iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026012

UUCD1 version

UUC-CiS-00232

Ensembl Protein ID

ENSCSAVP00000018103.1

UniProt Accession

H2ZKI7; H2ZKI7_CIOSA

Protein Name

Coatomer subunit beta'

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000010646.1	ENSCSAVT00000018297.1	ENSCSAVP00000018100.1
ENSCSAVG00000010646.1	ENSCSAVT00000018298.1	ENSCSAVP00000018101.1
ENSCSAVG00000010646.1	ENSCSAVT00000018299.1	ENSCSAVP00000018102.1
ENSCSAVG00000010646.1	ENSCSAVT00000018300.1	ENSCSAVP00000018103.1
ENSCSAVG00000010646.1	ENSCSAVT00000018301.1	ENSCSAVP00000018104.1
ENSCSAVG00000010646.1	ENSCSAVT00000018303.1	ENSCSAVP00000018106.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.60e-32	108.4	226	256
UBD/Beta-Prp	6.30e-70	235.7	12	296

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH+  + c++f ++ +++ +Gs Dgtik+W 
   Q: 226  GHSQNIVCVSFhPElPIIMTGSEDGTIKIWH 256
           8***********999***************5 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           +++++++cv+ +p +++++++ ++g + +w+ +t+ l++s++ ++ +v+a++f p++++ +tgs+D+ ++v++++t + +h++++h+d
   Q: 12   ARSDRVKCVDLHPTEPWMLVSLYNGNVHIWNHETQVLVKSFEICDLPVRATRFVPRKNWVITGSDDMQVRVFNYNTLERTHAFEAHTD 99
           67899*********************************************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtds 182
           +++s++++p++ ++++ s+d  i++wd+++++   ++++gh++ v+ +v++p++ n ++s+slD  +++W+l +++   tltg h++ 
   Q: 100  YIRSIAVHPTQPYILTSSDDMLIKLWDWDKKWSCAQVFEGHTHYVMQIVINPKDnNQFASASLDCSIKVWQLGSATPNFTLTG-HDKG 186
           ********************************9999**********************************************9.**** PP
   S: 183  vyslsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvi 268
           v+++++ s g  ++l+sg++d+  k+wd+q+++cv+tl+gh++n+ +v f+p+  ++++gs+Dg+i+iW   +  l +tl++  ++v+
   Q: 187  VNCVDYYSGGdkPYLISGADDRLTKIWDYQNKTCVQTLEGHSQNIVCVSFHPELPIIMTGSEDGTIKIWHANTYRLETTLNYGMERVW 274
           *****8887777**************************************************************************** PP
   S: 269  svavlsfgdnvlvlgsedskvni 291
           ++++   g n+++lg ++++++i
   Q: 275  CISA-MKGSNNIALGYDEGSIMI 296
           ****.444666666666666665 PP

Organism

Ciona savignyi

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

PLRLDIKRKL NARSDRVKCV DLHPTEPWML VSLYNGNVHI WNHETQVLVK SFEICDLPVR 60
ATRFVPRKNW VITGSDDMQV RVFNYNTLER THAFEAHTDY IRSIAVHPTQ PYILTSSDDM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTGAAATA ATTGTTTACT TATTTGTATA AACTTTTTCT GTAATTTTTA CCAGAATTAT 60
ACGGAATTTG AAAAATACCA TATATATACT TAATACGAGC TTTCCGCTTT TGCTCGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030663--C:COPI-coated vesicle membrane
GO:0000139--C:Golgi membrane
GO:0030117--C:membrane coat
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000654	Aegilops tauschii	51.09	0.00e+00	897.00
IUUC-Aml-002154	Ailuropoda melanoleuca	76.78	0.00e+00	1421.00
IUUC-Atr-003090	Amborella trichopoda	56.10	0.00e+00	1004.00
IUUC-Apl-003976	Anas platyrhynchos	77.36	0.00e+00	1436.00
IUUC-Aca-004301	Anolis carolinensis	77.87	0.00e+00	1443.00
IUUC-Aly-005643	Arabidopsis lyrata	58.40	0.00e+00	1021.00
IUUC-Ath-007630	Arabidopsis thaliana	59.12	0.00e+00	1038.00
IUUC-Ago-007914	Ashbya gossypii	44.89	0.00e+00	730.00
IUUC-Acl-008237	Aspergillus clavatus	53.39	0.00e+00	937.00
IUUC-Afl-008535	Aspergillus flavus	51.83	0.00e+00	883.00
IUUC-Afu-008845	Aspergillus fumigatus	52.24	0.00e+00	915.00
IUUC-Ani-009135	Aspergillus nidulans	53.27	0.00e+00	903.00
IUUC-Ang-009654	Aspergillus niger	55.31	0.00e+00	831.00
IUUC-Aor-009939	Aspergillus oryzae	52.45	0.00e+00	941.00
IUUC-Ate-010355	Aspergillus terreus	53.54	0.00e+00	895.00
IUUC-Ame-010922	Astyanax mexicanus	68.71	0.00e+00	1270.00
IUUC-Bgr-012249	Blumeria graminis	54.28	0.00e+00	914.00
IUUC-Bta-013579	Bos taurus	78.57	0.00e+00	1239.00
IUUC-Bci-013866	Botrytis cinerea	55.16	0.00e+00	910.00
IUUC-Bdi-015046	Brachypodium distachyon	59.09	0.00e+00	1037.00
IUUC-Bol-015466	Brassica oleracea	58.76	0.00e+00	1017.00
IUUC-Bra-016617	Brassica rapa	58.76	0.00e+00	1018.00
IUUC-Cel-018387	Caenorhabditis elegans	65.14	0.00e+00	1183.00
IUUC-Cja-019145	Callithrix jacchus	76.90	0.00e+00	1424.00
IUUC-Cfa-020564	Canis familiaris	76.90	0.00e+00	1423.00
IUUC-Cpo-022201	Cavia porcellus	76.24	0.00e+00	1421.00
IUUC-Cre-022938	Chlamydomonas reinhardtii	59.27	0.00e+00	979.00
IUUC-Csa-023383	Chlorocebus sabaeus	79.19	0.00e+00	1002.00
IUUC-Cho-024454	Choloepus hoffmanni	73.78	0.00e+00	1180.00
IUUC-Cin-025681	Ciona intestinalis	89.52	0.00e+00	1635.00
IUUC-Cgl-026649	Colletotrichum gloeosporioides	50.55	0.00e+00	812.00
IUUC-Cne-026986	Cryptococcus neoformans	49.52	0.00e+00	868.00
IUUC-Cme-027219	Cyanidioschyzon merolae	46.87	0.00e+00	830.00
IUUC-Dre-027846	Danio rerio	77.65	0.00e+00	1445.00
IUUC-Dor-030462	Dipodomys ordii	74.14	0.00e+00	1065.00
IUUC-Dse-031268	Dothistroma septosporum	53.68	0.00e+00	933.00
IUUC-Dme-031791	Drosophila melanogaster	68.51	0.00e+00	1215.00
IUUC-Ete-033166	Echinops telfairi	69.89	0.00e+00	848.00
IUUC-Eca-034180	Equus caballus	75.27	0.00e+00	1377.00
IUUC-Eeu-035086	Erinaceus europaeus	63.33	0.00e+00	634.00
IUUC-Fca-036265	Felis catus	76.90	0.00e+00	1423.00
IUUC-Fal-037202	Ficedula albicollis	76.71	0.00e+00	1383.00
IUUC-Fox-037711	Fusarium oxysporum	54.79	0.00e+00	855.00
IUUC-Fso-038268	Fusarium solani	54.35	0.00e+00	851.00
IUUC-Gmo-039046	Gadus morhua	77.37	0.00e+00	1424.00
IUUC-Ggr-039863	Gaeumannomyces graminis	54.31	0.00e+00	882.00
IUUC-Gga-041112	Gallus gallus	77.12	0.00e+00	1435.00
IUUC-Gac-041733	Gasterosteus aculeatus	76.87	0.00e+00	1387.00
IUUC-Gma-042910	Glycine max	58.82	0.00e+00	1045.00
IUUC-Ggo-044984	Gorilla gorilla	76.78	0.00e+00	1418.00
IUUC-Hsa-046698	Homo sapiens	76.66	0.00e+00	1418.00
IUUC-Hvu-047669	Hordeum vulgare	66.67	5.00e-158	548.00
IUUC-Itr-048212	Ictidomys tridecemlineatus	76.47	0.00e+00	1422.00
IUUC-Kpa-049265	Komagataella pastoris	49.88	0.00e+00	850.00
IUUC-Lch-050473	Latimeria chalumnae	72.76	0.00e+00	1449.00
IUUC-Lpe-051579	Leersia perrieri	59.60	0.00e+00	1030.00
IUUC-Loc-052675	Lepisosteus oculatus	77.66	0.00e+00	1439.00
IUUC-Lma-053218	Leptosphaeria maculans	53.43	0.00e+00	907.00
IUUC-Laf-053757	Loxodonta africana	76.17	0.00e+00	1416.00
IUUC-Mcc-054859	Macaca mulatta	76.90	0.00e+00	1422.00
IUUC-Meu-056174	Macropus eugenii	70.37	4.00e-162	563.00
IUUC-Mor-057264	Magnaporthe oryzae	54.85	0.00e+00	858.00
IUUC-Mpo-057538	Magnaporthe poae	54.06	0.00e+00	890.00
IUUC-Mtr-058310	Medicago truncatula	58.35	0.00e+00	1044.00
IUUC-Mla-058937	Melampsora laricipopulina	52.01	0.00e+00	874.00
IUUC-Mga-059875	Meleagris gallopavo	76.71	0.00e+00	1426.00
IUUC-Mvi-060240	Microbotryum violaceum	50.87	0.00e+00	878.00
IUUC-Mmr-061261	Microcebus murinus	76.90	0.00e+00	1422.00
IUUC-Mdo-062076	Monodelphis domestica	76.89	0.00e+00	1432.00
IUUC-Mmu-063324	Mus musculus	76.90	0.00e+00	1422.00
IUUC-Mac-064636	Musa acuminata	58.05	0.00e+00	1023.00
IUUC-Mpu-065961	Mustela putorius furo	76.78	0.00e+00	1420.00
IUUC-Mlu-067059	Myotis lucifugus	76.12	0.00e+00	1384.00
IUUC-Nfi-068277	Neosartorya fischeri	53.37	0.00e+00	905.00
IUUC-Ncr-068659	Neurospora crassa	52.88	0.00e+00	903.00
IUUC-Nle-069034	Nomascus leucogenys	76.90	0.00e+00	1422.00
IUUC-Opr-070334	Ochotona princeps	78.53	0.00e+00	1274.00
IUUC-Ont-071563	Oreochromis niloticus	77.05	0.00e+00	1430.00
IUUC-Oan-073416	Ornithorhynchus anatinus	76.52	0.00e+00	1370.00
IUUC-Ocu-074522	Oryctolagus cuniculus	76.78	0.00e+00	1417.00
IUUC-Oba-075760	Oryza barthii	57.38	0.00e+00	1018.00
IUUC-Obr-076201	Oryza brachyantha	58.15	0.00e+00	1039.00
IUUC-Ogl-077450	Oryza glaberrima	58.45	0.00e+00	1045.00
IUUC-Ogu-078994	Oryza glumaepatula	57.38	0.00e+00	1017.00
IUUC-Oin-079856	Oryza indica	56.74	0.00e+00	1015.00
IUUC-Olo-080731	Oryza longistaminata	56.58	0.00e+00	1000.00
IUUC-Ome-081762	Oryza meridionalis	53.89	0.00e+00	940.00
IUUC-Oni-082324	Oryza nivara	57.38	0.00e+00	1017.00
IUUC-Opu-083400	Oryza punctata	56.80	0.00e+00	1005.00
IUUC-Oru-084829	Oryza rufipogon	57.38	0.00e+00	1018.00
IUUC-Osa-086026	Oryza sativa	58.45	0.00e+00	1048.00
IUUC-Ola-087245	Oryzias latipes	72.98	0.00e+00	1427.00
IUUC-Olu-087655	Ostreococcus lucimarinus	57.62	0.00e+00	1014.00
IUUC-Oga-088163	Otolemur garnettii	74.70	0.00e+00	1368.00
IUUC-Oar-089842	Ovis aries	76.90	0.00e+00	1425.00
IUUC-Ptr-090501	Pan troglodytes	75.58	0.00e+00	1420.00
IUUC-Pan-092011	Papio anubis	76.90	0.00e+00	1422.00
IUUC-Psi-093308	Pelodiscus sinensis	77.24	0.00e+00	1434.00
IUUC-Pma-094695	Petromyzon marinus	70.19	0.00e+00	1262.00
IUUC-Pno-094785	Phaeosphaeria nodorum	60.21	2.00e-108	384.00
IUUC-Ppa-095911	Physcomitrella patens	58.93	0.00e+00	1065.00
IUUC-Pfo-096587	Poecilia formosa	77.07	0.00e+00	1427.00
IUUC-Pab-097926	Pongo abelii	74.91	0.00e+00	1337.00
IUUC-Pop-099634	Populus trichocarpa	58.93	0.00e+00	1037.00
IUUC-Pca-100965	Procavia capensis	74.31	0.00e+00	1384.00
IUUC-Ppe-101470	Prunus persica	58.21	0.00e+00	1043.00
IUUC-Pva-102451	Pteropus vampyrus	73.23	0.00e+00	1060.00
IUUC-Pgr-103453	Puccinia graminis	52.88	0.00e+00	907.00
IUUC-Ptt-103868	Puccinia triticina	52.75	0.00e+00	904.00
IUUC-Pte-104274	Pyrenophora teres	53.98	0.00e+00	928.00
IUUC-Pyt-104794	Pyrenophora triticirepentis	53.38	0.00e+00	879.00
IUUC-Rno-105979	Rattus norvegicus	67.75	0.00e+00	1058.00
IUUC-Sce-106269	Saccharomyces cerevisiae	47.11	0.00e+00	763.00
IUUC-Sha-106905	Sarcophilus harrisii	76.71	0.00e+00	1435.00
IUUC-Sja-107838	Schizosaccharomyces japonicus	47.66	0.00e+00	817.00
IUUC-Spo-108299	Schizosaccharomyces pombe	48.17	0.00e+00	827.00
IUUC-Smo-108695	Selaginella moellendorffii	58.16	0.00e+00	1028.00
IUUC-Sit-110239	Setaria italica	58.45	0.00e+00	1046.00
IUUC-Sly-111775	Solanum lycopersicum	58.88	0.00e+00	1031.00
IUUC-Stu-112906	Solanum tuberosum	58.17	0.00e+00	932.00
IUUC-Sar-113472	Sorex araneus	72.17	0.00e+00	969.00
IUUC-Sbi-114052	Sorghum bicolor	60.25	0.00e+00	1052.00
IUUC-Sre-115040	Sporisorium reilianum	50.50	0.00e+00	875.00
IUUC-Ssc-115593	Sus scrofa	76.78	0.00e+00	1421.00
IUUC-Tgu-117239	Taeniopygia guttata	77.24	0.00e+00	1439.00
IUUC-Tru-118025	Takifugu rubripes	76.96	0.00e+00	1431.00
IUUC-Tsy-118824	Tarsius syrichta	72.61	0.00e+00	986.00
IUUC-Tni-120142	Tetraodon nigroviridis	77.19	0.00e+00	1424.00
IUUC-Tca-121613	Theobroma cacao	58.93	0.00e+00	1044.00
IUUC-Tre-122072	Trichoderma reesei	54.12	0.00e+00	900.00
IUUC-Tvi-122546	Trichoderma virens	54.32	0.00e+00	885.00
IUUC-Tae-125292	Triticum aestivum	58.96	0.00e+00	1044.00
IUUC-Tur-126283	Triticum urartu	52.50	0.00e+00	894.00
IUUC-Tme-127041	Tuber melanosporum	56.09	0.00e+00	959.00
IUUC-Tbe-127770	Tupaia belangeri	74.89	0.00e+00	1077.00
IUUC-Ttr-129294	Tursiops truncatus	76.78	0.00e+00	1420.00
IUUC-Uma-129351	Ustilago maydis	49.39	0.00e+00	872.00
IUUC-Vda-129716	Verticillium dahliae	53.63	0.00e+00	922.00
IUUC-Vpa-130037	Vicugna pacos	67.08	0.00e+00	666.00
IUUC-Vvi-131689	Vitis vinifera	59.05	0.00e+00	1042.00
IUUC-Xtr-132633	Xenopus tropicalis	77.78	0.00e+00	1431.00
IUUC-Xma-133347	Xiphophorus maculatus	72.79	0.00e+00	1430.00
IUUC-Yli-134455	Yarrowia lipolytica	50.00	0.00e+00	835.00
IUUC-Zma-135867	Zea mays	58.81	0.00e+00	1045.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence