iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007116

UUCD1 version

UUC-ArT-01465

Ensembl Protein ID

AT3G24800.1

UniProt Accession

Q8LBL5; O82767; PRT1_ARATH

Genbank Protein ID

CAA11891.1; CAA11892.1; BAB02890.1; AEE76948.1; AAL87280.1; AAM45125.1; AAM64697.1

Protein Name

E3 ubiquitin-protein ligase PRT1; Proteolysis 1 protein; RING-type E3 ubiquitin transferase PRT1

Genbank Nucleotide ID

AJ224306; AJ224307; AB028609; CP002686; AY080799; AY114077; AY087139

Gene Name

PRT1; At3g24800; K7P8.9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G24800	AT3G24800.1	AT3G24800.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19255443

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	4.60e-05	24.3	19	68
E3 activity/RING/RING	2.40e-05	25.6	192	232

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqp 49
           e+p++flC + lel   P vl++G+     +++k ++  ++  cP++r p
   Q: 19   EIPDQFLCCVCLELLYKPIVLSCGHLSCFWCVHKSMNGFREsHCPICRDP 68
           69***********************8777777777766666667777766 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+ C+e + + p+vl+CgHv+++ C+  +     ++s +++C  C+
   Q: 192  CSACKELLVR-PVVLNCGHVYCEGCVVDM----AEESEKIKCQECN 232
           999*******.999***********8444....4666666666664 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Functions in the N-end rule pathway of protein degradation, where it specifically recognizes and ubiquitinates proteins with a N-terminal bulky aromatic amino acid (Phe). Does not act on aliphatic hydrophobic and basic N-terminal residues (Arg or Leu) containing proteins.

Protein Sequence
(Fasta)

MAETMKDITM KNDESQEEEI PDQFLCCVCL ELLYKPIVLS CGHLSCFWCV HKSMNGFRES 60
HCPICRDPYV HFPSVCQKLY FLLKKMYPLA HKKREEQVLK EEQERECFSP QIDLVLDLSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGCGGTGG ATATTGGCCC TTGCCGCAAA AGCAAAAGCT ATCGCCACCA CCGTGTCATA 60
AATCTCAGAT CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR000433--Znf_ZZ

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF13445--zf-RING_UBOX
PF00569--ZZ

SMART

SM00184--RING
SM00291--ZnF_ZZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

ath:AT3G24800

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000257	Aegilops tauschii	38.16	2.00e-51	195.00
IUUC-Aml-001856	Ailuropoda melanoleuca	36.78	2.00e-11	63.20
IUUC-Atr-002773	Amborella trichopoda	42.82	2.00e-82	299.00
IUUC-Apl-004001	Anas platyrhynchos	34.09	1.00e-10	60.50
IUUC-Aly-005558	Arabidopsis lyrata	89.69	0.00e+00	728.00
IUUC-Bta-012806	Bos taurus	31.33	9.00e-13	67.40
IUUC-Bdi-014243	Brachypodium distachyon	47.09	3.00e-78	284.00
IUUC-Bol-015948	Brassica oleracea	75.98	7.00e-165	572.00
IUUC-Bra-017661	Brassica rapa	74.35	4.00e-160	556.00
IUUC-Cja-019478	Callithrix jacchus	30.71	2.00e-11	63.20
IUUC-Cfa-021253	Canis familiaris	36.78	2.00e-11	63.50
IUUC-Cpo-022551	Cavia porcellus	32.06	1.00e-11	63.50
IUUC-Cre-023002	Chlamydomonas reinhardtii	39.39	6.00e-15	74.30
IUUC-Csa-023499	Chlorocebus sabaeus	36.90	3.00e-11	62.40
IUUC-Cho-024665	Choloepus hoffmanni	30.46	2.00e-12	65.50
IUUC-Dno-029161	Dasypus novemcinctus	33.93	2.00e-11	62.80
IUUC-Ete-032643	Echinops telfairi	32.50	3.00e-10	59.30
IUUC-Eca-034435	Equus caballus	32.69	2.00e-11	62.80
IUUC-Eeu-034787	Erinaceus europaeus	32.77	9.00e-12	63.90
IUUC-Fca-035970	Felis catus	35.63	3.00e-11	62.80
IUUC-Fal-036727	Ficedula albicollis	31.86	1.00e-11	63.50
IUUC-Gmo-039048	Gadus morhua	35.53	2.00e-08	53.10
IUUC-Gga-041098	Gallus gallus	38.33	1.00e-07	49.70
IUUC-Gma-042780	Glycine max	43.22	6.00e-86	310.00
IUUC-Ggo-045045	Gorilla gorilla	36.90	5.00e-11	61.60
IUUC-Hsa-046155	Homo sapiens	31.30	2.00e-11	63.20
IUUC-Hvu-047093	Hordeum vulgare	46.80	2.00e-78	285.00
IUUC-Itr-049066	Ictidomys tridecemlineatus	35.29	1.00e-10	60.10
IUUC-Lch-050654	Latimeria chalumnae	33.61	1.00e-13	70.10
IUUC-Lpe-051555	Leersia perrieri	43.04	5.00e-79	287.00
IUUC-Loc-051851	Lepisosteus oculatus	35.24	2.00e-11	63.20
IUUC-Laf-053600	Loxodonta africana	38.83	2.00e-12	66.60
IUUC-Mcc-054824	Macaca mulatta	36.90	3.00e-11	62.40
IUUC-Meu-056219	Macropus eugenii	47.22	2.00e-05	43.90
IUUC-Mor-057023	Magnaporthe oryzae	46.51	2.00e-05	44.30
IUUC-Mtr-058729	Medicago truncatula	47.65	4.00e-91	327.00
IUUC-Mga-059577	Meleagris gallopavo	36.36	7.00e-12	64.30
IUUC-Mmr-061031	Microcebus murinus	36.90	5.00e-11	61.60
IUUC-Mdo-062696	Monodelphis domestica	37.93	1.00e-12	67.00
IUUC-Mmu-063190	Mus musculus	30.43	9.00e-11	60.80
IUUC-Mac-064489	Musa acuminata	46.83	9.00e-89	319.00
IUUC-Mpu-065811	Mustela putorius furo	36.05	5.00e-11	61.60
IUUC-Mlu-067273	Myotis lucifugus	37.21	3.00e-11	62.40
IUUC-Nle-069226	Nomascus leucogenys	36.47	2.00e-11	62.80
IUUC-Opr-071014	Ochotona princeps	38.10	1.00e-11	63.50
IUUC-Ont-072113	Oreochromis niloticus	34.15	2.00e-09	56.20
IUUC-Oan-073600	Ornithorhynchus anatinus	37.14	3.00e-13	68.60
IUUC-Ocu-073920	Oryctolagus cuniculus	36.14	3.00e-10	59.30
IUUC-Oba-075420	Oryza barthii	43.14	1.00e-78	286.00
IUUC-Obr-076775	Oryza brachyantha	40.15	3.00e-74	271.00
IUUC-Ogl-077466	Oryza glaberrima	43.14	3.00e-78	284.00
IUUC-Ogu-079019	Oryza glumaepatula	43.71	4.00e-79	288.00
IUUC-Oin-079647	Oryza indica	43.14	2.00e-78	285.00
IUUC-Olo-080366	Oryza longistaminata	41.77	5.00e-45	174.00
IUUC-Ome-081125	Oryza meridionalis	42.47	2.00e-78	285.00
IUUC-Oni-082331	Oryza nivara	43.14	2.00e-78	285.00
IUUC-Opu-083181	Oryza punctata	42.51	2.00e-77	281.00
IUUC-Oru-085025	Oryza rufipogon	41.03	1.00e-67	249.00
IUUC-Osa-085632	Oryza sativa	43.14	1.00e-78	286.00
IUUC-Ola-087064	Oryzias latipes	32.93	9.00e-09	54.30
IUUC-Olu-087700	Ostreococcus lucimarinus	27.30	5.00e-26	111.00
IUUC-Oga-088121	Otolemur garnettii	33.65	1.00e-11	63.90
IUUC-Oar-090404	Ovis aries	31.58	5.00e-12	65.10
IUUC-Ptr-090824	Pan troglodytes	36.90	5.00e-11	61.60
IUUC-Pan-091820	Papio anubis	36.90	3.00e-11	62.40
IUUC-Psi-093328	Pelodiscus sinensis	32.28	8.00e-11	61.20
IUUC-Ppa-095542	Physcomitrella patens	34.87	4.00e-57	215.00
IUUC-Pfo-096138	Poecilia formosa	27.66	1.00e-10	60.10
IUUC-Pab-097808	Pongo abelii	36.90	4.00e-11	62.00
IUUC-Pop-099802	Populus trichocarpa	44.44	1.00e-73	270.00
IUUC-Pca-100409	Procavia capensis	36.17	3.00e-11	62.40
IUUC-Ppe-101330	Prunus persica	45.16	3.00e-86	311.00
IUUC-Pva-103043	Pteropus vampyrus	32.69	6.00e-12	64.70
IUUC-Rno-105559	Rattus norvegicus	30.43	9.00e-11	60.80
IUUC-Sha-107404	Sarcophilus harrisii	42.47	6.00e-10	58.20
IUUC-Sit-110342	Setaria italica	43.36	4.00e-75	274.00
IUUC-Sly-111024	Solanum lycopersicum	44.06	3.00e-84	304.00
IUUC-Stu-112506	Solanum tuberosum	45.00	4.00e-80	291.00
IUUC-Sbi-114720	Sorghum bicolor	48.84	1.00e-41	162.00
IUUC-Ssc-115421	Sus scrofa	35.96	7.00e-12	63.90
IUUC-Tgu-116564	Taeniopygia guttata	34.48	3.00e-11	62.40
IUUC-Tru-118271	Takifugu rubripes	32.53	2.00e-08	53.10
IUUC-Tsy-119122	Tarsius syrichta	34.31	1.00e-11	63.90
IUUC-Tni-120019	Tetraodon nigroviridis	34.15	4.00e-09	55.50
IUUC-Tca-121671	Theobroma cacao	44.63	6.00e-85	307.00
IUUC-Tae-124325	Triticum aestivum	46.28	2.00e-78	285.00
IUUC-Tur-126365	Triticum urartu	48.54	3.00e-47	181.00
IUUC-Tbe-127449	Tupaia belangeri	32.09	2.00e-11	63.20
IUUC-Vpa-130501	Vicugna pacos	37.68	3.00e-08	52.40
IUUC-Vvi-131151	Vitis vinifera	45.98	3.00e-93	334.00
IUUC-Xtr-132154	Xenopus tropicalis	30.65	1.00e-11	63.90
IUUC-Xma-133774	Xiphophorus maculatus	32.61	3.00e-10	59.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence