iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089971

Ensembl Protein ID

ENSOARP00000021091.1

UniProt Accession

W5QEE3; W5QEE3_SHEEP

Genbank Protein ID

ENSOARP00000021091

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AMGL01008390

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000019637.1	ENSOART00000021385.1	ENSOARP00000021091.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-90	302.1	228	857

Active Site

Position(s)	Description	Evidence
237	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
793	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...............kkkeklneenp.......kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                                  ep g+l+ ++ ++++e++++kk++
   Q: 228  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppdlA---------LtepleinVEPPGPLTLAMSQFLNEMQETKKGV 307
           5******************************8666666665544441.........0444555577899******************** PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           ++prel+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++ ++e     +e++kkk+ +s+++++F+g+l+
   Q: 308  MTPRELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKVDEElknkvKEYEKKKSVPSFVDRIFGGELT 396
           *******************************************************999999999999999******************* PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 397  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdseeekdddsylkerndipsgtskhlqkkakkqakkqakn 485
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 486  qrrqqkiqgkvlhlndvyaidhpednecevemslqgeadiksnhisqeevapkeycvnqkdlnghekmiesitdnqkstekaamknvsv 574
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 575  dndlevlassatecprnlngaylkegsngevdissgfenlnlnaalqpdeinieildddptpgtkvyevvnedpetafctlanreafnt 663
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lh+kRf  ++++ + +k+nk+++
   Q: 664  decSVQHCLYQFTRNEKLRDANKLLCEVCTRRQYsgpkanmkgerkhvytnAKKQMLISLAPPVLTLHFKRF--QQAGFNLRKVNKHIK 750
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 751  FPEILDLAPFCTLKCKNVAEehtRVLYSLYGVVEHSGTMRSGHYTAYAKTrtanthlsnlvlhgdipqdfemesTKGQWFHISDTHVQA 839
           *************9999988777899************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 840  VPTTKVLN---SQAYLLFYER 857
           ********...********98 PP

Organism

Ovis aries

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MQVRKQQLEL DMERGHAGFC SVAFNSSPGR KTGQAARPEG PLGDAAMGAV AVEPMCRHIR 60
KGLEQGNLKK ALVNVEWNIC QDCKTDNKVK DKSEEETEEN PSVWLCLKCG HQGCGRNSQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACTACTGC ACAATTGCAC TCATCTCACA TGCTAGTAAA GTAATGCTCA AAATTCTCCA 60
AGCCAAGCTT CAACAATATG TGAACTGTGA ATTTCCTGAT GTTCAAGCTG GTTTTAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.11	2.00e-29	125.00
IUUC-Bdi-014465	Brachypodium distachyon	30.49	2.00e-29	124.00
IUUC-Hvu-047146	Hordeum vulgare	30.89	4.00e-29	123.00
IUUC-Lpe-050703	Leersia perrieri	29.01	4.00e-28	120.00
IUUC-Mtr-057945	Medicago truncatula	31.42	1.00e-33	139.00
IUUC-Mvi-060391	Microbotryum violaceum	32.14	7.00e-19	89.70
IUUC-Ocu-074704	Oryctolagus cuniculus	89.40	0.00e+00	1433.00
IUUC-Oba-075094	Oryza barthii	29.88	5.00e-30	127.00
IUUC-Obr-076743	Oryza brachyantha	30.25	4.00e-30	127.00
IUUC-Ogl-077739	Oryza glaberrima	29.88	3.00e-30	127.00
IUUC-Ogu-078851	Oryza glumaepatula	29.88	5.00e-30	126.00
IUUC-Oin-079402	Oryza indica	29.88	5.00e-30	126.00
IUUC-Olo-080431	Oryza longistaminata	29.88	4.00e-30	126.00
IUUC-Ome-081580	Oryza meridionalis	29.88	6.00e-30	126.00
IUUC-Oni-082644	Oryza nivara	29.88	5.00e-30	126.00
IUUC-Oru-084546	Oryza rufipogon	29.88	5.00e-30	126.00
IUUC-Osa-085858	Oryza sativa	29.88	4.00e-30	127.00
IUUC-Sit-110283	Setaria italica	31.40	1.00e-30	129.00
IUUC-Sly-111487	Solanum lycopersicum	27.40	5.00e-38	153.00
IUUC-Sbi-113785	Sorghum bicolor	37.42	1.00e-23	105.00
IUUC-Tae-125785	Triticum aestivum	29.05	1.00e-27	119.00
IUUC-Tur-126788	Triticum urartu	28.75	2.00e-27	117.00
IUUC-Zma-135157	Zea mays	31.17	1.00e-26	115.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence