iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	1.00e-54	186.1	225	438

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++C++e+  ++++++leC+h++Ck+Clk+y+e++ik+gqv++++cp+++c++ +++ ++ke lve++l++ry++lll+++++ +a++ +
   Q: 225  CSICFCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCSSVATPGQVKE-LVEADLFARYDRLLLQSTLDLMADVVY 313
           **************************************************************.7************************** PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeek........................eeaeskel 156
           cp+p+C+l+v++e+    + + c++c+++fC+ C+ ++H  + Ck ++ekl + ++e+                        ee+esk +
   Q: 314  CPRPCCQLPVMQEPG--GTMAICSSCNFAFCTLCRLTYHGVSPCKVTAEKLIDLRNEYlqadeatkrfleqrygkrviqkalEEMESKDW 401
           **************6..56677999******************************999******************************** PP
   S: 157  leanskkCpkCkvyieknegCnhmtCakCkaefCwlC 193
           le+nsk+Cp+C ++i+k +gCn+mtC+ C+++fCw+C
   Q: 402  LEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVC 438
           ************************************* PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSAEDLEAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN 60
SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAAGTGC AAGGTTCGTT TTAAAAGAAG ACAGTATCTG TTGGGGAACA ACCGTGTGGA 60
GGTGGGTCTT TAGGTGCCCT CAAAGGCCAA GTGGATGGAC TCAGGAAGTG AAAGCTAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50908--RWD
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR
PF05773--RWD

SMART

SM00647--IBR
SM00591--RWD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0007165--P:signal transduction

KEGG

rno:619577

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001130	Aegilops tauschii	30.37	8.00e-53	201.00
IUUC-Aml-001458	Ailuropoda melanoleuca	92.10	0.00e+00	865.00
IUUC-Atr-002560	Amborella trichopoda	29.83	2.00e-44	173.00
IUUC-Apl-003680	Anas platyrhynchos	78.91	0.00e+00	751.00
IUUC-Aca-005000	Anolis carolinensis	68.78	0.00e+00	646.00
IUUC-Aly-006288	Arabidopsis lyrata	30.38	2.00e-53	204.00
IUUC-Ath-006719	Arabidopsis thaliana	30.60	8.00e-54	205.00
IUUC-Acl-008213	Aspergillus clavatus	24.78	7.00e-30	125.00
IUUC-Afl-008433	Aspergillus flavus	23.48	9.00e-31	128.00
IUUC-Afu-008772	Aspergillus fumigatus	26.09	8.00e-33	135.00
IUUC-Ani-009249	Aspergillus nidulans	27.19	6.00e-33	135.00
IUUC-Ang-009757	Aspergillus niger	27.90	6.00e-37	148.00
IUUC-Aor-009963	Aspergillus oryzae	23.48	2.00e-30	127.00
IUUC-Ate-010460	Aspergillus terreus	24.89	2.00e-31	130.00
IUUC-Ame-011312	Astyanax mexicanus	56.28	1.00e-143	503.00
IUUC-Bgr-012052	Blumeria graminis	25.71	3.00e-28	120.00
IUUC-Bta-013529	Bos taurus	91.86	0.00e+00	871.00
IUUC-Bci-013729	Botrytis cinerea	24.46	6.00e-28	119.00
IUUC-Bdi-014940	Brachypodium distachyon	32.55	3.00e-52	199.00
IUUC-Bra-016998	Brassica rapa	29.49	2.00e-50	194.00
IUUC-Cel-018547	Caenorhabditis elegans	30.39	2.00e-49	190.00
IUUC-Cja-019791	Callithrix jacchus	89.77	0.00e+00	851.00
IUUC-Cfa-020403	Canis familiaris	91.65	0.00e+00	867.00
IUUC-Cpo-022229	Cavia porcellus	87.94	0.00e+00	823.00
IUUC-Cre-022601	Chlamydomonas reinhardtii	33.18	1.00e-29	122.00
IUUC-Csa-024115	Chlorocebus sabaeus	90.61	0.00e+00	855.00
IUUC-Cho-024911	Choloepus hoffmanni	91.86	0.00e+00	868.00
IUUC-Cin-025578	Ciona intestinalis	40.86	3.00e-95	342.00
IUUC-Csv-026355	Ciona savignyi	39.00	1.00e-80	293.00
IUUC-Cgl-026439	Colletotrichum gloeosporioides	24.11	2.00e-26	114.00
IUUC-Cne-026782	Cryptococcus neoformans	26.10	8.00e-29	121.00
IUUC-Dre-027380	Danio rerio	56.36	9.00e-152	530.00
IUUC-Dno-029640	Dasypus novemcinctus	92.90	0.00e+00	879.00
IUUC-Dor-030681	Dipodomys ordii	92.69	0.00e+00	876.00
IUUC-Dse-031208	Dothistroma septosporum	24.13	2.00e-30	127.00
IUUC-Ete-033122	Echinops telfairi	58.99	2.00e-131	462.00
IUUC-Eca-033755	Equus caballus	90.47	0.00e+00	840.00
IUUC-Eeu-035034	Erinaceus europaeus	95.89	3.00e-71	262.00
IUUC-Fca-036461	Felis catus	92.48	0.00e+00	872.00
IUUC-Fal-037516	Ficedula albicollis	77.92	0.00e+00	739.00
IUUC-Fso-038307	Fusarium solani	24.21	3.00e-24	106.00
IUUC-Gmo-039563	Gadus morhua	54.90	3.00e-143	501.00
IUUC-Ggr-039920	Gaeumannomyces graminis	25.24	2.00e-24	108.00
IUUC-Gga-040331	Gallus gallus	77.31	0.00e+00	739.00
IUUC-Gac-042164	Gasterosteus aculeatus	57.38	9.00e-156	543.00
IUUC-Gma-044080	Glycine max	31.25	5.00e-58	218.00
IUUC-Ggo-045257	Gorilla gorilla	90.40	0.00e+00	856.00
IUUC-Hsa-046887	Homo sapiens	91.40	0.00e+00	837.00
IUUC-Hvu-047317	Hordeum vulgare	29.66	2.00e-49	190.00
IUUC-Itr-048199	Ictidomys tridecemlineatus	93.53	0.00e+00	884.00
IUUC-Lch-050155	Latimeria chalumnae	62.00	4.00e-161	561.00
IUUC-Lpe-051669	Leersia perrieri	31.05	2.00e-40	160.00
IUUC-Loc-051779	Lepisosteus oculatus	57.37	1.00e-150	526.00
IUUC-Lma-052969	Leptosphaeria maculans	23.61	6.00e-31	128.00
IUUC-Laf-053488	Loxodonta africana	89.56	0.00e+00	847.00
IUUC-Mcc-054701	Macaca mulatta	91.18	0.00e+00	833.00
IUUC-Meu-056577	Macropus eugenii	77.50	5.00e-113	401.00
IUUC-Mor-057157	Magnaporthe oryzae	24.44	1.00e-26	115.00
IUUC-Mpo-057518	Magnaporthe poae	25.74	1.00e-27	118.00
IUUC-Mtr-058125	Medicago truncatula	29.19	1.00e-45	177.00
IUUC-Mga-059906	Meleagris gallopavo	77.31	0.00e+00	737.00
IUUC-Mvi-060374	Microbotryum violaceum	33.21	8.00e-33	135.00
IUUC-Mmr-061786	Microcebus murinus	93.11	0.00e+00	880.00
IUUC-Mdo-062453	Monodelphis domestica	85.90	0.00e+00	780.00
IUUC-Mmu-063521	Mus musculus	94.74	0.00e+00	853.00
IUUC-Mac-065119	Musa acuminata	29.40	7.00e-39	155.00
IUUC-Mpu-066274	Mustela putorius furo	91.65	0.00e+00	868.00
IUUC-Mlu-067202	Myotis lucifugus	88.82	0.00e+00	799.00
IUUC-Nfi-068564	Neosartorya fischeri	25.43	3.00e-31	130.00
IUUC-Ncr-068823	Neurospora crassa	25.90	3.00e-29	124.00
IUUC-Nle-068987	Nomascus leucogenys	91.20	0.00e+00	837.00
IUUC-Opr-070453	Ochotona princeps	89.98	0.00e+00	850.00
IUUC-Ont-072611	Oreochromis niloticus	56.18	1.00e-154	539.00
IUUC-Oan-073738	Ornithorhynchus anatinus	78.71	0.00e+00	723.00
IUUC-Ocu-074396	Oryctolagus cuniculus	92.48	0.00e+00	869.00
IUUC-Oba-075472	Oryza barthii	32.39	2.00e-44	173.00
IUUC-Obr-076277	Oryza brachyantha	31.47	2.00e-47	184.00
IUUC-Ogl-077046	Oryza glaberrima	32.09	5.00e-43	169.00
IUUC-Ogu-078634	Oryza glumaepatula	32.39	1.00e-44	174.00
IUUC-Oin-080080	Oryza indica	29.57	2.00e-44	173.00
IUUC-Olo-080828	Oryza longistaminata	28.76	6.00e-42	166.00
IUUC-Ome-081387	Oryza meridionalis	29.33	4.00e-47	182.00
IUUC-Oni-082934	Oryza nivara	32.39	1.00e-44	174.00
IUUC-Opu-083719	Oryza punctata	28.57	1.00e-41	164.00
IUUC-Oru-084518	Oryza rufipogon	32.39	1.00e-44	174.00
IUUC-Ola-087312	Oryzias latipes	57.44	2.00e-153	535.00
IUUC-Olu-087661	Ostreococcus lucimarinus	29.39	1.00e-45	177.00
IUUC-Oga-089129	Otolemur garnettii	93.31	0.00e+00	876.00
IUUC-Oar-089839	Ovis aries	91.65	0.00e+00	870.00
IUUC-Ptr-091626	Pan troglodytes	91.18	0.00e+00	835.00
IUUC-Pan-092798	Papio anubis	91.18	0.00e+00	833.00
IUUC-Psi-093253	Pelodiscus sinensis	78.45	0.00e+00	747.00
IUUC-Pma-094512	Petromyzon marinus	54.06	8.00e-142	496.00
IUUC-Pno-094937	Phaeosphaeria nodorum	23.43	8.00e-29	121.00
IUUC-Ppa-095211	Physcomitrella patens	29.85	7.00e-53	201.00
IUUC-Pfo-097049	Poecilia formosa	52.88	2.00e-138	485.00
IUUC-Pab-097911	Pongo abelii	90.97	0.00e+00	833.00
IUUC-Pop-099841	Populus trichocarpa	29.98	4.00e-49	189.00
IUUC-Pca-100814	Procavia capensis	70.56	3.00e-180	624.00
IUUC-Ppe-101972	Prunus persica	30.33	4.00e-50	192.00
IUUC-Pva-103038	Pteropus vampyrus	91.44	0.00e+00	861.00
IUUC-Pgr-103277	Puccinia graminis	33.84	1.00e-39	157.00
IUUC-Ptt-103855	Puccinia triticina	31.15	3.00e-36	146.00
IUUC-Pte-104113	Pyrenophora teres	25.99	2.00e-26	113.00
IUUC-Pyt-104619	Pyrenophora triticirepentis	27.06	1.00e-28	120.00
IUUC-Sce-106287	Saccharomyces cerevisiae	27.65	3.00e-23	102.00
IUUC-Sha-106652	Sarcophilus harrisii	85.62	0.00e+00	788.00
IUUC-Spo-108167	Schizosaccharomyces pombe	29.06	1.00e-47	184.00
IUUC-Ssl-108396	Sclerotinia sclerotiorum	24.11	5.00e-09	56.60
IUUC-Smo-109393	Selaginella moellendorffii	30.92	2.00e-48	186.00
IUUC-Sit-110529	Setaria italica	34.61	2.00e-45	177.00
IUUC-Sly-111829	Solanum lycopersicum	30.48	2.00e-51	197.00
IUUC-Stu-112811	Solanum tuberosum	30.70	6.00e-52	199.00
IUUC-Sar-113259	Sorex araneus	84.10	2.00e-126	445.00
IUUC-Sbi-114591	Sorghum bicolor	32.33	2.00e-37	150.00
IUUC-Sre-115227	Sporisorium reilianum	28.06	2.00e-35	144.00
IUUC-Ssc-115293	Sus scrofa	90.61	0.00e+00	859.00
IUUC-Tgu-117335	Taeniopygia guttata	77.78	0.00e+00	731.00
IUUC-Tru-118458	Takifugu rubripes	55.93	4.00e-153	534.00
IUUC-Tsy-119475	Tarsius syrichta	83.72	0.00e+00	759.00
IUUC-Tni-119827	Tetraodon nigroviridis	55.49	1.00e-151	530.00
IUUC-Tca-121023	Theobroma cacao	31.95	2.00e-51	196.00
IUUC-Tre-121965	Trichoderma reesei	23.01	8.00e-29	121.00
IUUC-Tvi-122564	Trichoderma virens	21.74	1.00e-25	111.00
IUUC-Tae-124793	Triticum aestivum	34.20	2.00e-43	171.00
IUUC-Tur-126258	Triticum urartu	29.55	3.00e-44	172.00
IUUC-Tbe-127227	Tupaia belangeri	73.47	7.00e-78	284.00
IUUC-Ttr-128984	Tursiops truncatus	69.94	1.00e-174	605.00
IUUC-Uma-129565	Ustilago maydis	26.38	3.00e-33	137.00
IUUC-Vpa-130301	Vicugna pacos	92.28	0.00e+00	873.00
IUUC-Vvi-131244	Vitis vinifera	31.03	7.00e-52	198.00
IUUC-Xtr-132880	Xenopus tropicalis	57.68	5.00e-156	544.00
IUUC-Xma-134055	Xiphophorus maculatus	57.23	2.00e-155	542.00
IUUC-Yli-134342	Yarrowia lipolytica	28.57	9.00e-43	167.00
IUUC-Zma-135021	Zea mays	32.88	2.00e-40	160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence