iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091013

UUCD1 version

UUC-PaT-00151

Ensembl Protein ID

ENSPTRP00000022190.4

UniProt Accession

H2QJJ1; H2QJJ1_PANTR

Genbank Protein ID

JAA07153.1; JAA18109.1; JAA29927.1; JAA37341.1

Protein Name

Cullin 3

Genbank Nucleotide ID

AACZ03019104; GABF01004036; GABD01003173; GABE01007398

Gene Name

CUL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000012986.5	ENSPTRT00000024062.4	ENSPTRP00000022190.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.90e-230	766.8	37	665

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
           l++a+++i+r++++  ++eely+++y+++l+k+g+klY+ l+ev++e++ ++v+++v +s ++++L+t+n++W++++++++++r+i++y
   Q: 37   LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLiNKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 125
           799*********************************************99*************************************** PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleat 176
           +dr+yv++ ++v++v++L+l ++r+++v++  i+++l ++ll++i++eRkge+vdr  +++++++l+ L+l+ +++y+e+FEa+fle++
   Q: 126  MDRVYVQQ-NNVENVYNLGLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 213
           ********.******************************************************************************** PP
   S: 177  qefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykL 261
           +ef+++es++fl+en+ + Y+kkvear+nee er++++l++ste+++++vve+eli+kh+++++    ++lv++l++ ktedl++mykL
   Q: 214  AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVemenSGLVHMLKNGKTEDLGCMYKL 302
           ****************************************************************99999******************** PP
   S: 262  lsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspE 350
           +srv+ngl++++++++s+++eqgka++++e + k+p++y++ ll+lk+++++++ e+Fnnd+ F ++++ +fe+f+n n     ++spE
   Q: 303  FSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLN-----SRSPE 386
           *******************************************************************************.....***** PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           +l+ +iD++L+k++kglte+e+e++ldk++++f++++ekdvFe+yYk+hLa+RLl++ks+s+++E+++i+kLk+ecg++ftskLe+Mf+
   Q: 387  YLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFR 475
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekentees.esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael. 526
           d+++S++++++F+++ ++t  s  +v+l+v+vL++g+Wpt+s+t+k+++P+  ++++e+f++fYl khsgR+L++qh++g+a+l+a++ 
   Q: 476  DMSISNTTMDEFRQHLQATGVSlGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFy 564
           ********************99889**************************************************************** PP
   S: 527  .....................kkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepeskei 592
                                +++k++lqVstfQm++L++fnn+ek+++ee++++t++pe+eL r+lqsL+++k  ++vl+kep+skei
   Q: 565  gpvkkedgsevgvggaqvtgsNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEI 653
           *********999999998888888***************************************************************** PP
   S: 593  eeedlfsvNqef 604
           e++++f+vN++f
   Q: 654  ENGHIFTVNDQF 665
           **********99 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN 60
AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCAGGCGG AGGAGGAGAA GGAGGAGGAG GAGGACGACG TTCGGCCTGC GCAGTGAGAT 60
GTTTGTCCGT CGCCGCCGCC GCCGCCATCG CGGAGGAGCG CGATAAAGGG AGCCGAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0005827--C:polar microtubule
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0016477--P:cell migration
GO:0048208--P:COPII vesicle coating
GO:0040016--P:embryonic cleavage
GO:0044346--P:fibroblast apoptotic process
GO:0007369--P:gastrulation
GO:0007229--P:integrin-mediated signaling pathway
GO:0072576--P:liver morphogenesis
GO:0007080--P:mitotic metaphase plate congression
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032467--P:positive regulation of cytokinesis
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0017145--P:stem cell division
GO:0043149--P:stress fiber assembly
GO:0001831--P:trophectodermal cellular morphogenesis
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0016055--P:Wnt signaling pathway

KEGG

ptr:744812

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000335	Aegilops tauschii	47.07	0.00e+00	685.00
IUUC-Aml-002278	Ailuropoda melanoleuca	98.84	0.00e+00	1551.00
IUUC-Atr-002616	Amborella trichopoda	52.36	0.00e+00	774.00
IUUC-Apl-004172	Anas platyrhynchos	99.60	0.00e+00	1516.00
IUUC-Aca-004309	Anolis carolinensis	99.61	0.00e+00	1562.00
IUUC-Aly-005566	Arabidopsis lyrata	51.77	0.00e+00	771.00
IUUC-Ath-007587	Arabidopsis thaliana	52.16	0.00e+00	775.00
IUUC-Ago-007795	Ashbya gossypii	25.29	2.00e-48	187.00
IUUC-Acl-008317	Aspergillus clavatus	36.48	1.00e-144	506.00
IUUC-Afl-008727	Aspergillus flavus	36.53	3.00e-144	505.00
IUUC-Afu-008879	Aspergillus fumigatus	37.96	2.00e-132	466.00
IUUC-Ani-009393	Aspergillus nidulans	35.55	2.00e-135	476.00
IUUC-Ang-009626	Aspergillus niger	36.44	7.00e-141	494.00
IUUC-Aor-010207	Aspergillus oryzae	36.53	8.00e-144	504.00
IUUC-Ate-010305	Aspergillus terreus	37.16	5.00e-140	491.00
IUUC-Ame-011805	Astyanax mexicanus	96.61	0.00e+00	1513.00
IUUC-Bgr-012098	Blumeria graminis	36.02	6.00e-121	428.00
IUUC-Bta-013445	Bos taurus	99.74	0.00e+00	1564.00
IUUC-Bci-013612	Botrytis cinerea	36.61	2.00e-138	486.00
IUUC-Bdi-014269	Brachypodium distachyon	52.68	0.00e+00	749.00
IUUC-Bol-015350	Brassica oleracea	52.29	0.00e+00	773.00
IUUC-Bra-016763	Brassica rapa	52.42	0.00e+00	776.00
IUUC-Cel-018641	Caenorhabditis elegans	48.53	0.00e+00	730.00
IUUC-Cja-019175	Callithrix jacchus	99.87	0.00e+00	1566.00
IUUC-Cfa-020905	Canis familiaris	99.33	0.00e+00	1520.00
IUUC-Cpo-021293	Cavia porcellus	97.65	0.00e+00	1525.00
IUUC-Cre-022776	Chlamydomonas reinhardtii	48.30	0.00e+00	700.00
IUUC-Csa-023800	Chlorocebus sabaeus	100.00	0.00e+00	1568.00
IUUC-Cho-024839	Choloepus hoffmanni	98.68	0.00e+00	1350.00
IUUC-Cin-025201	Ciona intestinalis	71.63	0.00e+00	1028.00
IUUC-Csv-026107	Ciona savignyi	71.24	0.00e+00	1093.00
IUUC-Cgl-026630	Colletotrichum gloeosporioides	35.43	3.00e-124	439.00
IUUC-Cne-027048	Cryptococcus neoformans	34.80	3.00e-117	416.00
IUUC-Cme-027254	Cyanidioschyzon merolae	31.13	1.00e-88	320.00
IUUC-Dre-028488	Danio rerio	97.27	0.00e+00	1526.00
IUUC-Dno-029784	Dasypus novemcinctus	99.61	0.00e+00	1562.00
IUUC-Dor-030682	Dipodomys ordii	92.36	0.00e+00	1364.00
IUUC-Dse-031326	Dothistroma septosporum	35.74	3.00e-128	452.00
IUUC-Dme-032112	Drosophila melanogaster	69.43	0.00e+00	1080.00
IUUC-Ete-032347	Echinops telfairi	81.46	0.00e+00	1197.00
IUUC-Eca-033560	Equus caballus	99.60	0.00e+00	1517.00
IUUC-Eeu-034502	Erinaceus europaeus	97.65	0.00e+00	1341.00
IUUC-Fca-035544	Felis catus	99.73	0.00e+00	1517.00
IUUC-Fal-036751	Ficedula albicollis	99.73	0.00e+00	1519.00
IUUC-Fox-037857	Fusarium oxysporum	36.92	3.00e-137	482.00
IUUC-Fso-038163	Fusarium solani	36.73	4.00e-141	495.00
IUUC-Gmo-038830	Gadus morhua	96.88	0.00e+00	1523.00
IUUC-Ggr-039999	Gaeumannomyces graminis	33.76	7.00e-127	448.00
IUUC-Gga-040329	Gallus gallus	99.61	0.00e+00	1563.00
IUUC-Gac-041510	Gasterosteus aculeatus	96.51	0.00e+00	1520.00
IUUC-Gma-043659	Glycine max	52.34	0.00e+00	746.00
IUUC-Ggo-044903	Gorilla gorilla	99.87	0.00e+00	1517.00
IUUC-Hsa-046000	Homo sapiens	100.00	0.00e+00	1568.00
IUUC-Hvu-047831	Hordeum vulgare	52.60	0.00e+00	701.00
IUUC-Itr-049067	Ictidomys tridecemlineatus	99.78	0.00e+00	939.00
IUUC-Kpa-049372	Komagataella pastoris	34.94	7.00e-115	407.00
IUUC-Lch-050458	Latimeria chalumnae	97.39	0.00e+00	1520.00
IUUC-Lpe-051396	Leersia perrieri	51.63	0.00e+00	754.00
IUUC-Loc-052186	Lepisosteus oculatus	98.57	0.00e+00	1550.00
IUUC-Lma-053030	Leptosphaeria maculans	38.55	6.00e-144	504.00
IUUC-Laf-053684	Loxodonta africana	99.73	0.00e+00	1517.00
IUUC-Mcc-055770	Macaca mulatta	100.00	0.00e+00	1568.00
IUUC-Meu-056852	Macropus eugenii	100.00	0.00e+00	764.00
IUUC-Mor-057273	Magnaporthe oryzae	34.63	4.00e-132	465.00
IUUC-Mpo-057403	Magnaporthe poae	33.89	1.00e-128	454.00
IUUC-Mtr-058317	Medicago truncatula	51.84	0.00e+00	754.00
IUUC-Mla-059055	Melampsora laricipopulina	37.66	4.00e-133	468.00
IUUC-Mga-060076	Meleagris gallopavo	97.99	0.00e+00	1485.00
IUUC-Mvi-060470	Microbotryum violaceum	33.64	3.00e-135	476.00
IUUC-Mmr-060976	Microcebus murinus	99.74	0.00e+00	1564.00
IUUC-Mdo-062741	Monodelphis domestica	99.74	0.00e+00	1564.00
IUUC-Mmu-063905	Mus musculus	99.48	0.00e+00	1560.00
IUUC-Mac-064718	Musa acuminata	50.79	0.00e+00	730.00
IUUC-Mpu-066356	Mustela putorius furo	99.73	0.00e+00	1517.00
IUUC-Mlu-067768	Myotis lucifugus	99.20	0.00e+00	1514.00
IUUC-Nfi-068285	Neosartorya fischeri	37.20	1.00e-145	510.00
IUUC-Ncr-068883	Neurospora crassa	36.28	4.00e-138	485.00
IUUC-Nle-069638	Nomascus leucogenys	100.00	0.00e+00	1521.00
IUUC-Opr-070333	Ochotona princeps	90.61	0.00e+00	1267.00
IUUC-Ont-071601	Oreochromis niloticus	97.79	0.00e+00	1568.00
IUUC-Oan-073281	Ornithorhynchus anatinus	99.52	0.00e+00	1298.00
IUUC-Ocu-074504	Oryctolagus cuniculus	99.60	0.00e+00	1520.00
IUUC-Oba-075332	Oryza barthii	52.17	0.00e+00	748.00
IUUC-Obr-076790	Oryza brachyantha	49.21	0.00e+00	715.00
IUUC-Ogl-077655	Oryza glaberrima	52.16	0.00e+00	756.00
IUUC-Ogu-078458	Oryza glumaepatula	52.17	0.00e+00	748.00
IUUC-Oin-079567	Oryza indica	52.03	0.00e+00	754.00
IUUC-Olo-080930	Oryza longistaminata	52.89	0.00e+00	755.00
IUUC-Ome-081353	Oryza meridionalis	52.16	0.00e+00	756.00
IUUC-Oni-082378	Oryza nivara	52.16	0.00e+00	756.00
IUUC-Opu-084055	Oryza punctata	52.03	0.00e+00	756.00
IUUC-Oru-084202	Oryza rufipogon	52.17	0.00e+00	748.00
IUUC-Osa-085290	Oryza sativa	52.16	0.00e+00	757.00
IUUC-Ola-087562	Oryzias latipes	97.53	0.00e+00	1535.00
IUUC-Olu-087866	Ostreococcus lucimarinus	37.79	5.00e-140	491.00
IUUC-Oga-088833	Otolemur garnettii	99.73	0.00e+00	1517.00
IUUC-Oar-089958	Ovis aries	99.73	0.00e+00	1517.00
IUUC-Pan-091796	Papio anubis	99.33	0.00e+00	1512.00
IUUC-Psi-093564	Pelodiscus sinensis	97.99	0.00e+00	1483.00
IUUC-Pno-094939	Phaeosphaeria nodorum	38.22	4.00e-139	488.00
IUUC-Ppa-095920	Physcomitrella patens	51.84	0.00e+00	765.00
IUUC-Pfo-097498	Poecilia formosa	93.39	0.00e+00	1515.00
IUUC-Pab-098164	Pongo abelii	100.00	0.00e+00	1568.00
IUUC-Pop-099497	Populus trichocarpa	53.34	0.00e+00	790.00
IUUC-Pca-100702	Procavia capensis	91.67	0.00e+00	1391.00
IUUC-Ppe-101971	Prunus persica	51.96	0.00e+00	738.00
IUUC-Pva-103129	Pteropus vampyrus	99.61	0.00e+00	1563.00
IUUC-Pgr-103684	Puccinia graminis	36.44	5.00e-110	392.00
IUUC-Ptt-103961	Puccinia triticina	36.62	3.00e-109	389.00
IUUC-Pte-104325	Pyrenophora teres	37.94	8.00e-135	474.00
IUUC-Pyt-104746	Pyrenophora triticirepentis	36.97	9.00e-133	467.00
IUUC-Rno-105935	Rattus norvegicus	99.60	0.00e+00	1516.00
IUUC-Sce-106354	Saccharomyces cerevisiae	26.59	2.00e-52	200.00
IUUC-Sha-106569	Sarcophilus harrisii	99.12	0.00e+00	1382.00
IUUC-Sja-107676	Schizosaccharomyces japonicus	38.51	2.00e-154	539.00
IUUC-Spo-108135	Schizosaccharomyces pombe	37.48	4.00e-138	485.00
IUUC-Smo-109555	Selaginella moellendorffii	53.35	0.00e+00	786.00
IUUC-Sit-110763	Setaria italica	53.07	0.00e+00	765.00
IUUC-Sly-111090	Solanum lycopersicum	52.11	0.00e+00	766.00
IUUC-Stu-112351	Solanum tuberosum	52.24	0.00e+00	768.00
IUUC-Sar-113144	Sorex araneus	99.63	0.00e+00	1114.00
IUUC-Sbi-114690	Sorghum bicolor	52.29	0.00e+00	766.00
IUUC-Sre-115005	Sporisorium reilianum	37.90	1.00e-134	473.00
IUUC-Ssc-116053	Sus scrofa	99.45	0.00e+00	1139.00
IUUC-Tgu-116523	Taeniopygia guttata	99.73	0.00e+00	1517.00
IUUC-Tru-118189	Takifugu rubripes	93.88	0.00e+00	1444.00
IUUC-Tsy-118962	Tarsius syrichta	93.41	0.00e+00	1385.00
IUUC-Tni-120614	Tetraodon nigroviridis	57.09	0.00e+00	876.00
IUUC-Tca-121282	Theobroma cacao	52.81	0.00e+00	771.00
IUUC-Tre-122201	Trichoderma reesei	35.76	5.00e-133	468.00
IUUC-Tvi-122321	Trichoderma virens	36.36	3.00e-134	472.00
IUUC-Tae-124292	Triticum aestivum	52.03	0.00e+00	745.00
IUUC-Tur-126800	Triticum urartu	51.76	0.00e+00	741.00
IUUC-Tme-127053	Tuber melanosporum	40.48	8.00e-156	543.00
IUUC-Tbe-127427	Tupaia belangeri	84.92	0.00e+00	1160.00
IUUC-Ttr-128662	Tursiops truncatus	97.99	0.00e+00	1477.00
IUUC-Uma-129597	Ustilago maydis	38.26	2.00e-133	469.00
IUUC-Vda-129726	Verticillium dahliae	35.26	2.00e-133	469.00
IUUC-Vpa-130809	Vicugna pacos	99.46	0.00e+00	741.00
IUUC-Vvi-131630	Vitis vinifera	52.68	0.00e+00	760.00
IUUC-Xtr-131887	Xenopus tropicalis	98.44	0.00e+00	1544.00
IUUC-Xma-133517	Xiphophorus maculatus	97.66	0.00e+00	1538.00
IUUC-Yli-134576	Yarrowia lipolytica	33.46	3.00e-111	395.00
IUUC-Zma-135030	Zea mays	52.73	0.00e+00	772.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence