iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053848

Ensembl Protein ID

ENSLAFP00000028480.1

UniProt Accession

G3UKX1; G3UKX1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

BRWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000015097.3	ENSLAFT00000032755.1	ENSLAFP00000028480.1
ENSLAFG00000015097.3	ENSLAFT00000015107.3	ENSLAFP00000012652.3
ENSLAFG00000015097.3	ENSLAFT00000034792.1	ENSLAFP00000018780.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-34	117.2	188	225
UBD/Beta-Prp	2.60e-53	181.5	290	547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + v+c+af  + +++ +GsdD+ +k+W+++ g+ll
   Q: 188  GHLSAVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGRLL 225
           8**********955599***************999987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsl 100
           +++++++++dgt+  w+++ ++l      l+  ++  ++v+ ++  fs  g +l+tgs+D++i+ +   +++++ +  l+ h+d+v s+
   Q: 290  QRYMVSTGADGTVCFWQWDLESLkfsprpLKFTEKPRPGVQMLCssFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSI 378
           689*****************99999988777778888888755522888888**************99999****************** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
           +f+ +gd+++sGs+d t+r+w  e+ ++ +                 ++  +  v+++++++d++++v++ +D +++ Wd+ tg+ll+ 
   Q: 379  QFCNNGDRFLSGSRDGTARIWRFEQLEWRSIlldmstrmsgdlsseEERFMKPKVTMIAWNQDDSIVVTAVNDHVLKAWDSYTGQLLHN 467
           *************************999988999********998877777888*********************************** PP
   S: 175  ltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l g h d v  l+   fds  + ++s+++dg++ +wd+ +g+ ++ + +         v + +fs+++++++++ s+g + i+
   Q: 468  LLG-HADEVFVLEthpFDS--RIMLSAGHDGSIFIWDITKGTKMKHYFNMIegqgfGAVFDCKFSQDGQHFACTDSHGHLMIF 547
           **9.*********555555..99******************999999887667777888899999999999999999988776 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

PSPPCPARPG LDPAPSVFPA ELYFLIARYL SAGPCRRAAQ VLVQELEQYQ LLPKRLDWEG 60
NEHNRSYEEL VLSNKHVAPD HLLQICQRIG PILDKEIPPS ISRVTSLLGA GRQSLLRTAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTCCCCTC CTTGTCCCGC CCGCCCTGGT CTTGACCCGG CTCCTTCCGT TTTTCCCGCA 60
GAGCTGTACT TCCTCATCGC CCGGTACCTA TCGGCGGGCC CATGTCGGAG AGCGGCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	29.84	4.00e-60	227.00
IUUC-Aml-002332	Ailuropoda melanoleuca	83.89	0.00e+00	3266.00
IUUC-Atr-002600	Amborella trichopoda	29.33	2.00e-67	251.00
IUUC-Apl-004083	Anas platyrhynchos	57.05	0.00e+00	2086.00
IUUC-Aca-004348	Anolis carolinensis	72.17	0.00e+00	1916.00
IUUC-Aly-006517	Arabidopsis lyrata	30.34	3.00e-73	271.00
IUUC-Ath-006577	Arabidopsis thaliana	29.96	2.00e-72	268.00
IUUC-Ame-010718	Astyanax mexicanus	70.37	0.00e+00	1165.00
IUUC-Bta-013217	Bos taurus	86.46	0.00e+00	3619.00
IUUC-Bdi-014797	Brachypodium distachyon	29.09	5.00e-58	220.00
IUUC-Bol-015737	Brassica oleracea	29.33	2.00e-71	265.00
IUUC-Bra-017961	Brassica rapa	29.29	1.00e-70	262.00
IUUC-Cja-019966	Callithrix jacchus	85.65	0.00e+00	3528.00
IUUC-Cfa-021037	Canis familiaris	86.42	0.00e+00	3563.00
IUUC-Cpo-021934	Cavia porcellus	90.29	0.00e+00	2718.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	34.39	1.00e-34	142.00
IUUC-Csa-023352	Chlorocebus sabaeus	85.56	0.00e+00	3330.00
IUUC-Cho-024690	Choloepus hoffmanni	79.64	0.00e+00	1357.00
IUUC-Dre-028205	Danio rerio	69.65	0.00e+00	1139.00
IUUC-Dno-028938	Dasypus novemcinctus	84.58	0.00e+00	3565.00
IUUC-Ete-032717	Echinops telfairi	72.51	0.00e+00	971.00
IUUC-Eca-034349	Equus caballus	88.22	0.00e+00	3514.00
IUUC-Fca-035485	Felis catus	85.95	0.00e+00	3056.00
IUUC-Fal-037307	Ficedula albicollis	69.97	0.00e+00	2373.00
IUUC-Gma-043340	Glycine max	30.22	5.00e-70	260.00
IUUC-Ggo-045500	Gorilla gorilla	86.52	0.00e+00	3585.00
IUUC-Hsa-046350	Homo sapiens	86.41	0.00e+00	3583.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	93.67	0.00e+00	1151.00
IUUC-Lch-049662	Latimeria chalumnae	65.54	0.00e+00	2058.00
IUUC-Lpe-051619	Leersia perrieri	30.85	8.00e-69	256.00
IUUC-Mcc-054638	Macaca mulatta	86.37	0.00e+00	3559.00
IUUC-Meu-056739	Macropus eugenii	78.49	0.00e+00	1094.00
IUUC-Mtr-058094	Medicago truncatula	30.48	9.00e-72	266.00
IUUC-Mga-060165	Meleagris gallopavo	76.74	0.00e+00	2256.00
IUUC-Mmr-061227	Microcebus murinus	87.31	0.00e+00	3629.00
IUUC-Mdo-062074	Monodelphis domestica	70.95	0.00e+00	2818.00
IUUC-Mmu-064075	Mus musculus	80.57	0.00e+00	2930.00
IUUC-Mac-065343	Musa acuminata	30.31	3.00e-75	277.00
IUUC-Mpu-066643	Mustela putorius furo	87.30	0.00e+00	2938.00
IUUC-Mlu-067735	Myotis lucifugus	84.71	0.00e+00	3436.00
IUUC-Nle-069402	Nomascus leucogenys	89.33	0.00e+00	2931.00
IUUC-Oan-072954	Ornithorhynchus anatinus	69.71	0.00e+00	2782.00
IUUC-Ocu-074456	Oryctolagus cuniculus	85.10	0.00e+00	3535.00
IUUC-Oba-075709	Oryza barthii	29.94	6.00e-59	223.00
IUUC-Obr-076619	Oryza brachyantha	30.67	3.00e-69	257.00
IUUC-Opu-083233	Oryza punctata	30.23	2.00e-63	238.00
IUUC-Oru-085195	Oryza rufipogon	29.94	6.00e-59	223.00
IUUC-Olu-087745	Ostreococcus lucimarinus	28.20	3.00e-55	210.00
IUUC-Oga-087938	Otolemur garnettii	79.76	0.00e+00	3109.00
IUUC-Oar-090214	Ovis aries	86.15	0.00e+00	3502.00
IUUC-Ptr-091213	Pan troglodytes	86.62	0.00e+00	3541.00
IUUC-Pan-092444	Papio anubis	85.86	0.00e+00	3546.00
IUUC-Psi-093271	Pelodiscus sinensis	65.59	0.00e+00	2145.00
IUUC-Pma-094427	Petromyzon marinus	68.12	1.00e-132	465.00
IUUC-Ppa-095793	Physcomitrella patens	29.15	2.00e-73	271.00
IUUC-Pfo-097318	Poecilia formosa	62.72	0.00e+00	1776.00
IUUC-Pab-097573	Pongo abelii	85.41	0.00e+00	3473.00
IUUC-Pop-099672	Populus trichocarpa	31.03	3.00e-72	267.00
IUUC-Ppe-101849	Prunus persica	29.73	8.00e-75	276.00
IUUC-Pva-102782	Pteropus vampyrus	86.14	0.00e+00	3531.00
IUUC-Rno-105687	Rattus norvegicus	76.53	0.00e+00	3178.00
IUUC-Sha-106680	Sarcophilus harrisii	71.31	0.00e+00	2839.00
IUUC-Sly-111348	Solanum lycopersicum	30.23	4.00e-75	277.00
IUUC-Sar-113519	Sorex araneus	79.85	0.00e+00	1753.00
IUUC-Sbi-114195	Sorghum bicolor	28.79	8.00e-58	218.00
IUUC-Tgu-116513	Taeniopygia guttata	76.40	0.00e+00	2264.00
IUUC-Tsy-118921	Tarsius syrichta	87.75	0.00e+00	1979.00
IUUC-Tca-121615	Theobroma cacao	29.94	2.00e-67	251.00
IUUC-Tae-125478	Triticum aestivum	30.16	5.00e-69	257.00
IUUC-Tur-126809	Triticum urartu	30.06	9.00e-67	249.00
IUUC-Tbe-127663	Tupaia belangeri	76.16	0.00e+00	1266.00
IUUC-Ttr-128561	Tursiops truncatus	84.29	0.00e+00	3395.00
IUUC-Vpa-130444	Vicugna pacos	83.64	0.00e+00	3279.00
IUUC-Vvi-131362	Vitis vinifera	30.75	5.00e-74	273.00
IUUC-Xma-133633	Xiphophorus maculatus	63.95	0.00e+00	1124.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence