iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018618

Ensembl Protein ID

F26E4.1

UniProt Accession

G5EDR3; 2AB1_CAEEL

Genbank Protein ID

AAD51977.1; CAB03008.1

Protein Name

Serine/threonine-protein phosphatase 2A regulatory subunit sur-6; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit sur-6; Serine/threonine-protein phosphatase 2A regulatory subunit B sur-6

Genbank Nucleotide ID

AF174643; BX284601

Gene Name

sur-6; F26E4.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00006352	F26E4.1	F26E4.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
circBase	microRNA	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.30e-13	48.3	134	162

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 5    svtclaf....sd.tllvsGsdDgtikvWD 29
           +++ +++    +  ++++s ++D+tik+W 
   Q: 134  KINQIRWlkkkNAaNFILS-TNDKTIKLWK 162
           6999999999633556555.68*******8 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Probable regulatory subunit of serine/threonine phosphatase let-92. Together with let-92 and constant regulatory subunit paa-1, positively regulates centriole duplication during early embryonic cell divisions by preventing the degradation of sas-5 and kinase zyg-1 (PubMed:21497766). In addition, during vulva development, may play a role with phosphatase let-92 and regulatory subunit paa-1 in the induction of vulva cell precursors by positively regulating let-60/Ras-MAP kinase signaling, probably by promoting lin-45 activation (PubMed:10521400, PubMed:14724126). In intestinal epithelial cells, may play a role in the late secretory pathway probably by regulating the exocyst, a protein complex involved in targeting secretory vesicles to the plasma membrane (PubMed:24192838).

Protein Sequence
(Fasta)

MVMEVDEPAV AATTSQNQPQ EHANDFDMDT SEGPIENDET FEPVDQINWK FNQVKGNIDA 60
DVHTEADVIS CVEFSHDGEY LATGDKGGRV VIFQRDQSGK YVKGVRSREY NVYSTFQSHE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCATTAAA AATAGTCGTC ATTCCCGTGT CTCAAACACT TTAATCTTCG TCACATCCAG 60
TGATTAGGAA GGGAAGAGAA CCAAAGAAAC AACGAAAAAG AGGAAAAATT TGAATAATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000009--PP2A_PR55
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1

Pfam

PF00400--WD40

PRINTS

PR00600--PP2APR55

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0000278--P:mitotic cell cycle
GO:0002119--P:nematode larval development
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0040026--P:positive regulation of vulval development

KEGG

cel:CELE_F26E4.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000361	Aegilops tauschii	48.68	2.00e-124	437.00
IUUC-Aml-001197	Ailuropoda melanoleuca	65.33	2.00e-162	563.00
IUUC-Atr-002520	Amborella trichopoda	48.12	2.00e-125	441.00
IUUC-Apl-004226	Anas platyrhynchos	64.89	2.00e-162	563.00
IUUC-Aca-005147	Anolis carolinensis	64.89	2.00e-162	563.00
IUUC-Aly-006304	Arabidopsis lyrata	50.10	6.00e-132	462.00
IUUC-Ath-007621	Arabidopsis thaliana	50.51	1.00e-131	461.00
IUUC-Ago-007825	Ashbya gossypii	50.65	5.00e-128	449.00
IUUC-Acl-008202	Aspergillus clavatus	53.62	1.00e-132	465.00
IUUC-Afl-008646	Aspergillus flavus	52.92	3.00e-134	470.00
IUUC-Afu-009027	Aspergillus fumigatus	53.29	6.00e-133	466.00
IUUC-Ani-009191	Aspergillus nidulans	55.11	4.00e-137	480.00
IUUC-Ang-009769	Aspergillus niger	54.04	1.00e-135	475.00
IUUC-Aor-010030	Aspergillus oryzae	54.01	2.00e-132	464.00
IUUC-Ate-010549	Aspergillus terreus	53.98	7.00e-134	469.00
IUUC-Ame-011776	Astyanax mexicanus	64.67	2.00e-161	560.00
IUUC-Bgr-012221	Blumeria graminis	50.84	6.00e-138	482.00
IUUC-Bta-012702	Bos taurus	64.60	2.00e-162	563.00
IUUC-Bci-013801	Botrytis cinerea	53.33	4.00e-137	479.00
IUUC-Bdi-014767	Brachypodium distachyon	47.81	1.00e-122	431.00
IUUC-Bol-015829	Brassica oleracea	52.22	2.00e-133	468.00
IUUC-Bra-018100	Brassica rapa	50.51	2.00e-133	468.00
IUUC-Cja-019036	Callithrix jacchus	64.89	2.00e-162	563.00
IUUC-Cfa-021248	Canis familiaris	64.89	2.00e-162	564.00
IUUC-Cpo-022172	Cavia porcellus	64.89	2.00e-162	563.00
IUUC-Cre-022876	Chlamydomonas reinhardtii	52.31	2.00e-129	454.00
IUUC-Csa-023864	Chlorocebus sabaeus	64.89	1.00e-162	564.00
IUUC-Cho-024810	Choloepus hoffmanni	65.35	2.00e-160	557.00
IUUC-Cin-025380	Ciona intestinalis	63.28	1.00e-162	564.00
IUUC-Csv-026097	Ciona savignyi	64.22	2.00e-162	564.00
IUUC-Cgl-026750	Colletotrichum gloeosporioides	52.18	3.00e-134	470.00
IUUC-Cne-026887	Cryptococcus neoformans	55.24	5.00e-139	486.00
IUUC-Cme-027332	Cyanidioschyzon merolae	46.15	5.00e-110	390.00
IUUC-Dre-027406	Danio rerio	64.16	1.00e-158	551.00
IUUC-Dno-028876	Dasypus novemcinctus	65.62	1.00e-163	568.00
IUUC-Dor-030390	Dipodomys ordii	64.27	1.00e-151	528.00
IUUC-Dse-031305	Dothistroma septosporum	52.46	2.00e-135	474.00
IUUC-Dme-032131	Drosophila melanogaster	63.41	3.00e-164	570.00
IUUC-Ete-032410	Echinops telfairi	61.09	8.00e-106	375.00
IUUC-Eca-033882	Equus caballus	65.07	2.00e-162	564.00
IUUC-Fca-035978	Felis catus	65.36	5.00e-162	562.00
IUUC-Fal-037650	Ficedula albicollis	65.27	1.00e-166	577.00
IUUC-Fox-037988	Fusarium oxysporum	52.65	9.00e-134	468.00
IUUC-Fso-038460	Fusarium solani	52.62	3.00e-134	470.00
IUUC-Gmo-038834	Gadus morhua	64.91	7.00e-162	562.00
IUUC-Ggr-039883	Gaeumannomyces graminis	53.25	1.00e-136	478.00
IUUC-Gga-041009	Gallus gallus	64.89	2.00e-162	563.00
IUUC-Gac-042571	Gasterosteus aculeatus	62.74	8.00e-162	561.00
IUUC-Gma-044088	Glycine max	50.89	6.00e-129	452.00
IUUC-Ggo-044599	Gorilla gorilla	64.89	2.00e-162	563.00
IUUC-Hsa-045992	Homo sapiens	66.07	1.00e-161	561.00
IUUC-Hvu-047813	Hordeum vulgare	49.79	1.00e-125	442.00
IUUC-Itr-048651	Ictidomys tridecemlineatus	64.89	1.00e-162	564.00
IUUC-Kpa-049100	Komagataella pastoris	50.96	2.00e-135	474.00
IUUC-Lch-050206	Latimeria chalumnae	65.85	2.00e-165	573.00
IUUC-Lpe-050866	Leersia perrieri	50.52	8.00e-127	445.00
IUUC-Loc-052663	Lepisosteus oculatus	62.53	3.00e-161	560.00
IUUC-Lma-053162	Leptosphaeria maculans	51.55	2.00e-131	461.00
IUUC-Laf-053403	Loxodonta africana	65.33	3.00e-162	563.00
IUUC-Mcc-054713	Macaca mulatta	66.29	3.00e-162	563.00
IUUC-Meu-056756	Macropus eugenii	61.25	2.00e-141	493.00
IUUC-Mor-057270	Magnaporthe oryzae	52.82	3.00e-133	467.00
IUUC-Mpo-057327	Magnaporthe poae	53.03	3.00e-137	480.00
IUUC-Mtr-058561	Medicago truncatula	57.95	4.00e-99	353.00
IUUC-Mla-059127	Melampsora laricipopulina	53.88	6.00e-142	495.00
IUUC-Mga-059946	Meleagris gallopavo	64.89	2.00e-162	563.00
IUUC-Mvi-060503	Microbotryum violaceum	51.12	2.00e-139	487.00
IUUC-Mmr-061468	Microcebus murinus	65.85	7.00e-165	572.00
IUUC-Mdo-062340	Monodelphis domestica	64.89	2.00e-162	563.00
IUUC-Mmu-064151	Mus musculus	64.89	1.00e-162	564.00
IUUC-Mac-064977	Musa acuminata	49.40	4.00e-127	446.00
IUUC-Mpu-066190	Mustela putorius furo	65.33	3.00e-162	563.00
IUUC-Mlu-066933	Myotis lucifugus	66.44	4.00e-167	579.00
IUUC-Nfi-068532	Neosartorya fischeri	53.50	2.00e-133	468.00
IUUC-Ncr-068905	Neurospora crassa	53.51	1.00e-138	485.00
IUUC-Nle-069157	Nomascus leucogenys	66.36	2.00e-156	544.00
IUUC-Opr-070857	Ochotona princeps	65.07	5.00e-160	556.00
IUUC-Ont-071603	Oreochromis niloticus	66.37	7.00e-162	561.00
IUUC-Oan-073540	Ornithorhynchus anatinus	72.20	3.00e-122	429.00
IUUC-Ocu-074222	Oryctolagus cuniculus	64.89	1.00e-162	564.00
IUUC-Oba-075715	Oryza barthii	49.09	1.00e-128	451.00
IUUC-Obr-076686	Oryza brachyantha	49.08	6.00e-130	456.00
IUUC-Ogl-077077	Oryza glaberrima	49.70	7.00e-125	439.00
IUUC-Ogu-078251	Oryza glumaepatula	49.20	1.00e-128	451.00
IUUC-Oin-079114	Oryza indica	49.80	1.00e-126	445.00
IUUC-Olo-080525	Oryza longistaminata	49.37	6.00e-127	446.00
IUUC-Ome-081334	Oryza meridionalis	49.38	2.00e-126	444.00
IUUC-Oni-082387	Oryza nivara	49.09	3.00e-125	441.00
IUUC-Opu-083739	Oryza punctata	48.24	8.00e-130	456.00
IUUC-Oru-084892	Oryza rufipogon	49.20	7.00e-129	452.00
IUUC-Osa-085954	Oryza sativa	49.38	2.00e-126	444.00
IUUC-Ola-087128	Oryzias latipes	64.68	1.00e-160	558.00
IUUC-Olu-087882	Ostreococcus lucimarinus	49.20	2.00e-129	454.00
IUUC-Oga-089168	Otolemur garnettii	64.89	2.00e-162	564.00
IUUC-Oar-089815	Ovis aries	64.60	2.00e-162	563.00
IUUC-Ptr-091110	Pan troglodytes	64.60	2.00e-162	563.00
IUUC-Pan-092846	Papio anubis	66.29	3.00e-162	563.00
IUUC-Psi-093292	Pelodiscus sinensis	66.07	4.00e-165	573.00
IUUC-Pma-094603	Petromyzon marinus	63.96	6.00e-69	251.00
IUUC-Pno-094992	Phaeosphaeria nodorum	52.18	3.00e-133	466.00
IUUC-Ppa-095378	Physcomitrella patens	49.22	9.00e-132	462.00
IUUC-Pfo-097174	Poecilia formosa	64.98	6.00e-164	568.00
IUUC-Pab-098146	Pongo abelii	64.89	1.00e-162	564.00
IUUC-Pop-099639	Populus trichocarpa	48.80	5.00e-126	443.00
IUUC-Pca-100882	Procavia capensis	65.10	1.00e-91	328.00
IUUC-Ppe-102006	Prunus persica	56.91	7.00e-99	353.00
IUUC-Pva-102279	Pteropus vampyrus	65.07	1.00e-161	561.00
IUUC-Pgr-103671	Puccinia graminis	48.39	1.00e-112	398.00
IUUC-Ptt-103844	Puccinia triticina	52.70	7.00e-135	472.00
IUUC-Pte-104403	Pyrenophora teres	52.28	4.00e-134	469.00
IUUC-Pyt-104776	Pyrenophora triticirepentis	51.96	6.00e-134	469.00
IUUC-Rno-105484	Rattus norvegicus	65.11	9.00e-163	565.00
IUUC-Sce-106284	Saccharomyces cerevisiae	53.95	3.00e-117	414.00
IUUC-Sha-106616	Sarcophilus harrisii	65.07	1.00e-162	564.00
IUUC-Sja-107757	Schizosaccharomyces japonicus	54.66	9.00e-138	482.00
IUUC-Spo-108186	Schizosaccharomyces pombe	54.12	2.00e-136	477.00
IUUC-Smo-109273	Selaginella moellendorffii	50.94	8.00e-130	455.00
IUUC-Sit-110793	Setaria italica	50.10	2.00e-132	464.00
IUUC-Sly-111422	Solanum lycopersicum	48.90	3.00e-126	444.00
IUUC-Stu-111999	Solanum tuberosum	46.76	6.00e-123	433.00
IUUC-Sbi-114087	Sorghum bicolor	50.00	4.00e-127	446.00
IUUC-Sre-115166	Sporisorium reilianum	54.01	1.00e-136	478.00
IUUC-Ssc-115355	Sus scrofa	64.89	1.00e-162	564.00
IUUC-Tgu-116737	Taeniopygia guttata	64.67	7.00e-162	561.00
IUUC-Tru-118130	Takifugu rubripes	64.54	4.00e-162	562.00
IUUC-Tsy-119206	Tarsius syrichta	63.92	1.00e-153	535.00
IUUC-Tni-119681	Tetraodon nigroviridis	66.29	3.00e-166	576.00
IUUC-Tca-121708	Theobroma cacao	57.10	6.00e-100	356.00
IUUC-Tre-122188	Trichoderma reesei	52.30	1.00e-132	465.00
IUUC-Tvi-122271	Trichoderma virens	52.17	1.00e-134	471.00
IUUC-Tae-125241	Triticum aestivum	49.59	8.00e-125	439.00
IUUC-Tur-126274	Triticum urartu	50.32	3.00e-122	430.00
IUUC-Tme-127130	Tuber melanosporum	55.93	5.00e-135	472.00
IUUC-Tbe-127340	Tupaia belangeri	62.41	1.00e-146	511.00
IUUC-Ttr-128725	Tursiops truncatus	65.11	6.00e-160	555.00
IUUC-Uma-129346	Ustilago maydis	54.11	3.00e-137	480.00
IUUC-Vda-130007	Verticillium dahliae	52.93	4.00e-135	473.00
IUUC-Vpa-130425	Vicugna pacos	65.58	8.00e-161	558.00
IUUC-Vvi-130930	Vitis vinifera	56.77	2.00e-98	351.00
IUUC-Xtr-131852	Xenopus tropicalis	64.49	3.00e-166	577.00
IUUC-Xma-133741	Xiphophorus maculatus	65.20	4.00e-164	569.00
IUUC-Zma-135704	Zea mays	49.48	7.00e-127	446.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence