iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011500

Ensembl Protein ID

ENSAMXP00000014213.1

UniProt Accession

W5L301; W5L301_ASTMX

Genbank Protein ID

ENSAMXP00000014213

Protein Name

Presenilin

Genbank Nucleotide ID

APWO01109670

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000013813.1	ENSAMXT00000014214.1	ENSAMXP00000014213.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.30e-09	36.4	257	295

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++++FP l+ys+++v+L+ ++++ e+  n+  
   Q: 257  VETAQERNEPMFPGLIYSSTMVWLVGMADNGETRNNSSS 295
           89******************************9999876 PP

Organism

Astyanax mexicanus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MAEVNSVSTD GTEANRHTDI GNPTSAVQAG PELNGQPPSA RPPQVVTDSE EEEDEELTLK 60
YGAKHVIMLF VPVTLCMVVV VATIKSVSFY TQKDGQQLIY TPFREDTETV GQRALNSILN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAGTTAATT AGCGTCACTG CTACTGTGGG CTGACTGCTC AGTGACTGAG CGCTAAAGAG 60
TATAAAACTA TTATAACTGG AGTTTAAAAA CTTTTAAATA TGTGTTTTTG ACAATGAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	75.96	3.00e-126	444.00
IUUC-Apl-003727	Anas platyrhynchos	77.70	1.00e-149	523.00
IUUC-Aca-004582	Anolis carolinensis	76.72	5.00e-151	527.00
IUUC-Bta-013026	Bos taurus	77.15	2.00e-148	518.00
IUUC-Bdi-014196	Brachypodium distachyon	32.60	7.00e-27	115.00
IUUC-Cja-019994	Callithrix jacchus	79.80	2.00e-149	521.00
IUUC-Cfa-020074	Canis familiaris	80.15	4.00e-150	524.00
IUUC-Cpo-022237	Cavia porcellus	74.50	1.00e-148	519.00
IUUC-Csa-023537	Chlorocebus sabaeus	72.96	3.00e-150	524.00
IUUC-Cho-024735	Choloepus hoffmanni	70.10	1.00e-131	462.00
IUUC-Dre-028689	Danio rerio	85.43	7.00e-169	586.00
IUUC-Dno-029758	Dasypus novemcinctus	79.80	6.00e-150	523.00
IUUC-Eeu-035134	Erinaceus europaeus	75.73	8.00e-111	393.00
IUUC-Fca-036243	Felis catus	80.15	6.00e-150	523.00
IUUC-Fal-036600	Ficedula albicollis	78.40	1.00e-150	525.00
IUUC-Gmo-039665	Gadus morhua	75.21	2.00e-114	405.00
IUUC-Gga-040993	Gallus gallus	78.59	4.00e-151	528.00
IUUC-Gac-042342	Gasterosteus aculeatus	76.58	3.00e-144	504.00
IUUC-Hsa-046822	Homo sapiens	72.96	5.00e-150	524.00
IUUC-Hvu-047141	Hordeum vulgare	33.66	3.00e-22	99.80
IUUC-Lch-049946	Latimeria chalumnae	72.30	3.00e-130	458.00
IUUC-Loc-052469	Lepisosteus oculatus	68.44	1.00e-146	512.00
IUUC-Laf-053979	Loxodonta africana	74.82	3.00e-136	478.00
IUUC-Mcc-055682	Macaca mulatta	72.96	5.00e-150	524.00
IUUC-Meu-056004	Macropus eugenii	62.95	3.00e-116	411.00
IUUC-Mga-059466	Meleagris gallopavo	78.35	6.00e-151	527.00
IUUC-Mdo-062122	Monodelphis domestica	76.87	2.00e-149	521.00
IUUC-Mmu-063176	Mus musculus	78.89	1.00e-142	499.00
IUUC-Mpu-065927	Mustela putorius furo	76.96	9.00e-150	523.00
IUUC-Mlu-067079	Myotis lucifugus	79.80	3.00e-151	528.00
IUUC-Nle-070180	Nomascus leucogenys	72.96	5.00e-150	524.00
IUUC-Opr-070847	Ochotona princeps	69.98	4.00e-142	498.00
IUUC-Ont-071846	Oreochromis niloticus	84.00	6.00e-164	570.00
IUUC-Oan-072783	Ornithorhynchus anatinus	78.53	2.00e-112	398.00
IUUC-Ocu-074527	Oryctolagus cuniculus	73.42	6.00e-151	527.00
IUUC-Ogl-077097	Oryza glaberrima	30.77	2.00e-25	110.00
IUUC-Opu-084176	Oryza punctata	31.13	5.00e-26	112.00
IUUC-Osa-085602	Oryza sativa	30.77	3.00e-25	109.00
IUUC-Oar-090348	Ovis aries	75.23	1.00e-149	522.00
IUUC-Ptr-091060	Pan troglodytes	72.96	5.00e-150	524.00
IUUC-Pan-091855	Papio anubis	68.88	2.00e-133	469.00
IUUC-Psi-093505	Pelodiscus sinensis	78.49	4.00e-151	527.00
IUUC-Pfo-097396	Poecilia formosa	83.06	2.00e-174	605.00
IUUC-Pab-098591	Pongo abelii	73.59	9.00e-151	526.00
IUUC-Pca-101029	Procavia capensis	75.71	1.00e-136	479.00
IUUC-Pva-102244	Pteropus vampyrus	76.63	4.00e-142	498.00
IUUC-Rno-105861	Rattus norvegicus	74.33	1.00e-144	506.00
IUUC-Sha-107045	Sarcophilus harrisii	76.54	6.00e-151	527.00
IUUC-Smo-109325	Selaginella moellendorffii	36.62	4.00e-34	139.00
IUUC-Sit-110624	Setaria italica	33.96	2.00e-25	109.00
IUUC-Sar-113169	Sorex araneus	73.88	3.00e-107	382.00
IUUC-Ssc-115766	Sus scrofa	80.15	2.00e-149	522.00
IUUC-Tru-117732	Takifugu rubripes	82.28	1.00e-160	559.00
IUUC-Tsy-119624	Tarsius syrichta	66.10	9.00e-130	456.00
IUUC-Tni-119852	Tetraodon nigroviridis	75.71	1.00e-153	535.00
IUUC-Tur-126237	Triticum urartu	34.43	7.00e-23	101.00
IUUC-Tbe-128148	Tupaia belangeri	61.46	5.00e-104	370.00
IUUC-Ttr-128793	Tursiops truncatus	78.89	1.00e-144	506.00
IUUC-Vpa-130625	Vicugna pacos	65.58	7.00e-118	417.00
IUUC-Xtr-131790	Xenopus tropicalis	76.98	3.00e-139	488.00
IUUC-Xma-133377	Xiphophorus maculatus	81.60	4.00e-170	590.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence