iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-42	141.1	205	238
UBD/Beta-Prp	4.00e-45	154.6	568	817

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDl 30
           gH+d+++++++     d +l+s+s D+ i++W+l
   Q: 205  GHEDWIRGVEWatfgRDLFLASCSQDCLIRIWRL 238
           8************998799*************96 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgs.....rdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvw...dls........... 82
           i cv++ ++k+lla+++     + + i++w++t++k ++sl  h+ +vt++ fspd+k+l+ +s+Drt  +w   d+            
   Q: 568  IFCVTCNNSKTLLASACkaaqkEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWkrqDVTsaefdpffslf 656
           66899999999999999332223568**********************************************77744477666666665 PP
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdg.nllvs 154
           +++  +t   h++ ++s+++sp+++++ +Gs+d+ + vw      c ++                + s  ++v  c v++p +  +++ 
   Q: 657  AFTNKITS-VHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGE----CNSSynpmehpinpcssildVGSCVTAVSVCPVLNPAQrYIVAV 740
           33333333.48899999**********************43....2222223468*******9999999999***********555566 PP
   S: 155  GslDrtvrlWdl........ktgkllrtl..tgghtdsvyslsfdsng............kelvsgsldgtvklwdlq 210
           G   +++ +++            ++++t   +  ht  ++ l ++s +             +++s+++d tvk++ + 
   Q: 741  GLESGKICIYSWsktnqetkDWTSCVETTpsQ-SHTLGIRRLCWKSCSgsteqseegtewLDFASCGEDHTVKIYRVN 817
           77789****99885665555444555555955.5******99988777788889999*99***************985 PP

Organism

Rattus norvegicus

Functional Description
(View)

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).

Protein Sequence
(Fasta)

MVSSVLEVSY VFCCPNRARG ALSWNSGPGG LLAFGTSCSV VLYDPQKKVV ITNLNGHTAR 60
VNCLHWIRTE DGSPSTELVS GASDNRVIHW ELENNQVLKS VRLQGHEGPV YAVHGIYQSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGAGTGTC TGGGCCAGTG ACCATCTGGC ATCATGGTTT CTTCTGTGTT GGAGGTGTCT 60
TATGTGTTTT GCTGCCCGAA CCGGGCTCGA GGAGCTTTGA GTTGGAATTC CGGGCCCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0033588--C:Elongator holoenzyme complex
GO:0000123--C:histone acetyltransferase complex
GO:0000502--C:proteasome complex
GO:0008023--C:transcription elongation factor complex
GO:0061133--F:endopeptidase activator activity
GO:0043248--P:proteasome assembly
GO:0046425--P:regulation of JAK-STAT cascade
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006368--P:transcription elongation from RNA polymerase II promoter

KEGG

rno:307545

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000056	Aegilops tauschii	33.04	7.00e-117	414.00
IUUC-Aml-002049	Ailuropoda melanoleuca	65.36	0.00e+00	944.00
IUUC-Atr-002456	Amborella trichopoda	34.27	1.00e-117	417.00
IUUC-Apl-004053	Anas platyrhynchos	64.11	0.00e+00	1036.00
IUUC-Aca-004535	Anolis carolinensis	54.36	0.00e+00	919.00
IUUC-Aly-005746	Arabidopsis lyrata	34.73	2.00e-121	430.00
IUUC-Ath-006664	Arabidopsis thaliana	34.61	1.00e-116	414.00
IUUC-Ago-007971	Ashbya gossypii	32.05	3.00e-90	326.00
IUUC-Acl-008173	Aspergillus clavatus	32.59	2.00e-106	380.00
IUUC-Afl-008665	Aspergillus flavus	26.96	2.00e-33	137.00
IUUC-Afu-008976	Aspergillus fumigatus	32.13	8.00e-103	368.00
IUUC-Ani-009284	Aspergillus nidulans	31.32	5.00e-100	358.00
IUUC-Ang-009809	Aspergillus niger	31.59	1.00e-98	354.00
IUUC-Aor-009959	Aspergillus oryzae	31.60	2.00e-97	350.00
IUUC-Ate-010442	Aspergillus terreus	29.83	2.00e-95	343.00
IUUC-Ame-011409	Astyanax mexicanus	52.18	0.00e+00	867.00
IUUC-Bgr-012137	Blumeria graminis	31.73	6.00e-104	372.00
IUUC-Bta-012892	Bos taurus	78.72	0.00e+00	1371.00
IUUC-Bci-013944	Botrytis cinerea	30.99	2.00e-89	324.00
IUUC-Bdi-014512	Brachypodium distachyon	34.41	8.00e-123	434.00
IUUC-Bol-015741	Brassica oleracea	34.00	4.00e-121	429.00
IUUC-Bra-017367	Brassica rapa	34.28	1.00e-121	430.00
IUUC-Cel-018712	Caenorhabditis elegans	34.08	3.00e-89	322.00
IUUC-Cja-018865	Callithrix jacchus	65.70	0.00e+00	1152.00
IUUC-Cfa-021006	Canis familiaris	79.19	0.00e+00	1363.00
IUUC-Cpo-021370	Cavia porcellus	76.36	0.00e+00	1315.00
IUUC-Csa-023845	Chlorocebus sabaeus	79.42	0.00e+00	1380.00
IUUC-Cho-024640	Choloepus hoffmanni	79.22	0.00e+00	813.00
IUUC-Cin-025772	Ciona intestinalis	41.39	3.00e-158	552.00
IUUC-Csv-025891	Ciona savignyi	38.11	2.00e-153	536.00
IUUC-Cgl-026443	Colletotrichum gloeosporioides	32.02	2.00e-99	357.00
IUUC-Cne-027081	Cryptococcus neoformans	30.53	5.00e-96	345.00
IUUC-Cme-027225	Cyanidioschyzon merolae	28.16	3.00e-50	193.00
IUUC-Dre-028250	Danio rerio	53.70	0.00e+00	868.00
IUUC-Dno-028847	Dasypus novemcinctus	78.09	0.00e+00	1344.00
IUUC-Dor-030351	Dipodomys ordii	76.54	0.00e+00	1299.00
IUUC-Dse-031317	Dothistroma septosporum	33.15	6.00e-97	348.00
IUUC-Dme-032019	Drosophila melanogaster	41.41	3.00e-174	605.00
IUUC-Ete-033194	Echinops telfairi	70.20	0.00e+00	698.00
IUUC-Eca-033779	Equus caballus	78.57	0.00e+00	1364.00
IUUC-Eeu-034790	Erinaceus europaeus	64.16	0.00e+00	1036.00
IUUC-Fca-036090	Felis catus	79.50	0.00e+00	1270.00
IUUC-Fal-037663	Ficedula albicollis	58.32	0.00e+00	953.00
IUUC-Fox-037828	Fusarium oxysporum	30.15	6.00e-97	348.00
IUUC-Fso-038462	Fusarium solani	30.87	6.00e-97	348.00
IUUC-Gmo-039450	Gadus morhua	54.23	0.00e+00	899.00
IUUC-Ggr-040023	Gaeumannomyces graminis	29.28	1.00e-84	308.00
IUUC-Gga-040480	Gallus gallus	61.92	0.00e+00	1056.00
IUUC-Gac-041544	Gasterosteus aculeatus	54.96	0.00e+00	932.00
IUUC-Gma-044048	Glycine max	35.52	2.00e-128	453.00
IUUC-Ggo-045381	Gorilla gorilla	74.82	0.00e+00	1282.00
IUUC-Hsa-046096	Homo sapiens	67.49	0.00e+00	1184.00
IUUC-Hvu-047494	Hordeum vulgare	33.65	4.00e-124	439.00
IUUC-Itr-048823	Ictidomys tridecemlineatus	74.08	0.00e+00	984.00
IUUC-Kpa-049241	Komagataella pastoris	30.70	7.00e-96	345.00
IUUC-Lch-050512	Latimeria chalumnae	60.82	0.00e+00	845.00
IUUC-Lpe-051448	Leersia perrieri	34.47	1.00e-122	434.00
IUUC-Loc-051882	Lepisosteus oculatus	56.59	0.00e+00	961.00
IUUC-Lma-053023	Leptosphaeria maculans	32.87	3.00e-106	379.00
IUUC-Laf-054519	Loxodonta africana	77.85	0.00e+00	1348.00
IUUC-Mcc-055580	Macaca mulatta	67.12	0.00e+00	1165.00
IUUC-Meu-056606	Macropus eugenii	52.47	3.00e-122	432.00
IUUC-Mor-057109	Magnaporthe oryzae	30.65	4.00e-97	349.00
IUUC-Mpo-057297	Magnaporthe poae	27.71	1.00e-85	311.00
IUUC-Mtr-058348	Medicago truncatula	35.84	1.00e-130	460.00
IUUC-Mla-059159	Melampsora laricipopulina	29.21	6.00e-81	295.00
IUUC-Mga-059778	Meleagris gallopavo	53.65	0.00e+00	641.00
IUUC-Mvi-060447	Microbotryum violaceum	32.12	1.00e-106	380.00
IUUC-Mmr-061139	Microcebus murinus	66.22	0.00e+00	1158.00
IUUC-Mdo-061866	Monodelphis domestica	67.87	0.00e+00	1183.00
IUUC-Mmu-063390	Mus musculus	88.94	0.00e+00	1506.00
IUUC-Mac-064693	Musa acuminata	35.05	1.00e-129	457.00
IUUC-Mpu-066547	Mustela putorius furo	78.57	0.00e+00	1329.00
IUUC-Mlu-067156	Myotis lucifugus	77.97	0.00e+00	1360.00
IUUC-Nfi-068616	Neosartorya fischeri	32.99	8.00e-105	374.00
IUUC-Ncr-068915	Neurospora crassa	29.06	6.00e-90	325.00
IUUC-Nle-069958	Nomascus leucogenys	77.68	0.00e+00	1330.00
IUUC-Opr-071093	Ochotona princeps	64.44	0.00e+00	701.00
IUUC-Ont-072178	Oreochromis niloticus	56.59	0.00e+00	948.00
IUUC-Oan-073667	Ornithorhynchus anatinus	62.48	0.00e+00	1060.00
IUUC-Ocu-074662	Oryctolagus cuniculus	77.82	0.00e+00	1355.00
IUUC-Oba-075577	Oryza barthii	35.29	1.00e-128	454.00
IUUC-Obr-076566	Oryza brachyantha	35.13	2.00e-130	459.00
IUUC-Ogl-077054	Oryza glaberrima	35.25	2.00e-128	453.00
IUUC-Ogu-078846	Oryza glumaepatula	35.29	1.00e-128	454.00
IUUC-Oin-079084	Oryza indica	35.41	2.00e-128	453.00
IUUC-Olo-080933	Oryza longistaminata	32.27	9.00e-104	371.00
IUUC-Ome-081500	Oryza meridionalis	32.98	5.00e-111	395.00
IUUC-Oni-082352	Oryza nivara	35.22	7.00e-127	448.00
IUUC-Opu-084116	Oryza punctata	35.21	6.00e-125	441.00
IUUC-Oru-085249	Oryza rufipogon	35.41	2.00e-128	453.00
IUUC-Osa-086270	Oryza sativa	35.41	2.00e-128	453.00
IUUC-Ola-086625	Oryzias latipes	49.65	0.00e+00	813.00
IUUC-Olu-087638	Ostreococcus lucimarinus	32.36	2.00e-80	293.00
IUUC-Oga-088634	Otolemur garnettii	62.78	0.00e+00	1101.00
IUUC-Oar-089475	Ovis aries	78.62	0.00e+00	1345.00
IUUC-Ptr-091131	Pan troglodytes	79.78	0.00e+00	1384.00
IUUC-Pan-092869	Papio anubis	79.06	0.00e+00	1367.00
IUUC-Psi-093146	Pelodiscus sinensis	67.96	0.00e+00	952.00
IUUC-Pma-094479	Petromyzon marinus	52.23	0.00e+00	645.00
IUUC-Pno-095061	Phaeosphaeria nodorum	27.73	2.00e-65	243.00
IUUC-Ppa-095618	Physcomitrella patens	36.09	4.00e-129	456.00
IUUC-Pfo-096816	Poecilia formosa	54.67	0.00e+00	910.00
IUUC-Pab-097548	Pongo abelii	79.30	0.00e+00	1375.00
IUUC-Pop-099643	Populus trichocarpa	37.34	5.00e-137	481.00
IUUC-Pca-100983	Procavia capensis	62.47	0.00e+00	1012.00
IUUC-Ppe-101301	Prunus persica	35.10	1.00e-126	447.00
IUUC-Pva-102460	Pteropus vampyrus	78.93	0.00e+00	1364.00
IUUC-Pgr-103507	Puccinia graminis	30.11	5.00e-83	302.00
IUUC-Ptt-103892	Puccinia triticina	28.59	6.00e-67	249.00
IUUC-Pte-104283	Pyrenophora teres	33.42	1.00e-101	363.00
IUUC-Pyt-104465	Pyrenophora triticirepentis	31.19	1.00e-98	353.00
IUUC-Sce-106459	Saccharomyces cerevisiae	31.50	2.00e-95	343.00
IUUC-Sha-106586	Sarcophilus harrisii	51.23	0.00e+00	851.00
IUUC-Sja-107868	Schizosaccharomyces japonicus	31.22	4.00e-84	306.00
IUUC-Spo-108302	Schizosaccharomyces pombe	33.20	4.00e-92	332.00
IUUC-Smo-108861	Selaginella moellendorffii	35.53	9.00e-128	451.00
IUUC-Sit-109915	Setaria italica	34.69	4.00e-128	452.00
IUUC-Sly-111714	Solanum lycopersicum	35.10	4.00e-131	462.00
IUUC-Stu-112631	Solanum tuberosum	34.24	1.00e-127	450.00
IUUC-Sar-113200	Sorex araneus	68.36	0.00e+00	1136.00
IUUC-Sbi-114582	Sorghum bicolor	35.06	1.00e-128	454.00
IUUC-Sre-115001	Sporisorium reilianum	29.77	1.00e-51	199.00
IUUC-Ssc-115519	Sus scrofa	78.81	0.00e+00	1359.00
IUUC-Tgu-116987	Taeniopygia guttata	62.58	0.00e+00	1027.00
IUUC-Tru-118476	Takifugu rubripes	53.49	0.00e+00	880.00
IUUC-Tsy-119230	Tarsius syrichta	64.89	4.00e-150	525.00
IUUC-Tni-120448	Tetraodon nigroviridis	37.10	2.00e-141	496.00
IUUC-Tca-121650	Theobroma cacao	35.81	4.00e-130	459.00
IUUC-Tre-122086	Trichoderma reesei	31.70	2.00e-95	343.00
IUUC-Tvi-122397	Trichoderma virens	31.69	1.00e-93	337.00
IUUC-Tae-125778	Triticum aestivum	34.29	2.00e-125	443.00
IUUC-Tur-126578	Triticum urartu	33.57	2.00e-123	436.00
IUUC-Tme-126927	Tuber melanosporum	29.99	4.00e-93	336.00
IUUC-Tbe-127922	Tupaia belangeri	65.62	1.00e-116	414.00
IUUC-Ttr-128918	Tursiops truncatus	79.66	0.00e+00	1375.00
IUUC-Uma-129474	Ustilago maydis	25.21	1.00e-40	162.00
IUUC-Vda-129944	Verticillium dahliae	30.93	5.00e-89	322.00
IUUC-Vpa-130693	Vicugna pacos	76.15	0.00e+00	1301.00
IUUC-Vvi-130949	Vitis vinifera	35.25	3.00e-123	436.00
IUUC-Xtr-132639	Xenopus tropicalis	52.52	0.00e+00	867.00
IUUC-Xma-134223	Xiphophorus maculatus	59.45	5.00e-176	610.00
IUUC-Yli-134601	Yarrowia lipolytica	33.82	4.00e-107	382.00
IUUC-Zma-135952	Zea mays	35.38	3.00e-128	452.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence