iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	21606687; 23341779; 24497840

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	3.00e-12	47.2	660	700

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGF.dreealqaLraannnleaAveyLldg 41
           e+ ++le+l+eMGF d+ ++++ L  +n+++  +v++Ll+g
   Q: 660  EWDPILEELQEMGFcDDVTNKRLLKKNNGSIKGVVMDLLTG 700
           6889**********8888*********************87 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Autophagic substrate degraded in the vacuole by non-selective autophagy. Requires ATG8 protein expression to be recognized as an autophagic substrate (PubMed:21606687). Acts probably as a receptor for autophagosomal degradation of ubiquitinated proteins. Targets ubiquitinated protein aggregates derived from denatured or damaged non-native proteins generated under stress conditions (PubMed:23341779). Functions additively with the E3 ubiquitin-protein ligase CHIP for autophagosomal degradation of proteotoxic agregates formed under stress conditions (PubMed:24497840).

Protein Sequence
(Fasta)

MESTANALVV KVSYGGVLRR FRVPVKANGQ LDLEMAGLKE KIAALFNLSA DAELSLTYSD 60
EDGDVVALVD DNDLFDVTNQ RLKFLKINVN AGVSTNSAAP ESSGSSTPAG MPNPVSKIQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGGTTGTT TACGAGAAAA GCGGATTACG GGTACGCTTC TTCTAAGATA AATCTCTCCC 60
CGATTCTCTC TTTTTCTCGC TAGATACTCT TTTTCTTCAA TTAGGGTTTC TTCTCGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0346--Stress response
KW-0813--Transport
KW-0926--Vacuole
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032350--N_BRCA1_central
IPR000270--PB1_dom
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS50135--ZF_ZZ_2

Pfam

PF16158--N_BRCA1_IG
PF00564--PB1
PF00569--ZZ

SMART

SM00666--PB1
SM00291--ZnF_ZZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005773--C:vacuole
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051258--P:protein polymerization
GO:0015031--P:protein transport

