iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021710

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

AAKN02026943

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000006661.3	ENSCPOT00000006727.2	ENSCPOP00000006000.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-45	150.4	145	180
UBD/Beta-Prp	5.50e-60	203.0	15	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9986 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           67788888999888899************************************************************************ PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSDFPG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++
   Q: 191  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
           ***********************************************************766.45554 PP

Organism

Cavia porcellus

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACCC CTGTGGTCAC CAAGACAGCC TGGAAGTTAC GTGAGTAATC TGCAGTTTTC 60
TTTATTACCC CATTCTGTTA GCTGTTTGTT GCTGGCCAAC TCATTCTCAC AGCTTTGTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	47.84	6.00e-86	312.00
IUUC-Aml-002187	Ailuropoda melanoleuca	87.79	0.00e+00	1103.00
IUUC-Atr-002899	Amborella trichopoda	51.21	9.00e-104	371.00
IUUC-Apl-003305	Anas platyrhynchos	76.82	0.00e+00	1016.00
IUUC-Aca-004635	Anolis carolinensis	79.88	0.00e+00	969.00
IUUC-Aly-005711	Arabidopsis lyrata	51.16	2.00e-101	363.00
IUUC-Ath-007606	Arabidopsis thaliana	51.16	3.00e-101	363.00
IUUC-Ame-010870	Astyanax mexicanus	55.73	8.00e-95	340.00
IUUC-Bta-012527	Bos taurus	93.51	0.00e+00	1172.00
IUUC-Bdi-014652	Brachypodium distachyon	53.18	1.00e-103	370.00
IUUC-Bol-015242	Brassica oleracea	50.17	2.00e-99	357.00
IUUC-Bra-017390	Brassica rapa	50.50	6.00e-100	358.00
IUUC-Cja-019706	Callithrix jacchus	93.91	0.00e+00	1098.00
IUUC-Cfa-020139	Canis familiaris	78.78	0.00e+00	763.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.81	2.00e-69	256.00
IUUC-Csa-023546	Chlorocebus sabaeus	95.11	0.00e+00	1061.00
IUUC-Cin-025156	Ciona intestinalis	42.56	2.00e-157	549.00
IUUC-Csv-025962	Ciona savignyi	49.32	2.00e-89	321.00
IUUC-Dre-028215	Danio rerio	61.98	0.00e+00	851.00
IUUC-Dno-029314	Dasypus novemcinctus	92.98	0.00e+00	1124.00
IUUC-Dor-030482	Dipodomys ordii	95.57	0.00e+00	1222.00
IUUC-Dme-032188	Drosophila melanogaster	39.48	4.00e-59	223.00
IUUC-Eca-034143	Equus caballus	93.74	0.00e+00	1180.00
IUUC-Fca-035924	Felis catus	94.81	0.00e+00	1164.00
IUUC-Fal-037387	Ficedula albicollis	78.79	0.00e+00	999.00
IUUC-Gmo-038692	Gadus morhua	58.78	0.00e+00	750.00
IUUC-Gga-040597	Gallus gallus	78.27	0.00e+00	1046.00
IUUC-Gac-042004	Gasterosteus aculeatus	61.24	0.00e+00	820.00
IUUC-Gma-044134	Glycine max	32.28	1.00e-106	380.00
IUUC-Ggo-044761	Gorilla gorilla	95.42	0.00e+00	1102.00
IUUC-Hsa-045698	Homo sapiens	95.11	0.00e+00	1129.00
IUUC-Hvu-047649	Hordeum vulgare	52.92	9.00e-104	371.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	94.50	0.00e+00	1153.00
IUUC-Lch-049674	Latimeria chalumnae	67.69	0.00e+00	917.00
IUUC-Lpe-051554	Leersia perrieri	54.18	6.00e-106	378.00
IUUC-Loc-052623	Lepisosteus oculatus	66.52	0.00e+00	899.00
IUUC-Laf-054587	Loxodonta africana	95.14	0.00e+00	1188.00
IUUC-Mcc-055851	Macaca mulatta	95.42	0.00e+00	1102.00
IUUC-Meu-056704	Macropus eugenii	89.06	0.00e+00	1172.00
IUUC-Mtr-058053	Medicago truncatula	52.82	2.00e-105	376.00
IUUC-Mga-059608	Meleagris gallopavo	77.93	0.00e+00	1036.00
IUUC-Mmr-061154	Microcebus murinus	93.90	0.00e+00	1130.00
IUUC-Mdo-062365	Monodelphis domestica	85.45	0.00e+00	1106.00
IUUC-Mmu-063754	Mus musculus	94.38	0.00e+00	1162.00
IUUC-Mac-064667	Musa acuminata	52.90	2.00e-101	362.00
IUUC-Mpu-066245	Mustela putorius furo	94.35	0.00e+00	1124.00
IUUC-Mlu-067692	Myotis lucifugus	94.44	0.00e+00	1143.00
IUUC-Nle-070051	Nomascus leucogenys	92.84	0.00e+00	1081.00
IUUC-Opr-070855	Ochotona princeps	95.11	0.00e+00	1179.00
IUUC-Ont-071883	Oreochromis niloticus	59.43	0.00e+00	827.00
IUUC-Oan-073293	Ornithorhynchus anatinus	89.59	0.00e+00	1036.00
IUUC-Ocu-074644	Oryctolagus cuniculus	95.73	0.00e+00	1190.00
IUUC-Oba-075448	Oryza barthii	55.18	3.00e-107	382.00
IUUC-Obr-076385	Oryza brachyantha	54.18	3.00e-106	379.00
IUUC-Ogl-077427	Oryza glaberrima	55.18	1.00e-107	384.00
IUUC-Ogu-079022	Oryza glumaepatula	49.20	1.00e-98	354.00
IUUC-Oin-079811	Oryza indica	52.73	2.00e-104	373.00
IUUC-Olo-080245	Oryza longistaminata	52.73	2.00e-104	374.00
IUUC-Ome-081239	Oryza meridionalis	54.61	7.00e-104	371.00
IUUC-Oni-082640	Oryza nivara	55.18	3.00e-107	382.00
IUUC-Opu-083748	Oryza punctata	51.52	6.00e-107	382.00
IUUC-Oru-084609	Oryza rufipogon	55.18	3.00e-107	382.00
IUUC-Osa-086267	Oryza sativa	49.20	9.00e-99	354.00
IUUC-Ola-087483	Oryzias latipes	56.21	0.00e+00	635.00
IUUC-Oga-087964	Otolemur garnettii	94.66	0.00e+00	1187.00
IUUC-Oar-089483	Ovis aries	92.01	0.00e+00	1138.00
IUUC-Ptr-091387	Pan troglodytes	95.27	0.00e+00	1130.00
IUUC-Pan-092623	Papio anubis	95.42	0.00e+00	1102.00
IUUC-Psi-093830	Pelodiscus sinensis	81.09	0.00e+00	1057.00
IUUC-Pma-094135	Petromyzon marinus	45.50	2.00e-41	161.00
IUUC-Ppa-095379	Physcomitrella patens	55.14	2.00e-98	353.00
IUUC-Pfo-096755	Poecilia formosa	58.14	0.00e+00	803.00
IUUC-Pab-097564	Pongo abelii	94.34	0.00e+00	971.00
IUUC-Pop-099149	Populus trichocarpa	52.82	7.00e-105	375.00
IUUC-Pca-100357	Procavia capensis	99.05	7.00e-126	444.00
IUUC-Ppe-101237	Prunus persica	52.82	1.00e-104	374.00
IUUC-Pva-102397	Pteropus vampyrus	90.08	0.00e+00	1073.00
IUUC-Rno-105349	Rattus norvegicus	94.66	0.00e+00	1200.00
IUUC-Smo-109409	Selaginella moellendorffii	54.61	2.00e-102	366.00
IUUC-Sit-110360	Setaria italica	54.52	4.00e-106	379.00
IUUC-Sly-111307	Solanum lycopersicum	53.51	4.00e-100	358.00
IUUC-Stu-112462	Solanum tuberosum	52.74	1.00e-96	347.00
IUUC-Sar-112953	Sorex araneus	82.02	7.00e-109	387.00
IUUC-Sbi-114389	Sorghum bicolor	47.32	4.00e-95	342.00
IUUC-Ssc-115949	Sus scrofa	90.98	0.00e+00	871.00
IUUC-Tgu-117461	Taeniopygia guttata	77.66	0.00e+00	1026.00
IUUC-Tru-117865	Takifugu rubripes	58.60	0.00e+00	788.00
IUUC-Tsy-119036	Tarsius syrichta	80.82	7.00e-86	310.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.79	0.00e+00	781.00
IUUC-Tca-121185	Theobroma cacao	51.83	7.00e-102	365.00
IUUC-Tae-125263	Triticum aestivum	53.25	4.00e-104	372.00
IUUC-Tur-126181	Triticum urartu	48.30	4.00e-95	342.00
IUUC-Tbe-127518	Tupaia belangeri	81.66	0.00e+00	640.00
IUUC-Ttr-128172	Tursiops truncatus	93.89	0.00e+00	1133.00
IUUC-Vvi-131489	Vitis vinifera	53.49	3.00e-105	376.00
IUUC-Xtr-132915	Xenopus tropicalis	72.43	0.00e+00	962.00
IUUC-Xma-134133	Xiphophorus maculatus	57.85	0.00e+00	794.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence