iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001971

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01083483

Gene Name

TRAF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000017804.1	ENSAMET00000019571.1	ENSAMEP00000018818.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-31	106.2	397	428
UBD/Beta-Prp	1.60e-48	165.5	397	673

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH+++v+cl+  s  +ll sGs D+tikvWD+
   Q: 397  GHQGPVWCLCVySMgDLLFSGSSDKTIKVWDT 428
           8*********778889***************6 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdv.ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           gh+  ++ c+++   ++ll++gs d+tikvwd+ tt k+ ++l+gh++ v a++++     l +gs D ti vwd+++ + v t+++h+
   Q: 397  GHQG-PVWCLCVYSMGDLLFSGSSDKTIKVWDTcTTYKCQKTLEGHDGIVLALCIQGC--KLYSGSADCTIIVWDIQNLQKVNTIRAHD 482
           5555.55569999*******************846678899***************99..6**************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdl.etgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           + v++l +s   + l sGs  + i+vwd+  t+ +l++ l+g +++v+ +v  +  ++l sGs+ +t+++Wd++t ++++ l+    +s
   Q: 483  NPVCTLVSSH--NMLFSGS-LKAIKVWDIvGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSY-QTIKIWDIRTLDCIHVLQT-SGGS 564
           *****99999..9******.9*******7368888888**************99..*******9.79***************99.**** PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           vys++++    ++v g + + + +wd++++e vrtl+gh  +v+ +++   p+++ + s+s D+s+r+W +++  +++tl +h+ sv++
   Q: 565  VYSIAVTN--HHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVIstPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTA 651
           *******9..8***********************************99888************************************** PP
   S: 270  vavlsfgdnvlvlgsedskvniwkl 294
            av   ++  l++g+ ds+v++w +
   Q: 652  LAV---SRGRLFSGAVDSTVKVWTC 673
           **9...*****************86 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MSSGKNARYS RFSGGPTTLP TPDATAATRM ETTFGPAFSA VTTITKADGT STYKQHRRTP 60
SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS MSLRSTFSLP EEDEEPEPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTCGG GCAAGAACGC CCGCTACAGC CGCTTCTCCG GGGGGCCAAC CACCCTTCCC 60
ACCCCAGACG CCACAGCCGC GGTAAGAGGG CGCTGTGGGT GTGGGCCCCC CAGCGGACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001370--BIR_rpt
IPR020472--G-protein_beta_WD-40_rep
IPR008974--TRAF-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00400--WD40
PF13445--zf-RING_UBOX

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000185--P:activation of MAPKKK activity
GO:0006915--P:apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004098	Anas platyrhynchos	94.57	0.00e+00	1196.00
IUUC-Aca-004852	Anolis carolinensis	87.88	0.00e+00	974.00
IUUC-Ame-011275	Astyanax mexicanus	82.18	0.00e+00	928.00
IUUC-Bta-013153	Bos taurus	97.47	0.00e+00	1273.00
IUUC-Cja-019243	Callithrix jacchus	96.04	0.00e+00	1227.00
IUUC-Cfa-020036	Canis familiaris	98.37	0.00e+00	1297.00
IUUC-Cpo-022194	Cavia porcellus	96.57	0.00e+00	1265.00
IUUC-Csa-023363	Chlorocebus sabaeus	97.47	0.00e+00	1283.00
IUUC-Cin-025279	Ciona intestinalis	58.18	0.00e+00	795.00
IUUC-Csv-026163	Ciona savignyi	64.20	0.00e+00	766.00
IUUC-Dre-027998	Danio rerio	89.91	0.00e+00	1105.00
IUUC-Dno-029356	Dasypus novemcinctus	94.27	2.00e-128	451.00
IUUC-Dor-030750	Dipodomys ordii	94.50	0.00e+00	1227.00
IUUC-Eca-033671	Equus caballus	81.94	0.00e+00	986.00
IUUC-Eeu-034765	Erinaceus europaeus	97.70	5.00e-166	577.00
IUUC-Fca-035843	Felis catus	97.77	0.00e+00	1286.00
IUUC-Fal-037237	Ficedula albicollis	92.87	0.00e+00	1230.00
IUUC-Gmo-038779	Gadus morhua	81.16	0.00e+00	1008.00
IUUC-Gga-040579	Gallus gallus	92.42	0.00e+00	1224.00
IUUC-Gac-042233	Gasterosteus aculeatus	85.58	0.00e+00	1124.00
IUUC-Gma-042711	Glycine max	26.81	3.00e-19	89.70
IUUC-Ggo-045147	Gorilla gorilla	97.47	0.00e+00	1285.00
IUUC-Hsa-046117	Homo sapiens	97.33	0.00e+00	1282.00
IUUC-Itr-048899	Ictidomys tridecemlineatus	97.18	0.00e+00	1280.00
IUUC-Lch-050593	Latimeria chalumnae	90.95	0.00e+00	1183.00
IUUC-Loc-052444	Lepisosteus oculatus	89.82	0.00e+00	1212.00
IUUC-Laf-053499	Loxodonta africana	90.87	0.00e+00	1173.00
IUUC-Mcc-055038	Macaca mulatta	97.62	0.00e+00	1285.00
IUUC-Meu-056610	Macropus eugenii	93.85	0.00e+00	939.00
IUUC-Mtr-057641	Medicago truncatula	27.73	2.00e-19	90.10
IUUC-Mga-060183	Meleagris gallopavo	92.00	0.00e+00	1218.00
IUUC-Mmr-061133	Microcebus murinus	95.55	0.00e+00	1206.00
IUUC-Mdo-062312	Monodelphis domestica	95.10	0.00e+00	1254.00
IUUC-Mmu-063844	Mus musculus	96.14	0.00e+00	1232.00
IUUC-Mpu-066552	Mustela putorius furo	97.77	0.00e+00	1259.00
IUUC-Mlu-067719	Myotis lucifugus	96.43	0.00e+00	1239.00
IUUC-Nle-070045	Nomascus leucogenys	98.09	0.00e+00	1201.00
IUUC-Opr-070927	Ochotona princeps	95.54	0.00e+00	1233.00
IUUC-Ont-072680	Oreochromis niloticus	85.08	0.00e+00	1134.00
IUUC-Oan-073521	Ornithorhynchus anatinus	94.00	2.00e-52	196.00
IUUC-Ogu-077987	Oryza glumaepatula	25.86	3.00e-19	89.70
IUUC-Oru-085210	Oryza rufipogon	25.60	2.00e-19	90.50
IUUC-Ola-087454	Oryzias latipes	88.75	0.00e+00	1177.00
IUUC-Oga-088380	Otolemur garnettii	97.03	0.00e+00	1275.00
IUUC-Oar-089558	Ovis aries	80.55	0.00e+00	1016.00
IUUC-Ptr-091606	Pan troglodytes	97.47	0.00e+00	1285.00
IUUC-Pan-092227	Papio anubis	97.62	0.00e+00	1285.00
IUUC-Psi-093853	Pelodiscus sinensis	85.26	0.00e+00	1007.00
IUUC-Pma-094541	Petromyzon marinus	81.19	3.00e-152	530.00
IUUC-Pfo-096237	Poecilia formosa	85.18	0.00e+00	1122.00
IUUC-Pab-097589	Pongo abelii	97.62	0.00e+00	1286.00
IUUC-Pca-100375	Procavia capensis	94.17	0.00e+00	1184.00
IUUC-Pva-102434	Pteropus vampyrus	97.33	0.00e+00	1277.00
IUUC-Rno-105443	Rattus norvegicus	96.43	0.00e+00	1236.00
IUUC-Sha-106517	Sarcophilus harrisii	94.81	0.00e+00	1249.00
IUUC-Ssc-115990	Sus scrofa	96.58	0.00e+00	1266.00
IUUC-Tgu-117222	Taeniopygia guttata	92.69	0.00e+00	1221.00
IUUC-Tru-118392	Takifugu rubripes	88.03	0.00e+00	1134.00
IUUC-Tni-120220	Tetraodon nigroviridis	87.11	0.00e+00	1126.00
IUUC-Tca-121793	Theobroma cacao	27.11	1.00e-20	94.40
IUUC-Tur-126339	Triticum urartu	26.69	1.00e-17	84.00
IUUC-Tbe-128045	Tupaia belangeri	99.31	2.00e-161	562.00
IUUC-Ttr-128203	Tursiops truncatus	94.06	0.00e+00	1219.00
IUUC-Xtr-132043	Xenopus tropicalis	91.08	0.00e+00	1235.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence