iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21388379

Classification

Family	E-value	Score	Start	End
DUB/USP	1.30e-70	239.1	199	523
ULD/UDP/UBQ/UBQ_Other	7.60e-05	23.4	593	644

Active Site

Position(s)	Description	Evidence
208	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
455	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           +GlkN+g+tCYmNS+LQ+L++ip +r+++ +     ++ ++++ p++++  +lq+lf +l ++++++v+++el+k++++    +++++q+D+qE+ ++
   Q: 199  VGLKNQGATCYMNSLLQTLYHIPYFRKAVYH-----MPTTENDAPTASIPLALQSLFYKL-QYNDTSVATKELTKSFGWDT--YDSFMQHDVQELNRV 288
           6******************************.....555555789***************.88999************877..67************* PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           l ++le+++                          k +  + +i++lF+g+  + i c + d +s+r+e+f+dl+l+v+g +     ++  +++++++
   Q: 289  LCEKLEDKM--------------------------KGTVVEGTIQQLFEGHHMNYIECINVDFKSTRKESFYDLQLDVKGCK-----DVYASFDKYVE 355
           *********..........................7899*******************************************.....9********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls....pfctspeekqkekkkYeLiavvvHsGsl 290
            e+leg+nky+ e   ++q+a+k + +  +P+vL l+LkRf+++  ++   kin+++efpleLdl+    ++++  + + ++++ Y L++v+vHsG++
   Q: 356  VERLEGDNKYHAEGH-GLQDAKKGVLFIDFPPVLQLQLKRFEYDFMRDTMVKINDRYEFPLELDLDredgKYLSP-DADRSVRNLYTLHSVLVHSGGV 451
           ***********9985.79***********************************************9777666666.666678**************** PP
   S: 291  ssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg........................staYvlfYkr 337
           ++GHY+a+++   +++W++fdD++Vt+ + ++ lee+                         s+aY+l+Y r
   Q: 452  HGGHYYAFIRPtLSDQWYKFDDERVTKEDLKRALEEQYggeeelpqtnpgfnnnppfkftkySNAYMLVYIR 523
           **********945677*************9999997779*******************************87 PP

ULD/UDP/UBQ/UBQ_Other

   S: 10   gs.eltlkvnpsdtVaeLKekiekklgippeqqrLiyk....GkiLeddktL 56
           +  + ++++ ++++++++Ke++ k++g+p++ qr +++    ++  +++++L
   Q: 593  HDkVRSFRIQKQTPFQQFKEEVAKEFGVPVQLQRFWIWakrqNHTYRPNRPL 644
           44488999***************************98844442222555444 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MTMMTPPPVD QPEDEEMLVP NSDLVDGPAQ PMEVTQPETA ASTVENQPAE DPPTLKFTWT 60
IPNFSRQNTR KHYSDVFVVG GYKWRILIFP KGNNVDHLSM YLDVSDAASL PYGWSRYAQF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTAAGTCTT ATACGTGCCG CTTTCTCATT GGTCTGTCTC GCTTGATAGA CCCAACCTCG 60
GAGAAATTAT AAATCTGAGC CCGTATACTG TGAAATTACA TTAATGACCC TTTAAATTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005829--C:cytosol
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G06600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000761	Aegilops tauschii	75.99	0.00e+00	1690.00
IUUC-Aml-002408	Ailuropoda melanoleuca	36.33	3.00e-164	572.00
IUUC-Aca-004518	Anolis carolinensis	35.30	5.00e-158	551.00
IUUC-Aly-006427	Arabidopsis lyrata	99.19	0.00e+00	2207.00
IUUC-Ago-007849	Ashbya gossypii	33.58	3.00e-141	496.00
IUUC-Acl-008327	Aspergillus clavatus	39.07	0.00e+00	648.00
IUUC-Afl-008491	Aspergillus flavus	38.68	0.00e+00	637.00
IUUC-Afu-008804	Aspergillus fumigatus	38.28	9.00e-174	603.00
IUUC-Ani-009257	Aspergillus nidulans	30.11	5.00e-32	134.00
IUUC-Aor-009998	Aspergillus oryzae	37.93	2.00e-177	615.00
IUUC-Ate-010428	Aspergillus terreus	38.70	0.00e+00	629.00
IUUC-Ame-010903	Astyanax mexicanus	35.35	1.00e-165	577.00
IUUC-Bgr-012132	Blumeria graminis	34.65	2.00e-160	559.00
IUUC-Bta-013192	Bos taurus	36.52	4.00e-165	575.00
IUUC-Bci-013924	Botrytis cinerea	35.90	3.00e-165	575.00
IUUC-Bdi-015069	Brachypodium distachyon	81.79	0.00e+00	1807.00
IUUC-Bol-015621	Brassica oleracea	95.49	0.00e+00	2125.00
IUUC-Bra-017080	Brassica rapa	95.07	0.00e+00	2137.00
IUUC-Cel-018219	Caenorhabditis elegans	27.99	4.00e-101	362.00
IUUC-Cja-019006	Callithrix jacchus	36.39	5.00e-164	571.00
IUUC-Cfa-020361	Canis familiaris	36.33	5.00e-164	571.00
IUUC-Cpo-022320	Cavia porcellus	36.42	4.00e-164	571.00
IUUC-Cre-022708	Chlamydomonas reinhardtii	55.78	5.00e-144	503.00
IUUC-Csa-024050	Chlorocebus sabaeus	35.59	1.00e-164	573.00
IUUC-Cho-024434	Choloepus hoffmanni	31.45	2.00e-86	313.00
IUUC-Cin-025689	Ciona intestinalis	34.65	5.00e-154	538.00
IUUC-Cgl-026650	Colletotrichum gloeosporioides	37.02	2.00e-176	612.00
IUUC-Cne-026968	Cryptococcus neoformans	41.99	0.00e+00	736.00
IUUC-Cme-027103	Cyanidioschyzon merolae	38.58	8.00e-129	454.00
IUUC-Dre-028510	Danio rerio	35.43	7.00e-166	577.00
IUUC-Dor-030611	Dipodomys ordii	50.46	2.00e-83	303.00
IUUC-Dse-031433	Dothistroma septosporum	35.74	2.00e-171	596.00
IUUC-Dme-031583	Drosophila melanogaster	34.71	1.00e-159	557.00
IUUC-Ete-033191	Echinops telfairi	35.81	6.00e-159	554.00
IUUC-Eca-034122	Equus caballus	36.33	5.00e-164	571.00
IUUC-Fca-036377	Felis catus	36.24	2.00e-163	569.00
IUUC-Fal-036964	Ficedula albicollis	36.52	6.00e-170	590.00
IUUC-Fso-038084	Fusarium solani	35.77	1.00e-172	600.00
IUUC-Gmo-038644	Gadus morhua	34.98	2.00e-167	582.00
IUUC-Ggr-040029	Gaeumannomyces graminis	35.76	6.00e-171	594.00
IUUC-Gga-040944	Gallus gallus	36.52	1.00e-169	590.00
IUUC-Gma-043081	Glycine max	83.04	0.00e+00	1858.00
IUUC-Ggo-044947	Gorilla gorilla	36.33	5.00e-164	571.00
IUUC-Hsa-046278	Homo sapiens	35.65	1.00e-164	573.00
IUUC-Hvu-047749	Hordeum vulgare	81.45	0.00e+00	1523.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	37.56	4.00e-153	535.00
IUUC-Kpa-049121	Komagataella pastoris	32.11	6.00e-134	471.00
IUUC-Lch-049847	Latimeria chalumnae	35.68	1.00e-168	586.00
IUUC-Lpe-051543	Leersia perrieri	79.93	0.00e+00	1742.00
IUUC-Lma-053169	Leptosphaeria maculans	37.53	2.00e-177	616.00
IUUC-Laf-053566	Loxodonta africana	36.42	3.00e-164	572.00
IUUC-Mcc-055549	Macaca mulatta	36.33	4.00e-164	571.00
IUUC-Meu-056887	Macropus eugenii	28.86	2.00e-66	247.00
IUUC-Mor-057149	Magnaporthe oryzae	35.29	1.00e-167	583.00
IUUC-Mtr-058583	Medicago truncatula	82.60	0.00e+00	1851.00
IUUC-Mla-058899	Melampsora laricipopulina	39.22	0.00e+00	691.00
IUUC-Mvi-060207	Microbotryum violaceum	38.28	0.00e+00	679.00
IUUC-Mmr-060946	Microcebus murinus	35.59	1.00e-164	573.00
IUUC-Mdo-062079	Monodelphis domestica	36.56	4.00e-148	518.00
IUUC-Mmu-063678	Mus musculus	36.52	1.00e-163	570.00
IUUC-Mpu-066744	Mustela putorius furo	36.33	6.00e-164	571.00
IUUC-Mlu-067949	Myotis lucifugus	36.37	7.00e-163	567.00
IUUC-Nfi-068342	Neosartorya fischeri	38.96	3.00e-176	612.00
IUUC-Ncr-068818	Neurospora crassa	37.41	0.00e+00	632.00
IUUC-Nle-070064	Nomascus leucogenys	35.65	1.00e-164	573.00
IUUC-Ont-072095	Oreochromis niloticus	35.11	3.00e-166	578.00
IUUC-Oan-073483	Ornithorhynchus anatinus	36.24	1.00e-162	566.00
IUUC-Ocu-073967	Oryctolagus cuniculus	36.42	2.00e-159	556.00
IUUC-Oba-075823	Oryza barthii	78.40	0.00e+00	1710.00
IUUC-Obr-076514	Oryza brachyantha	82.90	0.00e+00	1805.00
IUUC-Ogl-077131	Oryza glaberrima	82.88	0.00e+00	1793.00
IUUC-Ogu-078038	Oryza glumaepatula	77.12	0.00e+00	1736.00
IUUC-Oin-079574	Oryza indica	77.35	0.00e+00	1738.00
IUUC-Olo-081067	Oryza longistaminata	78.96	0.00e+00	1662.00
IUUC-Ome-081879	Oryza meridionalis	82.08	0.00e+00	1788.00
IUUC-Oni-082461	Oryza nivara	79.09	0.00e+00	1757.00
IUUC-Opu-083199	Oryza punctata	81.35	0.00e+00	1748.00
IUUC-Oru-085109	Oryza rufipogon	80.27	0.00e+00	1724.00
IUUC-Ola-086640	Oryzias latipes	35.15	4.00e-167	581.00
IUUC-Olu-087874	Ostreococcus lucimarinus	45.25	0.00e+00	907.00
IUUC-Oga-089059	Otolemur garnettii	34.10	2.00e-141	496.00
IUUC-Ptr-091334	Pan troglodytes	36.33	5.00e-164	571.00
IUUC-Pan-091717	Papio anubis	36.33	4.00e-164	571.00
IUUC-Psi-093933	Pelodiscus sinensis	35.53	2.00e-168	585.00
IUUC-Pma-094648	Petromyzon marinus	37.78	2.00e-159	556.00
IUUC-Pno-095020	Phaeosphaeria nodorum	37.48	1.00e-166	580.00
IUUC-Ppa-095922	Physcomitrella patens	79.02	0.00e+00	1774.00
IUUC-Pfo-096181	Poecilia formosa	35.20	1.00e-165	577.00
IUUC-Pop-100083	Populus trichocarpa	86.94	0.00e+00	1941.00
IUUC-Ppe-101523	Prunus persica	86.94	0.00e+00	1912.00
IUUC-Pva-102472	Pteropus vampyrus	36.79	2.00e-160	559.00
IUUC-Pgr-103463	Puccinia graminis	39.34	0.00e+00	690.00
IUUC-Ptt-103716	Puccinia triticina	39.20	0.00e+00	639.00
IUUC-Pte-104360	Pyrenophora teres	38.26	3.00e-174	605.00
IUUC-Pyt-104581	Pyrenophora triticirepentis	37.34	1.00e-174	607.00
IUUC-Rno-105816	Rattus norvegicus	35.68	6.00e-165	574.00
IUUC-Sce-106230	Saccharomyces cerevisiae	33.82	1.00e-128	454.00
IUUC-Sha-107439	Sarcophilus harrisii	36.42	7.00e-164	570.00
IUUC-Sja-107690	Schizosaccharomyces japonicus	35.51	2.00e-151	529.00
IUUC-Spo-108019	Schizosaccharomyces pombe	36.74	3.00e-154	538.00
IUUC-Smo-109308	Selaginella moellendorffii	78.73	0.00e+00	1751.00
IUUC-Sit-110268	Setaria italica	82.10	0.00e+00	1790.00
IUUC-Sly-111774	Solanum lycopersicum	82.61	0.00e+00	1862.00
IUUC-Stu-112387	Solanum tuberosum	82.79	0.00e+00	1868.00
IUUC-Sar-113685	Sorex araneus	35.99	9.00e-160	557.00
IUUC-Sbi-114424	Sorghum bicolor	82.10	0.00e+00	1808.00
IUUC-Ssc-116297	Sus scrofa	35.59	2.00e-164	572.00
IUUC-Tgu-116767	Taeniopygia guttata	35.71	4.00e-169	588.00
IUUC-Tni-119890	Tetraodon nigroviridis	35.68	1.00e-163	570.00
IUUC-Tca-121501	Theobroma cacao	87.58	0.00e+00	1949.00
IUUC-Tre-122169	Trichoderma reesei	35.79	2.00e-168	585.00
IUUC-Tvi-122600	Trichoderma virens	36.76	9.00e-174	603.00
IUUC-Tae-123032	Triticum aestivum	81.18	0.00e+00	1818.00
IUUC-Tur-126501	Triticum urartu	72.49	0.00e+00	1577.00
IUUC-Tme-127045	Tuber melanosporum	37.48	1.00e-178	619.00
IUUC-Ttr-129161	Tursiops truncatus	35.76	5.00e-163	568.00
IUUC-Vpa-130141	Vicugna pacos	36.08	2.00e-54	207.00
IUUC-Vvi-131308	Vitis vinifera	86.15	0.00e+00	1919.00
IUUC-Xma-133949	Xiphophorus maculatus	35.35	6.00e-165	574.00
IUUC-Yli-134527	Yarrowia lipolytica	34.16	3.00e-152	532.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence