243.00
IUUC-Cne-026978	Cryptococcus neoformans	38.50	2.00e-72	266.00
IUUC-Dre-028284	Danio rerio	85.35	0.00e+00	847.00
IUUC-Dno-029951	Dasypus novemcinctus	87.02	0.00e+00	1535.00
IUUC-Dor-030362	Dipodomys ordii	78.23	0.00e+00	1368.00
IUUC-Dse-031186	Dothistroma septosporum	34.00	7.00e-61	228.00
IUUC-Dme-031766	Drosophila melanogaster	56.63	7.00e-158	551.00
IUUC-Ete-032279	Echinops telfairi	36.48	2.00e-55	210.00
IUUC-Eca-033842	Equus caballus	43.14	5.00e-75	276.00
IUUC-Eeu-034487	Erinaceus europaeus	51.44	9.00e-61	228.00
IUUC-Fca-036187	Felis catus	90.51	0.00e+00	1642.00
IUUC-Fox-038067	Fusarium oxysporum	37.19	1.00e-65	243.00
IUUC-Fso-038263	Fusarium solani	36.21	1.00e-65	244.00
IUUC-Gmo-038473	Gadus morhua	77.55	0.00e+00	763.00
IUUC-Ggr-040062	Gaeumannomyces graminis	38.83	2.00e-64	239.00
IUUC-Gga-040501	Gallus gallus	94.23	0.00e+00	1725.00
IUUC-Gac-042335	Gasterosteus aculeatus	84.32	0.00e+00	839.00
IUUC-Gma-043738	Glycine max	42.15	5.00e-66	245.00
IUUC-Ggo-045380	Gorilla gorilla	88.99	0.00e+00	1632.00
IUUC-Hsa-046925	Homo sapiens	89.37	0.00e+00	1654.00
IUUC-Hvu-047285	Hordeum vulgare	42.65	5.00e-72	264.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	88.54	0.00e+00	1592.00
IUUC-Kpa-049281	Komagataella pastoris	38.13	9.00e-71	261.00
IUUC-Lch-050325	Latimeria chalumnae	84.45	0.00e+00	1511.00
IUUC-Lpe-051214	Leersia perrieri	42.94	6.00e-75	275.00
IUUC-Loc-052231	Lepisosteus oculatus	81.95	0.00e+00	1470.00
IUUC-Lma-053263	Leptosphaeria maculans	39.05	1.00e-73	271.00
IUUC-Laf-054490	Loxodonta africana	83.57	0.00e+00	1575.00
IUUC-Mcc-055265	Macaca mulatta	88.92	0.00e+00	1663.00
IUUC-Meu-056676	Macropus eugenii	87.42	0.00e+00	751.00
IUUC-Mor-057095	Magnaporthe oryzae	36.10	7.00e-67	248.00
IUUC-Mpo-057389	Magnaporthe poae	37.98	1.00e-63	237.00
IUUC-Mtr-058463	Medicago truncatula	39.12	1.00e-68	253.00
IUUC-Mla-059143	Melampsora laricipopulina	40.16	1.00e-68	253.00
IUUC-Mmr-061633	Microcebus murinus	80.40	0.00e+00	1444.00
IUUC-Mdo-062198	Monodelphis domestica	42.57	1.00e-75	278.00
IUUC-Mmu-063089	Mus musculus	88.47	0.00e+00	1587.00
IUUC-Mac-064630	Musa acuminata	41.19	2.00e-71	263.00
IUUC-Mpu-065887	Mustela putorius furo	88.99	0.00e+00	1648.00
IUUC-Mlu-067470	Myotis lucifugus	89.79	0.00e+00	1661.00
IUUC-Nfi-068404	Neosartorya fischeri	38.93	1.00e-70	260.00
IUUC-Ncr-068672	Neurospora crassa	36.95	4.00e-67	249.00
IUUC-Nle-069099	Nomascus leucogenys	84.91	0.00e+00	1055.00
IUUC-Opr-071074	Ochotona princeps	43.86	2.00e-85	310.00
IUUC-Ont-071613	Oreochromis niloticus	72.57	0.00e+00	1271.00
IUUC-Oan-073275	Ornithorhynchus anatinus	92.60	0.00e+00	1690.00
IUUC-Ocu-074627	Oryctolagus cuniculus	44.70	2.00e-83	304.00
IUUC-Oba-075489	Oryza barthii	42.53	1.00e-73	270.00
IUUC-Obr-076150	Oryza brachyantha	42.53	1.00e-74	273.00
IUUC-Ogl-077437	Oryza glaberrima	42.53	4.00e-74	272.00
IUUC-Ogu-078370	Oryza glumaepatula	43.10	2.00e-74	273.00
IUUC-Oin-079210	Oryza indica	43.10	2.00e-74	273.00
IUUC-Olo-080971	Oryza longistaminata	44.33	5.00e-65	241.00
IUUC-Oni-082031	Oryza nivara	43.10	2.00e-74	273.00
IUUC-Opu-083471	Oryza punctata	43.10	2.00e-74	273.00
IUUC-Oru-084755	Oryza rufipogon	43.10	2.00e-74	273.00
IUUC-Osa-085447	Oryza sativa	43.10	2.00e-74	273.00
IUUC-Ola-087031	Oryzias latipes	67.50	0.00e+00	1189.00
IUUC-Oga-088201	Otolemur garnettii	82.60	0.00e+00	1461.00
IUUC-Oar-089997	Ovis aries	80.95	0.00e+00	1363.00
IUUC-Ptr-091116	Pan troglodytes	89.28	0.00e+00	1670.00
IUUC-Pan-092132	Papio anubis	90.21	0.00e+00	1099.00
IUUC-Pma-094347	Petromyzon marinus	71.37	0.00e+00	710.00
IUUC-Pno-095131	Phaeosphaeria nodorum	45.65	2.00e-64	239.00
IUUC-Ppa-095550	Physcomitrella patens	42.90	7.00e-72	265.00
IUUC-Pfo-096293	Poecilia formosa	70.00	0.00e+00	1191.00
IUUC-Pab-098491	Pongo abelii	86.34	0.00e+00	1572.00
IUUC-Pop-099174	Populus trichocarpa	38.34	3.00e-69	256.00
IUUC-Pca-101004	Procavia capensis	76.74	0.00e+00	877.00
IUUC-Ppe-101644	Prunus persica	40.46	5.00e-72	265.00
IUUC-Pva-102961	Pteropus vampyrus	67.00	0.00e+00	825.00
IUUC-Ptt-103841	Puccinia triticina	38.40	1.00e-67	251.00
IUUC-Pte-104383	Pyrenophora teres	39.07	1.00e-71	264.00
IUUC-Pyt-104427	Pyrenophora triticirepentis	40.24	7.00e-71	261.00
IUUC-Rno-105005	Rattus norvegicus	88.75	0.00e+00	1561.00
IUUC-Sce-106274	Saccharomyces cerevisiae	35.92	1.00e-65	244.00
IUUC-Sha-107646	Sarcophilus harrisii	66.38	0.00e+00	1028.00
IUUC-Sja-107915	Schizosaccharomyces japonicus	37.25	3.00e-71	262.00
IUUC-Spo-108300	Schizosaccharomyces pombe	38.46	3.00e-73	269.00
IUUC-Smo-109615	Selaginella moellendorffii	42.86	3.00e-77	282.00
IUUC-Sit-110160	Setaria italica	41.79	3.00e-69	256.00
IUUC-Sly-111164	Solanum lycopersicum	43.23	9.00e-77	281.00
IUUC-Stu-112685	Solanum tuberosum	38.16	2.00e-57	216.00
IUUC-Sar-113692	Sorex araneus	34.45	2.00e-45	177.00
IUUC-Sbi-114301	Sorghum bicolor	41.38	1.00e-67	250.00
IUUC-Sre-115013	Sporisorium reilianum	39.90	2.00e-68	253.00
IUUC-Ssc-115428	Sus scrofa	88.43	0.00e+00	1598.00
IUUC-Tgu-116776	Taeniopygia guttata	93.10	0.00e+00	1711.00
IUUC-Tru-118180	Takifugu rubripes	83.47	0.00e+00	828.00
IUUC-Tsy-119468	Tarsius syrichta	83.77	0.00e+00	736.00
IUUC-Tni-120196	Tetraodon nigroviridis	69.71	0.00e+00	1252.00
IUUC-Tca-121312	Theobroma cacao	43.31	4.00e-75	275.00
IUUC-Tre-121930	Trichoderma reesei	38.73	2.00e-71	263.00
IUUC-Tvi-122373	Trichoderma virens	37.68	6.00e-68	251.00
IUUC-Tae-123064	Triticum aestivum	40.80	5.00e-67	247.00
IUUC-Tme-127027	Tuber melanosporum	38.17	7.00e-61	227.00
IUUC-Tbe-127675	Tupaia belangeri	38.64	1.00e-19	92.00
IUUC-Ttr-128360	Tursiops truncatus	81.56	0.00e+00	944.00
IUUC-Uma-129408	Ustilago maydis	43.07	1.00e-68	254.00
IUUC-Vda-129994	Verticillium dahliae	41.54	3.00e-62	233.00
IUUC-Vpa-130525	Vicugna pacos	57.89	2.00e-16	80.50
IUUC-Vvi-131038	Vitis vinifera	40.56	6.00e-75	275.00
IUUC-Xtr-132956	Xenopus tropicalis	80.06	0.00e+00	1444.00
IUUC-Xma-134265	Xiphophorus maculatus	69.32	0.00e+00	1203.00
IUUC-Yli-134680	Yarrowia lipolytica	40.10	2.00e-67	250.00
IUUC-Zma-135110	Zea mays	41.95	4.00e-70	258.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence