iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	PHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20846524

Classification

Family	E-value	Score	Start	End
DUB/USP	4.60e-61	205.3	461	911

Active Site

Position(s)	Description	Evidence
469	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
861	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...................wkskkk.................. 66
           G+ N  N C+m SvLQ+L+ ++++ + ++   ++++n +   +++ +ll+++ ++ +++                   +    +                  
   Q: 461  GIINRANICFMSSVLQVLLYCKPFIDVINVLSTRNTNSRV-GTSSCKLLDACLTMYKQFdketyekkflenaddaektT----Esdakkssksksfqhcata 557
           9***************************997777776654.67777788877777777755555555555555544441....0333444455667777777 PP
   S: 67   .avsprellkalkkeaeefs...gyeqqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsde.............................. 129
            av+p e++k+l+++ + f+     +q+Da+Efl++lldql+eel +           ++e ++  ++ +de                              
   Q: 558  dAVKPDEFYKTLSTIPK-FKdlqWGHQEDAEEFLTHLLDQLHEELISaidglT-----DNEIQNMLQSINDEqlkvffirnlsrygkaefiknasprlkeli 653
           7***********98765.444449*********************76333332.....33333333333333666779************************ PP
   S: 130  ...............................aeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkkeslqdcLesftkeee 199
                                          a +++ +  +s+is+lF+gq++s +  ++ ++++  + +pf++++l++++   +   +l+ ++++f++ e 
   Q: 654  ekygvinddsteengwhevsgsskrgkktktAAKRTVEIVPSPISKLFGGQFRSVLDIPNNKESQsITLDPFQTIQLDISDAGVN---DLETAFKKFSEYEL 752
           *********************99988777766666667777****************988877666*****************88...************** PP
   S: 200  legenkyycekckkkqeaekklklkklPevLilhLkRf.............sfseeqksrekinkkvefpleLdlsp.fcts....peekqkekkkYeLiav 283
           l      + ++  +++ea+k++ ++klP+vL +++kRf             +++ ++++ eki kk+++  eL + +  ++s    ++++  ++++Y+L++v
   Q: 753  LP-----FKSSSGNDVEAKKQTFIDKLPQVLLIQFKRFsfinnvnkdnamtNYNAYNGRIEKIRKKIKYGHELIIPEeSMSSitlkNNTSGIDDRRYKLTGV 849
           *7.....5556677999*********************7777777777777777777777777777776666443321333322224444445********* PP
   S: 284  vvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYkrr 338
           ++H+G s+++GHY+a+v++++++ W+++dD ++te++ ++vl+  +     +taY+l+Y++r
   Q: 850  IYHHGvSSDGGHYTADVYHSEHNkWYRIDDVNITELEDDDVLKGGEeasdsRTAYILMYQKR 911
           *******************66666*******************6669************985 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Plays a role in regulation of silencing by interacting with SIR4. Also, in conjunction with BRE5, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of SEC23.

Protein Sequence
(Fasta)

MNMQDANKEE SYSMYPKTSS PPPPTPTNMQ IPIYQAPLQM YGYTQAPYLY PTQIPAYSFN 60
MVNQNQPIYH QSGSPHHLPP QNNINGGSTT NNNNINKKKW HSNGITNNNG SSGNQGANSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACATGC AAGACGCTAA CAAAGAAGAG TCGTACTCGA TGTACCCGAA AACCTCTTCT 60
CCACCACCAC CTACGCCAAC CAATATGCAG ATTCCTATTT ATCAAGCGCC TTTGCAGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990861--C:Ubp3-Bre5 deubiquitination complex
GO:0003729--F:mRNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0047484--P:regulation of response to osmotic stress
GO:0034517--P:ribophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YER151C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	25.54	4.00e-29	121.00
IUUC-Aml-001584	Ailuropoda melanoleuca	28.69	7.00e-41	160.00
IUUC-Atr-002927	Amborella trichopoda	27.57	4.00e-34	137.00
IUUC-Apl-003988	Anas platyrhynchos	26.95	5.00e-36	144.00
IUUC-Aca-004461	Anolis carolinensis	30.31	1.00e-26	112.00
IUUC-Aly-006038	Arabidopsis lyrata	24.89	1.00e-28	119.00
IUUC-Ath-007328	Arabidopsis thaliana	25.11	3.00e-29	121.00
IUUC-Ago-007717	Ashbya gossypii	45.35	1.00e-167	581.00
IUUC-Acl-008188	Aspergillus clavatus	30.57	5.00e-56	210.00
IUUC-Afl-008456	Aspergillus flavus	31.67	2.00e-45	174.00
IUUC-Afu-009067	Aspergillus fumigatus	30.92	2.00e-56	212.00
IUUC-Ani-009483	Aspergillus nidulans	30.57	2.00e-56	212.00
IUUC-Ang-009639	Aspergillus niger	35.20	3.00e-37	148.00
IUUC-Aor-010040	Aspergillus oryzae	29.77	4.00e-54	204.00
IUUC-Ate-010310	Aspergillus terreus	29.82	4.00e-55	207.00
IUUC-Ame-011012	Astyanax mexicanus	26.10	1.00e-18	86.70
IUUC-Bgr-012311	Blumeria graminis	32.72	2.00e-44	172.00
IUUC-Bta-013299	Bos taurus	27.63	1.00e-39	156.00
IUUC-Bci-013783	Botrytis cinerea	31.00	3.00e-53	201.00
IUUC-Bdi-015039	Brachypodium distachyon	25.00	4.00e-32	130.00
IUUC-Bol-015806	Brassica oleracea	25.43	3.00e-33	134.00
IUUC-Bra-017877	Brassica rapa	25.92	3.00e-32	131.00
IUUC-Cja-018715	Callithrix jacchus	28.05	9.00e-40	156.00
IUUC-Cfa-020194	Canis familiaris	28.54	2.00e-41	162.00
IUUC-Cpo-022272	Cavia porcellus	26.71	1.00e-38	152.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	24.93	4.00e-20	90.90
IUUC-Csa-023310	Chlorocebus sabaeus	28.27	2.00e-40	159.00
IUUC-Cin-025616	Ciona intestinalis	25.19	2.00e-39	155.00
IUUC-Csv-026043	Ciona savignyi	27.03	2.00e-38	150.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	31.14	1.00e-47	183.00
IUUC-Cne-026962	Cryptococcus neoformans	28.64	7.00e-45	174.00
IUUC-Cme-027113	Cyanidioschyzon merolae	23.63	2.00e-23	102.00
IUUC-Dre-028072	Danio rerio	28.03	4.00e-38	151.00
IUUC-Dno-029489	Dasypus novemcinctus	27.57	2.00e-40	159.00
IUUC-Dse-031553	Dothistroma septosporum	31.15	8.00e-57	213.00
IUUC-Dme-031759	Drosophila melanogaster	24.69	9.00e-29	120.00
IUUC-Ete-032549	Echinops telfairi	23.68	4.00e-13	68.20
IUUC-Eca-033380	Equus caballus	27.57	1.00e-40	159.00
IUUC-Eeu-034818	Erinaceus europaeus	28.47	1.00e-37	149.00
IUUC-Fca-035535	Felis catus	25.21	5.00e-28	117.00
IUUC-Fal-036627	Ficedula albicollis	27.00	3.00e-42	164.00
IUUC-Fox-037904	Fusarium oxysporum	33.41	2.00e-50	192.00
IUUC-Fso-038170	Fusarium solani	29.83	2.00e-41	162.00
IUUC-Gmo-039499	Gadus morhua	26.54	2.00e-32	132.00
IUUC-Ggr-040042	Gaeumannomyces graminis	31.06	3.00e-53	201.00
IUUC-Gga-040571	Gallus gallus	27.38	1.00e-36	146.00
IUUC-Gac-041345	Gasterosteus aculeatus	28.27	1.00e-33	136.00
IUUC-Gma-044407	Glycine max	26.29	2.00e-32	131.00
IUUC-Ggo-044652	Gorilla gorilla	28.27	2.00e-40	158.00
IUUC-Hsa-045864	Homo sapiens	28.27	2.00e-40	158.00
IUUC-Hvu-047071	Hordeum vulgare	26.84	6.00e-35	139.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	29.18	5.00e-42	163.00
IUUC-Kpa-049132	Komagataella pastoris	37.89	4.00e-91	326.00
IUUC-Lch-050040	Latimeria chalumnae	26.45	1.00e-32	132.00
IUUC-Loc-052449	Lepisosteus oculatus	27.08	2.00e-33	135.00
IUUC-Lma-053248	Leptosphaeria maculans	30.22	3.00e-52	198.00
IUUC-Laf-054121	Loxodonta africana	27.40	4.00e-41	161.00
IUUC-Mcc-055514	Macaca mulatta	28.27	1.00e-40	159.00
IUUC-Mor-057243	Magnaporthe oryzae	31.10	9.00e-53	200.00
IUUC-Mpo-057439	Magnaporthe poae	30.46	2.00e-50	192.00
IUUC-Mtr-058457	Medicago truncatula	26.41	9.00e-36	142.00
IUUC-Mla-058958	Melampsora laricipopulina	28.03	2.00e-45	175.00
IUUC-Mga-060157	Meleagris gallopavo	27.32	4.00e-35	140.00
IUUC-Mvi-060442	Microbotryum violaceum	38.60	1.00e-30	127.00
IUUC-Mmr-061062	Microcebus murinus	28.16	1.00e-40	159.00
IUUC-Mdo-062253	Monodelphis domestica	26.64	1.00e-38	152.00
IUUC-Mmu-064050	Mus musculus	28.07	6.00e-42	163.00
IUUC-Mac-065619	Musa acuminata	27.53	2.00e-35	140.00
IUUC-Mpu-066554	Mustela putorius furo	28.69	5.00e-41	160.00
IUUC-Mlu-068003	Myotis lucifugus	28.40	2.00e-41	161.00
IUUC-Nfi-068612	Neosartorya fischeri	29.48	1.00e-51	196.00
IUUC-Ncr-068878	Neurospora crassa	32.09	1.00e-44	172.00
IUUC-Nle-069661	Nomascus leucogenys	28.48	3.00e-41	161.00
IUUC-Ont-071266	Oreochromis niloticus	34.33	2.00e-27	115.00
IUUC-Oan-073442	Ornithorhynchus anatinus	28.06	9.00e-46	176.00
IUUC-Ocu-073788	Oryctolagus cuniculus	28.13	1.00e-37	149.00
IUUC-Oba-075085	Oryza barthii	27.49	1.00e-24	104.00
IUUC-Obr-076663	Oryza brachyantha	26.68	2.00e-30	125.00
IUUC-Ogl-076937	Oryza glaberrima	27.03	4.00e-35	140.00
IUUC-Ogu-078909	Oryza glumaepatula	27.27	9.00e-33	133.00
IUUC-Oin-079617	Oryza indica	27.68	1.00e-35	142.00
IUUC-Oni-082914	Oryza nivara	27.27	8.00e-33	133.00
IUUC-Oru-084878	Oryza rufipogon	27.27	7.00e-33	133.00
IUUC-Osa-085822	Oryza sativa	27.27	5.00e-37	146.00
IUUC-Ola-086931	Oryzias latipes	27.63	2.00e-33	135.00
IUUC-Oga-088443	Otolemur garnettii	27.49	2.00e-40	158.00
IUUC-Oar-089325	Ovis aries	28.02	1.00e-39	156.00
IUUC-Ptr-091584	Pan troglodytes	30.47	1.00e-25	109.00
IUUC-Pan-092551	Papio anubis	27.68	3.00e-38	151.00
IUUC-Psi-093366	Pelodiscus sinensis	25.49	9.00e-14	69.70
IUUC-Pno-095136	Phaeosphaeria nodorum	28.26	2.00e-44	172.00
IUUC-Ppa-095574	Physcomitrella patens	26.68	6.00e-33	133.00
IUUC-Pfo-097462	Poecilia formosa	34.76	1.00e-27	116.00
IUUC-Pab-098547	Pongo abelii	28.48	3.00e-41	161.00
IUUC-Pop-099529	Populus trichocarpa	27.92	1.00e-36	145.00
IUUC-Pca-101066	Procavia capensis	29.61	7.00e-31	127.00
IUUC-Ppe-102110	Prunus persica	26.46	4.00e-35	140.00
IUUC-Pva-103015	Pteropus vampyrus	28.22	4.00e-42	164.00
IUUC-Ptt-103998	Puccinia triticina	29.77	1.00e-46	179.00
IUUC-Pte-104417	Pyrenophora teres	29.16	4.00e-47	181.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	29.61	1.00e-46	179.00
IUUC-Rno-105533	Rattus norvegicus	28.07	9.00e-43	166.00
IUUC-Sha-106590	Sarcophilus harrisii	33.48	4.00e-31	127.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	31.67	3.00e-49	187.00
IUUC-Spo-108353	Schizosaccharomyces pombe	31.97	3.00e-55	207.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	31.37	2.00e-53	202.00
IUUC-Smo-109645	Selaginella moellendorffii	27.14	5.00e-22	95.90
IUUC-Sit-110781	Setaria italica	27.10	9.00e-33	133.00
IUUC-Sly-111797	Solanum lycopersicum	31.91	2.00e-28	118.00
IUUC-Stu-112188	Solanum tuberosum	26.80	7.00e-34	136.00
IUUC-Sbi-114862	Sorghum bicolor	25.98	6.00e-24	103.00
IUUC-Sre-115162	Sporisorium reilianum	31.25	2.00e-58	219.00
IUUC-Ssc-115505	Sus scrofa	30.59	9.00e-33	131.00
IUUC-Tgu-116535	Taeniopygia guttata	26.82	5.00e-42	164.00
IUUC-Tru-117542	Takifugu rubripes	27.62	2.00e-39	155.00
IUUC-Tni-120200	Tetraodon nigroviridis	28.05	6.00e-39	153.00
IUUC-Tca-121548	Theobroma cacao	29.59	6.00e-13	67.40
IUUC-Tre-122124	Trichoderma reesei	31.84	4.00e-53	201.00
IUUC-Tvi-122457	Trichoderma virens	28.57	1.00e-42	166.00
IUUC-Tae-125646	Triticum aestivum	26.68	1.00e-36	146.00
IUUC-Tme-127180	Tuber melanosporum	31.24	3.00e-57	214.00
IUUC-Tbe-127530	Tupaia belangeri	26.52	1.00e-17	82.80
IUUC-Ttr-128549	Tursiops truncatus	31.44	2.00e-20	92.40
IUUC-Uma-129381	Ustilago maydis	31.52	1.00e-58	219.00
IUUC-Vda-129889	Verticillium dahliae	30.38	3.00e-48	184.00
IUUC-Vpa-130100	Vicugna pacos	32.47	3.00e-23	101.00
IUUC-Vvi-131366	Vitis vinifera	28.63	2.00e-37	148.00
IUUC-Xtr-132048	Xenopus tropicalis	28.60	9.00e-36	143.00
IUUC-Xma-133593	Xiphophorus maculatus	27.43	5.00e-34	137.00
IUUC-Yli-134338	Yarrowia lipolytica	36.52	1.00e-26	113.00
IUUC-Zma-135255	Zea mays	27.54	4.00e-34	138.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence