iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-057729

Ensembl Protein ID

AES64478

UniProt Accession

Q2HT48; Q2HT48_MEDTR

Genbank Protein ID

ABD32996.1; AES64478.1

Protein Name

E3 ubiquitin-protein ligase UPL5-like protein; HECT; Ubiquitin

Genbank Nucleotide ID

AC150798; CM001218

Gene Name

MTR_2g025810; MtrDRAFT_AC150798g1v2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_2g025810	AES64478	AES64478

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-91	307.7	478	807
ULD/UDP/UBQ/UBQ_Other	1.50e-11	45.5	41	113

Active Site

Position(s)	Description	Evidence
781	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgk 103
           ++l+  l++ f++E++++  Gv re++ l+++e++np + lf+  +nd++ ++pn +s++ n  hlk+F f Gr++++al ++  + + + ++f+k+l g+
   Q: 478  KSLQGDLFMAFKNEKATGP-GVLREWFVLVCQEIFNPRNALFVACPNDHRRFFPNTASMV-NALHLKYFIFSGRIIALALKKKVRVGIVFDRVFFKQLAGN 576
           6788899***********9.**************************************99.67************************************** PP
   S: 104  .klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
             ++led+ + dp +y s k+i+e++ + i+  +l ltfs++ e+lg +++ eL+pgGe+  V  +N+e+Yv+l+++ r+ ++i eq+ +f +Gf ++i+ 
   Q: 577  yIITLEDIRDADPIMYSSCKQILEMEADYIDSDALGLTFSIEVEELGHREVIELCPGGESLVVDSKNREKYVHLLIQSRFVTSISEQISHFAQGFADIISC 677
           56899********************99999*9******************************************************************987 PP
   S: 204  ellslF...teeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPs 300
           ++l+ F   ++e+++ +++G+ ++i+ved+k++tky +gy+e++++i wFw+++ ++ +e++k +L F+T+ + lP++Gf  l+ rl +++  + d++lPs
   Q: 678  SSLEFFqflHHEDFDWMLHGSeNDISVEDWKAHTKY-HGYKENDRQISWFWKIVGRMPAEQKKVLLFFWTSVKHLPVEGFHGLNSRLLICKSHEPDNHLPS 777
           76655522279**********9**************.88************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieet 330
           s+TCf+ L+ P+Yss  i++++L + ++e 
   Q: 778  SHTCFYKLCFPPYSSIAIMQDRLGIITQEH 807
           ***********************7666554 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekk 73
           q++v+ +  + +  ++ ++ dtV  + ++i++k++ip e qrLiy Gk L+  ++L+++g+ ++  + l+ + 
   Q: 41   QFFVRMMWKCnTIVIHASREDTVESILQQISSKTKIPIEYQRLIYNGKQLQQQQSLSQCGIENDANLQLVGQL 113
           67788888888888899****************************************************9876 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MSSIIKTLIG GCFYGTTADH HSNHSPELKF NDTKTTSSEL QFFVRMMWKC NTIVIHASRE 60
DTVESILQQI SSKTKIPIEY QRLIYNGKQL QQQQSLSQCG IENDANLQLV GQLRSIVRSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCATCGA TCATTAAAAC CCTCATCGGC GGTTGTTTCT ATGGCACCAC CGCCGACCAC 60
CACAGCAACC ATTCCCCGGA GCTCAAATTC AATGACACCA AAACGACGTC GTCAGAGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50237--HECT
PS50053--UBIQUITIN_2

Pfam

PF00632--HECT
PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00119--HECTc
SM00213--UBQ

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mtr:MTR_2g025810

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence