iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132717

Ensembl Protein ID

ENSXETP00000025715.4

UniProt Accession

F7E291; F7E291_XENTR

Genbank Protein ID

ENSXETP00000025715

Protein Name

Pleckstrin homology domain-interacting protein

Genbank Nucleotide ID

AAMC01054698

Gene Name

phip

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000011747.4	ENSXETT00000025715.4	ENSXETP00000025715.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-34	116.7	182	219
UBD/Beta-Prp	9.70e-67	225.4	183	399

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W++++g+ll
   Q: 182  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWSTDDGRLL 219
           8**********955599******************987 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s ++cv+f + ++ ++tgs+d  +k+w++++g ll++l gh ae++++  + +  +++ gs D++i++w l+t+ ++ +l+gh++s+
   Q: 183  HLSSVYCVTFDRTGRRIFTGSDDCLVKIWSTDDGRLLATLRGHAAEISDMAVNFENTMIAAGSCDKMIRIWCLRTCAPLAILQGHSASI 271
           5567889*****************************************999999999******************************** PP
   S: 98   lslsfsp....sgdklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl..lr 173
           +sl+fsp    s+ +l s+++d ti  w ++ g+   +      t++++ gv ++ ++ ++g   l++Gs+D ++r++   +g+   + 
   Q: 272  TSLQFSPlcngSKRYLSSTGADGTICFWLWDAGTLKINprptkyTERPRPGVQMICSSFSSGgMFLATGSTDHVIRVYYFGSGQPekIS 360
           *********77779999**********8888888887788************9988887777799*************99666651166 PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtge 213
           +l+  htd+v s++f+ +g+++vsgs+dgt ++w++++ e
   Q: 361  ELEF-HTDKVDSIQFSNTGNRFVSGSRDGTARIWQFKRRE 399
           7788.*******************************9876 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MSSLNNQHST ELKSELYFLI ARFLEDGPCQ QAAQVLIREV EEKELLPKRV DWTGKEHART 60
YQNLVKYYRH LAPDHLLQIC QRIGPLLEKE VPQSVPGVQT LLGAGRQSLL RTNKSCKHVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTTGCAT GGTGGAGAGC GCAGGCTTCC CTTTCTCCTT CCTGCTCTAA ACCCTGACAG 60
CTCCAGGGGC AGGGCCCGGG GATCCGCTCC GGCGGCGGTA GCGGGAGGAG GAGGGAAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	30.89	3.00e-64	241.00
IUUC-Aml-002299	Ailuropoda melanoleuca	75.95	0.00e+00	2538.00
IUUC-Atr-002600	Amborella trichopoda	30.74	2.00e-70	261.00
IUUC-Apl-003700	Anas platyrhynchos	76.08	0.00e+00	2515.00
IUUC-Aca-004474	Anolis carolinensis	73.58	0.00e+00	2560.00
IUUC-Aly-006406	Arabidopsis lyrata	31.24	4.00e-70	260.00
IUUC-Ath-006801	Arabidopsis thaliana	31.24	7.00e-70	259.00
IUUC-Ame-010602	Astyanax mexicanus	59.48	0.00e+00	1652.00
IUUC-Bta-013125	Bos taurus	75.56	0.00e+00	2471.00
IUUC-Bdi-014797	Brachypodium distachyon	32.87	3.00e-56	214.00
IUUC-Bol-015737	Brassica oleracea	31.46	2.00e-72	268.00
IUUC-Bra-017961	Brassica rapa	31.91	6.00e-72	266.00
IUUC-Cja-018868	Callithrix jacchus	74.43	0.00e+00	2629.00
IUUC-Cfa-021179	Canis familiaris	75.23	0.00e+00	2525.00
IUUC-Cpo-022077	Cavia porcellus	72.09	0.00e+00	2432.00
IUUC-Csa-023618	Chlorocebus sabaeus	75.94	0.00e+00	2622.00
IUUC-Cho-024794	Choloepus hoffmanni	80.62	0.00e+00	759.00
IUUC-Csv-025813	Ciona savignyi	43.16	0.00e+00	632.00
IUUC-Dre-028508	Danio rerio	57.57	0.00e+00	1645.00
IUUC-Dno-030048	Dasypus novemcinctus	75.69	0.00e+00	2547.00
IUUC-Dor-030195	Dipodomys ordii	78.10	0.00e+00	1261.00
IUUC-Dme-031752	Drosophila melanogaster	51.20	0.00e+00	679.00
IUUC-Ete-032650	Echinops telfairi	55.80	0.00e+00	1207.00
IUUC-Eca-034274	Equus caballus	76.00	0.00e+00	2496.00
IUUC-Eeu-034688	Erinaceus europaeus	85.35	0.00e+00	1201.00
IUUC-Fca-035451	Felis catus	78.76	0.00e+00	2390.00
IUUC-Fal-037465	Ficedula albicollis	75.70	0.00e+00	2546.00
IUUC-Gmo-039451	Gadus morhua	66.01	0.00e+00	680.00
IUUC-Gga-040798	Gallus gallus	76.60	0.00e+00	2637.00
IUUC-Gac-042435	Gasterosteus aculeatus	54.55	0.00e+00	1583.00
IUUC-Gma-043340	Glycine max	31.70	1.00e-72	269.00
IUUC-Ggo-045347	Gorilla gorilla	74.59	0.00e+00	2562.00
IUUC-Hsa-046757	Homo sapiens	76.22	0.00e+00	2616.00
IUUC-Hvu-047706	Hordeum vulgare	31.56	9.00e-39	153.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	61.60	0.00e+00	740.00
IUUC-Lch-050646	Latimeria chalumnae	71.60	0.00e+00	2520.00
IUUC-Lpe-051619	Leersia perrieri	30.06	4.00e-69	257.00
IUUC-Loc-052672	Lepisosteus oculatus	75.44	0.00e+00	2257.00
IUUC-Laf-054140	Loxodonta africana	75.51	0.00e+00	2535.00
IUUC-Mcc-055061	Macaca mulatta	75.67	0.00e+00	2608.00
IUUC-Meu-056321	Macropus eugenii	56.98	0.00e+00	820.00
IUUC-Mtr-058094	Medicago truncatula	32.37	4.00e-75	276.00
IUUC-Mga-060063	Meleagris gallopavo	61.02	0.00e+00	1734.00
IUUC-Mmr-061262	Microcebus murinus	59.40	0.00e+00	1775.00
IUUC-Mdo-061903	Monodelphis domestica	76.54	0.00e+00	2641.00
IUUC-Mmu-063772	Mus musculus	75.92	0.00e+00	2608.00
IUUC-Mac-065343	Musa acuminata	30.49	1.00e-74	275.00
IUUC-Mpu-066359	Mustela putorius furo	75.13	0.00e+00	2298.00
IUUC-Mlu-068082	Myotis lucifugus	60.07	0.00e+00	1748.00
IUUC-Nle-070094	Nomascus leucogenys	75.98	0.00e+00	2570.00
IUUC-Opr-070971	Ochotona princeps	62.42	0.00e+00	788.00
IUUC-Ont-072221	Oreochromis niloticus	72.77	0.00e+00	1288.00
IUUC-Oan-073185	Ornithorhynchus anatinus	73.87	0.00e+00	2491.00
IUUC-Ocu-074033	Oryctolagus cuniculus	77.63	0.00e+00	2347.00
IUUC-Oba-075709	Oryza barthii	31.18	2.00e-56	215.00
IUUC-Obr-076619	Oryza brachyantha	29.66	2.00e-70	261.00
IUUC-Ogl-077493	Oryza glaberrima	38.38	4.00e-30	127.00
IUUC-Ogu-078641	Oryza glumaepatula	38.38	7.00e-30	126.00
IUUC-Oin-079669	Oryza indica	31.43	3.00e-53	203.00
IUUC-Olo-080755	Oryza longistaminata	31.86	2.00e-55	211.00
IUUC-Oni-082991	Oryza nivara	24.67	9.00e-31	129.00
IUUC-Opu-083233	Oryza punctata	29.17	2.00e-64	242.00
IUUC-Oru-085195	Oryza rufipogon	31.18	2.00e-56	214.00
IUUC-Ola-086648	Oryzias latipes	67.47	0.00e+00	2001.00
IUUC-Olu-087745	Ostreococcus lucimarinus	27.23	7.00e-55	209.00
IUUC-Oga-088578	Otolemur garnettii	75.15	0.00e+00	2507.00
IUUC-Oar-090247	Ovis aries	75.71	0.00e+00	2473.00
IUUC-Ptr-091266	Pan troglodytes	75.70	0.00e+00	2538.00
IUUC-Pan-092734	Papio anubis	76.00	0.00e+00	2622.00
IUUC-Psi-093408	Pelodiscus sinensis	60.03	0.00e+00	1753.00
IUUC-Pma-094427	Petromyzon marinus	64.16	9.00e-131	459.00
IUUC-Ppa-095793	Physcomitrella patens	29.56	7.00e-72	266.00
IUUC-Pfo-096515	Poecilia formosa	59.18	0.00e+00	992.00
IUUC-Pab-098402	Pongo abelii	76.13	0.00e+00	2616.00
IUUC-Pop-099185	Populus trichocarpa	31.89	2.00e-74	275.00
IUUC-Pca-101128	Procavia capensis	88.98	0.00e+00	1328.00
IUUC-Ppe-101849	Prunus persica	31.93	2.00e-75	278.00
IUUC-Pva-102512	Pteropus vampyrus	61.94	0.00e+00	1537.00
IUUC-Rno-106013	Rattus norvegicus	74.46	0.00e+00	2480.00
IUUC-Sha-107496	Sarcophilus harrisii	76.19	0.00e+00	2580.00
IUUC-Sit-110017	Setaria italica	31.56	6.00e-56	213.00
IUUC-Sly-111348	Solanum lycopersicum	31.07	1.00e-75	278.00
IUUC-Sar-113520	Sorex araneus	65.46	0.00e+00	1063.00
IUUC-Sbi-114195	Sorghum bicolor	29.67	2.00e-59	223.00
IUUC-Ssc-115461	Sus scrofa	72.72	0.00e+00	2461.00
IUUC-Tgu-116821	Taeniopygia guttata	76.40	0.00e+00	2585.00
IUUC-Tru-118186	Takifugu rubripes	55.89	0.00e+00	1556.00
IUUC-Tsy-119132	Tarsius syrichta	79.42	0.00e+00	1759.00
IUUC-Tni-120110	Tetraodon nigroviridis	55.82	0.00e+00	1543.00
IUUC-Tca-121615	Theobroma cacao	32.23	7.00e-61	229.00
IUUC-Tae-125478	Triticum aestivum	30.70	2.00e-73	271.00
IUUC-Tur-126809	Triticum urartu	30.69	2.00e-71	265.00
IUUC-Tbe-127479	Tupaia belangeri	72.43	0.00e+00	1117.00
IUUC-Ttr-129265	Tursiops truncatus	60.61	0.00e+00	1719.00
IUUC-Vpa-130160	Vicugna pacos	73.34	0.00e+00	2401.00
IUUC-Vvi-131362	Vitis vinifera	30.91	5.00e-74	273.00
IUUC-Xma-133633	Xiphophorus maculatus	57.78	0.00e+00	1575.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence