iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007588

UUCD1 version

UUC-ArT-01622

Ensembl Protein ID

AT1G70660.1

UniProt Accession

Q9CAB6; Q8L9N0; UEV1B_ARATH

Genbank Protein ID

AAG52343.1; AEE35096.1; AAO42048.1; AAO50476.1; AAM65883.1

Protein Name

Ubiquitin-conjugating enzyme E2 variant 1B; Protein MMS ZWEI HOMOLOG 2

Genbank Nucleotide ID

AC011663; CP002684; BT004011; BT004943; AY088344

Gene Name

UEV1B; MMZ2; At1g70660; F5A18.16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G70660	AT1G70660.2	AT1G70660.2
AT1G70660	AT1G70660.1	AT1G70660.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UEV	E2_UEV	18178771; 17586653

Classification

Family	E-value	Score	Start	End
E2/UBC	1.90e-17	64.2	32	133
E2/UEV	5.80e-71	237.9	1	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 17   isakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvllsiqsllae 111
           +s++++d +d  ++ w  +ilGp++t Yeg++F+l++ + +dYP +PP+v+f ++i   +v+++ G v  s +   ++W+   ++e+ l+++++ + +
   Q: 32   VSYGMDDADDilMQSWTGTILGPHNTAYEGKIFQLKLFCGKDYPESPPTVRFQSRINMACVNPEnGVVDPSHFPMLSNWRREFTMEDLLIQLKKEMMS 129
           45566666568899************************************************998999988887789***************998844 PP
   S: 112  pnpe 115
            +++
   Q: 130  SQNR 133
           3333 PP

E2/UEV

   S: 2    vseselkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevndsnGv 99
           ++++e+kvvvprnfrlleele+gekg+gdgtvsyg+dD+ddil++s+tgtI+gp++tayeg+I+qlklf+gk+YPe+PPtvrf+s+inma+vn++nGv
   Q: 1    MGSEEEKVVVPRNFRLLEELERGEKGIGDGTVSYGMDDADDILMQSWTGTILGPHNTAYEGKIFQLKLFCGKDYPESPPTVRFQSRINMACVNPENGV 98
           56899********************************************************************************************* PP
   S: 100  vdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGn 143
           vdp+++p+L+nW+re+++e++l+qlkke++s++nrkl+qP eGn
   Q: 99   VDPSHFPMLSNWRREFTMEDLLIQLKKEMMSSQNRKLAQPLEGN 142
           *******************************************8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. May play a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Protein Sequence
(Fasta)

MGSEEEKVVV PRNFRLLEEL ERGEKGIGDG TVSYGMDDAD DILMQSWTGT ILGPHNTAYE 60
GKIFQLKLFC GKDYPESPPT VRFQSRINMA CVNPENGVVD PSHFPMLSNW RREFTMEDLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTTTCTT CCTTCCATTT TTCACAATTC ATATCCTGTC TGATGAACAG TAGCTGTTAG 60
ACTCTCTCTC TTTCTCTCTT CTCTGTTCTT CTTCATCTTC TCTAGCCGAA TCCATCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

KEGG

ath:AT1G70660

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006356	Arabidopsis lyrata	97.48	9.00e-88	314.00
IUUC-Bgr-012010	Blumeria graminis	54.14	9.00e-36	141.00
IUUC-Bdi-014011	Brachypodium distachyon	72.50	2.00e-64	236.00
IUUC-Bra-016758	Brassica rapa	89.94	2.00e-81	293.00
IUUC-Cel-018398	Caenorhabditis elegans	47.41	3.00e-32	130.00
IUUC-Cgl-026596	Colletotrichum gloeosporioides	54.89	3.00e-37	146.00
IUUC-Fox-037803	Fusarium oxysporum	55.64	2.00e-38	150.00
IUUC-Ggr-039839	Gaeumannomyces graminis	42.86	3.00e-24	103.00
IUUC-Gac-041936	Gasterosteus aculeatus	51.49	6.00e-32	129.00
IUUC-Gma-042869	Glycine max	78.62	1.00e-69	254.00
IUUC-Lma-053194	Leptosphaeria maculans	56.82	7.00e-37	145.00
IUUC-Mor-056915	Magnaporthe oryzae	35.37	6.00e-19	86.30
IUUC-Mpo-057437	Magnaporthe poae	42.86	3.00e-24	103.00
IUUC-Olu-087815	Ostreococcus lucimarinus	42.76	2.00e-21	94.00
IUUC-Pte-104176	Pyrenophora teres	56.06	2.00e-37	146.00
IUUC-Pyt-104517	Pyrenophora triticirepentis	56.06	2.00e-37	146.00
IUUC-Sly-111607	Solanum lycopersicum	79.38	1.00e-70	258.00
IUUC-Stu-112160	Solanum tuberosum	79.38	1.00e-70	258.00
IUUC-Sre-114909	Sporisorium reilianum	53.03	5.00e-35	139.00
IUUC-Tre-121971	Trichoderma reesei	55.64	9.00e-38	148.00
IUUC-Tvi-122622	Trichoderma virens	54.89	4.00e-37	145.00
IUUC-Uma-129419	Ustilago maydis	53.03	5.00e-35	139.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence