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Tag Content
iUUCD ID IUUC-Oan-073191
Ensembl Protein ID ENSOANP00000006246.2
UniProt Accession F6U0B5; F6U0B5_ORNAN
Protein Name Ubiquitin-related modifier 1
Gene Name URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOANG00000003949.2 ENSOANT00000006248.2 ENSOANP00000006246.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 42.86 2.00e-14 71.20 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Ornithorhynchus anatinus
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
LCLRPNCRGG VELLFDGVKK HLVTLPSQAE PWDIRHLLVW IQSNLLKERP ELFIQGDSVR 60
PGILVLINDA DWELLGELDY QLKDQDNIIF ISTLHGG 97
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Protein Fasta Sequence


>IUUC-Oan-073191|ULD,UBQ_Other|Ornithorhynchus anatinus
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Nucleotide Sequence
(Fasta)
CTCTGTCTCC GTCCAAATTG CAGAGGTGGA GTCGAACTCC TGTTTGACGG CGTGAAGAAG 60
CACCTGGTGA CCTTGCCCAG CCAGGCAGAG CCCTGTGAGT AGCTGATCTG TGCAGGCTGT 120
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Nucleotide Fasta Sequence


>IUUC-Oan-073191|ULD,UBQ_Other|Ornithorhynchus anatinus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 79.38 7.00e-42 160.00
IUUC-Atr-003089 Amborella trichopoda 60.44 2.00e-27 112.00
IUUC-Apl-003382 Anas platyrhynchos 84.44 5.00e-42 160.00
IUUC-Aca-004981 Anolis carolinensis 76.29 1.00e-41 160.00
IUUC-Aly-005517 Arabidopsis lyrata 55.32 4.00e-28 115.00
IUUC-Ath-006718 Arabidopsis thaliana 55.95 1.00e-23 100.00
IUUC-Ago-007917 Ashbya gossypii 40.66 8.00e-17 77.40
IUUC-Acl-008054 Aspergillus clavatus 70.00 5.00e-16 74.70
IUUC-Afl-008704 Aspergillus flavus 55.06 4.00e-21 91.30
IUUC-Aor-009890 Aspergillus oryzae 52.48 5.00e-23 99.00
IUUC-Bta-012448 Bos taurus 80.41 5.00e-42 161.00
IUUC-Bci-013865 Botrytis cinerea 46.24 2.00e-19 86.70
IUUC-Bdi-014980 Brachypodium distachyon 63.38 7.00e-24 101.00
IUUC-Bol-016055 Brassica oleracea 53.66 1.00e-23 100.00
IUUC-Bra-016845 Brassica rapa 53.66 1.00e-23 100.00
IUUC-Cel-018485 Caenorhabditis elegans 34.38 1.00e-08 50.40
IUUC-Cja-019587 Callithrix jacchus 81.44 3.00e-42 161.00
IUUC-Cfa-020653 Canis familiaris 81.44 4.00e-42 161.00
IUUC-Cpo-021622 Cavia porcellus 81.44 3.00e-42 161.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 53.33 2.00e-23 99.80
IUUC-Csa-023756 Chlorocebus sabaeus 88.06 4.00e-30 122.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 46.24 7.00e-20 88.20
IUUC-Cne-026953 Cryptococcus neoformans 53.40 4.00e-27 112.00
IUUC-Cme-027314 Cyanidioschyzon merolae 46.67 3.00e-16 75.50
IUUC-Dre-027884 Danio rerio 73.20 2.00e-39 152.00
IUUC-Dno-029262 Dasypus novemcinctus 86.76 8.00e-30 122.00
IUUC-Dor-030601 Dipodomys ordii 75.38 1.00e-21 93.60
IUUC-Dme-031893 Drosophila melanogaster 61.80 3.00e-28 115.00
IUUC-Ete-032773 Echinops telfairi 84.09 6.00e-40 154.00
IUUC-Eca-034187 Equus caballus 82.47 3.00e-42 162.00
IUUC-Eeu-034808 Erinaceus europaeus 78.35 3.00e-41 158.00
IUUC-Fca-036107 Felis catus 81.44 1.00e-42 162.00
IUUC-Fal-036607 Ficedula albicollis 82.22 1.00e-40 156.00
IUUC-Fox-037698 Fusarium oxysporum 46.81 4.00e-20 89.00
IUUC-Gmo-039492 Gadus morhua 78.65 2.00e-39 152.00
IUUC-Ggr-039965 Gaeumannomyces graminis 47.31 1.00e-17 81.30
IUUC-Gga-041268 Gallus gallus 78.35 2.00e-41 159.00
IUUC-Gac-042111 Gasterosteus aculeatus 83.15 2.00e-41 159.00
IUUC-Gma-043240 Glycine max 62.50 2.00e-22 96.30
IUUC-Ggo-045176 Gorilla gorilla 86.57 2.00e-23 100.00
IUUC-Hsa-046077 Homo sapiens 79.38 2.00e-35 139.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 85.39 4.00e-35 137.00
IUUC-Kpa-049157 Komagataella pastoris 44.44 1.00e-17 80.10
IUUC-Lch-049889 Latimeria chalumnae 79.78 4.00e-41 158.00
IUUC-Lpe-050783 Leersia perrieri 65.08 7.00e-22 94.40
IUUC-Loc-052400 Lepisosteus oculatus 73.20 1.00e-39 153.00
IUUC-Lma-053259 Leptosphaeria maculans 48.39 1.00e-19 87.40
IUUC-Laf-053596 Loxodonta africana 78.79 3.00e-40 155.00
IUUC-Mcc-054845 Macaca mulatta 85.39 3.00e-41 159.00
IUUC-Meu-055968 Macropus eugenii 88.76 2.00e-42 162.00
IUUC-Mor-057126 Magnaporthe oryzae 44.09 5.00e-16 75.50
IUUC-Mpo-057311 Magnaporthe poae 48.39 6.00e-19 85.50
IUUC-Mtr-058266 Medicago truncatula 59.38 2.00e-21 93.20
IUUC-Mla-058847 Melampsora laricipopulina 42.11 9.00e-13 64.70
IUUC-Mga-059468 Meleagris gallopavo 84.44 8.00e-42 160.00
IUUC-Mvi-060235 Microbotryum violaceum 61.19 1.00e-17 81.60
IUUC-Mdo-061948 Monodelphis domestica 86.52 1.00e-41 160.00
IUUC-Mmu-063946 Mus musculus 82.47 7.00e-43 164.00
IUUC-Mac-064812 Musa acuminata 70.31 5.00e-25 104.00
IUUC-Mpu-066763 Mustela putorius furo 81.44 4.00e-41 158.00
IUUC-Mlu-066970 Myotis lucifugus 89.55 2.00e-30 122.00
IUUC-Ncr-068824 Neurospora crassa 45.74 6.00e-18 81.60
IUUC-Nle-069849 Nomascus leucogenys 88.06 4.00e-30 122.00
IUUC-Opr-070227 Ochotona princeps 81.44 3.00e-42 161.00
IUUC-Ont-072530 Oreochromis niloticus 85.39 1.00e-42 163.00
IUUC-Ocu-074460 Oryctolagus cuniculus 82.47 2.00e-42 162.00
IUUC-Oba-075499 Oryza barthii 65.62 3.00e-22 97.10
IUUC-Obr-076896 Oryza brachyantha 62.50 2.00e-21 95.10
IUUC-Ogl-077834 Oryza glaberrima 65.62 9.00e-23 97.40
IUUC-Ogu-078622 Oryza glumaepatula 65.62 9.00e-23 97.40
IUUC-Oin-079358 Oryza indica 65.62 2.00e-22 97.80
IUUC-Olo-081035 Oryza longistaminata 53.61 4.00e-23 100.00
IUUC-Oni-082425 Oryza nivara 65.62 9.00e-23 97.40
IUUC-Opu-083461 Oryza punctata 65.08 6.00e-22 95.90
IUUC-Oru-084875 Oryza rufipogon 59.15 8.00e-21 90.50
IUUC-Oga-089128 Otolemur garnettii 82.47 3.00e-42 162.00
IUUC-Oar-089896 Ovis aries 80.41 5.00e-42 161.00
IUUC-Ptr-091618 Pan troglodytes 86.57 2.00e-23 100.00
IUUC-Pan-092238 Papio anubis 88.06 5.00e-30 122.00
IUUC-Psi-093879 Pelodiscus sinensis 82.02 1.00e-40 156.00
IUUC-Pma-094484 Petromyzon marinus 77.22 1.00e-32 130.00
IUUC-Ppa-095801 Physcomitrella patens 56.79 1.00e-21 94.00
IUUC-Pfo-097192 Poecilia formosa 85.39 8.00e-42 160.00
IUUC-Pab-098203 Pongo abelii 85.39 2.00e-35 139.00
IUUC-Pop-099614 Populus trichocarpa 53.57 4.00e-23 98.60
IUUC-Pca-100507 Procavia capensis 88.06 3.00e-30 122.00
IUUC-Ppe-101174 Prunus persica 57.14 3.00e-26 108.00
IUUC-Pva-102735 Pteropus vampyrus 79.38 3.00e-38 149.00
IUUC-Pgr-103510 Puccinia graminis 41.05 1.00e-10 57.80
IUUC-Ptt-103918 Puccinia triticina 37.89 6.00e-10 55.50
IUUC-Pte-104173 Pyrenophora teres 49.46 1.00e-20 90.90
IUUC-Pyt-104806 Pyrenophora triticirepentis 49.46 1.00e-20 90.90
IUUC-Rno-105820 Rattus norvegicus 83.51 3.00e-43 165.00
IUUC-Sce-106366 Saccharomyces cerevisiae 42.86 6.00e-15 71.20
IUUC-Sja-107727 Schizosaccharomyces japonicus 39.58 6.00e-16 75.10
IUUC-Spo-108074 Schizosaccharomyces pombe 37.76 9.00e-09 50.80
IUUC-Smo-108944 Selaginella moellendorffii 60.67 8.00e-26 107.00
IUUC-Sit-110277 Setaria italica 64.06 1.00e-22 96.70
IUUC-Sly-111505 Solanum lycopersicum 52.38 9.00e-24 100.00
IUUC-Stu-112076 Solanum tuberosum 53.57 3.00e-24 102.00
IUUC-Sbi-114274 Sorghum bicolor 56.58 5.00e-23 98.60
IUUC-Sre-114953 Sporisorium reilianum 56.38 7.00e-24 101.00
IUUC-Ssc-115418 Sus scrofa 81.44 5.00e-42 161.00
IUUC-Tgu-117311 Taeniopygia guttata 82.22 1.00e-40 155.00
IUUC-Tru-118598 Takifugu rubripes 79.78 7.00e-40 154.00
IUUC-Tni-120109 Tetraodon nigroviridis 77.78 3.00e-37 145.00
IUUC-Tca-120942 Theobroma cacao 55.42 7.00e-24 100.00
IUUC-Tre-122099 Trichoderma reesei 50.54 1.00e-16 77.00
IUUC-Tvi-122285 Trichoderma virens 50.50 1.00e-17 80.50
IUUC-Tae-125193 Triticum aestivum 67.19 1.00e-22 96.70
IUUC-Tur-126677 Triticum urartu 56.58 7.00e-20 88.20
IUUC-Tme-127120 Tuber melanosporum 48.39 6.00e-20 88.20
IUUC-Tbe-128050 Tupaia belangeri 55.67 8.00e-24 100.00
IUUC-Ttr-129019 Tursiops truncatus 79.38 5.00e-39 151.00
IUUC-Uma-129483 Ustilago maydis 52.00 2.00e-22 96.30
IUUC-Vda-129690 Verticillium dahliae 43.75 4.00e-18 82.40
IUUC-Vvi-131174 Vitis vinifera 56.63 3.00e-23 99.00
IUUC-Xma-133862 Xiphophorus maculatus 85.39 8.00e-42 160.00
IUUC-Yli-134398 Yarrowia lipolytica 48.35 3.00e-18 82.40
IUUC-Zma-134964 Zea mays 55.56 5.00e-22 95.10
Created Date 25-Jun-2017

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