KEGG

ath:AT4G24690

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001137	Aegilops tauschii	46.15	3.00e-44	173.00
IUUC-Aml-002034	Ailuropoda melanoleuca	34.55	5.00e-15	73.90
IUUC-Atr-003106	Amborella trichopoda	39.18	5.00e-69	255.00
IUUC-Apl-003851	Anas platyrhynchos	36.52	2.00e-14	74.30
IUUC-Aca-004390	Anolis carolinensis	34.55	2.00e-15	75.50
IUUC-Aly-006000	Arabidopsis lyrata	90.86	0.00e+00	1258.00
IUUC-Ago-007828	Ashbya gossypii	41.03	3.00e-03	36.20
IUUC-Acl-008033	Aspergillus clavatus	34.23	2.00e-13	70.50
IUUC-Afl-008503	Aspergillus flavus	28.04	1.00e-14	74.30
IUUC-Afu-008992	Aspergillus fumigatus	32.28	1.00e-13	71.60
IUUC-Ani-009220	Aspergillus nidulans	27.27	2.00e-17	83.60
IUUC-Ang-009700	Aspergillus niger	30.43	6.00e-12	65.50
IUUC-Aor-010141	Aspergillus oryzae	28.04	1.00e-14	74.30
IUUC-Ate-010391	Aspergillus terreus	27.04	4.00e-15	77.00
IUUC-Ame-011130	Astyanax mexicanus	38.18	9.00e-17	80.10
IUUC-Bgr-011970	Blumeria graminis	30.47	4.00e-13	69.70
IUUC-Bta-012882	Bos taurus	34.23	6.00e-15	73.20
IUUC-Bci-013961	Botrytis cinerea	34.65	5.00e-16	79.30
IUUC-Bdi-014744	Brachypodium distachyon	54.11	3.00e-66	246.00
IUUC-Bol-016421	Brassica oleracea	74.43	0.00e+00	1032.00
IUUC-Bra-016895	Brassica rapa	77.72	0.00e+00	1039.00
IUUC-Cel-018277	Caenorhabditis elegans	27.37	1.00e-06	46.20
IUUC-Cja-019251	Callithrix jacchus	34.23	2.00e-15	75.10
IUUC-Cfa-020453	Canis familiaris	34.55	3.00e-15	74.70
IUUC-Cpo-022257	Cavia porcellus	35.45	8.00e-16	76.30
IUUC-Cre-022890	Chlamydomonas reinhardtii	47.06	1.00e-05	42.40
IUUC-Csa-024055	Chlorocebus sabaeus	34.23	2.00e-15	75.50
IUUC-Cho-024901	Choloepus hoffmanni	35.29	9.00e-13	67.40
IUUC-Cin-025291	Ciona intestinalis	34.23	8.00e-12	63.20
IUUC-Csv-026267	Ciona savignyi	30.53	2.00e-13	69.70
IUUC-Cgl-026677	Colletotrichum gloeosporioides	34.11	2.00e-15	77.00
IUUC-Cne-026958	Cryptococcus neoformans	38.81	4.00e-06	46.60
IUUC-Cme-027152	Cyanidioschyzon merolae	28.26	3.00e-06	46.20
IUUC-Dre-028775	Danio rerio	37.27	6.00e-17	80.50
IUUC-Dno-029146	Dasypus novemcinctus	34.55	5.00e-15	74.30
IUUC-Dor-030521	Dipodomys ordii	35.00	3.00e-12	64.70
IUUC-Dse-031315	Dothistroma septosporum	37.30	2.00e-17	84.00
IUUC-Ete-032729	Echinops telfairi	38.64	4.00e-06	44.30
IUUC-Eca-033862	Equus caballus	34.55	3.00e-15	74.70
IUUC-Fca-035369	Felis catus	34.55	2.00e-15	75.10
IUUC-Fal-037400	Ficedula albicollis	35.77	3.00e-15	77.00
IUUC-Fox-037767	Fusarium oxysporum	31.21	1.00e-13	71.20
IUUC-Fso-038322	Fusarium solani	26.10	3.00e-15	77.00
IUUC-Gmo-039306	Gadus morhua	36.36	5.00e-16	77.40
IUUC-Ggr-039790	Gaeumannomyces graminis	31.58	5.00e-12	66.20
IUUC-Gga-040557	Gallus gallus	35.14	5.00e-16	77.40
IUUC-Gac-042189	Gasterosteus aculeatus	38.18	3.00e-17	81.60
IUUC-Gma-044280	Glycine max	53.38	4.00e-89	322.00
IUUC-Ggo-044838	Gorilla gorilla	34.23	2.00e-15	75.50
IUUC-Hsa-046338	Homo sapiens	34.23	2.00e-15	75.50
IUUC-Hvu-047467	Hordeum vulgare	43.35	9.00e-92	330.00
IUUC-Itr-048172	Ictidomys tridecemlineatus	35.83	6.00e-14	72.80
IUUC-Lch-050368	Latimeria chalumnae	37.84	6.00e-17	80.50
IUUC-Lpe-051565	Leersia perrieri	50.00	8.00e-68	251.00
IUUC-Loc-052938	Lepisosteus oculatus	36.36	3.00e-16	78.60
IUUC-Lma-053158	Leptosphaeria maculans	33.33	8.00e-14	71.60
IUUC-Laf-053897	Loxodonta africana	34.55	8.00e-15	73.60
IUUC-Mcc-055768	Macaca mulatta	34.92	5.00e-14	72.80
IUUC-Meu-056136	Macropus eugenii	38.14	9.00e-14	71.20
IUUC-Mor-057101	Magnaporthe oryzae	33.63	9.00e-13	68.60
IUUC-Mpo-057563	Magnaporthe poae	32.54	1.00e-14	74.70
IUUC-Mtr-058592	Medicago truncatula	56.93	1.00e-85	310.00
IUUC-Mla-059018	Melampsora laricipopulina	42.20	7.00e-20	88.20
IUUC-Mga-059604	Meleagris gallopavo	35.45	5.00e-16	77.40
IUUC-Mvi-060452	Microbotryum violaceum	37.21	1.00e-14	75.50
IUUC-Mmr-061682	Microcebus murinus	34.55	5.00e-15	74.30
IUUC-Mdo-061908	Monodelphis domestica	35.45	4.00e-16	77.40
IUUC-Mmu-063205	Mus musculus	34.55	5.00e-15	74.30
IUUC-Mac-064456	Musa acuminata	46.44	3.00e-98	352.00
IUUC-Mpu-065953	Mustela putorius furo	34.55	3.00e-15	74.70
IUUC-Mlu-067887	Myotis lucifugus	32.14	3.00e-15	77.00
IUUC-Nfi-068336	Neosartorya fischeri	31.97	1.00e-13	71.20
IUUC-Ncr-068640	Neurospora crassa	25.19	1.00e-11	65.10
IUUC-Nle-068992	Nomascus leucogenys	34.55	2.00e-15	75.10
IUUC-Opr-070967	Ochotona princeps	34.55	3.00e-15	74.70
IUUC-Ont-071773	Oreochromis niloticus	36.94	7.00e-17	80.50
IUUC-Oan-072758	Ornithorhynchus anatinus	35.45	8.00e-16	76.60
IUUC-Ocu-073962	Oryctolagus cuniculus	34.55	3.00e-15	74.70
IUUC-Oba-075551	Oryza barthii	53.33	2.00e-68	253.00
IUUC-Obr-076023	Oryza brachyantha	53.78	3.00e-67	249.00
IUUC-Ogl-076946	Oryza glaberrima	53.33	2.00e-68	253.00
IUUC-Ogu-078367	Oryza glumaepatula	53.33	2.00e-68	253.00
IUUC-Oin-079583	Oryza indica	53.33	2.00e-68	253.00
IUUC-Olo-080804	Oryza longistaminata	34.93	4.00e-72	265.00
IUUC-Ome-081656	Oryza meridionalis	53.33	2.00e-68	253.00
IUUC-Oni-082599	Oryza nivara	53.33	2.00e-68	253.00
IUUC-Opu-083123	Oryza punctata	53.33	2.00e-68	253.00
IUUC-Oru-084697	Oryza rufipogon	45.33	4.00e-55	209.00
IUUC-Osa-085636	Oryza sativa	45.33	4.00e-55	209.00
IUUC-Ola-087050	Oryzias latipes	38.18	4.00e-17	81.30
IUUC-Oga-088976	Otolemur garnettii	34.55	3.00e-15	75.10
IUUC-Oar-090044	Ovis aries	34.55	2.00e-15	74.70
IUUC-Ptr-091534	Pan troglodytes	34.55	1.00e-15	75.50
IUUC-Pan-091725	Papio anubis	34.55	2.00e-15	75.50
IUUC-Psi-093398	Pelodiscus sinensis	37.61	4.00e-15	76.60
IUUC-Pma-094658	Petromyzon marinus	33.33	5.00e-14	70.50
IUUC-Pno-095009	Phaeosphaeria nodorum	34.13	2.00e-15	77.40
IUUC-Ppa-095723	Physcomitrella patens	33.01	9.00e-64	237.00
IUUC-Pfo-096761	Poecilia formosa	36.94	6.00e-17	80.50
IUUC-Pab-098767	Pongo abelii	34.55	2.00e-15	75.50
IUUC-Pop-099888	Populus trichocarpa	44.14	3.00e-141	494.00
IUUC-Pca-100636	Procavia capensis	34.55	3.00e-15	74.30
IUUC-Ppe-101351	Prunus persica	49.42	1.00e-130	459.00
IUUC-Pva-102727	Pteropus vampyrus	34.55	3.00e-15	74.70
IUUC-Pgr-103390	Puccinia graminis	37.84	2.00e-17	85.10
IUUC-Ptt-103754	Puccinia triticina	38.33	5.00e-18	85.90
IUUC-Pte-104190	Pyrenophora teres	32.03	2.00e-14	73.90
IUUC-Pyt-104763	Pyrenophora triticirepentis	32.81	1.00e-14	74.70
IUUC-Rno-105086	Rattus norvegicus	34.23	6.00e-15	73.20
IUUC-Sha-106861	Sarcophilus harrisii	38.98	2.00e-14	74.30
IUUC-Sja-108012	Schizosaccharomyces japonicus	25.93	1.00e-05	43.10
IUUC-Spo-108198	Schizosaccharomyces pombe	25.33	1.00e-11	63.50
IUUC-Ssl-108620	Sclerotinia sclerotiorum	34.40	5.00e-16	79.30
IUUC-Smo-109175	Selaginella moellendorffii	49.11	2.00e-21	95.50
IUUC-Sit-110140	Setaria italica	53.12	1.00e-66	247.00
IUUC-Sly-111022	Solanum lycopersicum	47.68	1.00e-112	399.00
IUUC-Stu-112479	Solanum tuberosum	50.10	9.00e-113	400.00
IUUC-Sar-113740	Sorex araneus	35.83	8.00e-14	72.00
IUUC-Sbi-114660	Sorghum bicolor	43.95	1.00e-51	197.00
IUUC-Ssc-116108	Sus scrofa	35.83	6.00e-14	72.80
IUUC-Tgu-117107	Taeniopygia guttata	34.55	9.00e-16	76.60
IUUC-Tru-118418	Takifugu rubripes	36.94	3.00e-17	81.60
IUUC-Tsy-119265	Tarsius syrichta	36.00	2.00e-13	69.70
IUUC-Tni-120405	Tetraodon nigroviridis	36.94	3.00e-17	81.60
IUUC-Tca-120994	Theobroma cacao	55.23	3.00e-86	312.00
IUUC-Tre-122001	Trichoderma reesei	33.07	2.00e-13	70.90
IUUC-Tvi-122435	Trichoderma virens	34.15	1.00e-14	74.70
IUUC-Tae-123486	Triticum aestivum	44.08	9.00e-93	334.00
IUUC-Tur-126775	Triticum urartu	43.66	4.00e-90	325.00
IUUC-Tme-127010	Tuber melanosporum	32.46	2.00e-10	60.50
IUUC-Tbe-127236	Tupaia belangeri	34.71	3.00e-13	70.50
IUUC-Ttr-128373	Tursiops truncatus	34.55	4.00e-15	73.90
IUUC-Vda-129885	Verticillium dahliae	33.72	1.00e-03	37.70
IUUC-Vpa-130341	Vicugna pacos	34.23	1.00e-14	72.40
IUUC-Vvi-131325	Vitis vinifera	46.33	1.00e-105	377.00
IUUC-Xtr-132375	Xenopus tropicalis	34.88	8.00e-14	72.00
IUUC-Xma-133093	Xiphophorus maculatus	36.94	8.00e-17	80.50
IUUC-Yli-134387	Yarrowia lipolytica	50.00	6.00e-07	48.10
IUUC-Zma-135636	Zea mays	55.17	3.00e-65	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence