iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Hvu-047645

Ensembl Protein ID

MLOC_55312.1

UniProt Accession

M0WWU2; M0WWU2_HORVV

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MLOC_55312	MLOC_55312.2	MLOC_55312.2
MLOC_55312	MLOC_55312.1	MLOC_55312.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	5.70e-118	394.7	146	456
E3 adaptor/Cullin RING/DCX/DWD	6.50e-24	84.1	281	311
UBD/Beta-Prp	2.00e-48	166.2	196	451

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 2    ekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl.tghs 96
           e+ ldap + dd+yln+ldW+sknv++vaL++++ylw+a++++ s+l  + ++   +tsvsw  eg+++avG +++ ++++D+++++ +rtl   h 
   Q: 146  ERTLDAPGVVDDYYLNVLDWGSKNVVSVALENTLYLWNASDSSTSELVTVdDDYGPITSVSWACEGQHIAVGLNSSDIQLWDTSSNRMLRTLrGVHE 242
           689**********************************************9667778************************************55599 PP
   S: 97   arvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse.........Plkkfkehkaavka 184
           +rvg+L+Wn+ +l+sG+ dg+i+ +dvr++ ++++t+++h+ evCGl+w+ + ++LasGGnDn v++wdas  +          l++f++h aavka
   Q: 243  SRVGSLAWNSSILTSGGMDGKIVNNDVRMRSHMVQTYRGHEAEVCGLRWSGSLQQLASGGNDNLVHIWDASMASsnpslgynrWLHRFSDHLAAVKA 339
           9********************************************************************987766767777667899********** PP
   S: 185  iawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgea 281
           +aw+P+q++lLasGGG +Drcikfwnt tg +l+++dtg+qvc llw k++kel+s+ Gf ++ +tlwkyps+ k+ael+gh++Rvl+la spdg++
   Q: 340  LAWCPFQSNLLASGGGGNDRCIKFWNTHTGLCLNSVDTGAQVCALLWNKNEKELLSACGFVQKPLTLWKYPSMVKLAELEGHTSRVLCLAQSPDGST 436
           ************************************************************************************************* PP
   S: 282  ivtaagDetlrfwklfdkkk 301
           ++++a+Detlrfw++f +++
   Q: 437  VASVAADETLRFWNVFGTSE 456
           ****************8765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+++v++l++  +   l+sG++D+ +++WD
   Q: 281  GHEAEVCGLRWsGSlQQLASGGNDNLVHIWD 311
           8**********744788************** PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlsls 101
           +++ ++it+v ++ +++++a+g  ++ i++wd+++  +lr+l   he+ v ++ ++++  il +g+ D+ i  +d++  + +v+t++ghe++v+ l+
   Q: 196  DDDYGPITSVSWACEGQHIAVGLNSSDIQLWDTSSNRMLRTLrGVHESRVGSLAWNSS--ILTSGGMDGKIVNNDVRmRSHMVQTYRGHEAEVCGLR 290
           566789************************************888*************..***********999**978899*************** PP
   S: 102  fspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdg.nllvsG..slDrtvrlWdlktgkllrtltgghtdsvysls 187
           +s s + l+sG++d+ +++wd +  +   +         +s h ++v  +++ p++ nll+sG  ++Dr++++W+  tg +l         +v  l 
   Q: 291  WSGSLQQLASGGNDNLVHIWDASMASSNPSlgynrwlhRFSDHLAAVKALAWCPFQsNLLASGggGNDRCIKFWNTHTGLCLNSVD--TGAQVCALL 385
           **********************9999999899999999************************73369******************5..589999*** PP
   S: 188  fdsngkelvs..gsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           +++n kel+s  g   + ++lw + +   + +l+ght+ v++++ sp++  ++s+++D+++r+W++
   Q: 386  WNKNEKELLSacGFVQKPLTLWKYPSMVKLAELEGHTSRVLCLAQSPDGSTVASVAADETLRFWNV 451
           *******99933346899**********************************************95 PP

Organism

Hordeum vulgare

Protein Sequence
(Fasta)

MEAAGSSSSR PPKRRRPGLR PSTSLEMAGA RTPYMPSLCT NSKNPSTKCY GDRFIPDRSA 60
MDMDMAYYLL TEPKKDKENE AVVSPSKEAY RRLLAEKLLG SRTRILAFRN KPPEPEGMRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAAAGCTT CTATTCCTAA AATACCCCCA ACCAAATCTG TCGTGCGTTT CCGTCAGAAA 60
AAGGGGGAAT TCCGTCCAAC GTCGAACACC CCAAATCCCC CCGAAACCTC CGGCGGCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000267	Aegilops tauschii	97.84	0.00e+00	852.00
IUUC-Bdi-014464	Brachypodium distachyon	87.03	0.00e+00	844.00
IUUC-Oin-080069	Oryza indica	78.45	0.00e+00	769.00
IUUC-Opu-083543	Oryza punctata	78.28	0.00e+00	753.00
IUUC-Osa-085604	Oryza sativa	78.66	0.00e+00	770.00
IUUC-Tae-123640	Triticum aestivum	97.27	0.00e+00	927.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence