iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009669

Ensembl Protein ID

CAK48279

UniProt Accession

A5ABI1; A5ABI1_ASPNC

Genbank Protein ID

CAK48279.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AM270218

Gene Name

An11g00460

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An11g00460	CAK48279	CAK48279

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-54	185.3	19	552

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGa............gglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlw + +q++l++++vllv+             g +G+E+lKnLvl G+g +t+vD + v+  +l+ +F++++e+ gks+Ae +++ l+elnpdv+
   Q: 19   YDRQLRLWAASGQQALEESRVLLVNSdepwgkhntgvsGVVGVETLKNLVLPGIGGFTIVDPALVTEPDLGVNFFLEEESLGKSRAEETCRLLRELNPDVD 119
           ************************96333333333333679************************************************************ PP
   S: 90   veah....eesiteleeeivFfkkfdvVv.laldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd.....dppqktiPfctlketp 180
           ++++    ++sitel +e  F+ ++++V+ ++  +r +   + ++  +  +p i +++ G++++ +  ++    + + ++     +++++ +P+++l+   
   Q: 120  GSFYtkteHKSITELLKEPDFLPQHKLVLvSGPVKRPSLEAICKAAKAFGIPVIYTRSVGFYSTFSLQLPAAFPIVETHPdpestQDLRLLNPWPELAAAG 220
           *9982222568999988877*******9615666777776777777777*********************8655555555499999*************96 PP
   S: 181  n..........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks....edeenfeeaieiavkafakttins.ikqllksfecdivt 266
           +           ++ +++++ l+ ++le+++++++++ +++++ek+e+++ v+s++++      een++ea+++++k++++++  s  ++++++ ec+   
   Q: 221  AsirnldslddHQHGHVPYILLLLHHLEQWKEAHNGQVPSNYKEKSEFREMVRSSARTsnpeGGEENYDEAVAAVLKSLNPFSLRSsLREIFEMEECKHPA 321
           66667788888**********************************************966655689********************9************** PP
   S: 267  kskspfwv.........................................................................sfcsnaealq.......... 284
            ++++fw+                                                                          fc+na+ ++          
   Q: 322  PDSANFWIiaaaireyyqrhsvlplpgslpdmkaqsadyvslqniykskarkdieevtkivrsleaqlgprpapasdkdieVFCKNAAHIKvihgrdipiv 422
           *********************************************************************************99999999996666655555 PP
   S: 285  .....vpekvekdeevvkasap........lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlra......eslgiepkldddlikeiagnii 366
                +    +k  +++    +        +++l  ++   ++ k+++   l+ e+  dsa+d +  a+  +       e+ + ++   +++ +e+ ++  
   Q: 423  dgeasI----LKAIRNNINIPDslvptflaFQVLDDIITDIQAGKKSEE-ALDDEQAWDSAIDRILGAL--KSedpsaiEEEDARE-RIQQAAQELRRTQG 515
           543331....222222211111244566668888888888888888876.4444444444555555554..331122224444444.44455667889999 PP
   S: 367  paiattnavvgGlaaqEviKvvsgkfeplknfflfda 403
           ++++ +++  gGl+aqE++Kv++ +++pl+n+ +fd+
   Q: 516  GELHNISSLTGGLVAQEALKVITRQYVPLDNTCIFDG 552
           ***********************************97 PP

Organism

Aspergillus niger

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

Protein Sequence
(Fasta)

MAEAFPSALV VPSSKERKYD RQLRLWAASG QQALEESRVL LVNSDEPWGK HNTGVSGVVG 60
VETLKNLVLP GIGGFTIVDP ALVTEPDLGV NFFLEEESLG KSRAEETCRL LRELNPDVDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGAGG CCTTCCCGAG TGCTTTGGTT GTACCATCCT CGAAAGAGAG GAAATATGAT 60
CGCCAATTGC GCTTGTGGGC AGCAAGTGGG CAGCAAGCTC TAGAAGAGTC CCGCGTGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	32.79	2.00e-74	271.00
IUUC-Aml-002333	Ailuropoda melanoleuca	33.57	3.00e-82	297.00
IUUC-Atr-002644	Amborella trichopoda	31.94	3.00e-64	237.00
IUUC-Apl-003446	Anas platyrhynchos	32.48	5.00e-74	270.00
IUUC-Aca-004450	Anolis carolinensis	32.34	9.00e-81	292.00
IUUC-Aly-006187	Arabidopsis lyrata	32.12	2.00e-74	271.00
IUUC-Ath-007600	Arabidopsis thaliana	32.67	6.00e-76	276.00
IUUC-Ago-007900	Ashbya gossypii	24.55	1.00e-30	125.00
IUUC-Acl-008333	Aspergillus clavatus	75.31	0.00e+00	845.00
IUUC-Afl-008529	Aspergillus flavus	78.15	0.00e+00	877.00
IUUC-Afu-009071	Aspergillus fumigatus	77.26	0.00e+00	872.00
IUUC-Ani-009443	Aspergillus nidulans	73.89	0.00e+00	804.00
IUUC-Aor-009914	Aspergillus oryzae	78.01	0.00e+00	876.00
IUUC-Ate-010450	Aspergillus terreus	76.55	0.00e+00	865.00
IUUC-Ame-011183	Astyanax mexicanus	34.22	3.00e-88	317.00
IUUC-Bgr-012111	Blumeria graminis	45.86	1.00e-126	445.00
IUUC-Bta-012583	Bos taurus	33.51	3.00e-83	300.00
IUUC-Bci-013892	Botrytis cinerea	47.95	1.00e-139	488.00
IUUC-Bdi-014592	Brachypodium distachyon	32.79	2.00e-72	264.00
IUUC-Bol-016401	Brassica oleracea	32.12	1.00e-78	285.00
IUUC-Bra-017506	Brassica rapa	31.94	3.00e-73	267.00
IUUC-Cel-018456	Caenorhabditis elegans	29.05	1.00e-59	222.00
IUUC-Cja-020007	Callithrix jacchus	33.33	2.00e-82	298.00
IUUC-Cfa-020324	Canis familiaris	33.33	3.00e-83	300.00
IUUC-Cpo-022248	Cavia porcellus	29.21	1.00e-42	165.00
IUUC-Csa-023149	Chlorocebus sabaeus	30.49	4.00e-59	220.00
IUUC-Cho-024537	Choloepus hoffmanni	26.83	3.00e-45	174.00
IUUC-Cin-025763	Ciona intestinalis	34.60	5.00e-78	283.00
IUUC-Csv-026113	Ciona savignyi	34.87	8.00e-82	296.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	44.83	4.00e-124	436.00
IUUC-Cne-026884	Cryptococcus neoformans	30.80	2.00e-60	224.00
IUUC-Dre-028140	Danio rerio	33.87	5.00e-86	310.00
IUUC-Dno-030033	Dasypus novemcinctus	35.51	6.00e-74	269.00
IUUC-Dor-030513	Dipodomys ordii	50.45	4.00e-24	103.00
IUUC-Dse-031536	Dothistroma septosporum	46.21	4.00e-138	483.00
IUUC-Dme-031683	Drosophila melanogaster	33.57	4.00e-77	280.00
IUUC-Ete-032420	Echinops telfairi	29.41	2.00e-62	231.00
IUUC-Eca-033992	Equus caballus	29.78	2.00e-56	211.00
IUUC-Eeu-034713	Erinaceus europaeus	51.85	4.00e-26	110.00
IUUC-Fca-036548	Felis catus	32.97	4.00e-82	296.00
IUUC-Fal-037600	Ficedula albicollis	31.03	5.00e-70	256.00
IUUC-Fox-038037	Fusarium oxysporum	46.19	2.00e-135	474.00
IUUC-Fso-038387	Fusarium solani	45.33	2.00e-137	480.00
IUUC-Gmo-038562	Gadus morhua	33.39	7.00e-85	306.00
IUUC-Ggr-040005	Gaeumannomyces graminis	46.56	5.00e-141	492.00
IUUC-Gga-041129	Gallus gallus	33.57	4.00e-79	287.00
IUUC-Gac-042558	Gasterosteus aculeatus	34.69	2.00e-85	308.00
IUUC-Gma-043610	Glycine max	31.90	2.00e-69	254.00
IUUC-Ggo-045611	Gorilla gorilla	33.51	5.00e-82	296.00
IUUC-Hsa-046563	Homo sapiens	33.69	8.00e-84	302.00
IUUC-Hvu-047790	Hordeum vulgare	30.27	8.00e-45	172.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	34.05	2.00e-82	298.00
IUUC-Kpa-049309	Komagataella pastoris	33.81	1.00e-70	258.00
IUUC-Lch-050038	Latimeria chalumnae	32.68	4.00e-75	273.00
IUUC-Lpe-051535	Leersia perrieri	29.90	2.00e-53	201.00
IUUC-Loc-051917	Lepisosteus oculatus	32.57	4.00e-74	270.00
IUUC-Lma-053112	Leptosphaeria maculans	48.96	1.00e-153	534.00
IUUC-Laf-053690	Loxodonta africana	32.97	1.00e-82	298.00
IUUC-Mcc-055117	Macaca mulatta	32.56	3.00e-78	283.00
IUUC-Meu-056761	Macropus eugenii	27.50	9.00e-55	206.00
IUUC-Mor-057230	Magnaporthe oryzae	46.48	9.00e-140	488.00
IUUC-Mpo-057514	Magnaporthe poae	47.38	4.00e-134	469.00
IUUC-Mtr-058551	Medicago truncatula	30.99	4.00e-68	250.00
IUUC-Mla-059183	Melampsora laricipopulina	33.16	2.00e-80	291.00
IUUC-Mga-060144	Meleagris gallopavo	32.55	4.00e-75	273.00
IUUC-Mvi-060221	Microbotryum violaceum	37.14	2.00e-64	238.00
IUUC-Mmr-061325	Microcebus murinus	32.80	9.00e-78	282.00
IUUC-Mdo-062532	Monodelphis domestica	33.87	2.00e-84	304.00
IUUC-Mmu-063956	Mus musculus	33.51	7.00e-84	302.00
IUUC-Mac-064521	Musa acuminata	30.92	1.00e-67	248.00
IUUC-Mpu-066716	Mustela putorius furo	35.28	1.00e-73	269.00
IUUC-Mlu-067459	Myotis lucifugus	32.92	2.00e-84	304.00
IUUC-Nfi-068245	Neosartorya fischeri	76.73	0.00e+00	867.00
IUUC-Ncr-068910	Neurospora crassa	47.99	2.00e-148	516.00
IUUC-Nle-070034	Nomascus leucogenys	31.68	5.00e-74	270.00
IUUC-Opr-070552	Ochotona princeps	33.85	9.00e-64	236.00
IUUC-Ont-071426	Oreochromis niloticus	33.69	1.00e-84	305.00
IUUC-Oan-073389	Ornithorhynchus anatinus	31.52	2.00e-54	204.00
IUUC-Ocu-074911	Oryctolagus cuniculus	33.27	9.00e-83	299.00
IUUC-Oba-075437	Oryza barthii	31.34	3.00e-61	227.00
IUUC-Obr-076684	Oryza brachyantha	30.98	2.00e-56	211.00
IUUC-Ogl-077170	Oryza glaberrima	31.34	3.00e-61	227.00
IUUC-Ogu-078844	Oryza glumaepatula	30.87	5.00e-54	203.00
IUUC-Oin-079105	Oryza indica	31.34	3.00e-61	227.00
IUUC-Olo-080943	Oryza longistaminata	28.19	1.00e-47	182.00
IUUC-Oni-082891	Oryza nivara	28.80	4.00e-55	207.00
IUUC-Opu-083457	Oryza punctata	31.52	1.00e-60	225.00
IUUC-Oru-084960	Oryza rufipogon	28.19	9.00e-48	182.00
IUUC-Osa-085358	Oryza sativa	31.52	3.00e-61	227.00
IUUC-Ola-086420	Oryzias latipes	32.10	2.00e-54	204.00
IUUC-Olu-087625	Ostreococcus lucimarinus	27.46	3.00e-38	151.00
IUUC-Oga-088810	Otolemur garnettii	33.51	7.00e-84	302.00
IUUC-Oar-089196	Ovis aries	33.15	2.00e-81	294.00
IUUC-Ptr-090617	Pan troglodytes	33.51	5.00e-83	300.00
IUUC-Pan-092761	Papio anubis	33.69	3.00e-84	303.00
IUUC-Psi-093191	Pelodiscus sinensis	31.50	1.00e-74	272.00
IUUC-Pma-094380	Petromyzon marinus	38.50	4.00e-75	273.00
IUUC-Pno-095084	Phaeosphaeria nodorum	46.35	2.00e-134	472.00
IUUC-Ppa-095798	Physcomitrella patens	29.98	7.00e-65	239.00
IUUC-Pfo-096467	Poecilia formosa	33.81	7.00e-85	306.00
IUUC-Pab-098255	Pongo abelii	35.73	2.00e-74	271.00
IUUC-Pop-099722	Populus trichocarpa	31.89	7.00e-74	269.00
IUUC-Pca-100807	Procavia capensis	34.87	4.00e-24	103.00
IUUC-Ppe-101280	Prunus persica	32.55	9.00e-76	275.00
IUUC-Pva-102333	Pteropus vampyrus	32.50	8.00e-75	272.00
IUUC-Pgr-103401	Puccinia graminis	31.56	3.00e-72	264.00
IUUC-Ptt-103889	Puccinia triticina	29.69	4.00e-70	257.00
IUUC-Pte-104355	Pyrenophora teres	50.87	8.00e-158	548.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	50.35	8.00e-158	548.00
IUUC-Rno-105810	Rattus norvegicus	32.97	5.00e-82	296.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.87	2.00e-29	121.00
IUUC-Sha-106770	Sarcophilus harrisii	38.00	7.00e-49	185.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	30.52	1.00e-68	252.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.01	5.00e-77	280.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	48.49	4.00e-142	496.00
IUUC-Smo-109296	Selaginella moellendorffii	32.32	2.00e-74	271.00
IUUC-Sit-110157	Setaria italica	32.49	1.00e-72	265.00
IUUC-Sly-111105	Solanum lycopersicum	31.63	9.00e-74	269.00
IUUC-Stu-112469	Solanum tuberosum	31.80	2.00e-74	271.00
IUUC-Sar-113083	Sorex araneus	23.90	2.00e-41	161.00
IUUC-Sbi-113813	Sorghum bicolor	31.44	2.00e-69	254.00
IUUC-Sre-115058	Sporisorium reilianum	36.17	5.00e-65	240.00
IUUC-Tgu-116772	Taeniopygia guttata	31.83	9.00e-72	262.00
IUUC-Tru-118686	Takifugu rubripes	33.45	3.00e-85	307.00
IUUC-Tsy-119111	Tarsius syrichta	34.25	2.00e-38	151.00
IUUC-Tni-120231	Tetraodon nigroviridis	30.18	3.00e-71	261.00
IUUC-Tca-121491	Theobroma cacao	31.72	1.00e-67	248.00
IUUC-Tre-122103	Trichoderma reesei	46.14	3.00e-136	476.00
IUUC-Tvi-122672	Trichoderma virens	45.80	4.00e-134	469.00
IUUC-Tae-125684	Triticum aestivum	32.79	6.00e-75	273.00
IUUC-Tur-126487	Triticum urartu	31.81	3.00e-70	257.00
IUUC-Tme-127097	Tuber melanosporum	38.45	1.00e-96	345.00
IUUC-Ttr-128465	Tursiops truncatus	31.00	3.00e-66	244.00
IUUC-Uma-129645	Ustilago maydis	37.12	8.00e-69	253.00
IUUC-Vda-129989	Verticillium dahliae	42.15	6.00e-106	375.00
IUUC-Vpa-130529	Vicugna pacos	31.54	2.00e-70	258.00
IUUC-Vvi-131059	Vitis vinifera	31.65	6.00e-73	266.00
IUUC-Xtr-132002	Xenopus tropicalis	34.05	2.00e-84	305.00
IUUC-Xma-133930	Xiphophorus maculatus	34.46	1.00e-82	298.00
IUUC-Yli-134505	Yarrowia lipolytica	33.45	8.00e-77	279.00
IUUC-Zma-135895	Zea mays	32.07	1.00e-69	255.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence