iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033479

UUCD1 version

UUC-EqC-01046

Ensembl Protein ID

ENSECAP00000001034.1

UniProt Accession

F6VLV8; F6VLV8_HORSE

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000000423.1	ENSECAT00000001336.1	ENSECAP00000001034.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-90	304.2	195	824

Active Site

Position(s)	Description	Evidence
204	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
760	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 195  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 274
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+prel+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 275  VTPRELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGSSTEKLDEElknkvKDYEKKKSVPSFVDRIFGGELT 363
           ************************************************************999999999******************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 364  STIMCDECRTVSLVHESFLDLSLPVLDDQSAKKSindknlkktmededkdseeekdndsymkerndipsgtskhlqkkakkqakkqakn 452
           *****************************99998******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 453  qrrqqkiqgkvlhlndictvdhpednecevemspqeevdmntnhisqeevvhkdsyvnqkdlngqekmieivtdnqksteevdmkntnm 541
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 542  dndlgvlasspaecsrdlngahlkegsdgevdisssfkdlslnaalqpdeinieilddshtpgtkvyevvnedpetafctlanretfnt 630
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 631  decSIQHCLYQFTRNEKLRDANKLLCEVCTRRQYngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 717
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   k+ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 718  FPEILDLAPFCTLKCKNVAEentKVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemqsTKGQWFHISDTHVQA 806
           *************999988777799*************************9999999999999999999998888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 807  VPTTKVLN---SQAYLLFYER 824
           ********...********98 PP

Organism

Equus caballus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPTDDSSESL EPMCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGGAGCTG ACTGCCCAGC CGAAAGGCCC AATAGGGGAT GCAGTTATGG GCGCTGTCGT 60
TGTGGGTGAG TTCTGGTCCC ACTGACTCTG ACTCACGGTC ACCGCTCGCC TGATTACCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ecb:100053798

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.19	4.00e-29	123.00
IUUC-Aml-001931	Ailuropoda melanoleuca	92.49	0.00e+00	1431.00
IUUC-Atr-003015	Amborella trichopoda	31.97	2.00e-35	144.00
IUUC-Apl-004145	Anas platyrhynchos	63.11	0.00e+00	907.00
IUUC-Aca-004314	Anolis carolinensis	59.41	0.00e+00	892.00
IUUC-Aly-006422	Arabidopsis lyrata	30.24	3.00e-30	127.00
IUUC-Ath-006732	Arabidopsis thaliana	32.43	9.00e-33	135.00
IUUC-Ame-011659	Astyanax mexicanus	49.20	6.00e-110	392.00
IUUC-Bta-013362	Bos taurus	91.77	0.00e+00	1427.00
IUUC-Bdi-014465	Brachypodium distachyon	30.89	2.00e-29	124.00
IUUC-Bol-015941	Brassica oleracea	30.31	1.00e-32	135.00
IUUC-Bra-016751	Brassica rapa	30.14	1.00e-30	128.00
IUUC-Cja-019177	Callithrix jacchus	92.26	0.00e+00	1465.00
IUUC-Cfa-020051	Canis familiaris	93.22	0.00e+00	1449.00
IUUC-Cpo-021886	Cavia porcellus	81.81	0.00e+00	1302.00
IUUC-Csa-024103	Chlorocebus sabaeus	92.50	0.00e+00	1471.00
IUUC-Cho-024315	Choloepus hoffmanni	78.82	1.00e-132	466.00
IUUC-Cin-025775	Ciona intestinalis	48.94	2.00e-39	154.00
IUUC-Csv-026075	Ciona savignyi	50.48	3.00e-58	219.00
IUUC-Cme-027348	Cyanidioschyzon merolae	38.51	6.00e-20	92.40
IUUC-Dre-028388	Danio rerio	52.11	4.00e-121	429.00
IUUC-Dno-029409	Dasypus novemcinctus	89.95	0.00e+00	1431.00
IUUC-Dor-030443	Dipodomys ordii	78.36	0.00e+00	648.00
IUUC-Ete-032807	Echinops telfairi	85.89	0.00e+00	699.00
IUUC-Eeu-034835	Erinaceus europaeus	83.18	0.00e+00	662.00
IUUC-Fca-036320	Felis catus	93.34	0.00e+00	1493.00
IUUC-Fal-037029	Ficedula albicollis	60.71	0.00e+00	865.00
IUUC-Gmo-039480	Gadus morhua	52.83	2.00e-114	406.00
IUUC-Gga-040527	Gallus gallus	64.47	0.00e+00	934.00
IUUC-Gac-042343	Gasterosteus aculeatus	51.49	7.00e-115	408.00
IUUC-Gma-044402	Glycine max	28.90	2.00e-33	137.00
IUUC-Ggo-045598	Gorilla gorilla	92.02	0.00e+00	1458.00
IUUC-Hsa-046598	Homo sapiens	91.90	0.00e+00	1450.00
IUUC-Hvu-047146	Hordeum vulgare	30.37	2.00e-28	121.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	91.54	0.00e+00	1450.00
IUUC-Lch-050536	Latimeria chalumnae	56.31	4.00e-129	455.00
IUUC-Lpe-050703	Leersia perrieri	30.03	3.00e-28	120.00
IUUC-Loc-051814	Lepisosteus oculatus	57.25	2.00e-128	452.00
IUUC-Laf-053732	Loxodonta africana	87.11	0.00e+00	1417.00
IUUC-Mcc-054661	Macaca mulatta	92.87	0.00e+00	1473.00
IUUC-Meu-055967	Macropus eugenii	74.03	4.00e-158	551.00
IUUC-Mtr-057945	Medicago truncatula	31.21	3.00e-34	140.00
IUUC-Mga-059551	Meleagris gallopavo	63.69	0.00e+00	939.00
IUUC-Mvi-060391	Microbotryum violaceum	33.16	7.00e-20	92.80
IUUC-Mmr-061747	Microcebus murinus	92.56	0.00e+00	1436.00
IUUC-Mdo-062220	Monodelphis domestica	69.89	0.00e+00	1067.00
IUUC-Mmu-063582	Mus musculus	81.79	0.00e+00	1257.00
IUUC-Mac-064941	Musa acuminata	32.34	2.00e-38	154.00
IUUC-Mpu-066339	Mustela putorius furo	92.37	0.00e+00	1474.00
IUUC-Mlu-067511	Myotis lucifugus	85.85	0.00e+00	1337.00
IUUC-Nle-069252	Nomascus leucogenys	92.87	0.00e+00	1474.00
IUUC-Opr-070969	Ochotona princeps	85.84	0.00e+00	1310.00
IUUC-Ont-071786	Oreochromis niloticus	51.42	2.00e-117	416.00
IUUC-Ocu-074704	Oryctolagus cuniculus	90.98	0.00e+00	1410.00
IUUC-Oba-075094	Oryza barthii	29.05	1.00e-29	125.00
IUUC-Obr-076743	Oryza brachyantha	29.72	3.00e-30	127.00
IUUC-Ogl-077739	Oryza glaberrima	29.05	8.00e-30	125.00
IUUC-Ogu-078851	Oryza glumaepatula	29.05	9.00e-30	125.00
IUUC-Oin-079402	Oryza indica	29.05	1.00e-29	125.00
IUUC-Olo-080431	Oryza longistaminata	29.05	1.00e-29	125.00
IUUC-Ome-081580	Oryza meridionalis	29.05	1.00e-29	125.00
IUUC-Oni-082644	Oryza nivara	29.05	1.00e-29	125.00
IUUC-Opu-083452	Oryza punctata	28.79	1.00e-29	125.00
IUUC-Oru-084546	Oryza rufipogon	29.05	1.00e-29	125.00
IUUC-Osa-085858	Oryza sativa	29.05	9.00e-30	125.00
IUUC-Ola-086795	Oryzias latipes	49.56	1.00e-112	400.00
IUUC-Oga-088713	Otolemur garnettii	91.17	0.00e+00	1449.00
IUUC-Oar-089887	Ovis aries	92.26	0.00e+00	1434.00
IUUC-Ptr-091670	Pan troglodytes	92.14	0.00e+00	1463.00
IUUC-Pan-092293	Papio anubis	92.87	0.00e+00	1473.00
IUUC-Psi-093101	Pelodiscus sinensis	67.18	0.00e+00	944.00
IUUC-Ppa-095825	Physcomitrella patens	36.99	1.00e-32	135.00
IUUC-Pfo-097202	Poecilia formosa	44.41	0.00e+00	641.00
IUUC-Pab-098773	Pongo abelii	91.47	0.00e+00	1133.00
IUUC-Pop-099136	Populus trichocarpa	29.82	1.00e-38	155.00
IUUC-Pca-101069	Procavia capensis	70.89	0.00e+00	873.00
IUUC-Ppe-101794	Prunus persica	31.44	1.00e-34	142.00
IUUC-Pva-103092	Pteropus vampyrus	86.40	0.00e+00	686.00
IUUC-Rno-105237	Rattus norvegicus	83.21	0.00e+00	1276.00
IUUC-Sha-106889	Sarcophilus harrisii	73.64	0.00e+00	1134.00
IUUC-Sit-110283	Setaria italica	32.65	7.00e-31	129.00
IUUC-Sly-111487	Solanum lycopersicum	28.50	4.00e-38	153.00
IUUC-Stu-112820	Solanum tuberosum	29.31	2.00e-37	150.00
IUUC-Sar-113530	Sorex araneus	83.21	0.00e+00	1316.00
IUUC-Sbi-113785	Sorghum bicolor	40.00	2.00e-25	111.00
IUUC-Ssc-116091	Sus scrofa	91.82	0.00e+00	1414.00
IUUC-Tgu-117478	Taeniopygia guttata	60.29	0.00e+00	880.00
IUUC-Tru-118640	Takifugu rubripes	53.28	3.00e-120	426.00
IUUC-Tsy-119042	Tarsius syrichta	78.29	0.00e+00	912.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.40	1.00e-179	623.00
IUUC-Tca-121701	Theobroma cacao	28.24	1.00e-36	148.00
IUUC-Tae-125351	Triticum aestivum	29.45	5.00e-27	116.00
IUUC-Tur-126788	Triticum urartu	28.83	1.00e-26	115.00
IUUC-Tbe-127309	Tupaia belangeri	77.92	0.00e+00	1118.00
IUUC-Ttr-128271	Tursiops truncatus	92.38	0.00e+00	1463.00
IUUC-Vpa-130674	Vicugna pacos	91.63	0.00e+00	1338.00
IUUC-Xtr-131869	Xenopus tropicalis	52.17	0.00e+00	792.00
IUUC-Xma-134195	Xiphophorus maculatus	45.49	0.00e+00	643.00
IUUC-Zma-135157	Zea mays	31.58	5.00e-27	116.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence