iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108094

UUCD1 version

UUC-ScP-00269

Ensembl Protein ID

SPAC10F6.05c.1:pep

UniProt Accession

O42646; P78897; Q1L844; UBC6_SCHPO

Genbank Protein ID

CAA15718.1; BAA13909.1

Protein Name

Ubiquitin-conjugating enzyme E2 6; E2 ubiquitin-conjugating enzyme 6; Ubiquitin carrier protein 6; Ubiquitin-protein ligase 6

Genbank Nucleotide ID

CU329670; D89248

Gene Name

ubc6; SPAC10F6.05c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC10F6.05c	SPAC10F6.05c.1	SPAC10F6.05c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.70e-31	105.8	9	142

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.eee 90
           Rl+ke+ +l+k+p+e + akp +e ++ ew++ i+Gp+dtpYegg+++ ++ fp+dYPfkPP ++++t+  ++ +++n+++Cls+ + +++
   Q: 9    RLMKEYLALQKNPVELVDAKPATE-NILEWHYIITGPPDTPYEGGQYHGTLIFPPDYPFKPPAIRMITP--SGRFQTNTRLCLSFSDfHPK 96
           9***********************.9*******************************************..8889999********889** PP
   S: 91   kWspalsvesvllsiqsllaepnpesplneeaa...ellkknreey 133
            W+p + v+++l++++s++++ ++  +  + +    +++ k+ +++
   Q: 97   SWNPSWMVSTILVGLVSFMTSDEITTGGIVTSEstrRTYAKDTKRF 142
           *******************998888775443331225666666655 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.

Protein Sequence
(Fasta)

MASKGAYKRL MKEYLALQKN PVELVDAKPA TENILEWHYI ITGPPDTPYE GGQYHGTLIF 60
PPDYPFKPPA IRMITPSGRF QTNTRLCLSF SDFHPKSWNP SWMVSTILVG LVSFMTSDEI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAGATTGAG CCCAACGAAA AAACCACAAA AATGCAAAAT TTCCTGACAT TTCTAACTTG 60
CCCTTAGCCT ATATCACGGA AAGTTGACTT TGTGCTGCTT TGTTAATGCC ACTACTTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

spo:SPAC10F6.05c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001180	Aegilops tauschii	53.52	3.00e-23	100.00
IUUC-Aml-002152	Ailuropoda melanoleuca	52.47	4.00e-49	185.00
IUUC-Atr-003156	Amborella trichopoda	51.53	1.00e-48	184.00
IUUC-Apl-004224	Anas platyrhynchos	55.84	8.00e-48	181.00
IUUC-Aca-005049	Anolis carolinensis	53.70	2.00e-49	186.00
IUUC-Aly-006195	Arabidopsis lyrata	51.88	3.00e-46	176.00
IUUC-Ath-006640	Arabidopsis thaliana	51.25	1.00e-45	174.00
IUUC-Ago-007987	Ashbya gossypii	60.61	7.00e-61	224.00
IUUC-Acl-008060	Aspergillus clavatus	65.73	5.00e-55	205.00
IUUC-Afl-008561	Aspergillus flavus	61.29	8.00e-55	204.00
IUUC-Afu-008860	Aspergillus fumigatus	59.26	8.00e-55	205.00
IUUC-Ani-009333	Aspergillus nidulans	58.64	8.00e-55	204.00
IUUC-Ang-009810	Aspergillus niger	65.73	9.00e-55	204.00
IUUC-Aor-010127	Aspergillus oryzae	61.29	8.00e-55	204.00
IUUC-Ate-010362	Aspergillus terreus	65.73	7.00e-55	204.00
IUUC-Ame-010627	Astyanax mexicanus	53.70	1.00e-49	187.00
IUUC-Bgr-012069	Blumeria graminis	64.34	8.00e-53	197.00
IUUC-Bta-012472	Bos taurus	53.09	4.00e-49	185.00
IUUC-Bci-013843	Botrytis cinerea	62.24	2.00e-52	197.00
IUUC-Bdi-014467	Brachypodium distachyon	51.85	2.00e-47	180.00
IUUC-Bol-016116	Brassica oleracea	51.25	2.00e-46	177.00
IUUC-Bra-017777	Brassica rapa	51.25	9.00e-46	174.00
IUUC-Cel-018278	Caenorhabditis elegans	57.50	4.00e-44	169.00
IUUC-Cja-018817	Callithrix jacchus	53.79	7.00e-41	158.00
IUUC-Cfa-020885	Canis familiaris	52.47	5.00e-49	185.00
IUUC-Cpo-022326	Cavia porcellus	53.16	1.00e-48	184.00
IUUC-Cre-022635	Chlamydomonas reinhardtii	51.25	3.00e-47	178.00
IUUC-Csa-023646	Chlorocebus sabaeus	53.09	3.00e-49	186.00
IUUC-Cho-025075	Choloepus hoffmanni	45.21	9.00e-31	124.00
IUUC-Cin-025389	Ciona intestinalis	53.75	3.00e-50	188.00
IUUC-Csv-026315	Ciona savignyi	53.75	6.00e-51	191.00
IUUC-Cgl-026602	Colletotrichum gloeosporioides	64.08	9.00e-53	197.00
IUUC-Cne-026808	Cryptococcus neoformans	49.65	6.00e-43	164.00
IUUC-Cme-027189	Cyanidioschyzon merolae	38.89	9.00e-24	102.00
IUUC-Dre-028455	Danio rerio	53.09	4.00e-49	186.00
IUUC-Dno-029667	Dasypus novemcinctus	52.47	8.00e-49	184.00
IUUC-Dor-030747	Dipodomys ordii	52.82	2.00e-39	154.00
IUUC-Dse-031231	Dothistroma septosporum	63.64	1.00e-53	201.00
IUUC-Dme-031841	Drosophila melanogaster	48.75	1.00e-47	181.00
IUUC-Ete-032258	Echinops telfairi	47.70	3.00e-44	169.00
IUUC-Eca-034179	Equus caballus	42.75	2.00e-34	137.00
IUUC-Eeu-034443	Erinaceus europaeus	54.46	2.00e-33	132.00
IUUC-Fca-036167	Felis catus	46.95	2.00e-37	147.00
IUUC-Fal-037114	Ficedula albicollis	55.84	9.00e-48	181.00
IUUC-Fox-037957	Fusarium oxysporum	70.40	8.00e-51	191.00
IUUC-Fso-038277	Fusarium solani	63.95	7.00e-54	201.00
IUUC-Gmo-039501	Gadus morhua	52.47	3.00e-49	186.00
IUUC-Ggr-040010	Gaeumannomyces graminis	62.94	2.00e-52	196.00
IUUC-Gga-041257	Gallus gallus	55.19	1.00e-47	180.00
IUUC-Gac-041433	Gasterosteus aculeatus	52.47	2.00e-49	187.00
IUUC-Gma-043529	Glycine max	51.88	4.00e-47	179.00
IUUC-Ggo-044437	Gorilla gorilla	53.79	5.00e-40	155.00
IUUC-Hsa-046693	Homo sapiens	53.09	4.00e-49	186.00
IUUC-Hvu-047328	Hordeum vulgare	44.44	5.00e-32	129.00
IUUC-Itr-048477	Ictidomys tridecemlineatus	53.09	5.00e-49	185.00
IUUC-Kpa-049391	Komagataella pastoris	57.14	1.00e-50	191.00
IUUC-Lch-049617	Latimeria chalumnae	55.19	5.00e-48	182.00
IUUC-Lpe-050949	Leersia perrieri	53.09	8.00e-49	184.00
IUUC-Loc-052157	Lepisosteus oculatus	53.80	2.00e-49	187.00
IUUC-Lma-053128	Leptosphaeria maculans	65.73	1.00e-54	204.00
IUUC-Laf-054455	Loxodonta africana	52.47	1.00e-48	184.00
IUUC-Mcc-054756	Macaca mulatta	53.09	3.00e-49	186.00
IUUC-Meu-056106	Macropus eugenii	54.46	2.00e-33	133.00
IUUC-Mor-057202	Magnaporthe oryzae	63.64	1.00e-52	197.00
IUUC-Mpo-057349	Magnaporthe poae	63.64	6.00e-53	198.00
IUUC-Mtr-058271	Medicago truncatula	49.40	6.00e-43	165.00
IUUC-Mla-058894	Melampsora laricipopulina	60.00	4.00e-53	197.00
IUUC-Mga-059493	Meleagris gallopavo	55.19	1.00e-47	180.00
IUUC-Mvi-060232	Microbotryum violaceum	56.41	3.00e-51	192.00
IUUC-Mmr-060957	Microcebus murinus	53.70	2.00e-49	186.00
IUUC-Mdo-062141	Monodelphis domestica	53.80	2.00e-49	186.00
IUUC-Mmu-063882	Mus musculus	52.47	1.00e-48	184.00
IUUC-Mac-064510	Musa acuminata	48.77	3.00e-45	172.00
IUUC-Mpu-065902	Mustela putorius furo	52.47	5.00e-49	185.00
IUUC-Mlu-068008	Myotis lucifugus	52.47	4.00e-47	179.00
IUUC-Nfi-068515	Neosartorya fischeri	59.26	5.00e-55	205.00
IUUC-Ncr-068755	Neurospora crassa	61.54	5.00e-52	195.00
IUUC-Nle-069166	Nomascus leucogenys	42.75	3.00e-34	136.00
IUUC-Opr-071201	Ochotona princeps	52.68	1.00e-32	130.00
IUUC-Ont-071311	Oreochromis niloticus	52.47	2.00e-49	186.00
IUUC-Oan-073310	Ornithorhynchus anatinus	52.47	1.00e-48	184.00
IUUC-Ocu-074514	Oryctolagus cuniculus	51.85	2.00e-48	183.00
IUUC-Oba-075200	Oryza barthii	53.09	8.00e-49	184.00
IUUC-Obr-076396	Oryza brachyantha	52.47	8.00e-49	184.00
IUUC-Ogl-077398	Oryza glaberrima	53.09	1.00e-48	184.00
IUUC-Ogu-078362	Oryza glumaepatula	53.09	8.00e-49	184.00
IUUC-Oin-079625	Oryza indica	53.09	8.00e-49	184.00
IUUC-Olo-080620	Oryza longistaminata	42.39	8.00e-33	131.00
IUUC-Ome-081187	Oryza meridionalis	53.09	9.00e-49	184.00
IUUC-Oni-082271	Oryza nivara	53.09	1.00e-48	184.00
IUUC-Opu-083487	Oryza punctata	53.09	1.00e-48	184.00
IUUC-Oru-085263	Oryza rufipogon	53.09	8.00e-49	184.00
IUUC-Osa-085694	Oryza sativa	53.09	8.00e-49	184.00
IUUC-Ola-086450	Oryzias latipes	53.16	2.00e-49	186.00
IUUC-Olu-087733	Ostreococcus lucimarinus	36.08	2.00e-27	113.00
IUUC-Oga-088054	Otolemur garnettii	48.88	4.00e-45	172.00
IUUC-Oar-089486	Ovis aries	53.09	4.00e-49	185.00
IUUC-Ptr-091314	Pan troglodytes	42.75	3.00e-34	136.00
IUUC-Pan-092633	Papio anubis	53.09	3.00e-49	186.00
IUUC-Psi-093668	Pelodiscus sinensis	41.35	5.00e-32	129.00
IUUC-Pno-095025	Phaeosphaeria nodorum	65.73	2.00e-54	203.00
IUUC-Ppa-095641	Physcomitrella patens	50.31	3.00e-47	179.00
IUUC-Pfo-096423	Poecilia formosa	53.55	3.00e-47	179.00
IUUC-Pab-097771	Pongo abelii	53.09	3.00e-49	186.00
IUUC-Pop-099714	Populus trichocarpa	52.12	1.00e-49	187.00
IUUC-Pca-100493	Procavia capensis	42.86	3.00e-26	109.00
IUUC-Ppe-102054	Prunus persica	51.25	7.00e-47	178.00
IUUC-Pva-102224	Pteropus vampyrus	52.47	2.00e-48	183.00
IUUC-Pgr-103332	Puccinia graminis	57.23	6.00e-54	201.00
IUUC-Ptt-103776	Puccinia triticina	57.23	4.00e-54	202.00
IUUC-Pte-104166	Pyrenophora teres	65.73	8.00e-55	204.00
IUUC-Pyt-104570	Pyrenophora triticirepentis	65.73	1.00e-54	204.00
IUUC-Rno-105593	Rattus norvegicus	52.47	1.00e-48	184.00
IUUC-Sce-106212	Saccharomyces cerevisiae	61.21	5.00e-61	225.00
IUUC-Sha-106767	Sarcophilus harrisii	53.16	7.00e-49	184.00
IUUC-Sja-107907	Schizosaccharomyces japonicus	56.90	9.00e-78	280.00
IUUC-Ssl-108556	Sclerotinia sclerotiorum	63.64	1.00e-53	201.00
IUUC-Smo-108965	Selaginella moellendorffii	53.99	1.00e-49	187.00
IUUC-Sit-110407	Setaria italica	54.32	1.00e-49	187.00
IUUC-Sly-110845	Solanum lycopersicum	47.37	2.00e-45	173.00
IUUC-Stu-112336	Solanum tuberosum	47.37	1.00e-45	174.00
IUUC-Sar-113063	Sorex araneus	43.38	1.00e-34	138.00
IUUC-Sbi-114327	Sorghum bicolor	54.32	9.00e-50	187.00
IUUC-Sre-115170	Sporisorium reilianum	55.76	7.00e-47	178.00
IUUC-Ssc-116385	Sus scrofa	53.09	4.00e-49	185.00
IUUC-Tgu-117041	Taeniopygia guttata	55.84	6.00e-48	181.00
IUUC-Tru-117697	Takifugu rubripes	52.47	1.00e-49	187.00
IUUC-Tsy-119024	Tarsius syrichta	49.69	6.00e-43	165.00
IUUC-Tni-120466	Tetraodon nigroviridis	51.52	2.00e-47	180.00
IUUC-Tca-121569	Theobroma cacao	41.95	4.00e-47	178.00
IUUC-Tre-121882	Trichoderma reesei	66.43	1.00e-54	203.00
IUUC-Tvi-122466	Trichoderma virens	65.03	8.00e-54	201.00
IUUC-Tae-124592	Triticum aestivum	50.30	9.00e-48	181.00
IUUC-Tur-126536	Triticum urartu	48.35	2.00e-46	176.00
IUUC-Tme-127051	Tuber melanosporum	65.03	3.00e-54	203.00
IUUC-Tbe-127743	Tupaia belangeri	42.65	9.00e-34	135.00
IUUC-Ttr-128466	Tursiops truncatus	53.09	4.00e-49	185.00
IUUC-Uma-129383	Ustilago maydis	56.36	3.00e-47	179.00
IUUC-Vda-130013	Verticillium dahliae	62.69	4.00e-49	186.00
IUUC-Vpa-130404	Vicugna pacos	42.65	7.00e-34	135.00
IUUC-Vvi-131251	Vitis vinifera	51.88	1.00e-43	167.00
IUUC-Xtr-132408	Xenopus tropicalis	52.47	4.00e-49	185.00
IUUC-Xma-133893	Xiphophorus maculatus	54.19	2.00e-47	180.00
IUUC-Yli-134618	Yarrowia lipolytica	65.75	8.00e-60	221.00
IUUC-Zma-135216	Zea mays	53.29	5.00e-50	188.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence