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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046673
UUCD1 version UUC-HoS-00238
Ensembl Protein ID ENSP00000311778.4
UniProt Accession Q8NF64; A4D2K7; D3DVL1; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8WTX8; Q96Q01; Q9BQH7; ZMIZ2_HUMAN
Genbank Protein ID AAR85526.1; BAC03396.1; AAP22368.1; EAL23750.1; EAW61083.1; EAW61084.1; EAW61085.1; AAH21924.1; AAI10436.1; BAB67779.1; CAH56269.1; CAB66507.1; BAA34789.1
Protein Name Zinc finger MIZ domain-containing protein 2; PIAS-like protein Zimp7
Genbank Nucleotide ID AY426594; AK090415; AC004859; CH236960; CH471128; CH471128; CH471128; BC021924; BC110435; AB067473; AL831933; AL136572; AB015330
Gene Name ZMIZ2; KIAA1886; ZIMP7; HRIHFB2007
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000122515.14 ENST00000413916.5 ENSP00000409648.1
ENSG00000122515.14 ENST00000309315.8 ENSP00000311778.4
ENSG00000122515.14 ENST00000416856.5 ENSP00000406820.1
ENSG00000122515.14 ENST00000433667.5 ENSP00000396601.1
ENSG00000122515.14 ENST00000265346.11 ENSP00000265346.7
ENSG00000122515.14 ENST00000615423.1 ENSP00000483853.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18218095
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.8 9.8 600 643
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+i + +++ + +  +C H+ ++d  + + ++ n +++++rCP+C+
   Q: 600  CPITFRRIQLPARGHDCRHIQCFDL-ESY-LQLNCERGTWRCPVCN 643
           8999888877666666888877777.899.8999***********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.
 Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.
Protein Sequence
(Fasta)
MNSMNPMKPA LPPAPHGDGS FAYESVPWQQ SATQPAGSLS VVTTVWGVGN ATQSQVLGNP 60
MGPAGSPSGS SMMPGVAGGS SALTSPQCLG QQAFAEGGAN KGYVQQGVYS RGGYPGAPGF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046673|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACTGCGAGC AGGAAGAGCG CAGTGGCTCT GCCGACGCCG CGTTCAGAAA GGTGTGGAGG 60
GGGCTGGGGG CGCAGGTCGC GATCAGGCTG CGTCTCCTGC CCGCCCAGCC ACCTGCGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046673|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004181--Znf_MIZ
PROSITE

PS51044--ZF_SP_RING
Pfam

PF02891--zf-MIZ
Gene Ontology

GO:0005739--C:mitochondrion
GO:0043596--C:nuclear replication fork
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG hsa:83637
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000547 Aegilops tauschii 25.20 3.00e-20 94.00
IUUC-Aml-001796 Ailuropoda melanoleuca 85.45 0.00e+00 1142.00
IUUC-Atr-002447 Amborella trichopoda 39.42 1.00e-19 92.40
IUUC-Aca-004330 Anolis carolinensis 73.38 0.00e+00 1078.00
IUUC-Aly-006247 Arabidopsis lyrata 33.82 3.00e-19 90.90
IUUC-Acl-008210 Aspergillus clavatus 27.31 5.00e-20 94.00
IUUC-Ame-011803 Astyanax mexicanus 63.76 0.00e+00 909.00
IUUC-Bta-012429 Bos taurus 87.88 0.00e+00 1210.00
IUUC-Bdi-014629 Brachypodium distachyon 29.68 3.00e-20 94.00
IUUC-Bol-015380 Brassica oleracea 40.45 8.00e-18 85.90
IUUC-Cja-019399 Callithrix jacchus 95.33 0.00e+00 1326.00
IUUC-Cpo-022300 Cavia porcellus 90.98 0.00e+00 1282.00
IUUC-Csa-023198 Chlorocebus sabaeus 98.48 0.00e+00 1407.00
IUUC-Dre-028458 Danio rerio 63.96 0.00e+00 921.00
IUUC-Dno-029968 Dasypus novemcinctus 85.36 0.00e+00 1191.00
IUUC-Dor-031089 Dipodomys ordii 88.41 0.00e+00 1057.00
IUUC-Ete-033093 Echinops telfairi 81.32 0.00e+00 978.00
IUUC-Eca-033989 Equus caballus 89.07 0.00e+00 1198.00
IUUC-Eeu-035000 Erinaceus europaeus 82.14 0.00e+00 1207.00
IUUC-Fca-035609 Felis catus 85.10 0.00e+00 1093.00
IUUC-Fal-036955 Ficedula albicollis 68.06 0.00e+00 1043.00
IUUC-Fox-038010 Fusarium oxysporum 23.91 4.00e-15 76.30
IUUC-Gga-040780 Gallus gallus 84.42 0.00e+00 732.00
IUUC-Gma-043279 Glycine max 30.47 7.00e-20 92.80
IUUC-Ggo-045514 Gorilla gorilla 99.67 0.00e+00 1452.00
IUUC-Hvu-047061 Hordeum vulgare 45.45 2.00e-21 97.80
IUUC-Itr-048081 Ictidomys tridecemlineatus 94.02 0.00e+00 1298.00
IUUC-Lch-049651 Latimeria chalumnae 68.94 0.00e+00 939.00
IUUC-Lpe-050930 Leersia perrieri 27.50 5.00e-21 96.70
IUUC-Loc-052223 Lepisosteus oculatus 71.70 0.00e+00 768.00
IUUC-Laf-053464 Loxodonta africana 82.10 0.00e+00 1163.00
IUUC-Mcc-055469 Macaca mulatta 83.51 0.00e+00 1234.00
IUUC-Mtr-058191 Medicago truncatula 25.81 6.00e-18 86.70
IUUC-Mmr-061471 Microcebus murinus 95.87 0.00e+00 1284.00
IUUC-Mdo-062717 Monodelphis domestica 83.98 0.00e+00 1315.00
IUUC-Mmu-064291 Mus musculus 90.87 0.00e+00 1320.00
IUUC-Mac-065353 Musa acuminata 25.76 9.00e-19 89.40
IUUC-Mlu-067936 Myotis lucifugus 86.70 0.00e+00 1067.00
IUUC-Opr-070184 Ochotona princeps 81.17 0.00e+00 1013.00
IUUC-Ocu-074348 Oryctolagus cuniculus 90.67 0.00e+00 1265.00
IUUC-Oba-075465 Oryza barthii 27.50 2.00e-20 94.70
IUUC-Obr-076593 Oryza brachyantha 27.15 4.00e-21 97.10
IUUC-Ogl-076986 Oryza glaberrima 27.50 3.00e-20 94.00
IUUC-Ogu-078271 Oryza glumaepatula 32.12 4.00e-21 97.40
IUUC-Oin-079468 Oryza indica 27.50 2.00e-20 95.10
IUUC-Olo-080754 Oryza longistaminata 27.50 2.00e-20 94.70
IUUC-Ome-081404 Oryza meridionalis 32.85 3.00e-22 100.00
IUUC-Oni-082630 Oryza nivara 27.50 2.00e-20 94.40
IUUC-Opu-083453 Oryza punctata 27.50 5.00e-21 96.70
IUUC-Oru-084397 Oryza rufipogon 27.50 3.00e-20 94.40
IUUC-Osa-085685 Oryza sativa 32.85 2.00e-21 98.20
IUUC-Oar-089910 Ovis aries 80.68 0.00e+00 1067.00
IUUC-Ptr-090782 Pan troglodytes 99.57 0.00e+00 1453.00
IUUC-Pan-092680 Papio anubis 98.59 0.00e+00 1439.00
IUUC-Ppa-095583 Physcomitrella patens 40.00 5.00e-21 96.70
IUUC-Pab-098739 Pongo abelii 99.57 0.00e+00 1449.00
IUUC-Pop-099745 Populus trichocarpa 27.06 6.00e-17 83.20
IUUC-Pca-100114 Procavia capensis 85.95 0.00e+00 1187.00
IUUC-Pva-103057 Pteropus vampyrus 76.27 0.00e+00 972.00
IUUC-Rno-106034 Rattus norvegicus 91.63 0.00e+00 1271.00
IUUC-Sha-107447 Sarcophilus harrisii 79.57 0.00e+00 1237.00
IUUC-Sit-110164 Setaria italica 28.20 3.00e-23 104.00
IUUC-Sly-111180 Solanum lycopersicum 36.27 2.00e-21 97.80
IUUC-Sar-113219 Sorex araneus 84.28 3.00e-153 535.00
IUUC-Sbi-114516 Sorghum bicolor 26.82 9.00e-23 102.00
IUUC-Ssc-115452 Sus scrofa 90.04 0.00e+00 1160.00
IUUC-Tgu-117033 Taeniopygia guttata 71.21 0.00e+00 998.00
IUUC-Tca-121811 Theobroma cacao 34.96 6.00e-19 90.10
IUUC-Tae-124127 Triticum aestivum 36.17 1.00e-23 105.00
IUUC-Tur-126304 Triticum urartu 26.45 9.00e-21 95.90
IUUC-Ttr-128184 Tursiops truncatus 89.39 0.00e+00 1209.00
IUUC-Vvi-131480 Vitis vinifera 32.84 3.00e-17 84.30
IUUC-Xtr-132124 Xenopus tropicalis 67.03 0.00e+00 1049.00
Created Date 25-Jun-2017

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